Strain Name:
C57BL/6J-MtgxR6239Btlr/Mmmh
Stock Number:
044363-MU
Citation ID:
RRID:MMRRC_044363-MU
Other Names:
R6239 (G1)
Major Collection:

Strain Information

Ttr
Name: transthyretin
Synonyms: prealbumin
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 22139
VEGA: 18
Homologene: 317
Pald1
Name: phosphatase domain containing, paladin 1
Synonyms: X99384, paladin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 27355
VEGA: 10
Homologene: 8453
Il4i1
Name: interleukin 4 induced 1
Synonyms: H-46, Fig1, Fig1-ps, H4, H-4, H46
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14204
Homologene: 22567
Dnmbp
Name: dynamin binding protein
Synonyms: Tuba, 2410003L07Rik, 2410003M15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 71972
Homologene: 9061
Ptpn3
Name: protein tyrosine phosphatase, non-receptor type 3
Synonyms: 9530011I20Rik, PTPCL, PTP-H1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 545622
HGNC: HGNC:9655
Homologene: 74451
Mast4
Name: microtubule associated serine/threonine kinase family member 4
Synonyms: 4930420O11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 328329
Homologene: 42094
Fus
Name: fused in sarcoma
Synonyms: translocated in liposarcoma, D430004D17Rik, hnRNP P2, Tls, pigpen, D930039C12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233908
HGNC: HGNC:4010
Homologene: 134091
Kmt2a
Name: lysine (K)-specific methyltransferase 2A
Synonyms: trithorax Drosophila, ALL-1, Mll1, Cxxc7, Mll, HTRX1, All1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214162
HGNC: HGNC:7132
Homologene: 4338
Hdac4
Name: histone deacetylase 4
Synonyms: 4932408F19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208727
Homologene: 55946
Gbf1
Name: golgi-specific brefeldin A-resistance factor 1
Synonyms: 1700083E03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107338
HGNC: HGNC:4181
Homologene: 37897
Snw1
Name: SNW domain containing 1
Synonyms: SKIP, NCoA-62, Skiip, SNW1, 2310008B08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 66354
VEGA: 12
Homologene: 56557
Rims2
Name: regulating synaptic membrane exocytosis 2
Synonyms: RIM2, Syt3-rs, 2810036I15Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 116838
VEGA: 15
Homologene: 81639
Prmt2
Name: protein arginine N-methyltransferase 2
Synonyms: Hrmt1l1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15468
HGNC: HGNC:5186
Homologene: 55587
Casz1
Name: castor zinc finger 1
Synonyms: D4Ertd432e, 2410019P08Rik, Cst, castor
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69743
Homologene: 9824
Creb3l1
Name: cAMP responsive element binding protein 3-like 1
Synonyms: BBF-2 (drosophila) homolog, Oasis
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26427
Homologene: 8058
Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Synonyms: cytochrome P450 subfamily I, polypeptide 1, P450-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13076
VEGA: 9
HGNC: HGNC:2595
Homologene: 68062
Trpv4
Name: transient receptor potential cation channel, subfamily V, member 4
Synonyms: VR-OAC, VRL-2, VROAC, Trp12, OTRPC4, 0610033B08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 63873
Homologene: 11003
Reg4
Name: regenerating islet-derived family, member 4
Synonyms: RELP, 2010002L15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67709
Homologene: 41671
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, Dnahc8, P1-Loop
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Osbpl7
Name: oxysterol binding protein-like 7
Synonyms: 4933437E18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71240
Homologene: 79672
Dcaf6
Name: DDB1 and CUL4 associated factor 6
Synonyms: NRIP, 1200006M05Rik, Iqwd1, PC326
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74106
Homologene: 10199
Acsl3
Name: acyl-CoA synthetase long-chain family member 3
Synonyms: C85929, Facl3, 2610510B12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74205
HGNC: HGNC:3570
Homologene: 3278
Zfp236
Name: zinc finger protein 236
Synonyms: LOC240456
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 329002
Homologene: 7198
Clmn
Name: calmin
Synonyms: 9330188N17Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 94040
VEGA: 12
Homologene: 11683
Cep152
Name: centrosomal protein 152
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99100
Homologene: 37159
Dennd2a
Name: DENN domain containing 2A
Synonyms: B930096L08Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 209773
Homologene: 35238
Styxl2
Name: serine/threonine/tyrosine interacting like 2
Synonyms: C130085G02Rik, Dusp27
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240892
Homologene: 18949
Pcdh12
Name: protocadherin 12
Synonyms: VE-cadherin-2, vascular endothelial cadherin-2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 53601
HGNC: HGNC:8657
Homologene: 9574
Cep295
Name: centrosomal protein 295
Synonyms: LOC382128, 5830418K08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319675
Homologene: 27936
Umod
Name: uromodulin
Synonyms: Tamm-Horsfall glycoprotein, uromucoid, urehr4, Urehd1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22242
Homologene: 2522
Trappc11
Name: trafficking protein particle complex 11
Synonyms: D030016E14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320714
Homologene: 11076
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Ptpro
Name: protein tyrosine phosphatase receptor type O
Synonyms: D28, PTPROt, Ptpn15, PTP-oc, GLEPP1, PTP-U2, PTP-BK, PTP-phi
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19277
HGNC: HGNC:9678
Homologene: 21564
Vwa3a
Name: von Willebrand factor A domain containing 3A
Synonyms: E030013G06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233813
Homologene: 18607
Vmn1r59
Name: vomeronasal 1 receptor 59
Synonyms: V1rd10
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404284
Homologene: 41799
Aox2
Name: aldehyde oxidase 2
Synonyms: Aox3l1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213043
Homologene: 84622
Gm19410
Name: predicted gene, 19410
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100502846
Homologene: 132117
Cspg4
Name: chondroitin sulfate proteoglycan 4
Synonyms: Cspg4a, AN2, 4732461B14Rik, NG2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 121021
VEGA: 9
HGNC: HGNC:2466
Homologene: 20445
Dnai4
Name: dynein axonemal intermediate chain 4
Synonyms: Wdr78
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242584
Homologene: 11702
Flg2
Name: filaggrin family member 2
Synonyms: EG229574
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229574
Homologene: 134146
Ift140
Name: intraflagellar transport 140
Synonyms: Tce5, Wdtc2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106633
Homologene: 40979
Slc13a3
Name: solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
Synonyms: NaDC-3, NaDC3, SDCT2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 114644
Homologene: 11266
Tmprss11f
Name: transmembrane protease, serine 11f
Synonyms: 4732406D01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243083
Homologene: 65356
Eml6
Name: echinoderm microtubule associated protein like 6
Synonyms: 2900083P10Rik, C230094A16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237711
Homologene: 104282
Apol7c
Name: apolipoprotein L 7c
Synonyms: 2210421G13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 108956
VEGA: 15
HGNC: HGNC:619
Homologene: 40940
Dennd2d
Name: DENN domain containing 2D
Synonyms: 2010308M01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72121
Homologene: 11776
Pabpc2
Name: poly(A) binding protein, cytoplasmic 2
Synonyms: Pabp2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 18459
Homologene: 56509
Dnase2a
Name: deoxyribonuclease II alpha
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13423
HGNC: HGNC:2960
Homologene: 68179
Itga2b
Name: integrin alpha 2b
Synonyms: GpIIb, alphaIIb, CD41, GP IIb, platelet glycoprotein IIb
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16399
HGNC: HGNC:6138
Homologene: 37304
Stpg4
Name: sperm tail PG rich repeat containing 4
Synonyms: 1700011E24Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 75467
Homologene: 18339
Ggt1
Name: gamma-glutamyltransferase 1
Synonyms: Ggtp, CD224, dwg, GGT
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14598
Homologene: 68450
Hhat
Name: hedgehog acyltransferase
Synonyms: Skn, 2810432O22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226861
Homologene: 41232
Sele
Name: selectin, endothelial cell
Synonyms: E-selectin, CD62E, Elam
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20339
Homologene: 389
Fam186b
Name: family with sequence similarity 186, member B
Synonyms: EG545136
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 545136
VEGA: 15
Homologene: 69502
Tmem222
Name: transmembrane protein 222
Synonyms: D4Ertd196e, 5730406H10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 52174
Homologene: 11999
Cyp2t4
Name: cytochrome P450, family 2, subfamily t, polypeptide 4
Synonyms: LOC384724
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384724
Homologene: 76639
B4galnt2
Name: beta-1,4-N-acetyl-galactosaminyl transferase 2
Synonyms: Dlb1, Dlb-1, Galgt2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14422
Homologene: 7329
Upk3a
Name: uroplakin 3A
Synonyms: 1110017C07Rik, Upk3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22270
VEGA: 15
Homologene: 5066
Slc11a1
Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
Synonyms: Nramp1, Lsh, Ity1, Ity, Nramp, host resistance locus Bcg/Ity/Lsh, Bcg, ity
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18173
Homologene: 73884
Lrit3
Name: leucine-rich repeat, immunoglobulin-like and transmembrane domains 3
Synonyms: LOC242235
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242235
Homologene: 19426
Castor1
Name: cytosolic arginine sensor for mTORC1 subunit 1
Synonyms: 2410008K03Rik, Gatsl3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71962
Homologene: 81920
6330408A02Rik
Name:
Type: Gene
Species: Mouse
Chromosome: 7
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 58,305,391 bp
  • G to A, chromosome 1 at 74,384,115 bp
  • T to A, chromosome 1 at 78,696,465 bp
  • T to C, chromosome 1 at 92,054,972 bp
  • A to G, chromosome 1 at 164,050,808 bp
  • A to T, chromosome 1 at 165,351,270 bp
  • A to T, chromosome 1 at 166,098,819 bp
  • A to T, chromosome 1 at 192,595,087 bp
  • T to C, chromosome 2 at 52,273,988 bp
  • A to G, chromosome 2 at 91,995,403 bp
  • A to T, chromosome 2 at 125,579,412 bp
  • T to C, chromosome 2 at 165,406,697 bp
  • A to T, chromosome 3 at 93,201,272 bp
  • A to G, chromosome 3 at 98,231,284 bp
  • T to A, chromosome 3 at 106,494,877 bp
  • A to T, chromosome 3 at 129,800,346 bp
  • C to A, chromosome 4 at 57,249,981 bp
  • A to C, chromosome 4 at 103,066,443 bp
  • T to A, chromosome 4 at 133,268,295 bp
  • A to G, chromosome 4 at 148,938,277 bp
  • G to T, chromosome 5 at 86,533,777 bp
  • G to A, chromosome 5 at 114,644,826 bp
  • A to G, chromosome 6 at 39,488,816 bp
  • A to T, chromosome 6 at 137,380,608 bp
  • G to A, chromosome 7 at 5,454,540 bp
  • C to A, chromosome 7 at 13,261,331 bp
  • A to T, chromosome 7 at 27,157,475 bp
  • A to G, chromosome 7 at 44,840,412 bp
  • C to T, chromosome 7 at 119,477,297 bp
  • A to T, chromosome 7 at 120,794,234 bp
  • C to T, chromosome 7 at 127,981,434 bp
  • A to T, chromosome 8 at 35,778,764 bp
  • G to A, chromosome 8 at 47,529,494 bp
  • G to T, chromosome 8 at 84,908,879 bp
  • T to C, chromosome 9 at 15,322,631 bp
  • T to C, chromosome 9 at 44,819,796 bp
  • A to G, chromosome 9 at 56,888,182 bp
  • T to A, chromosome 9 at 57,702,078 bp
  • T to C, chromosome 10 at 61,321,131 bp
  • A to G, chromosome 10 at 75,585,681 bp
  • A to T, chromosome 10 at 76,222,591 bp
  • A to G, chromosome 11 at 4,218,967 bp
  • T to C, chromosome 11 at 29,749,275 bp
  • C to T, chromosome 11 at 95,876,239 bp
  • G to A, chromosome 11 at 97,052,824 bp
  • C to T, chromosome 11 at 102,465,318 bp
  • A to T, chromosome 12 at 87,464,628 bp
  • A to T, chromosome 12 at 104,780,845 bp
  • A to G, chromosome 13 at 102,736,209 bp
  • A to T, chromosome 15 at 39,198,363 bp
  • T to C, chromosome 15 at 77,526,431 bp
  • T to A, chromosome 15 at 85,021,314 bp
  • T to C, chromosome 15 at 99,280,434 bp
  • T to C, chromosome 17 at 25,028,972 bp
  • C to T, chromosome 17 at 30,810,359 bp
  • T to C, chromosome 17 at 87,411,239 bp
  • T to C, chromosome 18 at 20,673,635 bp
  • T to C, chromosome 18 at 38,282,401 bp
  • T to A, chromosome 18 at 39,773,838 bp
  • G to T, chromosome 18 at 82,657,104 bp
  • C to T, chromosome 19 at 43,848,185 bp
  • A to G, chromosome 19 at 46,259,696 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6239 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044363-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.