Strain Name:
C57BL/6J-MtgxR6251Btlr
Stock Number:
044368-MU
Citation ID:
RRID:MMRRC_044368-MU
Other Names:
R6251 (G1)
Major Collection:

Gene Information

Wdr43
Name: WD repeat domain 43
Synonyms: 2610318G08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 72515
VEGA: 17
Homologene: 38810
Rap1a
Name: RAS-related protein 1a
Synonyms: Krev-1, Rap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 109905
HGNC: HGNC:9855
Homologene: 2162
Daam1
Name: dishevelled associated activator of morphogenesis 1
Synonyms: 1700066F09Rik, 2310028E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 208846
VEGA: 12
Homologene: 36635
Ccdc93
Name: coiled-coil domain containing 93
Synonyms: 4633402D15Rik, 9230102M16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 70829
Homologene: 10393
Zfr
Name: zinc finger RNA binding protein
Synonyms: C920030H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 22763
Homologene: 8009
Mdn1
Name: midasin AAA ATPase 1
Synonyms: LOC213784, D4Abb1e, 4833432B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 100019
Homologene: 39689
Stk39
Name: serine/threonine kinase 39
Synonyms: Rnl5, SPAK, RF005, DCHT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 53416
Homologene: 22739
Rnf114
Name: ring finger protein 114
Synonyms: Znf228, Zfp313, 1110008J21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 81018
Homologene: 10265
Cyb5r3
Name: cytochrome b5 reductase 3
Synonyms: 2500002N19Rik, Dia1, 0610016L08Rik, Dia-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 109754
HGNC: HGNC:2873
Homologene: 47921
Tctex1d2
Name: Tctex1 domain containing 2
Synonyms: 2410011K15Rik, 0610012D17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 66061
Homologene: 41625
Dnttip2
Name: deoxynucleotidyltransferase, terminal, interacting protein 2
Synonyms: 4930588M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 99480
Homologene: 124162
Cul5
Name: cullin 5
Synonyms: VACM-1, C330021I08Rik, 4921514I20Rik, 8430423K24Rik, C030032G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 75717
HGNC: HGNC:2556
Homologene: 2597
Nectin3
Name: nectin cell adhesion molecule 3
Synonyms: Pvrl3, 2610301B19Rik, 4921513D19Rik, 3000002N23Rik, nectin-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 58998
Homologene: 9162
Polr2b
Name: polymerase (RNA) II (DNA directed) polypeptide B
Synonyms: RPB2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231329
HGNC: HGNC:9188
Homologene: 722
Spink6
Name: serine peptidase inhibitor, Kazal type 6
Synonyms: EG433180
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 433180
VEGA: 18
Ms4a6d
Name: membrane-spanning 4-domains, subfamily A, member 6D
Synonyms: Ms4a11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 68774
Homologene: 130755
Notch1
Name: notch 1
Synonyms: lin-12, Tan1, N1, Motch A, 9930111A19Rik, Mis6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 18128
HGNC: HGNC:7881
Homologene: 32049
Pfkl
Name: phosphofructokinase, liver, B-type
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 18641
HGNC: HGNC:8876
Homologene: 55668
Extl3
Name: exostoses (multiple)-like 3
Synonyms: 2900009G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 54616
VEGA: 14
HGNC: HGNC:3518
Homologene: 1103
Kcnj14
Name: potassium inwardly-rectifying channel, subfamily J, member 14
Synonyms: A930026G01Rik, Kir2.4, IRK4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 211480
HGNC: HGNC:6260
Homologene: 27086
Cfap46
Name: cilia and flagella associated protein 46
Synonyms: 9330101J02Rik, Ttc40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 212124
Map3k5
Name: mitogen-activated protein kinase kinase kinase 5
Synonyms: ASK, ASK1, 7420452D20Rik, Mekk5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 26408
HGNC: HGNC:6857
Homologene: 38114
Kdm5d
Name: lysine (K)-specific demethylase 5D
Synonyms: Jarid1d, Smcy, HY
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
Alteration at locus: Chemically Induced
NCBI: 20592
Homologene: 55838
Pik3r4
Name: phosphoinositide-3-kinase regulatory subunit 4
Synonyms: p150, Vps15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 75669
HGNC: HGNC:8982
Homologene: 24678
Casq1
Name: calsequestrin 1
Synonyms: sCSQ, CSQ-1, CSQ, CSQ1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12372
HGNC: HGNC:1512
Homologene: 20329
Atp10b
Name: ATPase, class V, type 10B
Synonyms: 9030605H24Rik, 5930426O13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 319767
Homologene: 70969
Cacna1i
Name: calcium channel, voltage-dependent, alpha 1I subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 239556
HGNC: HGNC:1396
Homologene: 69331
Gpr87
Name: G protein-coupled receptor 87
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 84111
HGNC: HGNC:4538
Homologene: 13021
3100002H09Rik
Name: RIKEN cDNA 3100002H09 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
Gfra3
Name: glial cell line derived neurotrophic factor family receptor alpha 3
Synonyms: GFR alpha-3, GFRalpha3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 14587
VEGA: 18
HGNC: HGNC:4245
Homologene: 1146
Rtl1
Name: retrotransposon Gaglike 1
Synonyms: Mart1, Mor1, Mar
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 353326
VEGA: 12
Homologene: 120261
Tecpr1
Name: tectonin beta-propeller repeat containing 1
Synonyms: 2210010N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 70381
Homologene: 9120
Daglb
Name: diacylglycerol lipase, beta
Synonyms: E330036I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231871
Homologene: 34715
Arl6
Name: ADP-ribosylation factor-like 6
Synonyms: 2210411E14Rik, BBS3, 1110018H24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 56297
Homologene: 12960
Gm4778
Name: predicted gene 4778
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 212727
Arhgap26
Name: Rho GTPase activating protein 26
Synonyms: 4933432P15Rik, 2610010G17Rik, 1810044B20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 71302
Homologene: 36349
Evc
Name: EvC ciliary complex subunit 1
Synonyms: Ellis van Creveld gene syndrome
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 59056
HGNC: HGNC:3497
Homologene: 10949
Olfr382
Name: olfactory receptor 382
Synonyms: GA_x6K02T2P1NL-3676608-3675670, MOR135-14, MOR135-31_p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 258435
Homologene: 17252
Hivep3
Name: human immunodeficiency virus type I enhancer binding protein 3
Synonyms: Krc, E030045D18Rik, Schnurri-3, 2900056N03Rik, Shn3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 16656
Homologene: 7803
Tcte1
Name: t-complex-associated testis expressed 1
Synonyms: D17Sil1, Tcte-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 21645
VEGA: 17
Homologene: 8434
Olfr1200
Name: olfactory receptor 1200
Synonyms: GA_x6K02T2Q125-50243231-50242221, MOR225-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 257887
Homologene: 123770
Car15
Name: carbonic anhydrase 15
Synonyms: Cals2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 80733
Homologene: 113791
Asb3
Name: ankyrin repeat and SOCS box-containing 3
Synonyms: 2400011J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 65257
Homologene: 9391
Agmo
Name: alkylglycerol monooxygenase
Synonyms: A530016O06Rik, Tmem195
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 319660
Homologene: 45620
Trim63
Name: tripartite motif-containing 63
Synonyms: MuRF1, Rnf28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 433766
Homologene: 41878
Pigz
Name: phosphatidylinositol glycan anchor biosynthesis, class Z
Synonyms: F630022B06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 239827
Homologene: 130742
Olfr883
Name: olfactory receptor 883
Synonyms: MOR162-6, GA_x6K02T2PVTD-31705144-31706073
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258414
Homologene: 86689
Epn1
Name: epsin 1
Synonyms: Ibp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 13854
Homologene: 32172
Tmc7
Name: transmembrane channel-like gene family 7
Synonyms: C630024K23Rik, 1700030H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 209760
Homologene: 36424
Marc1
Name: mitochondrial amidoxime reducing component 1
Synonyms: 1300013F15Rik, Mosc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 66112
Homologene: 129604
Serpinb5
Name: serine (or cysteine) peptidase inhibitor, clade B, member 5
Synonyms: ovalbumin, Spi7, Maspin, 1110036M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 20724
HGNC: HGNC:8949
Homologene: 20580
AF067061
Name: cDNA sequence AF067061
Synonyms: clone L4 variable group of 2-cell-stage gene family, clone L8 variable group of 2-cell-stage gene family
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 236546
Dazap2
Name: DAZ associated protein 2
Synonyms: Prtb, gt6-12, Brbp, Gcap28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 23994
VEGA: 15
HGNC: HGNC:2684
Homologene: 8038
Ciart
Name: circadian associated repressor of transcription
Synonyms: Gm129, LOC229599
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229599
Homologene: 79670
Olfr1537
Name: olfactory receptor 1537
Synonyms: MOR171-41P, Olfr1537-ps1, MOR171-32P, K4, Olfr144, GA_x6K02T2PVTD-32935684-32934749, MOR171-32P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 257959
VEGA: 9
Homologene: 110610
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 106,875,065 bp
  • C to T, chromosome 1 at 121,434,540 bp
  • T to A, chromosome 1 at 172,216,840 bp
  • G to A, chromosome 1 at 184,795,451 bp
  • C to A, chromosome 2 at 26,474,170 bp
  • A to T, chromosome 2 at 68,307,039 bp
  • T to C, chromosome 2 at 88,768,288 bp
  • T to C, chromosome 2 at 167,514,729 bp
  • A to T, chromosome 3 at 59,179,107 bp
  • G to T, chromosome 3 at 94,265,901 bp
  • G to A, chromosome 3 at 95,881,011 bp
  • A to T, chromosome 3 at 105,731,995 bp
  • A to T, chromosome 3 at 122,275,256 bp
  • A to G, chromosome 4 at 32,748,590 bp
  • C to A, chromosome 4 at 120,094,940 bp
  • A to G, chromosome 4 at 124,610,652 bp
  • A to T, chromosome 4 at 134,323,226 bp
  • T to C, chromosome 5 at 37,300,499 bp
  • G to A, chromosome 5 at 77,348,294 bp
  • T to A, chromosome 5 at 143,489,934 bp
  • C to A, chromosome 5 at 144,198,576 bp
  • G to T, chromosome 7 at 5,095,926 bp
  • G to T, chromosome 7 at 5,095,936 bp
  • T to A, chromosome 7 at 45,818,016 bp
  • T to C, chromosome 7 at 118,561,038 bp
  • CCTTCTTCT to CCTTCT, chromosome 7 at 139,638,900 bp
  • G to GGGATTGC, chromosome 9 at 38,026,537 bp
  • TGTTT to TGTTTGCAGTTT, chromosome 9 at 38,026,545 bp
  • GTTT to GTTTGCTTTTT, chromosome 9 at 38,026,546 bp
  • TT to TTGCTGTGT, chromosome 9 at 38,026,548 bp
  • T to A, chromosome 9 at 39,238,218 bp
  • A to T, chromosome 9 at 53,646,794 bp
  • T to C, chromosome 9 at 105,654,048 bp
  • T to A, chromosome 10 at 20,138,260 bp
  • C to T, chromosome 10 at 77,989,565 bp
  • G to A, chromosome 11 at 31,055,559 bp
  • A to T, chromosome 11 at 43,235,746 bp
  • A to G, chromosome 11 at 73,516,708 bp
  • A to G, chromosome 12 at 37,252,539 bp
  • G to A, chromosome 12 at 71,988,949 bp
  • G to T, chromosome 12 at 109,593,649 bp
  • T to C, chromosome 13 at 120,263,371 bp
  • T to C, chromosome 14 at 65,076,926 bp
  • T to C, chromosome 15 at 12,160,591 bp
  • T to C, chromosome 15 at 80,336,682 bp
  • T to C, chromosome 15 at 83,154,716 bp
  • T to G, chromosome 15 at 100,616,983 bp
  • A to T, chromosome 16 at 17,837,363 bp
  • T to C, chromosome 16 at 31,945,606 bp
  • T to A, chromosome 16 at 32,426,909 bp
  • A to T, chromosome 16 at 46,395,150 bp
  • T to C, chromosome 16 at 59,618,806 bp
  • A to T, chromosome 17 at 45,535,159 bp
  • G to A, chromosome 17 at 71,650,053 bp
  • TGCGC to TGC, chromosome 18 at 34,695,811 bp
  • A to T, chromosome 18 at 39,357,827 bp
  • T to C, chromosome 18 at 44,074,431 bp
  • A to T, chromosome 19 at 11,587,140 bp
  • T to C, chromosome Y at 921,693 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6251 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044368-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.