Strain Name:
C57BL/6J-MtgxR6284Btlr/Mmmh
Stock Number:
044454-MU
Citation ID:
RRID:MMRRC_044454-MU
Other Names:
R6284 (G1)
Major Collection:

Strain Information

Dst
Name: dystonin
Synonyms: Macf2, A830042E19Rik, Bpag1, Bpag, bullous pemphigoid antigen 1, nmf203, athetoid, nmf339, BPAG1, BPAG1-n, 2310001O04Rik, bullous pemphigoid antigen 1, ah
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Slc29a1
Name: solute carrier family 29 (nucleoside transporters), member 1
Synonyms: ENT1, 1200014D21Rik, NBMPR-sensitive equilibrative nucleoside transporter
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 63959
Homologene: 37985
Bclaf1
Name: BCL2-associated transcription factor 1
Synonyms: 2810454G14Rik, 2610102K23Rik, 5730534O06Rik, 2700025J07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72567
Homologene: 8832
Ppa2
Name: pyrophosphatase (inorganic) 2
Synonyms: Sid6306, 1110013G13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74776
Homologene: 134244
Tnrc6a
Name: trinucleotide repeat containing 6a
Synonyms: CAGH26, D130023A07Rik, 3110054G10Rik, Tnrc6, 2010321I05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233833
Homologene: 41399
Kazn
Name: kazrin, periplakin interacting protein
Synonyms: 2310007B04Rik, 9030409G11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71529
Homologene: 16235
Adgrl2
Name: adhesion G protein-coupled receptor L2
Synonyms: Lphh1, Lec1, Lphn2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99633
Homologene: 22712
Braf
Name: Braf transforming gene
Synonyms: Braf2, Braf-2, 9930012E13Rik, D6Ertd631e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 109880
HGNC: HGNC:1097
Homologene: 3197
Akap1
Name: A kinase anchor protein 1
Synonyms: AKAP121, S-AKAP84, AKAP84, DAKAP1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11640
HGNC: HGNC:367
Homologene: 31165
Camsap2
Name: calmodulin regulated spectrin-associated protein family, member 2
Synonyms: Camsap1l1, 1600013L13Rik, 4930541M15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67886
Homologene: 18927
Cenpf
Name: centromere protein F
Synonyms: mitosin, Lek1, 6530404A22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108000
HGNC: HGNC:1857
Homologene: 22969
Elp1
Name: elongator complex protein 1
Synonyms: C78473, Ikbkap, IKAP, 3110040G09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230233
HGNC: HGNC:5959
Homologene: 2699
Nop14
Name: NOP14 nucleolar protein
Synonyms: Nol14, 2610033H07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75416
Homologene: 41773
Cul5
Name: cullin 5
Synonyms: VACM-1, C330021I08Rik, 4921514I20Rik, C030032G03Rik, 8430423K24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75717
HGNC: HGNC:2556
Homologene: 2597
Atp5f1a
Name: ATP synthase F1 subunit alpha
Synonyms: Mom2, D18Ertd206e, Atp5a1, Atpm
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 11946
HGNC: HGNC:823
Homologene: 2985
Oprl1
Name: opioid receptor-like 1
Synonyms: LC132, NOP, ORL1, MOR-C, XOR1, N/OFQ receptor, nociceptin/ orphaninFQ receptor, morc
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18389
HGNC: HGNC:8155
Homologene: 22609
Bod1l
Name: biorientation of chromosomes in cell division 1-like
Synonyms: A230054D04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 665775
Homologene: 45109
Tubb4a
Name: tubulin, beta 4A class IVA
Synonyms: Tubb, Tubb4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22153
VEGA: 17
Homologene: 55952
Glb1l2
Name: galactosidase, beta 1-like 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244757
Homologene: 71790
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Lyar
Name: Ly1 antibody reactive clone
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17089
Homologene: 41200
Trap1
Name: TNF receptor-associated protein 1
Synonyms: 2410002K23Rik, HSP75
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 68015
Homologene: 9457
Mis18bp1
Name: MIS18 binding protein 1
Synonyms: C79407
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217653
Homologene: 10147
Pnpla7
Name: patatin-like phospholipase domain containing 7
Synonyms: NRE, E430013P11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241274
Homologene: 62431
Peak1
Name: pseudopodium-enriched atypical kinase 1
Synonyms: 1110049L02Rik, C230081A13Rik, NKF3 kinase family member
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244895
Homologene: 18259
Marchf11
Name: membrane associated ring-CH-type finger 11
Synonyms: March11
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 211147
Homologene: 45584
Anpep
Name: alanyl aminopeptidase, membrane
Synonyms: Apn, aminopeptidase N, Cd13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16790
HGNC: HGNC:500
Homologene: 68163
Trpc6
Name: transient receptor potential cation channel, subfamily C, member 6
Synonyms: Trrp6, mtrp6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22068
VEGA: 9
Homologene: 37944
Fhip1a
Name: FHF complex subunit HOOK interacting protein 1A
Synonyms: Fam160a1, 9930021J17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229488
Homologene: 85149
Cfap74
Name: cilia and flagella associated protein 74
Synonyms: 2010015L04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 544678
Homologene: 129584
Stxbp5
Name: syntaxin binding protein 5 (tomosyn)
Synonyms: 4930565N16Rik, LGL3, 0710001E20Rik, tomosyn 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 78808
Homologene: 16402
Plcb2
Name: phospholipase C, beta 2
Synonyms: B230205M18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18796
HGNC: HGNC:9055
Homologene: 20957
Col6a6
Name: collagen, type VI, alpha 6
Synonyms: E330026B02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245026
Homologene: 18260
Ttc21a
Name: tetratricopeptide repeat domain 21A
Synonyms: 4921538N17Rik, Thm2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74052
Homologene: 14728
Atp6v0d2
Name: ATPase, H+ transporting, lysosomal V0 subunit D2
Synonyms: 1620401A02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242341
Homologene: 72090
Dthd1
Name: death domain containing 1
Synonyms: Gm17384
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100322896
Homologene: 123510
Zfp93
Name: zinc finger protein 93
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22755
Homologene: 117959
Myom1
Name: myomesin 1
Synonyms: skelemin, D430047A17Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17929
VEGA: 17
HGNC: HGNC:7613
Homologene: 31196
Cdh26
Name: cadherin-like 26
Synonyms: LOC381409
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381409
Homologene: 18643
Tlr1
Name: toll-like receptor 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21897
Homologene: 20694
Zfp938
Name: zinc finger protein 938
Synonyms: B230315N10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237411
Homologene: 135924
Pacsin1
Name: protein kinase C and casein kinase substrate in neurons 1
Synonyms: Syndapin I, A830061D09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 23969
HGNC: HGNC:8570
Homologene: 22674
Pnliprp1
Name: pancreatic lipase related protein 1
Synonyms: Plrp1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18946
VEGA: 19
HGNC: HGNC:9156
Homologene: 21253
Kcnj13
Name: potassium inwardly-rectifying channel, subfamily J, member 13
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100040591
HGNC: HGNC:6259
Homologene: 55638
Ube2z
Name: ubiquitin-conjugating enzyme E2Z
Synonyms: C030047H17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268470
Homologene: 11319
Erich2
Name: glutamate rich 2
Synonyms: 4933404M02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66748
Homologene: 75226
Zp1
Name: zona pellucida glycoprotein 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 22786
Homologene: 33483
Abca7
Name: ATP-binding cassette, sub-family A member 7
Synonyms: Abc51
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 27403
HGNC: HGNC:37
Homologene: 22783
Clstn2
Name: calsyntenin 2
Synonyms: Cst-2, CSTN2, CS2, 2900042C18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 64085
Homologene: 49698
Slco1a7
Name: solute carrier organic anion transporter family, member 1a7
Synonyms: Gm5724
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 435927
Myzap
Name: myocardial zonula adherens protein
Synonyms: Myozap, Gcom1, Grinl1a7
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102371
Homologene: 134156
Fam162b
Name: family with sequence similarity 162, member B
Synonyms: 9430073N08Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77296
VEGA: 10
Homologene: 82459
Rps6kb2
Name: ribosomal protein S6 kinase, polypeptide 2
Synonyms: S6K2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 58988
Homologene: 68374
Vmn1r211
Name: vomeronasal 1 receptor 211
Synonyms: V1rh20
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171277
Homologene: 110880
Taldo1
Name: transaldolase 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 21351
Homologene: 4916
Ccdc24
Name: coiled-coil domain containing 24
Synonyms: LOC381546
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381546
Lce1b
Name: late cornified envelope 1B
Synonyms: 1110029C13Rik, Sprrl5
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68720
Rrp7a
Name: ribosomal RNA processing 7 homolog A
Synonyms: 1110014J01Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 74778
Homologene: 41060
Zfp1002
Name: zinc finger protein 1002
Synonyms: Gm21994
Type: Gene
Species: Mouse
Chromosome: 2
0610030E20Rik
Name: RIKEN cDNA 0610030E20 gene
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68364
Homologene: 19243
Atp5me
Name: ATP synthase membrane subunit e
Synonyms: 2610008D24Rik, Lfm1, Atp5k
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11958
HGNC: HGNC:846
Homologene: 137205
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 34,229,085 bp
  • A to T, chromosome 1 at 87,386,886 bp
  • A to G, chromosome 1 at 136,304,437 bp
  • A to G, chromosome 1 at 189,652,742 bp
  • C to A, chromosome 2 at 25,016,618 bp
  • T to A, chromosome 2 at 70,539,684 bp
  • C to T, chromosome 2 at 118,717,301 bp
  • T to A, chromosome 2 at 150,255,278 bp
  • G to C, chromosome 2 at 178,449,884 bp
  • T to A, chromosome 2 at 181,717,991 bp
  • G to A, chromosome 3 at 85,672,688 bp
  • A to C, chromosome 3 at 92,656,104 bp
  • G to A, chromosome 3 at 133,370,417 bp
  • A to T, chromosome 3 at 148,826,507 bp
  • T to A, chromosome 4 at 19,922,605 bp
  • A to T, chromosome 4 at 56,762,281 bp
  • A to T, chromosome 4 at 117,869,653 bp
  • G to A, chromosome 4 at 142,117,197 bp
  • T to C, chromosome 4 at 155,451,796 bp
  • C to T, chromosome 5 at 34,641,491 bp
  • T to A, chromosome 5 at 38,225,995 bp
  • A to G, chromosome 5 at 41,818,787 bp
  • A to G, chromosome 5 at 62,814,041 bp
  • T to C, chromosome 5 at 64,927,099 bp
  • T to C, chromosome 5 at 108,434,059 bp
  • A to G, chromosome 6 at 39,688,282 bp
  • G to T, chromosome 6 at 72,347,454 bp
  • T to C, chromosome 6 at 141,725,393 bp
  • T to A, chromosome 7 at 24,275,629 bp
  • T to A, chromosome 7 at 79,825,802 bp
  • T to C, chromosome 7 at 123,171,335 bp
  • T to A, chromosome 7 at 141,398,583 bp
  • A to G, chromosome 9 at 8,643,600 bp
  • A to T, chromosome 9 at 26,767,448 bp
  • T to A, chromosome 9 at 53,445,376 bp
  • G to A, chromosome 9 at 53,623,735 bp
  • A to G, chromosome 9 at 56,260,296 bp
  • T to C, chromosome 9 at 71,558,925 bp
  • C to T, chromosome 9 at 97,454,674 bp
  • A to T, chromosome 9 at 105,727,227 bp
  • A to G, chromosome 9 at 119,943,962 bp
  • A to C, chromosome 10 at 9,767,179 bp
  • C to A, chromosome 10 at 9,767,187 bp
  • T to G, chromosome 10 at 20,322,160 bp
  • T to C, chromosome 10 at 51,585,502 bp
  • G to A, chromosome 10 at 80,004,410 bp
  • A to T, chromosome 10 at 82,227,566 bp
  • T to C, chromosome 11 at 88,844,568 bp
  • A to G, chromosome 11 at 96,050,407 bp
  • A to G, chromosome 12 at 65,138,787 bp
  • A to G, chromosome 13 at 22,852,084 bp
  • G to A, chromosome 15 at 26,409,346 bp
  • A to T, chromosome 15 at 83,121,860 bp
  • A to G, chromosome 16 at 4,060,809 bp
  • T to C, chromosome 17 at 27,708,504 bp
  • A to G, chromosome 17 at 45,589,921 bp
  • A to G, chromosome 17 at 57,080,833 bp
  • T to A, chromosome 17 at 67,810,096 bp
  • T to A, chromosome 17 at 71,022,892 bp
  • T to A, chromosome 18 at 77,778,468 bp
  • G to T, chromosome 19 at 4,161,187 bp
  • A to T, chromosome 19 at 10,916,503 bp
  • T to A, chromosome 19 at 58,734,984 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6284 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044454-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.