Strain Name:
C57BL/6J-MtgxR6391Btlr/Mmmh
Stock Number:
044540-MU
Citation ID:
RRID:MMRRC_044540-MU
Other Names:
R6391 (G1)
Major Collection:

Strain Information

Plin2
Name: perilipin 2
Synonyms: adipophilin, ADPH, Adrp, Adfp
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11520
HGNC: HGNC:248
Homologene: 872
Map2k6
Name: mitogen-activated protein kinase kinase 6
Synonyms: MAP kinase kinase 6, SAPKK3, Prkmk6, MKK6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 26399
HGNC: HGNC:6846
Homologene: 55686
Etaa1
Name: Ewing tumor-associated antigen 1
Synonyms: 5730466H23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68145
Homologene: 10369
Drosha
Name: drosha, ribonuclease type III
Synonyms: Etohi2, Rnasen, 1110013A17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14000
Homologene: 8293
Plk4
Name: polo like kinase 4
Synonyms: Stk18, Sak
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20873
Homologene: 7962
Dip2b
Name: disco interacting protein 2 homolog B
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239667
Homologene: 72227
Eed
Name: embryonic ectoderm development
Synonyms: l7Rn5, l(7)5Rn
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13626
HGNC: HGNC:3188
Homologene: 2814
Cct8
Name: chaperonin containing TCP1 subunit 8
Synonyms: Tcpq, Cctq
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12469
HGNC: HGNC:1623
Homologene: 4802
Slx4ip
Name: SLX4 interacting protein
Synonyms: 2210009G21Rik, 2410004I22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74243
Homologene: 49913
Grm4
Name: glutamate receptor, metabotropic 4
Synonyms: Gprc1d, mGluR4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268934
HGNC: HGNC:4596
Homologene: 20230
Dmbt1
Name: deleted in malignant brain tumors 1
Synonyms: Crpd, vomeroglandin, gp300, CRP-[a], MUCLIN, ebnerin, hensin, CRP-[b]
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12945
HGNC: HGNC:2926
Homologene: 68990
Lpin1
Name: lipin 1
Synonyms: Lipin1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 14245
VEGA: 12
Homologene: 9266
Fat1
Name: FAT atypical cadherin 1
Synonyms: mFat1, 2310038E12Rik, Fath
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Bcl7b
Name: B cell CLL/lymphoma 7B
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12054
HGNC: HGNC:1005
Homologene: 1290
Pigk
Name: phosphatidylinositol glycan anchor biosynthesis, class K
Synonyms: 3000001O05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329777
HGNC: HGNC:8965
Homologene: 4002
Dock8
Name: dedicator of cytokinesis 8
Synonyms: 1200017A24Rik, 5830472H07Rik, A130095G14Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 76088
VEGA: 19
Homologene: 52414
Piezo2
Name: piezo-type mechanosensitive ion channel component 2
Synonyms: Piezo2, Fam38b, 9030411M15Rik, Fam38b2, 9430028L06Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 667742
Homologene: 49695
F5
Name: coagulation factor V
Synonyms: Cf-5, Cf5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14067
HGNC: HGNC:3542
Homologene: 104
Or51a6
Name: olfactory receptor family 51 subfamily A member 6
Synonyms: GA_x6K02T2PBJ9-5666843-5665908, Olfr575, MOR8-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259118
Homologene: 122786
Gm7361
Name: predicted gene 7361
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 664837
Homologene: 69402
Wdr17
Name: WD repeat domain 17
Synonyms: 3010002I12Rik, B230207L18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244484
Homologene: 12460
Gm11639
Name: predicted gene 11639
Synonyms: Gm11639, Efcab15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 105242472
Vmn2r26
Name: vomeronasal 2, receptor 26
Synonyms: V2r1b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56552
Homologene: 135915
Unc79
Name: unc-79 homolog
Synonyms: 9030205A07Rik, Mlca3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217843
Homologene: 41397
Krt13
Name: keratin 13
Synonyms: Krt1-13, K13, Krt-1.13
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16663
HGNC: HGNC:6415
Homologene: 40740
Or4c120
Name: olfactory receptor family 4 subfamily C member 120
Synonyms: Olfr1225, MOR233-11, GA_x6K02T2Q125-50650037-50649102
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258893
Homologene: 17427
Zfp959
Name: zinc finger protein 959
Synonyms: BC011426
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224893
Homologene: 138295
Cnga1
Name: cyclic nucleotide gated channel alpha 1
Synonyms: Cncg
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12788
HGNC: HGNC:2148
Homologene: 55432
Pdzrn4
Name: PDZ domain containing RING finger 4
Synonyms: 1110017D07Rik, LNX4, SAMCAP3L
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239618
VEGA: 15
Homologene: 85433
Prb1a
Name: proline-rich protein BstNI subfamily 1A
Synonyms: Prb1, proline-rich proteoglycan 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381833
Vmn2r106
Name: vomeronasal 2, receptor 106
Synonyms: EG224576
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224576
Homologene: 135824
Fmo4
Name: flavin containing monooxygenase 4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226564
HGNC: HGNC:3772
Homologene: 68219
Ly9
Name: lymphocyte antigen 9
Synonyms: SLAMF3, CD229, Lgp100, T100
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17085
HGNC: HGNC:6730
Homologene: 1759
Sh3bp2
Name: SH3-domain binding protein 2
Synonyms: 3BP2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 24055
Homologene: 2276
Cst13
Name: cystatin 13
Synonyms: cystatin T, 1700006C19Rik, Cymg1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69294
Homologene: 41707
Cyp8b1
Name: cytochrome P450, family 8, subfamily b, polypeptide 1
Synonyms: sterol 12-alpha-hydrolase
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13124
HGNC: HGNC:2653
Homologene: 3233
Mylk2
Name: myosin, light polypeptide kinase 2, skeletal muscle
Synonyms: 9830004H17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228785
Homologene: 13223
Tmtc2
Name: transmembrane and tetratricopeptide repeat containing 2
Synonyms: D330034A10Rik, 8430438D04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 278279
Homologene: 25521
Pcdha9
Name: protocadherin alpha 9
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 192161
HGNC: HGNC:8664
Homologene: 130700
Or4c3
Name: olfactory receptor family 4 subfamily C member 3
Synonyms: MOR236-1, GA_x6K02T2Q125-51454183-51453257, Olfr1264
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258206
Homologene: 66365
Pom121l12
Name: POM121 membrane glycoprotein-like 12
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 432536
Homologene: 136280
Krtap3-3
Name: keratin associated protein 3-3
Synonyms: KRTAP3.3, KAP3.3, 2310020D06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66380
Homologene: 88905
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 162,793,969 bp
  • A to T, chromosome 1 at 164,193,493 bp
  • A to G, chromosome 1 at 171,601,008 bp
  • T to A, chromosome 2 at 89,170,598 bp
  • A to G, chromosome 2 at 90,021,631 bp
  • T to A, chromosome 2 at 137,046,749 bp
  • T to C, chromosome 2 at 148,828,191 bp
  • T to C, chromosome 2 at 152,917,395 bp
  • T to A, chromosome 3 at 40,808,973 bp
  • A to G, chromosome 3 at 152,740,849 bp
  • T to C, chromosome 4 at 86,661,999 bp
  • A to G, chromosome 5 at 26,258,962 bp
  • G to A, chromosome 5 at 34,561,603 bp
  • A to G, chromosome 5 at 72,612,359 bp
  • G to T, chromosome 5 at 135,180,025 bp
  • T to C, chromosome 6 at 124,061,389 bp
  • T to C, chromosome 6 at 132,207,176 bp
  • A to G, chromosome 7 at 89,976,941 bp
  • T to A, chromosome 7 at 102,955,415 bp
  • T to C, chromosome 7 at 131,058,254 bp
  • T to C, chromosome 8 at 44,952,342 bp
  • A to T, chromosome 8 at 54,661,460 bp
  • G to T, chromosome 9 at 121,915,798 bp
  • A to T, chromosome 10 at 105,573,690 bp
  • A to T, chromosome 11 at 14,599,489 bp
  • A to C, chromosome 11 at 17,946,833 bp
  • T to C, chromosome 11 at 99,550,664 bp
  • T to A, chromosome 11 at 100,119,376 bp
  • T to C, chromosome 11 at 104,994,317 bp
  • T to C, chromosome 11 at 110,490,877 bp
  • T to C, chromosome 12 at 16,564,553 bp
  • A to G, chromosome 12 at 103,021,010 bp
  • T to A, chromosome 15 at 12,889,717 bp
  • A to T, chromosome 15 at 92,680,537 bp
  • T to C, chromosome 15 at 100,151,276 bp
  • A to T, chromosome 16 at 87,487,678 bp
  • C to T, chromosome 17 at 20,268,463 bp
  • A to G, chromosome 17 at 27,435,320 bp
  • T to C, chromosome 17 at 55,895,854 bp
  • G to A, chromosome 18 at 36,997,919 bp
  • A to G, chromosome 18 at 63,106,293 bp
  • A to T, chromosome 19 at 25,095,550 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6391 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044540-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.