Strain Name:
C57BL/6J-MtgxR6397Btlr/Mmmh
Stock Number:
044545-MU
Citation ID:
RRID:MMRRC_044545-MU
Other Names:
R6397 (G1)
Major Collection:

Strain Information

Cdh1
Name: cadherin 1
Synonyms: uvomorulin, E-cad, L-CAM, E-cadherin, Ecad, UM
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12550
HGNC: HGNC:1748
Homologene: 20917
Tlr9
Name: toll-like receptor 9
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 81897
Homologene: 68126
Nrxn2
Name: neurexin II
Synonyms: neurexin II beta, 6430591O13Rik, neurexin II alpha
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18190
HGNC: HGNC:8009
Homologene: 86984
Ifi203
Name: interferon activated gene 203
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15950
HGNC: HGNC:5395
Homologene: 115929
Stau1
Name: staufen double-stranded RNA binding protein 1
Synonyms: 5830401L18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20853
Homologene: 3384
Map4
Name: microtubule-associated protein 4
Synonyms: Mtap4, MAP 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17758
HGNC: HGNC:6862
Homologene: 1780
Zc3h7b
Name: zinc finger CCCH type containing 7B
Synonyms: Scrg3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20286
VEGA: 15
Homologene: 9735
Yap1
Name: yes-associated protein 1
Synonyms: yorkie, Yki, Yap
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22601
Homologene: 4452
Dmbt1
Name: deleted in malignant brain tumors 1
Synonyms: MUCLIN, gp300, ebnerin, hensin, vomeroglandin, CRP-[b], CRP-[a], Crpd
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12945
HGNC: HGNC:2926
Homologene: 68990
Tuba1c
Name: tubulin, alpha 1C
Synonyms: M[a]6, Tuba6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22146
VEGA: 15
Homologene: 69045
Kazald1
Name: Kazal-type serine peptidase inhibitor domain 1
Synonyms: Bono1, Igfbp-rp10
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107250
Homologene: 12799
Sptbn2
Name: spectrin beta, non-erythrocytic 2
Synonyms: Spnb3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20743
VEGA: 19
Homologene: 48482
Zftraf1
Name: zinc finger TRAF type containing 1
Synonyms: Cyhr1, 1110031M01Rik, Chrp
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 54151
Homologene: 32791
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: LOC224126, 2210407G14Rik, E530005C20Rik, Hapip
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Nlgn1
Name: neuroligin 1
Synonyms: NL1, 6330415N05Rik, Nlg1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 192167
Homologene: 56690
Snx7
Name: sorting nexin 7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76561
Homologene: 22941
Nfatc1
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1
Synonyms: NFAT2, NFATc, NF-ATc, 2210017P03Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 18018
VEGA: 18
HGNC: HGNC:7775
Homologene: 32336
Pcdhb5
Name: protocadherin beta 5
Synonyms: PcdhbE, Pcdhb4A
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93876
HGNC: HGNC:8689
Homologene: 75103
Phf8l
Name: PHD finger protein 8 like
Synonyms: 4921501E09Rik, Phf8-ps
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74042
VEGA: 17
Homologene: 66275
Arfgef3
Name: ARFGEF family member 3
Synonyms: D10Bwg1379e, BIG3, B930094H20Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215821
VEGA: 10
Homologene: 41366
Pcdhb8
Name: protocadherin beta 8
Synonyms: PcdhbH, Pcdhb5C
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93879
HGNC: HGNC:8690
Homologene: 89038
Msrb3
Name: methionine sulfoxide reductase B3
Synonyms: D430026P16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320183
Homologene: 71327
Gm3486
Name: predicted gene 3486
Type: Gene
Species: Mouse
Chromosome: 14
Oprk1
Name: opioid receptor, kappa 1
Synonyms: KOR-1, R21, Oprk2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18387
HGNC: HGNC:8154
Homologene: 20253
Tchh
Name: trichohyalin
Synonyms: AHF, Thh
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99681
Homologene: 136273
Vmn2r86
Name: vomeronasal 2, receptor 86
Synonyms: EG625109
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 625109
Homologene: 129606
Or2ab1
Name: olfactory receptor family 2 subfamily AB member 1
Synonyms: GA_x6K02T2NKPP-822947-822000, MOR102-2, Olfr324
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 257892
Homologene: 79395
Vps45
Name: vacuolar protein sorting 45
Synonyms: mVps45
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22365
Homologene: 5250
Sall2
Name: spalt like transcription factor 2
Synonyms: Msal-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50524
Homologene: 9269
Dipk1a
Name: divergent protein kinase domain 1A
Synonyms: Fam69a, 2900024C23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67266
Homologene: 12104
Pstpip2
Name: proline-serine-threonine phosphatase-interacting protein 2
Synonyms: cmo
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 19201
VEGA: 18
HGNC: HGNC:9581
Homologene: 69150
Dnase1l1
Name: deoxyribonuclease 1-like 1
Synonyms: Dnase1ll, G4.8, Dnl1ll, 2310005K03Rik
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 69537
HGNC: HGNC:2957
Homologene: 4896
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 5,598,748 bp
  • C to A, chromosome 1 at 173,927,204 bp
  • A to G, chromosome 2 at 166,951,007 bp
  • T to A, chromosome 3 at 25,433,663 bp
  • A to G, chromosome 3 at 93,445,866 bp
  • A to G, chromosome 3 at 96,042,852 bp
  • A to G, chromosome 3 at 117,846,623 bp
  • T to A, chromosome 5 at 107,911,638 bp
  • T to C, chromosome 7 at 131,103,578 bp
  • T to C, chromosome 8 at 106,604,290 bp
  • T to C, chromosome 9 at 8,001,466 bp
  • A to G, chromosome 9 at 106,225,106 bp
  • T to A, chromosome 9 at 110,027,716 bp
  • G to T, chromosome 10 at 18,607,665 bp
  • G to A, chromosome 10 at 120,791,451 bp
  • A to T, chromosome 10 at 130,446,262 bp
  • A to G, chromosome 11 at 58,597,512 bp
  • G to A, chromosome 14 at 41,486,386 bp
  • T to A, chromosome 14 at 52,315,153 bp
  • A to T, chromosome 15 at 76,648,191 bp
  • A to T, chromosome 15 at 81,792,854 bp
  • G to A, chromosome 15 at 99,037,857 bp
  • A to G, chromosome 16 at 33,992,985 bp
  • T to C, chromosome 17 at 33,066,245 bp
  • T to A, chromosome 18 at 37,321,505 bp
  • C to T, chromosome 18 at 37,355,463 bp
  • T to G, chromosome 18 at 77,873,379 bp
  • C to T, chromosome 18 at 80,635,941 bp
  • A to T, chromosome 19 at 4,742,418 bp
  • A to G, chromosome 19 at 6,532,122 bp
  • A to G, chromosome 19 at 45,076,878 bp
  • C to T, chromosome X at 74,277,038 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6397 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044545-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.