Strain Name:
C57BL/6J-MtgxR6420Btlr/Mmmh
Stock Number:
044562-MU
Citation ID:
RRID:MMRRC_044562-MU
Other Names:
R6420 (G1)
Major Collection:

Strain Information

Tnrc6a
Name: trinucleotide repeat containing 6a
Synonyms: CAGH26, Tnrc6, D130023A07Rik, 3110054G10Rik, 2010321I05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233833
Homologene: 41399
Hdlbp
Name: high density lipoprotein (HDL) binding protein
Synonyms: 1110005P14Rik, D1Ertd101e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 110611
HGNC: HGNC:4857
Homologene: 38035
Urb2
Name: URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382038
Homologene: 8859
Epc2
Name: enhancer of polycomb homolog 2
Synonyms: D2Ertd694e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227867
Homologene: 32274
Dhx16
Name: DEAH-box helicase 16
Synonyms: 2410006N22Rik, DEAH (Asp-Glu-Ala-His) box polypeptide 16, DBP2, Ddx16
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 69192
HGNC: HGNC:2739
Homologene: 2658
Unc45a
Name: unc-45 myosin chaperone A
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101869
Homologene: 32423
Lrrk2
Name: leucine-rich repeat kinase 2
Synonyms: cI-46, LOC381026, 9330188B09Rik, D630001M17Rik, 4921513O20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66725
Homologene: 18982
Spag9
Name: sperm associated antigen 9
Synonyms: JLP, syd1, 4733401I23Rik, JIP4, Mapk8ip4, 3110018C07Rik, 4831406C20Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70834
Homologene: 2954
Arhgef17
Name: Rho guanine nucleotide exchange factor 17
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 207212
Homologene: 129601
Zfp846
Name: zinc finger protein 846
Synonyms: 2210010B09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244721
Homologene: 87243
Rad1
Name: RAD1 checkpoint DNA exonuclease
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19355
HGNC: HGNC:9806
Homologene: 37695
St3gal1
Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Synonyms: Siat4a, Siat4, CMP-N-acetylneuraminate: [beta-galactosidase alpha-2,3] sialytransferase, ST3GalI
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20442
VEGA: 15
Homologene: 7540
Scn1a
Name: sodium channel, voltage-gated, type I, alpha
Synonyms: Nav1.1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20265
Homologene: 21375
Ttn
Name: titin
Synonyms: connectin, shru, D330041I19Rik, 2310057K23Rik, mdm, D830007G01Rik, 2310074I15Rik, 1100001C23Rik, 2310036G12Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Nckap1l
Name: NCK associated protein 1 like
Synonyms: Hem1, 4930568P13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105855
VEGA: 15
HGNC: HGNC:4862
Homologene: 3901
Slc16a12
Name: solute carrier family 16 (monocarboxylic acid transporters), member 12
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240638
Homologene: 130007
Abca15
Name: ATP-binding cassette, sub-family A member 15
Synonyms: 4930500I12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320631
Homologene: 87255
Kdm7a
Name: lysine (K)-specific demethylase 7A
Synonyms: Jhdm1d, Kdm7a, A630082K20Rik, ENSMUSG00000073143
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 338523
Homologene: 25281
Map3k10
Name: mitogen-activated protein kinase kinase kinase 10
Synonyms: Mlk2, serine/threonine kinase, MKN28 kinase, mixed lineage kinase 2, MKN28 derived nonreceptor_type
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269881
HGNC: HGNC:6849
Homologene: 1834
Scara3
Name: scavenger receptor class A, member 3
Synonyms: C130058N24Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219151
VEGA: 14
Homologene: 9437
Pik3r5
Name: phosphoinositide-3-kinase regulatory subunit 5
Synonyms: Foap2, p101
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 320207
Homologene: 8627
Sema5b
Name: sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
Synonyms: Semag, SemG, SemG
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20357
Homologene: 8427
Or8k38
Name: olfactory receptor family 8 subfamily K member 38
Synonyms: Olfr1085, MOR191-1, GA_x6K02T2Q125-48147264-48146323
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258583
Pkd1l2
Name: polycystic kidney disease 1 like 2
Synonyms: 1700126L06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76645
Homologene: 124481
Zfp959
Name: zinc finger protein 959
Synonyms: BC011426
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224893
Homologene: 138295
A530064D06Rik
Name: RIKEN cDNA A530064D06 gene
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 328830
VEGA: 17
Homologene: 136361
Lgmn
Name: legumain
Synonyms: AEP, preprolegumain, Prsc1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19141
HGNC: HGNC:9472
Homologene: 38075
Or5b24
Name: olfactory receptor family 5 subfamily B member 24
Synonyms: MOR202-34, Olfr1449, GA_x6K02T2RE5P-3264213-3265157
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258300
Homologene: 17184
Zswim3
Name: zinc finger SWIM-type containing 3
Synonyms: 4921517A06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67538
Homologene: 15436
Gm10549
Name: predicted gene 10549
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 433171
VEGA: 18
Zfp62
Name: zinc finger protein 62
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22720
Homologene: 40686
Or8b41
Name: olfactory receptor family 8 subfamily B member 41
Synonyms: MOR162-15_p, MOR162-3, Olfr890, GA_x6K02T2PVTD-31822365-31823309
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258474
Homologene: 138311
Or8b39
Name: olfactory receptor family 8 subfamily B member 39
Synonyms: MOR162-5, Olfr887, GA_x6K02T2PVTD-31764095-31765024
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258415
Homologene: 133625
Asb13
Name: ankyrin repeat and SOCS box-containing 13
Synonyms: 6430573K02Rik, 2210015B19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 142688
Homologene: 11666
Or4d10
Name: olfactory receptor family 4 subfamily D member 10
Synonyms: GA_x6K02T2RE5P-2433425-2432490, MOR239-7, Olfr1425
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258155
Homologene: 17398
Slc25a23
Name: solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
Synonyms: SCaMC-3, 2310067G05Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66972
Homologene: 11467
Sord
Name: sorbitol dehydrogenase
Synonyms: Sdh-1, Sodh-1, Sdh1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20322
Homologene: 56080
Mup1
Name: major urinary protein 1
Synonyms: Ltn-1, Mup-1, Mup-a, Lvtn-1, Up-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17840
Homologene: 74304
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 93,431,004 bp
  • T to C, chromosome 2 at 49,451,900 bp
  • A to G, chromosome 2 at 66,273,198 bp
  • A to G, chromosome 2 at 76,712,275 bp
  • A to T, chromosome 2 at 86,658,166 bp
  • A to T, chromosome 2 at 122,264,121 bp
  • G to A, chromosome 2 at 164,820,733 bp
  • C to G, chromosome 4 at 60,501,759 bp
  • T to C, chromosome 6 at 39,165,168 bp
  • A to G, chromosome 7 at 27,663,284 bp
  • C to G, chromosome 7 at 80,339,652 bp
  • A to G, chromosome 7 at 100,930,062 bp
  • A to G, chromosome 7 at 120,397,128 bp
  • A to G, chromosome 7 at 123,171,074 bp
  • C to T, chromosome 8 at 117,013,899 bp
  • C to T, chromosome 8 at 124,047,199 bp
  • T to C, chromosome 9 at 20,593,711 bp
  • T to A, chromosome 9 at 38,085,594 bp
  • T to G, chromosome 9 at 38,143,315 bp
  • A to T, chromosome 11 at 49,216,513 bp
  • G to A, chromosome 11 at 68,475,424 bp
  • T to C, chromosome 11 at 94,086,302 bp
  • T to A, chromosome 12 at 102,423,719 bp
  • G to A, chromosome 13 at 3,643,574 bp
  • C to T, chromosome 14 at 65,938,252 bp
  • T to C, chromosome 15 at 10,488,012 bp
  • A to G, chromosome 15 at 67,111,346 bp
  • C to T, chromosome 15 at 91,812,346 bp
  • G to C, chromosome 15 at 103,491,466 bp
  • T to A, chromosome 16 at 35,663,146 bp
  • A to G, chromosome 17 at 35,883,014 bp
  • A to T, chromosome 17 at 48,166,398 bp
  • G to A, chromosome 17 at 55,898,094 bp
  • T to C, chromosome 17 at 57,052,780 bp
  • C to A, chromosome 18 at 33,464,305 bp
  • T to G, chromosome 19 at 12,073,960 bp
  • A to C, chromosome 19 at 12,935,220 bp
  • T to C, chromosome 19 at 34,672,697 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6420 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044562-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.