Strain Name:
C57BL/6J-MtgxR6442Btlr/Mmmh
Stock Number:
044580-MU
Citation ID:
RRID:MMRRC_044580-MU
Other Names:
R6442 (G1)
Major Collection:

Strain Information

Itga8
Name: integrin alpha 8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241226
HGNC: HGNC:6144
Homologene: 37396
Galnt10
Name: polypeptide N-acetylgalactosaminyltransferase 10
Synonyms: C330012K04Rik, GalNAc-T10, Galnt9
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 171212
Homologene: 14924
Cops3
Name: COP9 signalosome subunit 3
Synonyms: Csn3, Sgn3, COP9 complex S3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 26572
HGNC: HGNC:2239
Homologene: 2710
Ptpn5
Name: protein tyrosine phosphatase, non-receptor type 5
Synonyms: Step
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19259
HGNC: HGNC:9657
Homologene: 8423
Usp46
Name: ubiquitin specific peptidase 46
Synonyms: 1190009E20Rik, 2410018I08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69727
Homologene: 56957
Btla
Name: B and T lymphocyte associated
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208154
Homologene: 52233
Rsrc1
Name: arginine/serine-rich coiled-coil 1
Synonyms: 1200013F24Rik, SRrp53
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66880
Homologene: 41147
Sec24b
Name: SEC24 homolog B, COPII coat complex component
Synonyms: SEC24
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99683
Homologene: 55968
Hyal4
Name: hyaluronoglucosaminidase 4
Synonyms: 4632428M18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 77042
HGNC: HGNC:5323
Homologene: 69117
Reln
Name: reelin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Fcgbpl1
Name: Fc fragment of IgG binding protein like 1
Synonyms: 9530053A07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319482
Homologene: 130055
Nr1h5
Name: nuclear receptor subfamily 1, group H, member 5
Synonyms: FXRB
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 381463
Homologene: 131277
Rmnd5a
Name: required for meiotic nuclear division 5 homolog A
Synonyms: 1110007A06Rik, Gid2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68477
Homologene: 5668
Dpp6
Name: dipeptidylpeptidase 6
Synonyms: In(5)6H-p, LOC384168, Rw, Dpp-6, B930011P16Rik, Peplb
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13483
HGNC: HGNC:3010
Homologene: 22560
Cep126
Name: centrosomal protein 126
Synonyms: AK129341
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 234915
VEGA: 9
Homologene: 28313
Dis3l
Name: DIS3 like exosome 3'-5' exoribonuclease
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 213550
Homologene: 15797
Atp9a
Name: ATPase, class II, type 9A
Synonyms: Class II, IIa
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11981
Homologene: 69194
Tgs1
Name: trimethylguanosine synthase 1
Synonyms: Pimt, D4Ertd800e, Ncoa6ip
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 116940
Homologene: 32608
Or9i14
Name: olfactory receptor family 9 subfamily I member 14
Synonyms: MOR211-2, Olfr1499, GA_x6K02T2RE5P-4147744-4146800
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258792
Homologene: 17393
Or4f15
Name: olfactory receptor family 4 subfamily F member 15
Synonyms: MOR245-5, Olfr1309, GA_x6K02T2Q125-73031456-73030518
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258439
Homologene: 74054
Efcab5
Name: EF-hand calcium binding domain 5
Synonyms: 4930563A03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319634
Homologene: 63366
Hsd17b6
Name: hydroxysteroid (17-beta) dehydrogenase 6
Synonyms: 17betaHSD9, Rdh8, Hsd17b9
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 27400
VEGA: 10
Homologene: 20811
Zswim5
Name: zinc finger SWIM-type containing 5
Synonyms: 4933426E21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74464
Homologene: 18958
Sult1b1
Name: sulfotransferase family 1B, member 1
Synonyms: Dopa/tyrosine sulfotransferase
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56362
Homologene: 69169
Crocc2
Name: ciliary rootlet coiled-coil, rootletin family member 2
Synonyms: LOC381284, E030010N08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381284
Homologene: 141152
Vmn2r67
Name: vomeronasal 2, receptor 67
Synonyms: EG620672
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 620672
Homologene: 115466
Tmem80
Name: transmembrane protein 80
Synonyms: 5530601I19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71448
Homologene: 23629
Or4n4
Name: olfactory receptor family 4 subfamily N member 4
Synonyms: GA_x6K02T2PMLR-5975274-5974348, Olfr732, MOR241-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258659
Homologene: 72012
Slc26a9
Name: solute carrier family 26, member 9
Synonyms: anion transporter/exchanger-9, E030002L01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 320718
Homologene: 14179
Prdm11
Name: PR domain containing 11
Synonyms: 8030443D09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 100042784
Homologene: 82511
Gdf9
Name: growth differentiation factor 9
Synonyms: Gdf-9
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14566
HGNC: HGNC:4224
Homologene: 3851
Or6c214
Name: olfactory receptor family 6 subfamily C member 214
Synonyms: MOR117-1, Olfr807, GA_x6K02T2PULF-11434134-11433199
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258931
Homologene: 27300
Or3a4
Name: olfactory receptor family 3 subfamily A member 4
Synonyms: Olfr399, GA_x6K02T2P1NL-4211516-4210581, MOR255-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259006
Homologene: 27325
Sapcd2
Name: suppressor APC domain containing 2
Synonyms: ang, 6030458L21Rik, 2010317E24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72080
Homologene: 18664
Gm826
Name: predicted gene 826
Synonyms: Gm46773, LOC329554
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329554
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 93,185,053 bp
  • A to T, chromosome 1 at 131,758,817 bp
  • C to T, chromosome 2 at 12,230,143 bp
  • T to A, chromosome 2 at 25,376,122 bp
  • T to C, chromosome 2 at 76,721,634 bp
  • G to A, chromosome 2 at 92,975,645 bp
  • G to A, chromosome 2 at 111,983,529 bp
  • T to A, chromosome 2 at 160,327,408 bp
  • T to C, chromosome 2 at 168,649,561 bp
  • C to T, chromosome 3 at 66,994,649 bp
  • G to A, chromosome 3 at 102,941,111 bp
  • A to G, chromosome 3 at 129,996,701 bp
  • T to A, chromosome 4 at 3,604,760 bp
  • C to A, chromosome 4 at 116,951,005 bp
  • T to A, chromosome 5 at 21,932,776 bp
  • G to A, chromosome 5 at 27,718,509 bp
  • A to T, chromosome 5 at 74,016,716 bp
  • T to C, chromosome 5 at 87,535,053 bp
  • A to G, chromosome 6 at 24,765,850 bp
  • A to T, chromosome 6 at 71,394,675 bp
  • C to T, chromosome 7 at 28,144,186 bp
  • T to C, chromosome 7 at 47,083,083 bp
  • T to A, chromosome 7 at 85,155,838 bp
  • T to C, chromosome 7 at 141,335,926 bp
  • T to C, chromosome 9 at 8,100,563 bp
  • T to C, chromosome 9 at 64,307,555 bp
  • C to T, chromosome 10 at 127,993,767 bp
  • C to A, chromosome 10 at 129,755,408 bp
  • A to G, chromosome 11 at 53,433,688 bp
  • A to G, chromosome 11 at 57,765,622 bp
  • T to A, chromosome 11 at 59,827,954 bp
  • G to A, chromosome 11 at 74,054,679 bp
  • A to T, chromosome 11 at 77,105,434 bp
  • T to G, chromosome 14 at 50,281,369 bp
  • A to G, chromosome 16 at 45,224,458 bp
  • T to C, chromosome 16 at 45,250,350 bp
  • T to C, chromosome 19 at 13,815,628 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6442 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044580-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.