Strain Name:
C57BL/6J-MtgxR6443Btlr/Mmmh
Stock Number:
044581-MU
Citation ID:
RRID:MMRRC_044581-MU
Other Names:
R6443 (G1)
Major Collection:

Strain Information

Mtmr3
Name: myotubularin related protein 3
Synonyms: 1700092A20Rik, FYVE-DSP1, ZFYVE10
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74302
HGNC: HGNC:7451
Homologene: 23662
Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: 9930031C03Rik, brain spectrin, elf1, spectrin G, beta fodrin, Spnb2, non-erythrocytic, Spnb-2, elf3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20742
Homologene: 2354
Sstr2
Name: somatostatin receptor 2
Synonyms: Smstr2, Smstr-2, SSTR-2, sst2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20606
Homologene: 37427
Zfp523
Name: zinc finger protein 523
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224656
Homologene: 2569
Fkbp5
Name: FK506 binding protein 5
Synonyms: Dit1, D17Ertd592e, FKBP51
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14229
HGNC: HGNC:3721
Homologene: 3038
Slc6a4
Name: solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Synonyms: Sert, Htt, 5-HTT
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15567
Homologene: 817
Usp48
Name: ubiquitin specific peptidase 48
Synonyms: 2810449C13Rik, D330022K21Rik, Usp31
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 170707
Homologene: 12988
Kif1b
Name: kinesin family member 1B
Synonyms: Kif1b beta, A530096N05Rik, N-3 kinesin, D4Mil1e, KIF1Bp204, KIF1Bp130, Kif1b alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16561
Homologene: 99835
Rsf1
Name: remodeling and spacing factor 1
Synonyms: Hbxap, p325, XAP8, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Slc9a8
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 8
Synonyms: NHE8, 1200006P13Rik, 6430709P13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77031
Homologene: 75041
Lpin2
Name: lipin 2
Synonyms: 2610511G02Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 64898
Homologene: 8769
Lrrc1
Name: leucine rich repeat containing 1
Synonyms: A430093J20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214345
Homologene: 44445
Nr5a1
Name: nuclear receptor subfamily 5, group A, member 1
Synonyms: steroidogenic factor 1, adrenal 4-binding protein, Ftz-F1, SF1, Ftzf1, Ad4BP, SF-1, ELP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26423
HGNC: HGNC:7983
Homologene: 3638
Bcar1
Name: breast cancer anti-estrogen resistance 1
Synonyms: p130Cas, Cas, Crkas
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12927
HGNC: HGNC:971
Homologene: 7674
Eya3
Name: EYA transcriptional coactivator and phosphatase 3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14050
HGNC: HGNC:3521
Homologene: 1508
Glud1
Name: glutamate dehydrogenase 1
Synonyms: Glud, Gdh-X
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14661
Homologene: 55885
Tcf7
Name: transcription factor 7, T cell specific
Synonyms: Tcf1, TCF-1, T cell factor-1, T-cell factor 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21414
Homologene: 137220
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, Dnahc8, P1-Loop
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Aasdhppt
Name: aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Synonyms: LYS2, LYS5, AASD-PPT, 2810407B07Rik, 2010309J24Rik, CGI-80
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67618
Homologene: 9130
Txndc5
Name: thioredoxin domain containing 5
Synonyms: PC-TRP, ERp46
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105245
Homologene: 11125
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: Ryr, skrr, calcium release channel isoform 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20190
Homologene: 68069
Dnah12
Name: dynein, axonemal, heavy chain 12
Synonyms: Dnahc12, HL19, DLP12, LOC380889, Dnahc7l, 4921531P07Rik, Hdhc3, DHC3, HL-19
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110083
HGNC: HGNC:2943
Homologene: 56821
Nwd1
Name: NACHT and WD repeat domain containing 1
Synonyms: A230063L24Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 319555
Homologene: 72261
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20192
Homologene: 68151
Dclre1b
Name: DNA cross-link repair 1B
Synonyms: SNMIB, Apollo, mSNM1B
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 140917
Homologene: 32553
Ctss
Name: cathepsin S
Synonyms: Cat S
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13040
HGNC: HGNC:2545
Homologene: 20867
Ces1f
Name: carboxylesterase 1F
Synonyms: TGH-2, CesML1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234564
HGNC: HGNC:1863
Homologene: 134311
Vmn2r1
Name: vomeronasal 2, receptor 1
Synonyms: EG56544, V2r83
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56544
Homologene: 84832
Gm5114
Name: predicted gene 5114
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330513
Homologene: 45597
Apbb1
Name: amyloid beta precursor protein binding family B member 1
Synonyms: Fe65, Rir
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11785
HGNC: HGNC:581
Homologene: 898
Ppp1r36
Name: protein phosphatase 1, regulatory subunit 36
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 210762
VEGA: 12
Homologene: 52094
Actr6
Name: ARP6 actin-related protein 6
Synonyms: ArpX, 2010200J04Rik, CDA12, Arp6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67019
VEGA: 10
Homologene: 6451
Gramd2b
Name: GRAM domain containing 2B
Synonyms: Gramd3, 9030613F08Rik, 9130427A09Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 107022
VEGA: 18
Homologene: 32570
Or5ar1
Name: olfactory receptor family 5 subfamily AR member 1
Synonyms: GA_x6K02T2Q125-47320309-47319377, MOR180-1, Olfr1019
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259017
Homologene: 17464
Ephb4
Name: Eph receptor B4
Synonyms: Tyro11, b2b2412Clo, MDK2, Htk, Myk1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13846
HGNC: HGNC:3395
Homologene: 20939
Or6c214
Name: olfactory receptor family 6 subfamily C member 214
Synonyms: MOR117-1, Olfr807, GA_x6K02T2PULF-11434134-11433199
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258931
Homologene: 27300
Zfp354b
Name: zinc finger protein 354B
Synonyms: Kid2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 27274
Homologene: 32187
Pla1a
Name: phospholipase A1 member A
Synonyms: Ps-pla1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 85031
VEGA: 16
Homologene: 9294
Or1e1b-ps1
Name: olfactory receptor family 1 subfamily E member 1B, pseudogene 1
Synonyms: Olfr22-ps1, GA_x6K02T2P1NL-4111497-4112433, MOR135-18, MTPCR35
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258209
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 2 at 38,710,430 bp
  • T to G, chromosome 2 at 85,841,635 bp
  • T to C, chromosome 2 at 112,675,933 bp
  • G to A, chromosome 2 at 167,434,821 bp
  • T to A, chromosome 3 at 64,104,953 bp
  • A to C, chromosome 3 at 95,546,803 bp
  • T to A, chromosome 3 at 103,803,188 bp
  • T to C, chromosome 4 at 132,711,927 bp
  • T to A, chromosome 4 at 137,613,763 bp
  • T to C, chromosome 4 at 149,192,596 bp
  • G to A, chromosome 5 at 137,360,449 bp
  • A to T, chromosome 7 at 29,077,078 bp
  • C to A, chromosome 7 at 39,407,717 bp
  • G to GACGGCGGCT, chromosome 7 at 97,579,909 bp
  • T to A, chromosome 7 at 105,573,763 bp
  • G to A, chromosome 8 at 72,662,366 bp
  • T to A, chromosome 8 at 93,275,365 bp
  • A to T, chromosome 8 at 111,715,338 bp
  • A to G, chromosome 9 at 4,309,357 bp
  • A to G, chromosome 9 at 77,434,032 bp
  • T to C, chromosome 10 at 89,714,871 bp
  • C to A, chromosome 10 at 129,755,408 bp
  • A to T, chromosome 11 at 4,487,358 bp
  • T to C, chromosome 11 at 30,139,429 bp
  • A to G, chromosome 11 at 50,922,754 bp
  • G to T, chromosome 11 at 52,253,938 bp
  • A to T, chromosome 11 at 73,955,092 bp
  • A to G, chromosome 11 at 77,023,201 bp
  • G to A, chromosome 11 at 113,625,254 bp
  • A to G, chromosome 12 at 76,417,639 bp
  • A to G, chromosome 13 at 38,528,203 bp
  • C to A, chromosome 14 at 26,878,051 bp
  • T to C, chromosome 14 at 34,339,927 bp
  • T to C, chromosome 16 at 38,409,587 bp
  • A to T, chromosome 17 at 28,201,407 bp
  • G to T, chromosome 17 at 28,429,279 bp
  • A to G, chromosome 17 at 30,771,885 bp
  • T to C, chromosome 17 at 71,241,668 bp
  • G to A, chromosome 18 at 56,485,385 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6443 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044581-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.