Strain Name:
C57BL/6J-MtgxR6537Btlr/Mmmh
Stock Number:
044663-MU
Citation ID:
RRID:MMRRC_044663-MU
Other Names:
R6537 (G1)
Major Collection:

Strain Information

Cort
Name: cortistatin
Synonyms: CST, PCST
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12854
HGNC: HGNC:2257
Homologene: 997
Fxyd6
Name: FXYD domain-containing ion transport regulator 6
Synonyms: 0610030I18Rik, Php
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 59095
VEGA: 9
HGNC: HGNC:4030
Homologene: 11090
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, trabeculin alpha, Acf7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Kif1b
Name: kinesin family member 1B
Synonyms: Kif1b beta, A530096N05Rik, N-3 kinesin, D4Mil1e, KIF1Bp204, KIF1Bp130, Kif1b alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16561
Homologene: 99835
Ctdp1
Name: CTD phosphatase subunit 1
Synonyms: 4930563P03Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67655
HGNC: HGNC:2498
Homologene: 31254
Wrap53
Name: WD repeat containing, antisense to Trp53
Synonyms: Wdr79
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216853
Homologene: 9995
Lrp6
Name: low density lipoprotein receptor-related protein 6
Synonyms: skam26Jus, ska26, skax26, Cd
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16974
HGNC: HGNC:6698
Homologene: 1747
Ptcd3
Name: pentatricopeptide repeat domain 3
Synonyms: 2610034F17Rik, 2810422B04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 69956
Homologene: 41211
Dnmt3l
Name: DNA methyltransferase 3-like
Synonyms: ecat7, D6Ertd14e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 54427
HGNC: HGNC:2980
Homologene: 8362
Nrn1l
Name: neuritin 1-like
Synonyms: G630049C14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234700
Homologene: 18397
Znhit6
Name: zinc finger, HIT type 6
Synonyms: 2410019A14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229937
Homologene: 32378
Siglecf
Name: sialic acid binding Ig-like lectin F
Synonyms: mSiglec-F, Siglec5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233186
Homologene: 50482
Srcap
Name: Snf2-related CREBBP activator protein
Synonyms: D030022P06Rik, F630004O05Rik, B930091H02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043597
Homologene: 38213
Anapc4
Name: anaphase promoting complex subunit 4
Synonyms: D5Ertd249e, APC4, 2610306D21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52206
Homologene: 40873
Tek
Name: TEK receptor tyrosine kinase
Synonyms: Tie2, tie-2, Cd202b, Hyk
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21687
Homologene: 397
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 665700
Homologene: 90772
Slc7a8
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 8
Synonyms: LAT2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50934
VEGA: 14
Homologene: 8166
Trim45
Name: tripartite motif-containing 45
Synonyms: 4921530N01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229644
Homologene: 11865
Ctsq
Name: cathepsin Q
Synonyms: 1600010J02Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 104002
Homologene: 122226
Mdm1
Name: MDM1 nuclear protein
Synonyms: Mdm-1, transformed mouse 3T3 cell double minute 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17245
VEGA: 10
Homologene: 9692
Pappa
Name: pregnancy-associated plasma protein A
Synonyms: PAPP-A, IGFBP-4ase, 8430414N03Rik, PAG1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18491
HGNC: HGNC:8602
Homologene: 31097
Col6a4
Name: collagen, type VI, alpha 4
Synonyms: Dvwa, EG235580, Vwa6, 1110001D15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68553
Homologene: 130754
Ttbk1
Name: tau tubulin kinase 1
Synonyms: C330008L01Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106763
VEGA: 17
Homologene: 50342
Lrrc3b
Name: leucine rich repeat containing 3B
Synonyms: LRP15
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218763
VEGA: 14
Homologene: 14190
Tafa2
Name: TAFA chemokine like family member 2
Synonyms: Tafa-2, Tafa2, Sam2, Fam19a2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268354
VEGA: 10
Homologene: 18678
Pcsk1
Name: proprotein convertase subtilisin/kexin type 1
Synonyms: SPC3, prohormone convertase 1/3, Nec1, Nec-1, Phpp-1, PC1, PC3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18548
HGNC: HGNC:8743
Homologene: 379
Kyat3
Name: kynurenine aminotransferase 3
Synonyms: Kat3, Ccbl2, KATIII
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229905
Homologene: 2994
Cwc15
Name: CWC15 spliceosome-associated protein
Synonyms: 2900052N06Rik, 0610040D20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66070
Homologene: 9499
Gm10604
Name: predicted gene 10604
Type: Gene
Species: Mouse
Chromosome: 4
Gm43302
Name: predicted gene 43302
Type: Gene
Species: Mouse
Chromosome: 5
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 2 at 31,415,268 bp
  • C to T, chromosome 3 at 100,925,396 bp
  • A to G, chromosome 3 at 142,729,812 bp
  • A to G, chromosome 3 at 145,594,619 bp
  • A to C, chromosome 4 at 11,980,221 bp
  • T to A, chromosome 4 at 65,297,282 bp
  • A to G, chromosome 4 at 94,837,324 bp
  • C to T, chromosome 4 at 123,492,725 bp
  • C to T, chromosome 4 at 149,126,624 bp
  • T to C, chromosome 4 at 149,192,596 bp
  • T to C, chromosome 5 at 52,843,556 bp
  • A to G, chromosome 5 at 105,290,995 bp
  • T to C, chromosome 6 at 71,897,110 bp
  • T to C, chromosome 6 at 134,480,495 bp
  • C to T, chromosome 7 at 43,355,999 bp
  • T to C, chromosome 7 at 127,542,220 bp
  • G to T, chromosome 8 at 105,894,718 bp
  • A to G, chromosome 9 at 14,501,988 bp
  • A to G, chromosome 9 at 45,390,794 bp
  • G to A, chromosome 9 at 106,067,954 bp
  • G to A, chromosome 10 at 78,052,064 bp
  • A to G, chromosome 10 at 118,158,576 bp
  • T to A, chromosome 10 at 123,593,496 bp
  • T to C, chromosome 11 at 69,563,868 bp
  • A to T, chromosome 13 at 61,035,326 bp
  • T to C, chromosome 13 at 75,132,239 bp
  • T to C, chromosome 14 at 15,357,946 bp
  • C to T, chromosome 14 at 54,735,119 bp
  • C to T, chromosome 17 at 46,470,310 bp
  • G to T, chromosome 18 at 80,449,551 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6537 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044663-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.