Strain Name:
C57BL/6J-MtgxR6730Btlr/Mmmh
Stock Number:
044848-MU
Citation ID:
RRID:MMRRC_044848-MU
Other Names:
R6730 (G1)
Major Collection:

Strain Information

Ptpn3
Name: protein tyrosine phosphatase, non-receptor type 3
Synonyms: 9530011I20Rik, PTPCL, PTP-H1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 545622
HGNC: HGNC:9655
Homologene: 74451
Rabep1
Name: rabaptin, RAB GTPase binding effector protein 1
Synonyms: RAB5 effector protein, neurocrescin, rabaptin-5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 54189
Homologene: 3451
Usp30
Name: ubiquitin specific peptidase 30
Synonyms: D5Ertd483e, 6330590F17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100756
Homologene: 32789
Ago3
Name: argonaute RISC catalytic subunit 3
Synonyms: eIF2C3, argonaute 3, C130014L07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 214150
Homologene: 49799
Urb1
Name: URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
Synonyms: 5730405K23Rik, 4921511H13Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207932
Homologene: 45941
Rad17
Name: RAD17 checkpoint clamp loader component
Synonyms: 9430035O09Rik, MmRad24
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19356
VEGA: 13
HGNC: HGNC:9807
Homologene: 32117
Ccser2
Name: coiled-coil serine rich 2
Synonyms: 1700012P13Rik, Gcap14, 2900054P12Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 72972
Homologene: 10367
Camkv
Name: CaM kinase-like vesicle-associated
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235604
Homologene: 56983
Dync1i2
Name: dynein cytoplasmic 1 intermediate chain 2
Synonyms: 3110079H08Rik, Dncic2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13427
HGNC: HGNC:2964
Homologene: 37921
Erc2
Name: ELKS/RAB6-interacting/CAST family member 2
Synonyms: D14Ertd171e, CAST, ELKS2alpha
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 238988
Homologene: 69188
Eml2
Name: echinoderm microtubule associated protein like 2
Synonyms: 1600029N02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72205
Homologene: 8125
Svil
Name: supervillin
Synonyms: B430302E16Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225115
Homologene: 25090
Clvs2
Name: clavesin 2
Synonyms: Rlbp1l2, A330019N05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215890
Homologene: 27894
Skic2
Name: SKI2 subunit of superkiller complex
Synonyms: Ski2w, 4930534J06Rik, Skiv2l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 108077
Homologene: 123971
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77505
Homologene: 131117
Adam20
Name: a disintegrin and metallopeptidase domain 20
Synonyms: 4930529F22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 384806
HGNC: HGNC:199
Homologene: 128364
Adgrb3
Name: adhesion G protein-coupled receptor B3
Synonyms: Bai3, A830096D10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210933
HGNC: HGNC:945
Homologene: 1289
Ephb6
Name: Eph receptor B6
Synonyms: Mep, Cekl
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13848
HGNC: HGNC:3396
Homologene: 20940
Aknad1
Name: AKNA domain containing 1
Synonyms: 4921525H12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329738
Homologene: 51892
Pcsk6
Name: proprotein convertase subtilisin/kexin type 6
Synonyms: SPC4, PACE4, b2b2830Clo
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18553
HGNC: HGNC:8569
Homologene: 20569
Rab11fip1
Name: RAB11 family interacting protein 1 (class I)
Synonyms: 4833414G05Rik, 2010200K21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75767
Homologene: 11853
Or10a49
Name: olfactory receptor family 10 subfamily A member 49
Synonyms: Olfr517, GA_x6K02T2PBJ9-11199311-11198367, MOR268-4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258136
Homologene: 79413
Adam2
Name: a disintegrin and metallopeptidase domain 2
Synonyms: Ftnb, Ph30-beta, fertilin beta
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11495
VEGA: 14
HGNC: HGNC:198
Homologene: 1127
Adam10
Name: a disintegrin and metallopeptidase domain 10
Synonyms: kuzbanian, kuz, 1700031C13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11487
HGNC: HGNC:188
Homologene: 865
Tent5c
Name: terminal nucleotidyltransferase 5C
Synonyms: Fam46c, 4930431B09Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74645
Homologene: 56783
Fam149a
Name: family with sequence similarity 149, member A
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212326
Homologene: 27540
Slc2a7
Name: solute carrier family 2 (facilitated glucose transporter), member 7
Synonyms: OTTMUSG00000010396
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 435818
Homologene: 72470
Rxfp1
Name: relaxin/insulin-like family peptide receptor 1
Synonyms: LOC381489, Lgr7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 381489
Homologene: 11007
Ficd
Name: FIC domain containing
Synonyms: D5Ertd40e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231630
Homologene: 5139
Mettl18
Name: methyltransferase like 18
Synonyms: 2810422O20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 69962
Homologene: 32680
Vmn2r120
Name: vomeronasal 2, receptor 120
Synonyms: EG224916
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224916
Scnn1b
Name: sodium channel, nonvoltage-gated 1 beta
Synonyms: ENaC beta
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20277
Homologene: 133555
Or7h8
Name: olfactory receptor family 7 subfamily H member 8
Synonyms: GA_x6K02T2PVTD-13952555-13953490, Olfr871, MOR141-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258905
Homologene: 138319
Or4k47
Name: olfactory receptor family 4 subfamily K member 47
Synonyms: Olfr1297, GA_x6K02T2Q125-72673494-72672556, MOR248-4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258890
Homologene: 115545
Klhl18
Name: kelch-like 18
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270201
Homologene: 14805
Vmn1r177
Name: vomeronasal 1 receptor 177
Synonyms: V1rd12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384572
Homologene: 122945
Vmn2r106
Name: vomeronasal 2, receptor 106
Synonyms: EG224576
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224576
Homologene: 135824
Ly9
Name: lymphocyte antigen 9
Synonyms: SLAMF3, CD229, Lgp100, T100
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17085
HGNC: HGNC:6730
Homologene: 1759
Gstm6
Name: glutathione S-transferase, mu 6
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14867
HGNC: HGNC:4632
Homologene: 117950
Myoz2
Name: myozenin 2
Synonyms: 1110012I24Rik, Fatz-2, calsarcin-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 59006
HGNC: HGNC:1330
Homologene: 9583
Pars2
Name: prolyl-tRNA synthetase (mitochondrial)(putative)
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230577
Homologene: 5830
Csn1s2b
Name: casein alpha s2-like B
Synonyms: Csnd, Csne
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12992
Homologene: 49221
Ccl27a
Name: C-C motif chemokine ligand 27A
Synonyms: Ccl27, skinskine, ALP, CTACK, ILC, CTAK, ESkine, Scya27a, Scya27, PESKY, mILC, ESkine
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20301
Homologene: 134761
Ighv1-62-1
Name: immunoglobulin heavy variable 1-62-1
Synonyms: Gm9232
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 668544
4930455H04Rik
Name: RIKEN cDNA 4930455H04 gene
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74654
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 25,094,294 bp
  • C to T, chromosome 1 at 163,997,181 bp
  • T to A, chromosome 1 at 171,605,169 bp
  • T to A, chromosome 2 at 71,247,140 bp
  • A to G, chromosome 2 at 111,621,735 bp
  • T to A, chromosome 3 at 79,650,591 bp
  • T to A, chromosome 3 at 100,472,957 bp
  • T to A, chromosome 3 at 107,942,725 bp
  • G to A, chromosome 3 at 108,752,339 bp
  • T to A, chromosome 3 at 116,983,475 bp
  • C to A, chromosome 3 at 123,016,627 bp
  • T to A, chromosome 4 at 41,773,342 bp
  • T to C, chromosome 4 at 57,270,088 bp
  • C to T, chromosome 4 at 106,653,431 bp
  • T to C, chromosome 4 at 126,371,545 bp
  • T to C, chromosome 4 at 150,158,148 bp
  • T to A, chromosome 5 at 87,822,268 bp
  • T to C, chromosome 5 at 113,738,712 bp
  • T to C, chromosome 5 at 114,103,709 bp
  • C to T, chromosome 6 at 41,617,374 bp
  • G to A, chromosome 7 at 19,201,163 bp
  • T to A, chromosome 7 at 23,865,812 bp
  • G to T, chromosome 7 at 65,980,248 bp
  • T to C, chromosome 7 at 105,703,875 bp
  • A to T, chromosome 7 at 108,868,573 bp
  • C to T, chromosome 7 at 121,902,877 bp
  • G to A, chromosome 8 at 27,143,229 bp
  • T to C, chromosome 8 at 40,796,659 bp
  • T to A, chromosome 8 at 45,381,174 bp
  • T to C, chromosome 9 at 20,212,502 bp
  • G to T, chromosome 9 at 70,740,176 bp
  • T to C, chromosome 9 at 107,948,317 bp
  • C to T, chromosome 9 at 110,428,911 bp
  • A to G, chromosome 10 at 33,528,521 bp
  • A to G, chromosome 11 at 70,940,386 bp
  • A to T, chromosome 12 at 115,386,892 bp
  • T to C, chromosome 13 at 100,649,745 bp
  • A to C, chromosome 14 at 27,898,567 bp
  • C to A, chromosome 14 at 36,879,086 bp
  • A to T, chromosome 14 at 66,037,576 bp
  • T to C, chromosome 16 at 90,779,083 bp
  • T to A, chromosome 17 at 20,278,834 bp
  • G to A, chromosome 17 at 34,845,190 bp
  • T to A, chromosome 17 at 57,525,012 bp
  • A to G, chromosome 18 at 5,049,311 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6730 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044848-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.