Strain Name:
C57BL/6J-MtgxR6844Btlr/Mmmh
Stock Number:
044950-MU
Citation ID:
RRID:MMRRC_044950-MU
Other Names:
R6844 (G1)
Major Collection:

Strain Information

Casq2
Name: calsequestrin 2
Synonyms: cCSQ, ESTM52, Csq2, cardiac calsequestrin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12373
HGNC: HGNC:1513
Homologene: 20330
Eif3h
Name: eukaryotic translation initiation factor 3, subunit H
Synonyms: Eif3s3, 9430017H16Rik, 1110008A16Rik, EIF3-gamma, EIF3-P40
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68135
VEGA: 15
HGNC: HGNC:3273
Homologene: 2785
Tal1
Name: T cell acute lymphocytic leukemia 1
Synonyms: Scl, SCL/tal-1, bHLHa17, Hpt
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21349
Homologene: 2400
Synj2
Name: synaptojanin 2
Synonyms: SJ2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20975
Homologene: 117703
Mllt10
Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10
Synonyms: B130021D15Rik, D630001B22Rik, Af10
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17354
Homologene: 20973
Arhgap21
Name: Rho GTPase activating protein 21
Synonyms: 5530401C11Rik, ARHGAP10
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71435
Homologene: 10822
Nr2c1
Name: nuclear receptor subfamily 2, group C, member 1
Synonyms: 4831444H07Rik, TR2, Eenr, Tr2-11
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22025
HGNC: HGNC:7971
Homologene: 55731
Zmat3
Name: zinc finger matrin type 3
Synonyms: Wig1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22401
Homologene: 32545
Htr1a
Name: 5-hydroxytryptamine (serotonin) receptor 1A
Synonyms: 5-HT1A receptor, Gpcr18
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 15550
VEGA: 13
HGNC: HGNC:5286
Homologene: 20148
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: Coh1, 2310042E16Rik, 1810042B05Rik, C330002D13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Samd8
Name: sterile alpha motif domain containing 8
Synonyms: Smsr, 1700010P07Rik, 1110053F04Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67630
Homologene: 41670
Zfp949
Name: zinc finger protein 949
Synonyms: 4930422I07Rik, Nczf
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71640
Homologene: 129930
Gemin5
Name: gem nuclear organelle associated protein 5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216766
Homologene: 9155
Plxna2
Name: plexin A2
Synonyms: OCT, Plxn2, 2810428A13Rik, PlexA2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18845
HGNC: HGNC:9100
Homologene: 56427
Slc4a4
Name: solute carrier family 4 (anion exchanger), member 4
Synonyms: NBC, NBC1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54403
Homologene: 55776
Cd22
Name: CD22 antigen
Synonyms: Lyb8, Lyb-8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12483
HGNC: HGNC:1643
Homologene: 31052
Omp
Name: olfactory marker protein
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18378
HGNC: HGNC:8136
Homologene: 36195
Pdcd1
Name: programmed cell death 1
Synonyms: PD-1, Pdc1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18566
HGNC: HGNC:8760
Homologene: 3681
Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
Synonyms: MGM, 2210005L13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17833
HGNC: HGNC:7515
Homologene: 137237
Rapgef4
Name: Rap guanine nucleotide exchange factor (GEF) 4
Synonyms: 5730402K07Rik, 1300003D15Rik, cAMP-GEFII, 6330581N18Rik, Epac2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56508
Homologene: 4451
Fgfbp3
Name: fibroblast growth factor binding protein 3
Synonyms: 2610306H15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 72514
Homologene: 49899
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Cyp2b13
Name: cytochrome P450, family 2, subfamily b, polypeptide 13
Synonyms: phenobarbital inducible, type c
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13089
HGNC: HGNC:2615
Homologene: 74933
Ripor3
Name: RIPOR family member 3
Synonyms: 2310033K02Rik, Fam65c
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69553
Homologene: 15438
Jag2
Name: jagged 2
Synonyms: D12Ggc2e, Serh
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16450
VEGA: 12
HGNC: HGNC:6189
Homologene: 1677
Gpr22
Name: G protein-coupled receptor 22
Synonyms: 2900068K05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 73010
HGNC: HGNC:4477
Homologene: 18420
Top2b
Name: topoisomerase (DNA) II beta
Synonyms: Top-2, D230016L12Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21974
Homologene: 134711
Mybpc1
Name: myosin binding protein C, slow-type
Synonyms: Slow-type C-protein, 8030451F13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 109272
HGNC: HGNC:7549
Homologene: 1846
Slc6a13
Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 13
Synonyms: Gat2, Gabt3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14412
Homologene: 9592
Elovl4
Name: ELOVL fatty acid elongase 4
Synonyms: elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83603
Homologene: 41488
Ccdc188
Name: coiled-coil domain containing 188
Synonyms: Gm7873
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 102638083
VEGA: 16
Homologene: 90442
Itgax
Name: integrin alpha X
Synonyms: Cd11c, CD11C (p150) alpha polypeptide, CR4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16411
HGNC: HGNC:6152
Homologene: 55493
Lce1j
Name: late cornified envelope 1J
Synonyms: Sprrl8
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 545547
Cyp4a31
Name: cytochrome P450, family 4, subfamily a, polypeptide 31
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 666168
HGNC: HGNC:2642
Homologene: 128044
Arhgap18
Name: Rho GTPase activating protein 18
Synonyms: 4833419J07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 73910
Homologene: 14135
Ralyl
Name: RALY RNA binding protein-like
Synonyms: 0710005M24Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76897
Homologene: 18366
Sst
Name: somatostatin
Synonyms: SRIF, SOM, preprosomatostatin, Smst
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20604
VEGA: 16
Homologene: 819
Slc4a1ap
Name: solute carrier family 4 (anion exchanger), member 1, adaptor protein
Synonyms: kanadaptin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20534
Homologene: 7543
Serpinb9g
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9g
Synonyms: NK21B, 1600002F03Rik, ovalbumin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 93806
HGNC: HGNC:8955
Homologene: 69093
Shisa8
Name: shisa family member 8
Synonyms: AI848285, CKAMP39, Orf26
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 435145
VEGA: 15
Homologene: 46536
Gm3415
Name: predicted gene 3415
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100041578
Homologene: 86127
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 94,039,381 bp
  • T to C, chromosome 1 at 194,793,828 bp
  • A to G, chromosome 2 at 18,159,483 bp
  • A to G, chromosome 2 at 20,881,305 bp
  • A to G, chromosome 2 at 72,234,626 bp
  • A to T, chromosome 2 at 82,983,625 bp
  • C to T, chromosome 2 at 167,993,333 bp
  • A to G, chromosome 3 at 13,776,878 bp
  • A to G, chromosome 3 at 32,341,495 bp
  • A to G, chromosome 3 at 92,789,349 bp
  • A to T, chromosome 3 at 102,110,262 bp
  • C to T, chromosome 4 at 115,063,267 bp
  • T to A, chromosome 4 at 115,563,792 bp
  • T to A, chromosome 5 at 31,527,478 bp
  • T to A, chromosome 5 at 89,228,972 bp
  • T to C, chromosome 5 at 146,558,001 bp
  • T to A, chromosome 6 at 121,325,053 bp
  • T to A, chromosome 7 at 26,081,697 bp
  • G to T, chromosome 7 at 30,873,431 bp
  • T to A, chromosome 7 at 98,145,076 bp
  • T to A, chromosome 7 at 128,147,934 bp
  • C to T, chromosome 7 at 141,809,744 bp
  • T to A, chromosome 9 at 83,790,111 bp
  • A to G, chromosome 9 at 88,569,411 bp
  • G to A, chromosome 10 at 26,772,686 bp
  • T to A, chromosome 10 at 88,536,381 bp
  • T to A, chromosome 10 at 94,171,167 bp
  • T to C, chromosome 11 at 58,163,904 bp
  • C to A, chromosome 12 at 31,709,952 bp
  • T to C, chromosome 12 at 112,916,714 bp
  • A to T, chromosome 13 at 33,486,633 bp
  • A to G, chromosome 13 at 105,444,947 bp
  • A to T, chromosome 14 at 16,429,383 bp
  • T to C, chromosome 14 at 21,775,137 bp
  • T to A, chromosome 15 at 35,877,590 bp
  • T to C, chromosome 15 at 51,865,333 bp
  • T to C, chromosome 15 at 82,212,109 bp
  • G to A, chromosome 16 at 18,218,210 bp
  • C to T, chromosome 16 at 23,889,842 bp
  • A to G, chromosome 17 at 5,975,806 bp
  • C to A, chromosome 19 at 36,918,880 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6844 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044950-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.