Strain Name:
C57BL/6J-MtgxR6936Btlr/Mmmh
Stock Number:
045050-MU
Citation ID:
RRID:MMRRC_045050-MU
Other Names:
R6936 (G1)
Major Collection:

Strain Information

Fgg
Name: fibrinogen gamma chain
Synonyms: 3010002H13Rik, gamma-fibrinogen
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99571
HGNC: HGNC:3694
Homologene: 429
Arhgap10
Name: Rho GTPase activating protein 10
Synonyms: A930033B01Rik, PSGAP-s, PSGAP-m
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78514
Homologene: 12695
Dlx5
Name: distal-less homeobox 5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13395
HGNC: HGNC:2918
Homologene: 3825
Egf
Name: epidermal growth factor
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13645
HGNC: HGNC:3229
Homologene: 1483
Dbh
Name: dopamine beta hydroxylase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13166
HGNC: HGNC:2689
Homologene: 615
Gtf2i
Name: general transcription factor II I
Synonyms: BAP-135, 6030441I21Rik, TFII-I
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14886
HGNC: HGNC:4659
Homologene: 7748
Ak4
Name: adenylate kinase 4
Synonyms: D4Ertd274e, Ak-4, Ak-3, Ak3l1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11639
HGNC: HGNC:363
Homologene: 100316
Ak2
Name: adenylate kinase 2
Synonyms: Ak-2, D4Ertd220e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11637
HGNC: HGNC:362
Homologene: 1227
Mcmbp
Name: minichromosome maintenance complex binding protein
Synonyms: 1110007A13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210711
Homologene: 11749
Ascc3
Name: activating signal cointegrator 1 complex subunit 3
Synonyms: B630009I04Rik, Helic1, ASC1p200
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77987
VEGA: 10
Homologene: 4973
Cabin1
Name: calcineurin binding protein 1
Synonyms: A330070M20Rik, Cain, Ppp3in
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 104248
VEGA: 10
Homologene: 49307
Exoc6
Name: exocyst complex component 6
Synonyms: hbd, Sec15, Sec15l1, 4833405E05Rik, msec15
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107371
VEGA: 19
Homologene: 41305
Cnn3
Name: calponin 3, acidic
Synonyms: 1600014M03Rik, Calpo3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71994
HGNC: HGNC:2157
Homologene: 37533
Zkscan1
Name: zinc finger with KRAB and SCAN domains 1
Synonyms: 9130423L19Rik, KOX18, 5930429A01Rik, 9230118B16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74570
Homologene: 34523
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: Garnl1, Tulip1, 4930400K19Rik, 2310003F20Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56784
VEGA: 12
Homologene: 84805
Gpatch2
Name: G patch domain containing 2
Synonyms: 5830436K05Rik, Gpatc2, 5830433G22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67769
Homologene: 9976
Ghsr
Name: growth hormone secretagogue receptor
Synonyms: Ghsr1a, C530020I22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 208188
HGNC: HGNC:4267
Homologene: 57161
Fan1
Name: FANCD2/FANCI-associated nuclease 1
Synonyms: 6030441H18Rik, Mtmr15
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330554
Homologene: 45598
Ubr2
Name: ubiquitin protein ligase E3 component n-recognin 2
Synonyms: ENSMUSG00000043296, 9930021A08Rik, E130209G04Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224826
VEGA: 17
Homologene: 26151
Tm9sf3
Name: transmembrane 9 superfamily member 3
Synonyms: 2810031D16Rik, Smbp, 1810073M23Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107358
VEGA: 19
Homologene: 10588
Sec31a
Name: SEC31 homolog A, COPII coat complex component
Synonyms: Sec31l1, 1810024J13Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69162
Homologene: 42056
Cep72
Name: centrosomal protein 72
Synonyms: 2610029E11Rik, 4933440J22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 74470
VEGA: 13
Homologene: 10027
Tecpr2
Name: tectonin beta-propeller repeat containing 2
Synonyms: 4930573I19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104859
VEGA: 12
Homologene: 8897
Tmem120b
Name: transmembrane protein 120B
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330189
Homologene: 62404
Enpp1
Name: ectonucleotide pyrophosphatase/phosphodiesterase 1
Synonyms: Pca, Pca-1, E-NPP1, CD203c, NPP1, twy, 4833416E15Rik, PC-1, Ly-41, Npps, Pdnp1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18605
HGNC: HGNC:3356
Homologene: 38151
Bbs5
Name: Bardet-Biedl syndrome 5
Synonyms: 1700049I01Rik, 2700023J09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72569
HGNC: HGNC:970
Homologene: 12471
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: Dnahc5, Mdnah5, b2b1134Clo, b2b1154Clo, b2b1537Clo, b2b1565Clo, b2b3491Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Cyp2c70
Name: cytochrome P450, family 2, subfamily c, polypeptide 70
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226105
Homologene: 120027
Carmil3
Name: capping protein regulator and myosin 1 linker 3
Synonyms: Lrrc16b
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 268747
VEGA: 14
Homologene: 74564
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: E130113P14Rik, bl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231470
Homologene: 23516
Kcnh2
Name: potassium voltage-gated channel, subfamily H (eag-related), member 2
Synonyms: ether a go-go related, LQT, ERG1, Lqt2, merg1b, M-erg, merg1a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16511
HGNC: HGNC:6251
Homologene: 201
Hrnr
Name: hornerin
Synonyms: S100a18, A530063N20Rik, 1110033K19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68723
Homologene: 138092
Cyp2d26
Name: cytochrome P450, family 2, subfamily d, polypeptide 26
Synonyms: 1300006E06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 76279
VEGA: 15
Homologene: 130660
Cbfa2t3
Name: CBFA2/RUNX1 translocation partner 3
Synonyms: ETO-2, MTGR2, Eto2, A630044F12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12398
HGNC: HGNC:1537
Homologene: 74543
Ccdc157
Name: coiled-coil domain containing 157
Synonyms: 4930562D19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216516
Homologene: 72271
Tbpl2
Name: TATA box binding protein like 2
Synonyms: Trf3, LOC227606
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227606
Homologene: 133152
Tmem150c
Name: transmembrane protein 150C
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231503
Homologene: 18818
Hook2
Name: hook microtubule tethering protein 2
Synonyms: A630054I03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170833
Homologene: 8332
Or52r1c
Name: olfactory receptor family 52 subfamily R member 1C
Synonyms: GA_x6K02T2PBJ9-5796876-5797820, Olfr584, MOR30-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259056
Or4b13
Name: olfactory receptor family 4 subfamily B member 13
Synonyms: Olfr142, K20, GA_x6K02T2Q125-51607674-51606757, MOR227-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 406186
HGNC: HGNC:8290
Homologene: 45081
Mmp21
Name: matrix metallopeptidase 21
Synonyms: b2b2458Clo, b2b873Clo
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 214766
Homologene: 17519
Ubqln3
Name: ubiquilin 3
Synonyms: 4933400K24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244178
Homologene: 9700
Art1
Name: ADP-ribosyltransferase 1
Synonyms: Yac-1, ADPRT
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11870
HGNC: HGNC:723
Homologene: 128621
Semg1
Name: semenogelin 1
Synonyms: SVS II, semenoclotin, Svs2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 53878
Homologene: 49325
Serpinb5
Name: serine (or cysteine) peptidase inhibitor, clade B, member 5
Synonyms: ovalbumin, Spi7, Maspin, 1110036M19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20724
HGNC: HGNC:8949
Homologene: 20580
Adam1a
Name: a disintegrin and metallopeptidase domain 1a
Synonyms: fertilin alpha, PH-30 alpha, Ftna
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 280668
HGNC: HGNC:187
Homologene: 73803
Igkv7-33
Name: immunoglobulin kappa chain variable 7-33
Synonyms: U29423
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243461
HGNC: HGNC:5834
Gm1979
Name: predicted gene 1979
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100038949
Homologene: 69402
Pcdhga4
Name: protocadherin gamma subfamily A, 4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93712
HGNC: HGNC:8702
Homologene: 81866
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 106,870,418 bp
  • A to G, chromosome 1 at 187,233,236 bp
  • T to C, chromosome 2 at 24,094,941 bp
  • A to G, chromosome 2 at 27,172,797 bp
  • T to C, chromosome 2 at 69,654,354 bp
  • A to G, chromosome 2 at 90,252,334 bp
  • A to G, chromosome 2 at 164,237,628 bp
  • A to G, chromosome 3 at 27,372,325 bp
  • C to T, chromosome 3 at 83,008,420 bp
  • A to T, chromosome 3 at 93,332,360 bp
  • C to T, chromosome 3 at 121,450,053 bp
  • A to C, chromosome 3 at 129,681,204 bp
  • C to T, chromosome 4 at 101,447,259 bp
  • T to C, chromosome 4 at 128,999,212 bp
  • T to A, chromosome 5 at 24,324,339 bp
  • A to T, chromosome 5 at 26,002,030 bp
  • A to G, chromosome 5 at 96,768,352 bp
  • T to C, chromosome 5 at 100,083,718 bp
  • T to C, chromosome 5 at 100,392,510 bp
  • A to G, chromosome 5 at 121,519,362 bp
  • T to G, chromosome 5 at 123,116,224 bp
  • C to T, chromosome 5 at 134,242,785 bp
  • T to C, chromosome 5 at 138,093,305 bp
  • A to G, chromosome 6 at 6,879,585 bp
  • G to A, chromosome 6 at 70,058,801 bp
  • T to A, chromosome 7 at 64,372,486 bp
  • A to T, chromosome 7 at 102,106,770 bp
  • A to T, chromosome 7 at 103,085,814 bp
  • A to T, chromosome 7 at 104,142,310 bp
  • G to A, chromosome 7 at 128,725,196 bp
  • T to C, chromosome 7 at 133,678,975 bp
  • A to T, chromosome 8 at 77,310,747 bp
  • C to A, chromosome 8 at 85,002,998 bp
  • C to G, chromosome 8 at 122,647,739 bp
  • T to C, chromosome 10 at 24,651,339 bp
  • A to G, chromosome 10 at 50,729,961 bp
  • A to T, chromosome 10 at 75,715,758 bp
  • A to G, chromosome 11 at 4,144,030 bp
  • A to T, chromosome 11 at 9,298,568 bp
  • T to C, chromosome 12 at 55,786,212 bp
  • T to A, chromosome 12 at 110,944,863 bp
  • A to T, chromosome 13 at 74,040,087 bp
  • G to A, chromosome 14 at 55,501,561 bp
  • A to T, chromosome 15 at 28,409,268 bp
  • C to T, chromosome 15 at 82,792,540 bp
  • T to C, chromosome 17 at 46,973,031 bp
  • A to G, chromosome 18 at 37,687,405 bp
  • A to G, chromosome 19 at 37,571,863 bp
  • A to G, chromosome 19 at 40,167,563 bp
  • A to G, chromosome 19 at 41,223,199 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6936 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045050-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.