Strain Name:
C57BL/6J-MtgxR6950Btlr/Mmmh
Stock Number:
045062-MU
Citation ID:
RRID:MMRRC_045062-MU
Other Names:
R6950 (G1)
Major Collection:

Strain Information

Phf14
Name: PHD finger protein 14
Synonyms: 1110001C23Rik, 5730446A07Rik, 4932409F11Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75725
Homologene: 8775
Oxr1
Name: oxidation resistance 1
Synonyms: C7, C7B, 2210416C20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 170719
VEGA: 15
Homologene: 24993
Gch1
Name: GTP cyclohydrolase 1
Synonyms: GTPCH, GTP-CH
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14528
VEGA: 14
HGNC: HGNC:4193
Homologene: 132
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: slip, DNAPDcs, DNA-PKcs, DNA-PK, DOXNPH, XRCC7, dxnph
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Rapgef6
Name: Rap guanine nucleotide exchange factor (GEF) 6
Synonyms: PDZ-GEF2, RA-GEF-2, C030018K18Rik, Pdzgef2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192786
Homologene: 22968
Dock4
Name: dedicator of cytokinesis 4
Synonyms: EST N28122, 6330411N01Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238130
VEGA: 12
Homologene: 56680
Gapvd1
Name: GTPase activating protein and VPS9 domains 1
Synonyms: 4432404J10Rik, 2010005B09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66691
Homologene: 32637
Tiam1
Name: T cell lymphoma invasion and metastasis 1
Synonyms: D16Ium10e, D16Ium10
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 21844
Homologene: 2443
Zfp626
Name: zinc finger protein 626
Synonyms: 4933426I21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71163
Trpm4
Name: transient receptor potential cation channel, subfamily M, member 4
Synonyms: TRPM4B, 1110030C19Rik, LTRPC4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68667
Homologene: 23033
Neto2
Name: neuropilin (NRP) and tolloid (TLL)-like 2
Synonyms: 5530601C23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74513
Homologene: 32387
Igf2r
Name: insulin-like growth factor 2 receptor
Synonyms: M6P/IGF2R, mannose-6-phosphate receptor, cation independent, CD222, CI-MPR, Mpr300, IGF-II/CI-MPR
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16004
HGNC: HGNC:5467
Homologene: 676
Tenm3
Name: teneurin transmembrane protein 3
Synonyms: 2610100B16Rik, Odz3, Ten-m3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23965
Homologene: 22673
Smg5
Name: SMG5 nonsense mediated mRNA decay factor
Synonyms: Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229512
Homologene: 9095
Slc9a4
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 4
Synonyms: NHE4, D730009J23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 110895
Homologene: 72232
Irf8
Name: interferon regulatory factor 8
Synonyms: IRF-8, Myls, ICSBP, Icsbp1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 15900
HGNC: HGNC:5358
Homologene: 1629
Ube2t
Name: ubiquitin-conjugating enzyme E2T
Synonyms: 2700084L22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67196
Homologene: 40929
Agtpbp1
Name: ATP/GTP binding protein 1
Synonyms: Ccp1, atms, Nna1, 5730402G09Rik, 1700020N17Rik, 2900054O13Rik, 4930445M19Rik, 2310001G17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67269
Homologene: 9067
Hes1
Name: hes family bHLH transcription factor 1
Synonyms: Hry, bHLHb39
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 15205
HGNC: HGNC:5192
Homologene: 38067
Trp73
Name: transformation related protein 73
Synonyms: deltaNp73, TAp73, p73
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22062
Homologene: 3960
Xylt2
Name: xylosyltransferase II
Synonyms: E030002B02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217119
Homologene: 23349
Cdh8
Name: cadherin 8
Synonyms: cad8
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12564
HGNC: HGNC:1767
Homologene: 55604
Or4a78
Name: olfactory receptor family 4 subfamily A member 78
Synonyms: GA_x6K02T2Q125-51109312-51108356, Olfr1251, MOR231-24_p, MOR231-15P
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259145
Homologene: 74065
Nipsnap3b
Name: nipsnap homolog 3B
Synonyms: 2700063N13Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66536
Homologene: 75044
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Eogt
Name: EGF domain specific O-linked N-acetylglucosamine transferase
Synonyms: A130022J15Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101351
Homologene: 65276
Fbn2
Name: fibrillin 2
Synonyms: Fib-2, sy, Sne
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Ccr6
Name: C-C motif chemokine receptor 6
Synonyms: Cmkbr6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12458
VEGA: 17
HGNC: HGNC:1607
Homologene: 3214
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20192
Homologene: 68151
Ifngr1
Name: interferon gamma receptor 1
Synonyms: CD119, Ifgr, IFN-gamma R, IFN-gammaR, Ifngr, Nktar
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15979
HGNC: HGNC:5439
Homologene: 359
Trpc3
Name: transient receptor potential cation channel, subfamily C, member 3
Synonyms: Trrp3, Trp3, Trcp3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22065
Homologene: 20708
Atxn7
Name: ataxin 7
Synonyms: A430107N12Rik, ataxin-7, Sca7
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 246103
VEGA: 14
Homologene: 30967
Adcy2
Name: adenylate cyclase 2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 210044
VEGA: 13
HGNC: HGNC:233
Homologene: 75133
Tmem175
Name: transmembrane protein 175
Synonyms: 3010001K23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72392
Homologene: 12461
Tgm7
Name: transglutaminase 7
Synonyms: TGz
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 640543
Homologene: 14192
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: Mll4, C430014K11Rik, Mll2, bapa
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
Lratd2
Name: LRAT domain containing 1
Synonyms: D330050I23Rik, Fam84b
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 399603
Homologene: 18379
Ephb1
Name: Eph receptor B1
Synonyms: Net, Elkh, Elk, C130099E04Rik, Hek6, Cek6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270190
HGNC: HGNC:3392
Homologene: 20936
Naaladl1
Name: N-acetylated alpha-linked acidic dipeptidase-like 1
Synonyms: LOC381204
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 381204
Homologene: 21124
Vmn2r114
Name: vomeronasal 2, receptor 114
Synonyms: EG666002
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 666002
Homologene: 86604
Ces5a
Name: carboxylesterase 5A
Synonyms: cauxin, LOC244598, 1700122C07Rik, Ces7, 1700081L16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67935
Homologene: 74305
Cyp4f39
Name: cytochrome P450, family 4, subfamily f, polypeptide 39
Synonyms: 4732474A20Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320997
VEGA: 17
Homologene: 69814
Dffb
Name: DNA fragmentation factor, beta subunit
Synonyms: DFF40, CPAN, CAD, caspase-activated DNase, 40kDa, 5730477D02Rik, Didff
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13368
HGNC: HGNC:2773
Homologene: 3241
Ptpru
Name: protein tyrosine phosphatase receptor type U
Synonyms: RPTPlambda, Ptprl
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19273
HGNC: HGNC:9683
Homologene: 4168
Abcc1
Name: ATP-binding cassette, sub-family C member 1
Synonyms: Mrp1, Abcc1a, Mdrap, MRP, Abcc1b
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17250
HGNC: HGNC:51
Homologene: 133779
Or4z4
Name: olfactory receptor family 4 subfamily Z member 4
Synonyms: Olfr1427, GA_x6K02T2RE5P-2458473-2457538, MOR239-4
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258674
Homologene: 128080
Zfp119b
Name: zinc finger protein 119b
Synonyms: BC031441
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240120
Msl2
Name: MSL complex subunit 2
Synonyms: Msl2l1, E130103E02Rik, Rnf184
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 77853
Homologene: 10021
Or8c17
Name: olfactory receptor family 8 subfamily C member 17
Synonyms: MOR170-1, Olfr895, GA_x6K02T2PVTD-31962461-31963411
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258875
Homologene: 74253
Npb
Name: neuropeptide B
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 208990
Homologene: 102151
Zfp850
Name: zinc finger protein 850
Synonyms: C130069I09Rik, Gm4636
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043772
Nutm1
Name: NUT midline carcinoma, family member 1
Synonyms: Nut, BC125332
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 213765
Homologene: 18185
Cav3
Name: caveolin 3
Synonyms: M-caveolin, Cav-3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12391
HGNC: HGNC:1529
Homologene: 7255
Fam114a1
Name: family with sequence similarity 114, member A1
Synonyms: 1190001N04Rik, 9130005N14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68303
Homologene: 12259
Lrrc36
Name: leucine rich repeat containing 36
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270091
Homologene: 23090
Ifnl3
Name: interferon lambda 3
Synonyms: INF-lambda, Il28, IFL-1, Il28b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 338374
Homologene: 77540
Rgmb
Name: repulsive guidance molecule family member B
Synonyms: 1110059F19Rik, RGM domain family, member B, DRAGON
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68799
VEGA: 17
Homologene: 65355
Igfbpl1
Name: insulin-like growth factor binding protein-like 1
Synonyms: IGFBP-like protein, 2810011G06Rik, 2810453O06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 75426
Homologene: 10292
Hoxb2
Name: homeobox B2
Synonyms: Hox-2.8, Hoxbes2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103889
HGNC: HGNC:5113
Homologene: 37584
Cisd3
Name: CDGSH iron sulfur domain 3
Synonyms: Mel13
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217149
Homologene: 35399
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 40,602,885 bp
  • T to G, chromosome 1 at 134,971,357 bp
  • A to G, chromosome 2 at 34,684,245 bp
  • A to G, chromosome 2 at 82,985,988 bp
  • T to A, chromosome 2 at 89,667,551 bp
  • T to A, chromosome 2 at 112,248,559 bp
  • T to C, chromosome 2 at 112,686,825 bp
  • T to C, chromosome 2 at 121,093,647 bp
  • C to T, chromosome 3 at 36,638,590 bp
  • T to C, chromosome 3 at 88,349,269 bp
  • T to A, chromosome 4 at 45,815,494 bp
  • A to T, chromosome 4 at 53,015,136 bp
  • T to A, chromosome 4 at 131,776,352 bp
  • A to T, chromosome 4 at 153,970,092 bp
  • G to T, chromosome 4 at 154,062,053 bp
  • A to T, chromosome 5 at 64,979,979 bp
  • A to G, chromosome 5 at 108,643,082 bp
  • A to T, chromosome 6 at 12,006,855 bp
  • A to G, chromosome 6 at 97,134,382 bp
  • C to T, chromosome 6 at 112,472,210 bp
  • T to G, chromosome 7 at 27,818,914 bp
  • A to G, chromosome 7 at 27,990,514 bp
  • A to T, chromosome 7 at 28,523,007 bp
  • C to A, chromosome 7 at 45,319,280 bp
  • A to T, chromosome 8 at 48,240,479 bp
  • G to T, chromosome 8 at 85,670,443 bp
  • G to T, chromosome 8 at 93,530,774 bp
  • A to T, chromosome 8 at 99,030,763 bp
  • G to T, chromosome 8 at 105,425,389 bp
  • A to G, chromosome 8 at 120,755,125 bp
  • A to T, chromosome 9 at 38,268,546 bp
  • C to T, chromosome 9 at 101,101,975 bp
  • T to A, chromosome 9 at 102,194,909 bp
  • T to A, chromosome 10 at 19,607,293 bp
  • T to A, chromosome 11 at 54,676,380 bp
  • C to T, chromosome 11 at 94,667,629 bp
  • A to G, chromosome 11 at 96,351,901 bp
  • T to G, chromosome 11 at 97,686,160 bp
  • T to C, chromosome 11 at 120,608,647 bp
  • A to G, chromosome 12 at 40,733,314 bp
  • T to C, chromosome 13 at 59,450,266 bp
  • A to G, chromosome 13 at 68,888,065 bp
  • C to A, chromosome 14 at 14,095,511 bp
  • A to T, chromosome 14 at 47,189,266 bp
  • C to A, chromosome 15 at 41,820,555 bp
  • T to C, chromosome 15 at 60,823,714 bp
  • T to C, chromosome 15 at 98,840,020 bp
  • T to A, chromosome 16 at 14,411,616 bp
  • T to A, chromosome 16 at 15,815,986 bp
  • T to C, chromosome 16 at 30,067,271 bp
  • C to T, chromosome 16 at 89,860,204 bp
  • T to C, chromosome 17 at 8,257,066 bp
  • T to C, chromosome 17 at 12,718,718 bp
  • T to C, chromosome 17 at 15,807,786 bp
  • C to T, chromosome 17 at 23,310,163 bp
  • T to G, chromosome 17 at 32,492,306 bp
  • T to C, chromosome 17 at 55,939,137 bp
  • A to C, chromosome 18 at 58,035,921 bp
  • A to T, chromosome 19 at 6,105,981 bp
  • A to G, chromosome 19 at 12,099,390 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6950 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045062-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.