Strain Name:
C57BL/6J-MtgxR6959Btlr/Mmmh
Stock Number:
045069-MU
Citation ID:
RRID:MMRRC_045069-MU
Other Names:
R6959 (G1)
Major Collection:

Strain Information

Epb41l1
Name: erythrocyte membrane protein band 4.1 like 1
Synonyms: 4.1N, Epb4.1l1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13821
HGNC: HGNC:3378
Homologene: 8126
Rbx1
Name: ring-box 1
Synonyms: 1500002P15Rik, ROC1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 56438
VEGA: 15
HGNC: HGNC:9928
Homologene: 134530
Arhgef12
Name: Rho guanine nucleotide exchange factor 12
Synonyms: 2310014B11Rik, LARG
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69632
VEGA: 9
Homologene: 9088
Pdzd2
Name: PDZ domain containing 2
Synonyms: LOC223364, 4930537L06Rik, Pdzk3, A930022H17Rik, Gm21706
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68070
Homologene: 23393
Usp28
Name: ubiquitin specific peptidase 28
Synonyms: 9830148O20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235323
VEGA: 9
Homologene: 10840
Nf1
Name: neurofibromin 1
Synonyms: Mhdadsk9, neurofibromin, Nf-1, Dsk9
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18015
HGNC: HGNC:7765
Homologene: 226
Gse1
Name: genetic suppressor element 1, coiled-coil protein
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382034
Homologene: 40964
Cstf3
Name: cleavage stimulation factor, 3' pre-RNA, subunit 3
Synonyms: 4732468G05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228410
HGNC: HGNC:2485
Homologene: 1014
Cdk5rap2
Name: CDK5 regulatory subunit associated protein 2
Synonyms: an, 2900018K03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 214444
Homologene: 49533
Zfr
Name: zinc finger RNA binding protein
Synonyms: C920030H05Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22763
Homologene: 8009
Ywhaq
Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
Synonyms: 2700028P07Rik, 14-3-3 tau, 14-3-3 theta
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 22630
Homologene: 105677
Bltp1
Name: bridge-like lipid transfer protein family member 1
Synonyms: Tweek, FSA, 4932438A13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229227
Homologene: 52105
Ncapd2
Name: non-SMC condensin I complex, subunit D2
Synonyms: CAP-D2, 2810406C15Rik, CNAP1, 2810465G24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68298
Homologene: 6497
Igf2bp3
Name: insulin-like growth factor 2 mRNA binding protein 3
Synonyms: 2610101N11Rik, IMP3, Koc13
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 140488
Homologene: 4773
Galnt5
Name: polypeptide N-acetylgalactosaminyltransferase 5
Synonyms: ppGaNTase-T5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241391
HGNC: HGNC:4127
Homologene: 8733
Scube1
Name: signal peptide, CUB domain, EGF-like 1
Synonyms: 7330410C13Rik, A630023E24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 64706
Homologene: 11224
Slit2
Name: slit guidance ligand 2
Synonyms: Drad-1, E130320P19Rik, E030015M03Rik, Slil3, b2b1200.1Clo
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20563
Homologene: 3516
Sarnp
Name: SAP domain containing ribonucleoprotein
Synonyms: 1110005A23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66118
VEGA: 10
Homologene: 41628
Mei1
Name: meiotic double-stranded break formation protein 1
Synonyms: mei1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 74369
Homologene: 46535
Cd200r1
Name: CD200 receptor 1
Synonyms: Mox2r, OX2R, CD200R
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 57781
Homologene: 10957
Chodl
Name: chondrolectin
Synonyms: 3110074E07Rik, MT75, PRED12
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 246048
Homologene: 11795
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: Plc, perlecan, Pcn, per
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Incenp
Name: inner centromere protein
Synonyms: 2700067E22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16319
VEGA: 19
HGNC: HGNC:6058
Homologene: 9624
Reln
Name: reelin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Fat3
Name: FAT atypical cadherin 3
Synonyms: D430038H04Rik, LOC234973, LOC382129, 9430076A06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Calcrl
Name: calcitonin receptor-like
Synonyms: CRLR
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 54598
Homologene: 21179
Srp72
Name: signal recognition particle 72
Synonyms: 72kDa, 5730576P14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66661
Homologene: 38254
Ralgapa2
Name: Ral GTPase activating protein, alpha subunit 2 (catalytic)
Synonyms: RGC2, A230067G21Rik, AS250
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241694
Homologene: 28131
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: OTTMUSG00000005786, LOC380698
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Wdr64
Name: WD repeat domain 64
Synonyms: 4930511H01Rik, 4930415O10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75820
Homologene: 51634
Ttc21b
Name: tetratricopeptide repeat domain 21B
Synonyms: Thm1, 2410066K11Rik, line 158, aln
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 73668
Homologene: 57006
Ros1
Name: Ros1 proto-oncogene
Synonyms: Ros-1, c-ros
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19886
Homologene: 2207
Impg2
Name: interphotoreceptor matrix proteoglycan 2
Synonyms: PG10.2, IPM200, Spacrcan
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224224
Homologene: 9439
Hycc1
Name: hyccin PI4KA lipid kinase complex subunit 1
Synonyms: hyccin, Fam126a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 84652
Homologene: 57175
Idh3b
Name: isocitrate dehydrogenase 3 (NAD+) beta
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 170718
HGNC: HGNC:5385
Homologene: 5035
Tmco4
Name: transmembrane and coiled-coil domains 4
Synonyms: 4632413C14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 77056
Homologene: 57112
Tsfm
Name: Ts translation elongation factor, mitochondrial
Synonyms: EF-TS, EF-Tsmt, 2310050B20Rik, 9430024O13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66399
Homologene: 4184
Atp11a
Name: ATPase, class VI, type 11A
Synonyms: 4930558F19Rik, LOC100045280, 9130422H11Rik, Ih
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50770
Homologene: 75050
Cntnap5b
Name: contactin associated protein-like 5B
Synonyms: Caspr5-2, C230078M14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241175
Homologene: 104295
Lrit1
Name: leucine-rich repeat, immunoglobulin-like and transmembrane domains 1
Synonyms: Lrrc21
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239037
Homologene: 9215
Trim62
Name: tripartite motif-containing 62
Synonyms: Dear1, 6330414G21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67525
Homologene: 10071
4930544D05Rik
Name: RIKEN cDNA 4930544D05 gene
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 668433
Homologene: 109413
Galnt6
Name: polypeptide N-acetylgalactosaminyltransferase 6
Synonyms: GalNAc-T6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 207839
HGNC: HGNC:4128
Homologene: 5218
Mau2
Name: MAU2 sister chromatid cohesion factor
Synonyms: A930019L04Rik, 9130404D08Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74549
Homologene: 12574
Vmn2r86
Name: vomeronasal 2, receptor 86
Synonyms: EG625109
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 625109
Homologene: 129606
Or51b6b
Name: olfactory receptor family 51 subfamily B member 6B
Synonyms: Olfr623, MOR1-4, GA_x6K02T2PBJ9-6384836-6383883
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259126
Homologene: 133591
Mfsd11
Name: major facilitator superfamily domain containing 11
Synonyms: 2600014M03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69900
Homologene: 11517
Tspan10
Name: tetraspanin 10
Synonyms: Ocsp
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 208634
Homologene: 49972
Slc18b1
Name: solute carrier family 18, subfamily B, member 1
Synonyms: 1110021L09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 76306
Homologene: 33473
Btnl2
Name: butyrophilin-like 2
Synonyms: BTL-II, BTLN2, butyrophylin-like MHC class II associated, NG9
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 547431
HGNC: HGNC:1142
Homologene: 10482
Slc37a2
Name: solute carrier family 37 (glycerol-3-phosphate transporter), member 2
Synonyms: Slc37a1, cI-2, G3PP, ci2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56857
Homologene: 41357
Ttll1
Name: tubulin tyrosine ligase-like 1
Synonyms: 6330444E16Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 319953
HGNC: HGNC:1312
Homologene: 8174
Cfap157
Name: cilia and flagella associated protein 157
Synonyms: 1700019L03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227736
Homologene: 53056
Duoxa1
Name: dual oxidase maturation factor 1
Synonyms: Nip1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 213696
Homologene: 16043
Castor2
Name: cytosolic arginine sensor for mTORC1 subunit 2
Synonyms: Gats, Gatsl2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 80909
Homologene: 84866
Ikzf2
Name: IKAROS family zinc finger 2
Synonyms: Helios, Zfpn1a2, A730095J18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22779
Homologene: 22659
Kcne4
Name: potassium voltage-gated channel, Isk-related subfamily, gene 4
Synonyms: MiRP3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 57814
HGNC: HGNC:6244
Homologene: 10959
Malrd1
Name: MAM and LDL receptor class A domain containing 1
Synonyms: Gm13364, Gm13318, Diet1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 102635496
Homologene: 136214
Ccl22
Name: C-C motif chemokine ligand 22
Synonyms: Scya22, ABCD-1, MDC
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20299
Homologene: 7529
Gm5478
Name: predicted pseudogene 5478
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 432987
VEGA: 15
Ttc6
Name: tetratricopeptide repeat domain 6
Synonyms: EG639426, AU024163, 4921506M07Rik, Gm9813, LOC217602
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70846
Homologene: 78002
Ccdc196
Name: coiled-coil domain containing 196
Synonyms: Gm6657
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 626215
Homologene: 79089
Gm45861
Name: predicted gene 45861
Type: Gene
Species: Mouse
Chromosome: 8
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 69,538,770 bp
  • A to G, chromosome 1 at 78,817,886 bp
  • A to G, chromosome 1 at 100,274,472 bp
  • T to A, chromosome 1 at 175,705,989 bp
  • A to G, chromosome 2 at 16,218,009 bp
  • A to G, chromosome 2 at 32,784,248 bp
  • A to G, chromosome 2 at 57,999,219 bp
  • A to T, chromosome 2 at 66,231,312 bp
  • A to T, chromosome 2 at 84,370,084 bp
  • A to G, chromosome 2 at 104,649,462 bp
  • T to C, chromosome 2 at 122,303,837 bp
  • A to G, chromosome 2 at 130,281,527 bp
  • A to G, chromosome 2 at 146,342,701 bp
  • G to A, chromosome 2 at 156,499,587 bp
  • T to G, chromosome 3 at 36,967,189 bp
  • G to A, chromosome 4 at 70,360,669 bp
  • A to G, chromosome 4 at 128,909,162 bp
  • A to T, chromosome 4 at 137,519,289 bp
  • T to A, chromosome 4 at 139,010,499 bp
  • A to G, chromosome 5 at 21,976,564 bp
  • T to C, chromosome 5 at 23,991,756 bp
  • A to G, chromosome 5 at 48,238,385 bp
  • T to A, chromosome 5 at 76,994,223 bp
  • T to A, chromosome 5 at 94,447,032 bp
  • T to C, chromosome 5 at 134,135,213 bp
  • T to C, chromosome 6 at 49,117,148 bp
  • A to G, chromosome 6 at 125,168,920 bp
  • T to A, chromosome 7 at 103,660,843 bp
  • T to A, chromosome 8 at 12,820,467 bp
  • T to C, chromosome 8 at 27,548,185 bp
  • T to C, chromosome 8 at 70,033,228 bp
  • A to T, chromosome 8 at 94,746,900 bp
  • A to G, chromosome 8 at 120,570,971 bp
  • T to C, chromosome 9 at 15,996,885 bp
  • T to A, chromosome 9 at 37,241,334 bp
  • T to C, chromosome 9 at 43,015,953 bp
  • T to A, chromosome 9 at 49,001,542 bp
  • A to G, chromosome 10 at 23,826,044 bp
  • T to A, chromosome 10 at 52,163,994 bp
  • T to C, chromosome 10 at 127,022,909 bp
  • T to C, chromosome 10 at 128,848,268 bp
  • A to G, chromosome 10 at 130,446,531 bp
  • G to T, chromosome 11 at 59,037,585 bp
  • G to A, chromosome 11 at 70,616,659 bp
  • A to G, chromosome 11 at 79,549,468 bp
  • T to G, chromosome 11 at 116,861,669 bp
  • T to A, chromosome 11 at 120,444,696 bp
  • A to G, chromosome 12 at 21,396,280 bp
  • A to T, chromosome 12 at 57,658,142 bp
  • A to G, chromosome 12 at 78,202,296 bp
  • G to C, chromosome 14 at 37,060,095 bp
  • T to A, chromosome 14 at 47,720,256 bp
  • T to C, chromosome 15 at 12,150,323 bp
  • C to T, chromosome 15 at 12,375,907 bp
  • T to A, chromosome 15 at 81,470,962 bp
  • T to C, chromosome 15 at 82,124,875 bp
  • G to T, chromosome 15 at 83,502,196 bp
  • G to T, chromosome 15 at 83,629,435 bp
  • A to G, chromosome 15 at 100,714,125 bp
  • T to C, chromosome 15 at 101,645,448 bp
  • T to A, chromosome 16 at 44,790,176 bp
  • A to C, chromosome 16 at 56,268,330 bp
  • G to A, chromosome 16 at 78,946,684 bp
  • G to A, chromosome 17 at 34,363,359 bp
  • T to C, chromosome 19 at 9,876,770 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6959 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045069-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.