Strain Name:
C57BL/6J-MtgxR6972Btlr/Mmmh
Stock Number:
045082-MU
Citation ID:
RRID:MMRRC_045082-MU
Other Names:
R6972 (G1)
Major Collection:

Strain Information

Ntrk1
Name: neurotrophic tyrosine kinase, receptor, type 1
Synonyms: Tkr, TrkA
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18211
HGNC: HGNC:8031
Homologene: 1898
Fuz
Name: fuzzy planar cell polarity protein
Synonyms: 2600013E07Rik, b2b1273Clo
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70300
Homologene: 11840
Dcaf1
Name: DDB1 and CUL4 associated factor 1
Synonyms: Vprbp, B930007L02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 321006
Homologene: 8805
Ckap5
Name: cytoskeleton associated protein 5
Synonyms: 3110043H24Rik, 4930432B04Rik, D730027C18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75786
Homologene: 8844
Orc4
Name: origin recognition complex, subunit 4
Synonyms: Orc4, Orc4l, Orc4P, mMmORC4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26428
HGNC: HGNC:8490
Homologene: 8059
Resf1
Name: retroelement silencing factor 1
Synonyms: 2810474O19Rik, GET
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67246
Homologene: 19251
Akap9
Name: A kinase anchor protein 9
Synonyms: G1-448-15, 5730481H23Rik, mei2-5, AKAP450, repro12
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100986
HGNC: HGNC:379
Homologene: 134583
Chek2
Name: checkpoint kinase 2
Synonyms: CHK2, Rad53
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 50883
Homologene: 38289
Git1
Name: GIT ArfGAP 1
Synonyms: p95Cat, Cat-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216963
HGNC: HGNC:4272
Homologene: 32204
Bdp1
Name: B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
Synonyms: TAF3B1, Tfnr, TFC5, TFIIIB90, TFIIIB150, B130055N23Rik, G630013P12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 544971
Homologene: 34582
Ptprj
Name: protein tyrosine phosphatase receptor type J
Synonyms: RPTPJ, CD148, DEP-1, Scc1, Byp, Scc-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19271
HGNC: HGNC:9673
Homologene: 2130
Dcdc2a
Name: doublecortin domain containing 2a
Synonyms: Dcdc2, RU2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 195208
Homologene: 9483
Taf4b
Name: TATA-box binding protein associated factor 4b
Synonyms: 105kDa, 4932409F03Rik, Taf2c2, TAFII105, 2610524B04Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 72504
VEGA: 18
Homologene: 28266
Eml5
Name: echinoderm microtubule associated protein like 5
Synonyms: C130068M19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319670
VEGA: 12
Homologene: 26807
Trim29
Name: tripartite motif-containing 29
Synonyms: 4732461M22Rik, 1110047J21Rik, 2810431N19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72169
VEGA: 9
Homologene: 8100
Prg2
Name: proteoglycan 2, bone marrow
Synonyms: EMBP, mMBP-1, mMBP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19074
HGNC: HGNC:9362
Homologene: 2044
Nos3
Name: nitric oxide synthase 3, endothelial cell
Synonyms: 2310065A03Rik, ecNOS, Nos-3, eNOS
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18127
HGNC: HGNC:7876
Homologene: 504
Calcrl
Name: calcitonin receptor-like
Synonyms: CRLR
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 54598
Homologene: 21179
Skint3
Name: selection and upkeep of intraepithelial T cells 3
Synonyms: A430090E18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 195564
Vmn2r77
Name: vomeronasal 2, receptor 77
Synonyms: EG546983
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 546983
Homologene: 115466
Grm5
Name: glutamate receptor, metabotropic 5
Synonyms: 6430542K11Rik, Glu5R, mGluR5, Gprc1e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108071
HGNC: HGNC:4597
Homologene: 37354
Mybpc1
Name: myosin binding protein C, slow-type
Synonyms: Slow-type C-protein, 8030451F13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 109272
HGNC: HGNC:7549
Homologene: 1846
Nfic
Name: nuclear factor I/C
Synonyms: nuclear factor 1-C2, NF1-C, 1500041O16Rik, 1110019L22Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18029
HGNC: HGNC:7786
Homologene: 4088
Cd69
Name: CD69 antigen
Synonyms: 5830438K24Rik, AIM, VEA
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12515
HGNC: HGNC:1694
Homologene: 128584
Iqsec1
Name: IQ motif and Sec7 domain 1
Synonyms: cI-43, D6Ertd349e, BRAG2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232227
Homologene: 82429
Etv2
Name: ets variant 2
Synonyms: Etsrp71
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14008
HGNC: HGNC:3491
Homologene: 7308
Pcdhb14
Name: protocadherin beta 14
Synonyms: PcdhbN, Pcdhb17, 2210006M07Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93885
Homologene: 70876
Kcnh1
Name: potassium voltage-gated channel, subfamily H (eag-related), member 1
Synonyms: Kv10.1, Eag1, ether a go-go
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16510
HGNC: HGNC:6250
Homologene: 68242
Zfp687
Name: zinc finger protein 687
Synonyms: 4931408L03Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 78266
Homologene: 10827
Smarca5
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
Synonyms: D330027N15Rik, MommeD4, Snf2h, 4933427E24Rik, D030040M08Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 93762
Homologene: 55764
Or2ag16
Name: olfactory receptor family 2 subfamily AG member 16
Synonyms: Olfr698, MOR283-3, GA_x6K02T2PBJ9-9130754-9129519
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258595
Homologene: 133598
Plscr3
Name: phospholipid scramblase 3
Synonyms: 2610037N06Rik, 2210403O21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70310
Homologene: 23219
Pltp
Name: phospholipid transfer protein
Synonyms: Bpife, OD107
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18830
HGNC: HGNC:9093
Homologene: 4536
Abhd2
Name: abhydrolase domain containing 2
Synonyms: LABH2, 2210009N18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 54608
Homologene: 23121
Tafa2
Name: TAFA chemokine like family member 2
Synonyms: Tafa2, Sam2, Fam19a2, Tafa-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268354
VEGA: 10
Homologene: 18678
B3gnt7
Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
Synonyms: beta-3GnT7, C330001H22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227327
Homologene: 17049
Zeb2
Name: zinc finger E-box binding homeobox 2
Synonyms: D130016B08Rik, SIP1, Zfx1b, 9130203F04Rik, Zfhx1b
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 24136
Homologene: 8868
Lmcd1
Name: LIM and cysteine-rich domains 1
Synonyms: dyxin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 30937
HGNC: HGNC:6633
Homologene: 22823
Afg1l
Name: AFG1 like ATPase
Synonyms: Lace1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215951
Homologene: 5782
Gpr162
Name: G protein-coupled receptor 162
Synonyms: A-2, Grca
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14788
Homologene: 8400
Cyp4f14
Name: cytochrome P450, family 4, subfamily f, polypeptide 14
Synonyms: leukotriene B4 omega hydroxylase, 1300014O15Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 64385
VEGA: 17
Homologene: 81872
Gm15922
Name: predicted gene 15922
Type: Gene
Species: Mouse
Chromosome: 7
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 86,305,387 bp
  • A to G, chromosome 1 at 192,276,836 bp
  • T to C, chromosome 2 at 44,997,318 bp
  • T to C, chromosome 2 at 48,927,184 bp
  • T to G, chromosome 2 at 84,368,578 bp
  • G to A, chromosome 2 at 84,982,273 bp
  • G to A, chromosome 2 at 90,580,403 bp
  • T to A, chromosome 2 at 91,606,313 bp
  • A to G, chromosome 2 at 164,846,592 bp
  • A to T, chromosome 3 at 87,783,981 bp
  • A to G, chromosome 3 at 95,009,377 bp
  • T to A, chromosome 4 at 112,258,892 bp
  • A to G, chromosome 4 at 143,896,902 bp
  • A to G, chromosome 5 at 4,046,699 bp
  • A to T, chromosome 5 at 24,380,243 bp
  • T to C, chromosome 5 at 110,855,839 bp
  • T to C, chromosome 6 at 90,676,768 bp
  • C to T, chromosome 6 at 112,310,698 bp
  • C to T, chromosome 6 at 124,861,309 bp
  • T to C, chromosome 6 at 129,269,580 bp
  • T to A, chromosome 6 at 149,326,109 bp
  • C to G, chromosome 7 at 3,737,320 bp
  • T to C, chromosome 7 at 30,634,742 bp
  • T to C, chromosome 7 at 44,897,331 bp
  • A to G, chromosome 7 at 79,354,027 bp
  • T to C, chromosome 7 at 86,802,994 bp
  • T to C, chromosome 7 at 87,602,923 bp
  • A to G, chromosome 7 at 106,752,699 bp
  • A to G, chromosome 8 at 80,704,751 bp
  • T to A, chromosome 9 at 43,327,112 bp
  • T to A, chromosome 9 at 106,846,772 bp
  • T to C, chromosome 10 at 42,478,374 bp
  • C to A, chromosome 10 at 81,420,357 bp
  • T to C, chromosome 10 at 88,560,361 bp
  • A to G, chromosome 10 at 123,704,373 bp
  • G to A, chromosome 11 at 69,847,958 bp
  • T to G, chromosome 11 at 77,499,521 bp
  • T to C, chromosome 12 at 98,876,180 bp
  • A to T, chromosome 13 at 25,120,389 bp
  • T to C, chromosome 13 at 100,037,761 bp
  • C to T, chromosome 17 at 32,905,509 bp
  • T to C, chromosome 18 at 14,813,347 bp
  • T to A, chromosome 18 at 37,449,692 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6972 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045082-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.