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Strain Name:
C57BL/6J-MtgxR6979Btlr/Mmmh
Stock Number:
045087-MU
Citation ID:
RRID:MMRRC_045087-MU
Other Names:
R6979 (G1)
Major Collection:

Strain Information

Prkar2a
Name: protein kinase, cAMP dependent regulatory, type II alpha
Synonyms: RII(alpha), 1110061A24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19087
HGNC: HGNC:9391
Homologene: 3064
Mtrr
Name: 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 210009
VEGA: 13
HGNC: HGNC:7473
Homologene: 11419
Map4k5
Name: mitogen-activated protein kinase kinase kinase kinase 5
Synonyms: MAPKKKK5, GCKR, KHS, 4432415E19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 399510
HGNC: HGNC:6867
Homologene: 38199
Spen
Name: spen family transcription repressor
Synonyms: Mint
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56381
Homologene: 124461
Mtor
Name: mechanistic target of rapamycin kinase
Synonyms: FKBP-rapamycin-associated protein FRAP, 2610315D21Rik, RAPT1, RAFT1, flat, Frap1, mechanistic target of rapamycin (serine/threonine kinase)
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56717
HGNC: HGNC:3942
Homologene: 3637
Mat2a
Name: methionine adenosyltransferase 2A
Synonyms: D630045P18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232087
HGNC: HGNC:6904
Homologene: 38112
Cpne3
Name: copine III
Synonyms: 5730450C07Rik, PRO1071, CPN3, 5430428M23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70568
HGNC: HGNC:2316
Homologene: 20839
Polr1c
Name: polymerase (RNA) I polypeptide C
Synonyms: RPA40, 40kDa, Rpo1-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20016
Homologene: 3586
Dop1a
Name: DOP1 leucine zipper like protein A
Synonyms: B130005I07Rik, D9Ertd809e, Dopey1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320615
Homologene: 26645
Aspm
Name: abnormal spindle microtubule assembly
Synonyms: Sha1, Aspm, D330028K02Rik, MCPH5, Calmbp1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12316
Homologene: 7650
Tep1
Name: telomerase associated protein 1
Synonyms: Tp1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21745
VEGA: 14
Homologene: 5157
Zfp35
Name: zinc finger protein 35
Synonyms: Zfp-35
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 22694
Homologene: 133081
Tmem259
Name: transmembrane protein 259
Synonyms: membralin, ORF61
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216157
Homologene: 14122
Dmxl2
Name: Dmx-like 2
Synonyms: E130119P06Rik, 6430411K14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235380
HGNC: HGNC:2938
Homologene: 41022
Ube2l3
Name: ubiquitin-conjugating enzyme E2L 3
Synonyms: UbcM4, Ubce7
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22195
Homologene: 43226
Dapk1
Name: death associated protein kinase 1
Synonyms: 2310039H24Rik, D13Ucla1, 2810425C21Rik, DAP-Kinase
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69635
VEGA: 13
HGNC: HGNC:2674
Homologene: 3626
Unkl
Name: unkempt family like zinc finger
Synonyms: 1300004G08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74154
Homologene: 62673
Mpp7
Name: membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
Synonyms: 5430426E14Rik, 2810038M04Rik, LOC381166, 1110068J02Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 75739
VEGA: 18
Homologene: 1455
Pomt2
Name: protein-O-mannosyltransferase 2
Synonyms: A830009D15Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217734
VEGA: 12
Homologene: 5297
Ctnnd2
Name: catenin delta 2
Synonyms: Nprap, Catnd2, neurojugin, catenin (cadherin associated protein), delta 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18163
VEGA: 15
HGNC: HGNC:2516
Homologene: 55574
Ccnt2
Name: cyclin T2
Synonyms: 2900041I18Rik, CycT2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72949
HGNC: HGNC:1600
Homologene: 14043
Zfp420
Name: zinc finger protein 420
Synonyms: B230312I18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233058
Homologene: 129731
Ttn
Name: titin
Synonyms: connectin, L56, 1100001C23Rik, mdm, 2310036G12Rik, D830007G01Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Ctdspl
Name: CTD small phosphatase like
Synonyms: SCP3, HYA22, 2810418J22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69274
Homologene: 48881
Nwd1
Name: NACHT and WD repeat domain containing 1
Synonyms: A230063L24Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 319555
Homologene: 72261
Slx4
Name: SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
Synonyms: D16Bwg1016e, Btbd12
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 52864
Homologene: 23770
Or8h10
Name: olfactory receptor family 8 subfamily H member 10
Synonyms: GA_x6K02T2Q125-48465387-48464422, MOR206-4, Olfr1100
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258587
Homologene: 34954
Mroh5
Name: maestro heat-like repeat family member 5
Synonyms: LOC268816, Gm628
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 268816
Tmpo
Name: thymopoietin
Synonyms: TP, 5630400D24Rik, LAP2, lamina-associated polypeptide 2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21917
VEGA: 10
Homologene: 31144
H2-Q2
Name: histocompatibility 2, Q region locus 2
Synonyms: H-2Q2, Gm11132
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15013
Homologene: 128352
Mrc2
Name: mannose receptor, C type 2
Synonyms: novel lectin, Endo180, uPARAP
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17534
Homologene: 4408
Hes6
Name: hairy and enhancer of split 6
Synonyms: bHLHb41
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 55927
Homologene: 23111
Prl5a1
Name: prolactin family 5, subfamily a, member 1
Synonyms: 1600013P04Rik, PLP-L, D13Wsu14e, Prlpl
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 28078
Homologene: 11378
Foxg1
Name: forkhead box G1
Synonyms: BF-1, Hfh9, Hfhbf1, Bf1, 2900064B05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 15228
HGNC: HGNC:3811
Homologene: 3843
Mark1
Name: MAP/microtubule affinity regulating kinase 1
Synonyms: Emk3, B930025N23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226778
HGNC: HGNC:6896
Homologene: 49552
Polrmt
Name: polymerase (RNA) mitochondrial (DNA directed)
Synonyms: 1110018N15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216151
HGNC: HGNC:9200
Homologene: 37996
Or4a27
Name: olfactory receptor family 4 subfamily A member 27
Synonyms: GA_x6K02T2Q125-50202854-50201910, MOR225-14, MOR225-10P, Olfr1197
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 433449
Homologene: 123770
Vmn2r17
Name: vomeronasal 2, receptor 17
Synonyms: EG384221
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 384221
Homologene: 104825
Tcp11l1
Name: t-complex 11 like 1
Synonyms: C130096D04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320554
Homologene: 41260
Aadac
Name: arylacetamide deacetylase
Synonyms: Aada, 5033417E09Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67758
HGNC: HGNC:17
Homologene: 37436
Itgb5
Name: integrin beta 5
Synonyms: [b]5B, [b]5A, [b]-5, beta-5, beta5, [b]5, ESTM23
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16419
HGNC: HGNC:6160
Homologene: 20511
Dqx1
Name: DEAQ RNA-dependent ATPase
Synonyms: 2310066E11Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 93838
Homologene: 14143
Ptgs1
Name: prostaglandin-endoperoxide synthase 1
Synonyms: Cox-1, cyclooxygenase 1, Pghs1, COX1, Cox-3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19224
HGNC: HGNC:9604
Homologene: 743
Prpf38b
Name: PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
Synonyms: 1110021E09Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66921
Homologene: 9986
Itfg2
Name: integrin alpha FG-GAP repeat containing 2
Synonyms: 2700050P07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101142
Homologene: 10211
Prl3d3
Name: prolactin family 3, subfamily d, member 3
Synonyms: PL-Ig, Plig
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 215029
Homologene: 137215
Aspg
Name: asparaginase
Synonyms: A530050D06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104816
VEGA: 12
Homologene: 113390
Vmn1r51
Name: vomeronasal 1 receptor 51
Synonyms: V1r1, VN12, V1ra1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22296
Homologene: 130651
Smok3c
Name: sperm motility kinase 3C
Synonyms: EG622486
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 622486
Homologene: 128738
Ptchd1
Name: patched domain containing 1
Synonyms: 9630036J22Rik
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 211612
Homologene: 18302
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 91,413,088 bp
  • T to C, chromosome 1 at 127,775,136 bp
  • C to A, chromosome 1 at 139,480,485 bp
  • C to T, chromosome 1 at 184,912,628 bp
  • A to G, chromosome 2 at 36,251,299 bp
  • C to A, chromosome 2 at 76,724,793 bp
  • A to G, chromosome 2 at 86,978,233 bp
  • T to A, chromosome 2 at 88,729,184 bp
  • C to T, chromosome 2 at 104,706,439 bp
  • C to T, chromosome 3 at 60,040,003 bp
  • A to G, chromosome 3 at 108,911,324 bp
  • G to A, chromosome 4 at 19,533,098 bp
  • A to T, chromosome 4 at 141,478,063 bp
  • A to G, chromosome 4 at 148,524,473 bp
  • A to G, chromosome 5 at 109,428,399 bp
  • A to G, chromosome 5 at 138,064,725 bp
  • A to G, chromosome 6 at 72,435,113 bp
  • A to G, chromosome 6 at 83,061,011 bp
  • A to T, chromosome 6 at 90,129,204 bp
  • A to G, chromosome 6 at 124,317,986 bp
  • T to C, chromosome 6 at 128,411,591 bp
  • T to A, chromosome 7 at 29,876,021 bp
  • C to T, chromosome 8 at 72,667,660 bp
  • A to G, chromosome 9 at 54,450,879 bp
  • A to T, chromosome 9 at 86,521,642 bp
  • T to A, chromosome 9 at 108,733,143 bp
  • G to A, chromosome 9 at 119,040,530 bp
  • C to T, chromosome 10 at 79,746,566 bp
  • C to T, chromosome 10 at 79,978,557 bp
  • A to T, chromosome 10 at 91,152,497 bp
  • C to A, chromosome 11 at 105,348,635 bp
  • T to C, chromosome 12 at 49,384,784 bp
  • A to T, chromosome 12 at 69,822,848 bp
  • T to C, chromosome 12 at 87,130,351 bp
  • A to G, chromosome 12 at 112,120,944 bp
  • T to C, chromosome 12 at 114,937,228 bp
  • T to A, chromosome 13 at 27,157,562 bp
  • T to A, chromosome 13 at 28,151,206 bp
  • T to C, chromosome 13 at 60,748,281 bp
  • C to T, chromosome 13 at 68,570,003 bp
  • A to G, chromosome 14 at 50,838,637 bp
  • A to G, chromosome 15 at 30,619,230 bp
  • T to C, chromosome 15 at 73,793,129 bp
  • T to C, chromosome 16 at 3,985,015 bp
  • G to A, chromosome 16 at 17,159,977 bp
  • T to A, chromosome 16 at 33,919,986 bp
  • A to G, chromosome 17 at 25,199,916 bp
  • T to A, chromosome 17 at 35,345,647 bp
  • A to G, chromosome 17 at 46,246,169 bp
  • T to G, chromosome 18 at 7,355,049 bp
  • G to T, chromosome 18 at 24,003,870 bp
  • T to A, chromosome X at 155,574,712 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6979 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045087-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.