Strain Name:
C57BL/6J-MtgxR6992Btlr/Mmmh
Stock Number:
045098-MU
Citation ID:
RRID:MMRRC_045098-MU
Other Names:
R6992 (G1)
Major Collection:

Strain Information

Neurog1
Name: neurogenin 1
Synonyms: neurogenin, Math4C, ngn1, neurogenin 1, Neurod3, bHLHa6
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18014
VEGA: 13
HGNC: HGNC:7764
Homologene: 4490
Fancd2
Name: Fanconi anemia, complementation group D2
Synonyms: 2410150O07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 211651
HGNC: HGNC:3585
Homologene: 13212
Pdzd2
Name: PDZ domain containing 2
Synonyms: 4930537L06Rik, LOC223364, A930022H17Rik, Pdzk3, Gm21706
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68070
Homologene: 23393
Sema4b
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
Synonyms: SemC, Semac
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20352
Homologene: 8426
Mtor
Name: mechanistic target of rapamycin kinase
Synonyms: FKBP-rapamycin-associated protein FRAP, 2610315D21Rik, RAPT1, RAFT1, flat, Frap1, mechanistic target of rapamycin (serine/threonine kinase)
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56717
HGNC: HGNC:3942
Homologene: 3637
Dlgap4
Name: DLG associated protein 4
Synonyms: WBP16, SAP90/PSD-95-associated protein 4, PSD-95/SAP90 binding protein 4, DAP4, Sapap4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228836
Homologene: 8935
Usp32
Name: ubiquitin specific peptidase 32
Synonyms: 2900074J03Rik, 6430526O11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237898
Homologene: 13066
Mast4
Name: microtubule associated serine/threonine kinase family member 4
Synonyms: 4930420O11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 328329
Homologene: 42094
Sec23ip
Name: Sec23 interacting protein
Synonyms: D7Ertd373e, p125
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 207352
Homologene: 38288
Mrps27
Name: mitochondrial ribosomal protein S27
Synonyms: 2610028H14Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218506
VEGA: 13
Homologene: 41006
Ptprg
Name: protein tyrosine phosphatase receptor type G
Synonyms: 5430405N12Rik, RPTPgamma
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19270
HGNC: HGNC:9671
Homologene: 2129
Tnip1
Name: TNFAIP3 interacting protein 1
Synonyms: ABIN1, A20-binding inhibitor of NF-kappa B activation, VAN, Nef
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 57783
Homologene: 31355
Chd4
Name: chromodomain helicase DNA binding protein 4
Synonyms: D6Ertd380e, 9530019N15Rik, Mi-2beta
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 107932
HGNC: HGNC:1919
Homologene: 68175
Plekha5
Name: pleckstrin homology domain containing, family A member 5
Synonyms: PEPP2, 2810431N21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 109135
Homologene: 10377
Tmem245
Name: transmembrane protein 245
Synonyms: D730040F13Rik, A630051L19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242474
HGNC: HGNC:1363
Homologene: 41841
Mlh3
Name: mutL homolog 3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217716
VEGA: 12
HGNC: HGNC:7128
Homologene: 91153
Frem1
Name: Fras1 related extracellular matrix protein 1
Synonyms: eyem02Jus, heb, QBRICK, crf11, eyes2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329872
Homologene: 27049
Pole
Name: polymerase (DNA directed), epsilon
Synonyms: pol-epsilon
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18973
HGNC: HGNC:9177
Homologene: 4539
6030468B19Rik
Name: RIKEN cDNA 6030468B19 gene
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 77727
Homologene: 90660
Hspbp1
Name: HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
Synonyms: 1500019G21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66245
Homologene: 40827
Golm1
Name: golgi membrane protein 1
Synonyms: D030064E01Rik, PSEC0257, GP73, 2310001L02Rik, Golph2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105348
VEGA: 13
Homologene: 12346
Marchf7
Name: membrane associated ring-CH-type finger 7
Synonyms: Axot, Gtrgeo17, March7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 57438
Homologene: 10753
Inpp4a
Name: inositol polyphosphate-4-phosphatase, type I
Synonyms: 107kDa
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269180
HGNC: HGNC:6074
Homologene: 2871
Rtn3
Name: reticulon 3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20168
VEGA: 19
Homologene: 24934
Gstm4
Name: glutathione S-transferase, mu 4
Synonyms: Gstb-4, Gstb4, 1110004G14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14865
HGNC: HGNC:4636
Homologene: 37357
Klhl6
Name: kelch-like 6
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239743
Homologene: 15603
Adgrf5
Name: adhesion G protein-coupled receptor F5
Synonyms: 8430401C09Rik, Gpr116
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224792
VEGA: 17
Homologene: 9065
Txnip
Name: thioredoxin interacting protein
Synonyms: mVDUP1, THIF, Hyplip1, VDUP1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56338
Homologene: 38186
Col11a2
Name: collagen, type XI, alpha 2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12815
HGNC: HGNC:2187
Homologene: 22547
Or5b122
Name: olfactory receptor family 5 subfamily B member 122
Synonyms: GA_x6K02T2RE5P-3917859-3918806, MOR202-37, Olfr1484
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258288
Homologene: 110492
Tesk1
Name: testis specific protein kinase 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21754
Homologene: 4577
Cyp2b9
Name: cytochrome P450, family 2, subfamily b, polypeptide 9
Synonyms: Cyp2b, phenobarbitol inducible, type a
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13094
HGNC: HGNC:2615
Homologene: 74933
Antxr2
Name: anthrax toxin receptor 2
Synonyms: cI-35, CMG-2, CMG2, 2310046B19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71914
Homologene: 43236
Ppfia2
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
Synonyms: E130120L08Rik, Liprin-alpha2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 327814
VEGA: 10
HGNC: HGNC:9246
Homologene: 27953
Fcgbpl1
Name: Fc fragment of IgG binding protein like 1
Synonyms: 9530053A07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319482
Homologene: 130055
Cdc16
Name: CDC16 cell division cycle 16
Synonyms: 2810431D22Rik, 2700071J12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69957
HGNC: HGNC:1720
Homologene: 2899
Col14a1
Name: collagen, type XIV, alpha 1
Synonyms: 5730412L22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12818
HGNC: HGNC:2191
Homologene: 18741
Adam34
Name: a disintegrin and metallopeptidase domain 34
Synonyms: testase 4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 252866
Homologene: 78104
Or2b4
Name: olfactory receptor family 2 subfamily B member 4
Synonyms: GA_x6K02T2PSCP-2264806-2265753, MOR256-3, A3, Olfr124, SR1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 259064
Homologene: 74266
Slc8b1
Name: solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
Synonyms: Slc24a6, NCKX6, NCLX
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 170756
Homologene: 41602
Slco1a4
Name: solute carrier organic anion transporter family, member 1a4
Synonyms: Oatp2, Oatp1a4, Slc21a5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 28250
Homologene: 130782
Vmn2r66
Name: vomeronasal 2, receptor 66
Synonyms: F830104D24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233437
Homologene: 115466
Slc19a1
Name: solute carrier family 19 (folate transporter), member 1
Synonyms: reduced folate carrier, RFC1, RFC-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20509
Homologene: 57139
Ppm1d
Name: protein phosphatase 1D magnesium-dependent, delta isoform
Synonyms: Wip1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53892
HGNC: HGNC:9277
Homologene: 31185
Cd96
Name: CD96 antigen
Synonyms: Tactile, 1700109I12Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 84544
Homologene: 68489
Psg21
Name: pregnancy-specific beta-1-glycoprotein 21
Synonyms: cea8, 1600019C01Rik, 1600026N13Rik, 1600025N01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72242
Homologene: 110989
Il18rap
Name: interleukin 18 receptor accessory protein
Synonyms: AcPL accessory protein-like)
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16174
HGNC: HGNC:5989
Homologene: 2859
Vwa5b2
Name: von Willebrand factor A domain containing 5B2
Synonyms: EG328644
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 328643
Homologene: 28056
Hdac10
Name: histone deacetylase 10
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 170787
Homologene: 23749
Cc2d1a
Name: coiled-coil and C2 domain containing 1A
Synonyms: Freud-1, Tape
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212139
Homologene: 23040
Smpdl3b
Name: sphingomyelin phosphodiesterase, acid-like 3B
Synonyms: 1110054A24Rik, Asml3b
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100340
Homologene: 8708
Hook2
Name: hook microtubule tethering protein 2
Synonyms: A630054I03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170833
Homologene: 8332
4921539E11Rik
Name: RIKEN cDNA 4921539E11 gene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70941
Homologene: 52843
Klhdc1
Name: kelch domain containing 1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 271005
Homologene: 18155
Or10g6
Name: olfactory receptor family 10 subfamily G member 6
Synonyms: GA_x6K02T2PVTD-33720892-33721824, MOR223-8, Olfr981
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258283
VEGA: 9
Homologene: 64849
Rom1
Name: rod outer segment membrane protein 1
Synonyms: Rom-1, Tspan23, M101156, Rgsc1156
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19881
VEGA: 19
Homologene: 276
Plscr1l1
Name: phospholipid scramblase 1 like 1
Synonyms: 1700057G04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78459
Homologene: 134508
Serpina3k
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3K
Synonyms: 1300001I07Rik, contrapsin, Spi-2, MMCM2, MMSpi2, Spi2, RP54, alpha-1 antiproteinase, D12Rp54
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20714
HGNC: HGNC:16
Homologene: 111129
A730049H05Rik
Name: RIKEN cDNA A730049H05 gene
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74516
Wdr81
Name: WD repeat domain 81
Synonyms: nur5, shakey 5, MGC32441
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192652
Homologene: 13983
Igdcc3
Name: immunoglobulin superfamily, DCC subclass, member 3
Synonyms: 2810401C09Rik, WI-14920, Punc
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19289
VEGA: 9
HGNC: HGNC:9700
Homologene: 3590
Pcdhgb1
Name: protocadherin gamma subfamily B, 1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93699
HGNC: HGNC:8708
Homologene: 81867
Cntf
Name: ciliary neurotrophic factor
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12803
HGNC: HGNC:2169
Homologene: 8288
AC125199.3
Name:
Type: Gene
Species: Mouse
Chromosome: 16
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 37,389,691 bp
  • G to A, chromosome 1 at 40,542,035 bp
  • T to C, chromosome 2 at 60,229,084 bp
  • A to G, chromosome 2 at 156,748,940 bp
  • A to G, chromosome 3 at 96,559,123 bp
  • A to G, chromosome 3 at 108,044,665 bp
  • A to G, chromosome 4 at 43,447,006 bp
  • A to G, chromosome 4 at 56,937,940 bp
  • A to G, chromosome 4 at 82,940,362 bp
  • C to T, chromosome 4 at 103,242,793 bp
  • G to T, chromosome 4 at 132,745,141 bp
  • A to T, chromosome 4 at 148,464,475 bp
  • T to C, chromosome 5 at 97,960,705 bp
  • A to T, chromosome 5 at 110,332,499 bp
  • G to A, chromosome 5 at 120,527,815 bp
  • T to C, chromosome 6 at 92,827,994 bp
  • T to C, chromosome 6 at 113,571,018 bp
  • T to A, chromosome 6 at 125,114,376 bp
  • C to T, chromosome 6 at 140,543,908 bp
  • T to C, chromosome 6 at 141,819,604 bp
  • G to C, chromosome 7 at 4,664,715 bp
  • A to T, chromosome 7 at 18,654,743 bp
  • T to C, chromosome 7 at 26,201,139 bp
  • T to A, chromosome 7 at 28,140,183 bp
  • T to A, chromosome 7 at 80,220,152 bp
  • A to G, chromosome 7 at 85,005,228 bp
  • T to C, chromosome 7 at 128,765,440 bp
  • C to A, chromosome 8 at 13,759,188 bp
  • A to T, chromosome 8 at 43,652,605 bp
  • A to T, chromosome 8 at 84,134,913 bp
  • A to G, chromosome 8 at 85,002,556 bp
  • T to A, chromosome 9 at 40,022,600 bp
  • C to A, chromosome 9 at 65,181,571 bp
  • T to C, chromosome 9 at 92,354,672 bp
  • A to G, chromosome 10 at 77,049,706 bp
  • A to T, chromosome 10 at 106,474,854 bp
  • T to A, chromosome 11 at 54,918,716 bp
  • G to A, chromosome 11 at 75,451,786 bp
  • A to C, chromosome 11 at 85,032,088 bp
  • T to C, chromosome 11 at 85,332,352 bp
  • T to G, chromosome 11 at 117,797,768 bp
  • A to G, chromosome 12 at 69,253,757 bp
  • T to A, chromosome 12 at 85,235,720 bp
  • T to A, chromosome 12 at 104,341,107 bp
  • T to C, chromosome 13 at 56,251,550 bp
  • ACTTCTTCT to ACTTCT, chromosome 13 at 59,649,576 bp
  • A to G, chromosome 13 at 99,405,014 bp
  • C to T, chromosome 13 at 102,804,647 bp
  • T to A, chromosome 14 at 11,962,602 bp
  • T to C, chromosome 15 at 12,457,859 bp
  • T to A, chromosome 15 at 55,411,562 bp
  • T to C, chromosome 15 at 89,125,331 bp
  • G to T, chromosome 16 at 19,953,587 bp
  • T to A, chromosome 16 at 20,598,202 bp
  • A to G, chromosome 16 at 46,049,724 bp
  • G to T, chromosome 16 at 88,812,027 bp
  • C to T, chromosome 17 at 34,047,144 bp
  • T to A, chromosome 17 at 37,805,863 bp
  • T to C, chromosome 17 at 43,452,323 bp
  • A to G, chromosome 18 at 37,681,599 bp
  • A to G, chromosome 19 at 7,435,124 bp
  • G to A, chromosome 19 at 8,929,205 bp
  • A to T, chromosome 19 at 12,765,333 bp
  • A to G, chromosome 19 at 13,585,447 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6992 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045098-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.