Strain Name:
C57BL/6J-MtgxR7020Btlr/Mmmh
Stock Number:
045121-MU
Citation ID:
RRID:MMRRC_045121-MU
Other Names:
R7020 (G1)
Major Collection:

Strain Information

Jarid2
Name: jumonji and AT-rich interaction domain containing 2
Synonyms: Jmj, jumonji
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16468
HGNC: HGNC:6196
Homologene: 31279
Map2k6
Name: mitogen-activated protein kinase kinase 6
Synonyms: MAP kinase kinase 6, SAPKK3, Prkmk6, MKK6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 26399
HGNC: HGNC:6846
Homologene: 55686
Clcn7
Name: chloride channel, voltage-sensitive 7
Synonyms: ClC-7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26373
HGNC: HGNC:2025
Homologene: 56546
Usp34
Name: ubiquitin specific peptidase 34
Synonyms: A530081C03Rik, Murr2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17847
Homologene: 40978
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: 2810449H11Rik, D130015N03Rik, tbl
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Cep350
Name: centrosomal protein 350
Synonyms: 4933409L06Rik, 6430546F08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74081
Homologene: 8879
Xpo7
Name: exportin 7
Synonyms: 4930506C02Rik, Ranbp16
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 65246
VEGA: 14
Homologene: 22857
Cntrob
Name: centrobin, centrosomal BRCA2 interacting protein
Synonyms: Nip2, 9830165K03Rik, Lip8
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216846
Homologene: 14205
Slc30a5
Name: solute carrier family 30 (zinc transporter), member 5
Synonyms: Zntl1, 1810010K08Rik, ZTL1, ZnT-5, Znt5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69048
VEGA: 13
Homologene: 41503
Abhd3
Name: abhydrolase domain containing 3
Synonyms: LABH3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 106861
Homologene: 14055
Npc1
Name: NPC intracellular cholesterol transporter 1
Synonyms: D18Ertd139e, lcsd, D18Ertd723e, C85354, A430089E03Rik, nmf164
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 18145
HGNC: HGNC:7897
Homologene: 228
Macrod2
Name: mono-ADP ribosylhydrolase 2
Synonyms: 2610107G07Rik, 2900006F19Rik, 1110033L15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72899
Homologene: 85987
St8sia5
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
Synonyms: Siat8e, ST8SiaV
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225742
Homologene: 8331
Tap2
Name: transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Synonyms: PSF2, Ham-2, HAM2, Ham2, Tap-2, Abcb3, MTP2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21355
HGNC: HGNC:44
Homologene: 37323
Notch1
Name: notch 1
Synonyms: 9930111A19Rik, lin-12, N1, Motch A, Mis6, Tan1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18128
HGNC: HGNC:7881
Homologene: 32049
Pms1
Name: PMS1 homolog 1, mismatch repair system component
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227099
HGNC: HGNC:9121
Homologene: 449
Cd209b
Name: CD209b antigen
Synonyms: SIGNR1, mSIGNR1, 1810030I22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69165
Homologene: 84858
Wdr19
Name: WD repeat domain 19
Synonyms: DYF2, Ift144, C330027H04Rik, D330023L08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 213081
Homologene: 11842
Itgae
Name: integrin alpha E, epithelial-associated
Synonyms: CD103, alpha-E1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16407
HGNC: HGNC:6147
Homologene: 113560
Clcn1
Name: chloride channel, voltage-sensitive 1
Synonyms: Clc1, SMCC1, Clc-1, nmf355, NMF355
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12723
HGNC: HGNC:2019
Homologene: 63
Crb1
Name: crumbs family member 1, photoreceptor morphogenesis associated
Synonyms: A930008G09Rik, 7530426H14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 170788
HGNC: HGNC:2343
Homologene: 8092
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Spta1
Name: spectrin alpha, erythrocytic 1
Synonyms: Spna1, ihj, erythroid, Spna-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20739
Homologene: 74460
Ralgapa2
Name: Ral GTPase activating protein, alpha subunit 2 (catalytic)
Synonyms: RGC2, A230067G21Rik, AS250
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241694
Homologene: 28131
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: mXin beta, myomaxin, 2310003D02Rik, Cmya3, 2310008C07Rik, A530024P18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241431
Homologene: 19388
Myh7b
Name: myosin, heavy chain 7B, cardiac muscle, beta
Synonyms: Myh14
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668940
Homologene: 66117
Olfm2
Name: olfactomedin 2
Synonyms: A030009A06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244723
VEGA: 9
Homologene: 14380
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20192
Homologene: 68151
Gucy2g
Name: guanylate cyclase 2g
Synonyms: 2410077I05Rik, GC-G
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 73707
Homologene: 44544
Pik3ca
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
Synonyms: p110alpha, caPI3K, 6330412C24Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18706
HGNC: HGNC:8975
Homologene: 21249
Myo15b
Name: myosin XVB
Synonyms: LOC380737, E330039G21Rik, LOC217328
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217328
Vmn2r105
Name: vomeronasal 2, receptor 105
Synonyms: EG627743
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627743
Homologene: 129680
Pla2r1
Name: phospholipase A2 receptor 1
Synonyms: PLA2-I receptor, Pla2g1br, M-type receptor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18779
HGNC: HGNC:9042
Homologene: 32016
Pappa2
Name: pappalysin 2
Synonyms: pregnancy-associated plasma protein-E, pregnancy-associated plasma preproprotein-A2, placenta-specific 3, PLAC3, PAPP-A2, Pappe
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23850
Homologene: 10661
Rtl1
Name: retrotransposon Gaglike 1
Synonyms: Mart1, Mor1, Mar
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 353326
VEGA: 12
Homologene: 120261
Gucy2e
Name: guanylate cyclase 2e
Synonyms: GC1, ROS-GC1, GC-E
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14919
HGNC: HGNC:4689
Homologene: 55442
Mypn
Name: myopalladin
Synonyms: 1110056A04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 68802
VEGA: 10
Homologene: 23778
Gp1ba
Name: glycoprotein 1b, alpha polypeptide
Synonyms: GP Ib-alpha, GPIb-alpha, GPIba
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14723
HGNC: HGNC:4439
Homologene: 143
Iglon5
Name: IgLON family member 5
Synonyms: A230106M20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210094
Homologene: 46295
1700001K19Rik
Name: RIKEN cDNA 1700001K19 gene
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 66323
VEGA: 12
Homologene: 19832
Or5al7
Name: olfactory receptor family 5 subfamily AL member 7
Synonyms: Olfr1043, MOR185-7, GA_x6K02T2Q125-47631900-47630956
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258570
Homologene: 88364
Or2a7
Name: olfactory receptor family 2 subfamily A member 7
Synonyms: MOR261-6, Olfr13, GA_x6K02T2P3E9-4384160-4383228
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18310
Homologene: 27232
Sh2b2
Name: SH2B adaptor protein 2
Synonyms: Aps
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 23921
Homologene: 10309
Zfp639
Name: zinc finger protein 639
Synonyms: 6230400O18Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67778
Homologene: 9473
Zbtb49
Name: zinc finger and BTB domain containing 49
Synonyms: 4930518A03Rik, Zfp509
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75079
Homologene: 34825
Ptgs1
Name: prostaglandin-endoperoxide synthase 1
Synonyms: COX1, Cox-1, cyclooxygenase 1, Cox-3, Pghs1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19224
HGNC: HGNC:9604
Homologene: 743
Tcp11
Name: t-complex protein 11
Synonyms: D17Ken1, Tcp-11
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21463
Homologene: 8433
Cst13
Name: cystatin 13
Synonyms: cystatin T, 1700006C19Rik, Cymg1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69294
Homologene: 41707
Ovol1
Name: ovo like zinc finger 1
Synonyms: movo1, Ovo1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18426
VEGA: 19
HGNC: HGNC:8525
Homologene: 3354
Or5g23
Name: olfactory receptor family 5 subfamily G member 23
Synonyms: MOR175-9, Olfr1000, GA_x6K02T2Q125-47087719-47086775
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257899
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 53,189,382 bp
  • A to T, chromosome 1 at 139,231,603 bp
  • A to C, chromosome 1 at 155,928,331 bp
  • C to A, chromosome 1 at 158,848,009 bp
  • T to C, chromosome 1 at 174,209,352 bp
  • T to C, chromosome 2 at 26,481,574 bp
  • T to G, chromosome 2 at 36,251,029 bp
  • T to C, chromosome 2 at 60,447,399 bp
  • T to C, chromosome 2 at 67,525,569 bp
  • A to G, chromosome 2 at 85,608,632 bp
  • A to G, chromosome 2 at 86,162,019 bp
  • T to A, chromosome 2 at 112,753,078 bp
  • A to T, chromosome 2 at 142,389,875 bp
  • A to T, chromosome 2 at 146,346,718 bp
  • T to G, chromosome 2 at 148,823,209 bp
  • T to C, chromosome 2 at 155,631,751 bp
  • T to C, chromosome 3 at 32,436,279 bp
  • C to A, chromosome 3 at 32,520,112 bp
  • A to T, chromosome 5 at 38,213,367 bp
  • A to G, chromosome 5 at 65,256,314 bp
  • T to C, chromosome 5 at 136,224,299 bp
  • T to C, chromosome 6 at 42,298,820 bp
  • T to C, chromosome 6 at 43,174,162 bp
  • A to T, chromosome 7 at 43,476,895 bp
  • T to A, chromosome 8 at 3,918,783 bp
  • T to A, chromosome 9 at 20,668,568 bp
  • A to G, chromosome 9 at 66,486,078 bp
  • T to C, chromosome 10 at 63,192,510 bp
  • A to G, chromosome 11 at 23,393,954 bp
  • A to T, chromosome 11 at 69,232,793 bp
  • A to G, chromosome 11 at 69,303,092 bp
  • A to G, chromosome 11 at 70,640,313 bp
  • A to G, chromosome 11 at 73,111,369 bp
  • A to T, chromosome 11 at 110,506,714 bp
  • G to A, chromosome 11 at 115,866,667 bp
  • T to C, chromosome 12 at 109,592,315 bp
  • C to T, chromosome 12 at 110,668,541 bp
  • C to T, chromosome 13 at 44,884,824 bp
  • T to A, chromosome 13 at 100,824,913 bp
  • T to C, chromosome 14 at 70,666,023 bp
  • A to T, chromosome 16 at 32,751,810 bp
  • A to G, chromosome 17 at 20,209,074 bp
  • T to C, chromosome 17 at 25,146,351 bp
  • A to G, chromosome 17 at 28,071,705 bp
  • A to G, chromosome 17 at 34,214,414 bp
  • T to C, chromosome 18 at 10,645,127 bp
  • C to T, chromosome 18 at 12,198,537 bp
  • T to C, chromosome 18 at 77,246,180 bp
  • G to A, chromosome 19 at 5,560,233 bp
  • A to G, chromosome 19 at 55,233,050 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7020 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045121-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.