Strain Name:
C57BL/6J-MtgxR7303Btlr/Mmmh
Stock Number:
045364-MU
Citation ID:
RRID:MMRRC_045364-MU
Other Names:
R7303 (G1)
Major Collection:

Strain Information

Chrna6
Name: cholinergic receptor, nicotinic, alpha polypeptide 6
Synonyms: alpha6 nAChR, Acra6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11440
Homologene: 20888
Pepd
Name: peptidase D
Synonyms: Pep-4, peptidase D, Pep4, dal
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18624
HGNC: HGNC:8840
Homologene: 239
Ppcdc
Name: phosphopantothenoylcysteine decarboxylase
Synonyms: 1810057I13Rik, 8430432M10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66812
VEGA: 9
Homologene: 11049
Abl2
Name: ABL proto-oncogene 2, non-receptor tyrosine kinase
Synonyms: Abll, Arg
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11352
HGNC: HGNC:77
Homologene: 5278
Mast2
Name: microtubule associated serine/threonine kinase 2
Synonyms: MAST205, Mtssk
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17776
Homologene: 7428
Lrp5
Name: low density lipoprotein receptor-related protein 5
Synonyms: LRP7, LR3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16973
Homologene: 1746
Mapkapk5
Name: MAP kinase-activated protein kinase 5
Synonyms: MK5, PRAK
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17165
HGNC: HGNC:6889
Homologene: 69077
Pik3c2a
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Synonyms: PI3KC2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18704
HGNC: HGNC:8971
Homologene: 20581
Cad
Name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Synonyms: 2410008J01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69719
HGNC: HGNC:1424
Homologene: 1412
Chd9
Name: chromodomain helicase DNA binding protein 9
Synonyms: 1810014J18Rik, 9030205D12Rik, A330063D19Rik, AD013
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 109151
Homologene: 11844
Ufd1
Name: ubiquitin recognition factor in ER-associated degradation 1
Synonyms: Ufd1l, Ufd1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22230
Homologene: 39090
Mon2
Name: MON2 homolog, regulator of endosome to Golgi trafficking
Synonyms: SF21, 2610528O22Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67074
VEGA: 10
Homologene: 44309
Tasor
Name: transcription activation suppressor
Synonyms: Fam208a, D14Abb1e, 4933409E02Rik, MommeD6
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218850
VEGA: 14
Homologene: 9062
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: 2810449H11Rik, D130015N03Rik, tbl
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Mark3
Name: MAP/microtubule affinity regulating kinase 3
Synonyms: A430080F22Rik, ETK-1, 1600015G02Rik, C-TAK1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 17169
VEGA: 12
HGNC: HGNC:6897
Homologene: 55653
Abcg5
Name: ATP binding cassette subfamily G member 5
Synonyms: cmp, trac, Sterolin-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27409
Homologene: 31909
Aen
Name: apoptosis enhancing nuclease
Synonyms: Isg20l1, 2700083B06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68048
Homologene: 23382
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: enaptin165, nesprin-1, A330049M09Rik, C130039F11Rik, SYNE-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Mcm2
Name: minichromosome maintenance complex component 2
Synonyms: Mcmd2, BM28, CDCL1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17216
HGNC: HGNC:6944
Homologene: 3325
Aldh16a1
Name: aldehyde dehydrogenase 16 family, member A1
Synonyms: 2410004H02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69748
Homologene: 34938
Myh14
Name: myosin, heavy polypeptide 14
Synonyms: NMHC II-C, 2400004E04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71960
Homologene: 23480
Polr2b
Name: polymerase (RNA) II (DNA directed) polypeptide B
Synonyms: RPB2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231329
HGNC: HGNC:9188
Homologene: 722
Tra2a
Name: transformer 2 alpha
Synonyms: G430041M01Rik, mAWMS1, 1500010G04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101214
Homologene: 40866
Klhl23
Name: kelch-like 23
Synonyms: C130068N17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 277396
Homologene: 18628
Tm9sf3
Name: transmembrane 9 superfamily member 3
Synonyms: 2810031D16Rik, Smbp, 1810073M23Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107358
VEGA: 19
Homologene: 10588
Afg3l1
Name: AFG3-like AAA ATPase 1
Synonyms: 1700047G05Rik, 3110061K15Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 114896
HGNC: HGNC:314
Homologene: 134198
Abca3
Name: ATP-binding cassette, sub-family A member 3
Synonyms: ABC-C, Abc3, 1810036E22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27410
HGNC: HGNC:33
Homologene: 37437
Ftsj3
Name: FtsJ RNA 2'-O-methyltransferase 3
Synonyms: D11Ertd400e, Epcs3, C79843
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56095
Homologene: 5451
Slc9a5
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 5
Synonyms: LOC277973
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 277973
Homologene: 31247
Fam184b
Name: family with sequence similarity 184, member B
Synonyms: 9630031F12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 58227
Homologene: 137353
Cracr2b
Name: calcium release activated channel regulator 2B
Synonyms: Efcab4a, 6330520A15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 213573
Homologene: 45468
Myh7b
Name: myosin, heavy chain 7B, cardiac muscle, beta
Synonyms: Myh14
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668940
Homologene: 66117
Lrguk
Name: leucine-rich repeats and guanylate kinase domain containing
Synonyms: 4921528H16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74354
Homologene: 34923
Aox2
Name: aldehyde oxidase 2
Synonyms: Aox3l1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213043
Homologene: 84622
Rabgap1l
Name: RAB GTPase activating protein 1-like
Synonyms: Hh1, 8430421H08Rik, 9630005B12Rik, 5830411O09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 29809
Homologene: 8143
Ankar
Name: ankyrin and armadillo repeat containing
Synonyms: 4932422E22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 319695
Homologene: 85163
Itgad
Name: integrin, alpha D
Synonyms: Cd11d
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381924
HGNC: HGNC:6146
Homologene: 56919
Abcb5
Name: ATP-binding cassette, sub-family B member 5
Synonyms: 9230106F14Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 77706
HGNC: HGNC:46
Homologene: 83488
Wdr91
Name: WD repeat domain 91
Synonyms: 9530020G05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101240
Homologene: 8562
Spef2
Name: sperm flagellar 2
Synonyms: C230086A09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 320277
Homologene: 23371
Flnc
Name: filamin C, gamma
Synonyms: 1110055E19Rik, actin binding protein 280, Fln2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68794
HGNC: HGNC:3756
Homologene: 37481
Brme1
Name: break repair meiotic recombinase recruitment factor 1
Synonyms: 4930432K21Rik, Mamerr, Meiok21
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74666
Homologene: 11525
Ube2q1
Name: ubiquitin-conjugating enzyme E2Q family member 1
Synonyms: 1110002C01Rik, PRO3094, NICE-5, 2310012M18Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70093
Homologene: 9730
Cimap1d
Name: CIMAP1 family member D
Synonyms: Odf3l2, LOC382384
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 382384
VEGA: 10
Homologene: 16801
Mrc2
Name: mannose receptor, C type 2
Synonyms: uPARAP, novel lectin, Endo180
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17534
Homologene: 4408
Vmn1r13
Name: vomeronasal 1 receptor 13
Synonyms: V1rc5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113862
Homologene: 74368
Oosp1
Name: oocyte secreted protein 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 170834
Homologene: 87189
Kbtbd12
Name: kelch repeat and BTB (POZ) domain containing 12
Synonyms: 4833415F11Rik, 4933428M03Rik, Klhdc6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74589
Homologene: 52613
H2-Q1
Name: histocompatibility 2, Q region locus 1
Synonyms: Q1, Q1k, Q1d, Q1b, H-2Q1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15006
Homologene: 128352
Abca7
Name: ATP-binding cassette, sub-family A member 7
Synonyms: Abc51
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 27403
HGNC: HGNC:37
Homologene: 22783
Oog2
Name: oogenesin 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381570
Homologene: 77858
Gpr149
Name: G protein-coupled receptor 149
Synonyms: R35, 9630018L10Rik, Ieda, PGR10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229357
Homologene: 16359
H2-Q7
Name: histocompatibility 2, Q region locus 7
Synonyms: Qa-7, Ped, Qa7, H-2Q7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15018
Homologene: 128352
Tas2r134
Name: taste receptor, type 2, member 134
Synonyms: T2R134, Tas2r34
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 387511
Homologene: 66001
Golim4
Name: golgi integral membrane protein 4
Synonyms: P138, 3110027H23Rik, Golph4, GPP130
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 73124
Homologene: 8716
Or8k3b
Name: olfactory receptor family 8 subfamily K member 3B
Synonyms: GA_x6K02T2Q125-48182406-48181465, Olfr1087, MOR188-5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258843
Or13a28
Name: olfactory receptor family 13 subfamily A member 28
Synonyms: IH7, GA_x6K02T2PBJ9-42783826-42784758, Olfr61, MOR253-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18362
Homologene: 79374
Ccdc182
Name: coiled-coil domain containing 182
Synonyms: 1700106J16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74297
Homologene: 87544
Zfp51
Name: zinc finger protein 51
Synonyms: Zfp-51, zfec12
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22709
VEGA: 17
Homologene: 134003
Ang
Name: angiogenin, ribonuclease, RNase A family, 5
Synonyms: Rnase5a, Ang1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11727
VEGA: 14
HGNC: HGNC:483
Homologene: 74385
Fxyd1
Name: FXYD domain-containing ion transport regulator 1
Synonyms: PLM, PML, 1110006M24Rik, phospholemman, 0610012C17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56188
HGNC: HGNC:4025
Homologene: 3691
Hmgb2
Name: high mobility group box 2
Synonyms: Hmg2, HMG-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 97165
HGNC: HGNC:5000
Homologene: 37582
Cc2d2b
Name: coiled-coil and C2 domain containing 2B
Synonyms: EG668310
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 668310
Homologene: 141114
Scgb1b3
Name: secretoglobin, family 1B, member 3
Synonyms: Gm5325, Abpa3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384585
Homologene: 114479
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 58,334,765 bp
  • A to T, chromosome 1 at 72,659,033 bp
  • T to C, chromosome 1 at 156,641,250 bp
  • A to C, chromosome 1 at 160,682,097 bp
  • A to G, chromosome 2 at 51,628,133 bp
  • T to C, chromosome 2 at 69,824,701 bp
  • A to G, chromosome 2 at 86,690,822 bp
  • T to A, chromosome 2 at 155,618,740 bp
  • A to G, chromosome 3 at 62,595,070 bp
  • G to A, chromosome 3 at 75,878,053 bp
  • T to A, chromosome 3 at 89,776,591 bp
  • A to G, chromosome 4 at 116,308,311 bp
  • A to T, chromosome 4 at 144,195,342 bp
  • T to C, chromosome 5 at 31,060,213 bp
  • C to T, chromosome 5 at 45,542,226 bp
  • T to C, chromosome 5 at 77,321,021 bp
  • T to C, chromosome 5 at 121,540,574 bp
  • T to C, chromosome 6 at 29,460,850 bp
  • A to T, chromosome 6 at 34,029,476 bp
  • G to A, chromosome 6 at 34,884,323 bp
  • G to A, chromosome 6 at 49,250,987 bp
  • T to C, chromosome 6 at 57,210,602 bp
  • G to T, chromosome 6 at 88,614,112 bp
  • T to C, chromosome 6 at 88,887,946 bp
  • T to A, chromosome 7 at 31,054,318 bp
  • G to A, chromosome 7 at 31,375,958 bp
  • T to C, chromosome 7 at 35,021,772 bp
  • C to T, chromosome 7 at 44,611,701 bp
  • A to T, chromosome 7 at 45,147,904 bp
  • C to T, chromosome 7 at 78,902,456 bp
  • A to C, chromosome 7 at 116,405,943 bp
  • A to G, chromosome 7 at 128,190,179 bp
  • T to C, chromosome 7 at 140,638,354 bp
  • A to G, chromosome 7 at 141,463,202 bp
  • A to T, chromosome 8 at 27,406,991 bp
  • A to G, chromosome 8 at 57,512,728 bp
  • G to C, chromosome 8 at 84,161,233 bp
  • A to G, chromosome 8 at 91,051,904 bp
  • T to A, chromosome 8 at 105,356,713 bp
  • G to T, chromosome 8 at 123,501,269 bp
  • A to T, chromosome 9 at 57,414,675 bp
  • A to T, chromosome 9 at 66,450,816 bp
  • T to A, chromosome 10 at 5,256,805 bp
  • G to A, chromosome 10 at 79,642,691 bp
  • A to T, chromosome 10 at 80,014,988 bp
  • A to T, chromosome 10 at 123,038,459 bp
  • T to C, chromosome 11 at 88,294,216 bp
  • T to A, chromosome 11 at 105,325,803 bp
  • T to C, chromosome 11 at 106,254,680 bp
  • T to C, chromosome 12 at 111,655,536 bp
  • T to A, chromosome 12 at 118,911,560 bp
  • A to G, chromosome 14 at 27,471,852 bp
  • A to T, chromosome 14 at 51,101,516 bp
  • T to A, chromosome 15 at 9,647,490 bp
  • A to G, chromosome 16 at 18,817,965 bp
  • T to A, chromosome 17 at 21,463,796 bp
  • T to G, chromosome 17 at 24,398,521 bp
  • C to A, chromosome 17 at 35,321,336 bp
  • A to G, chromosome 17 at 35,440,061 bp
  • A to G, chromosome 17 at 84,670,346 bp
  • A to G, chromosome 19 at 3,591,774 bp
  • A to C, chromosome 19 at 11,668,410 bp
  • A to T, chromosome 19 at 40,808,994 bp
  • G to A, chromosome 19 at 41,238,759 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7303 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045364-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.