Strain Name:
C57BL/6J-MtgxR7285Btlr/Mmmh
Stock Number:
045393-MU
Citation ID:
RRID:MMRRC_045393-MU
Other Names:
R7285 (G1)
Major Collection:

Strain Information

Fn1
Name: fibronectin 1
Synonyms: Fn, Fn-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14268
HGNC: HGNC:3778
Homologene: 1533
Otx2
Name: orthodenticle homeobox 2
Synonyms: E130306E05Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18424
HGNC: HGNC:8522
Homologene: 11026
Abca12
Name: ATP-binding cassette, sub-family A member 12
Synonyms: 4833417A11Rik, 4832428G11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74591
Homologene: 45441
Mthfr
Name: methylenetetrahydrofolate reductase
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17769
HGNC: HGNC:7436
Homologene: 4349
Ece1
Name: endothelin converting enzyme 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230857
HGNC: HGNC:3146
Homologene: 1068
Prune1
Name: prune exopolyphosphatase
Synonyms: 9230112O05Rik, Prune-M1, Prune
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229589
Homologene: 41429
Dock1
Name: dedicator of cytokinesis 1
Synonyms: Dock180, b2b3190Clo, 9130006G06Rik, D630004B07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330662
HGNC: HGNC:2987
Homologene: 55575
Lpp
Name: LIM domain containing preferred translocation partner in lipoma
Synonyms: 9430020K16Rik, B130055L10Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 210126
VEGA: 16
HGNC: HGNC:6679
Homologene: 4075
Usp47
Name: ubiquitin specific peptidase 47
Synonyms: A630020C16Rik, 4930502N04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74996
Homologene: 9929
Arhgap12
Name: Rho GTPase activating protein 12
Synonyms: 2810011M08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 75415
Homologene: 23089
Ticrr
Name: TOPBP1-interacting checkpoint and replication regulator
Synonyms: 5730590G19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77011
Homologene: 67120
Dhcr24
Name: 24-dehydrocholesterol reductase
Synonyms: 2310076D10Rik, 5830417J06Rik, 3-beta-hydroxysterol delta-24 reductase, seladin-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74754
HGNC: HGNC:2859
Homologene: 8850
Ythdf3
Name: YTH N6-methyladenosine RNA binding protein 3
Synonyms: 9130022A11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229096
Homologene: 34991
Parvb
Name: parvin, beta
Synonyms: affixin, D15Gsk1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 170736
Homologene: 8342
Sin3a
Name: transcriptional regulator, SIN3A (yeast)
Synonyms: mSin3A, Sin3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20466
Homologene: 32124
Fam222b
Name: family with sequence similarity 222, member B
Synonyms: BC017647
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216971
Homologene: 10054
Parg
Name: poly (ADP-ribose) glycohydrolase
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 26430
HGNC: HGNC:8605
Homologene: 50532
Hexa
Name: hexosaminidase A
Synonyms: Hex-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15211
VEGA: 9
HGNC: HGNC:4878
Homologene: 20146
Lypla1
Name: lysophospholipase 1
Synonyms: Gm39587, Pla1a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18777
HGNC: HGNC:6737
Homologene: 100781
Dgcr2
Name: DiGeorge syndrome critical region gene 2
Synonyms: DGS-C, Dgsc, Lan, 9930034O06Rik, Sez12, Idd, Dgcr2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13356
HGNC: HGNC:2845
Homologene: 31292
Fbln1
Name: fibulin 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14114
HGNC: HGNC:3600
Homologene: 21295
Zfp12
Name: zinc finger protein 12
Synonyms: Zfp-12, Krox-7
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231866
Homologene: 65328
Kif13a
Name: kinesin family member 13A
Synonyms: 4930505I07Rik, N-3 kinesin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16553
VEGA: 13
Homologene: 22589
Sptbn2
Name: spectrin beta, non-erythrocytic 2
Synonyms: Spnb3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20743
VEGA: 19
Homologene: 48482
Eme2
Name: essential meiotic structure-specific endonuclease subunit 2
Synonyms: 2810013J18Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 193838
Homologene: 19180
Osbpl10
Name: oxysterol binding protein-like 10
Synonyms: 4933433D06Rik, C820004B04Rik, OPR-10
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74486
Homologene: 69240
Magi3
Name: membrane associated guanylate kinase, WW and PDZ domain containing 3
Synonyms: 4732496O19Rik, 6530407C02Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99470
Homologene: 26431
Katnal2
Name: katanin p60 subunit A-like 2
Synonyms: 3110023G01Rik, 4933439B08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 71206
Homologene: 41725
Nbeal1
Name: neurobeachin like 1
Synonyms: A530050O19Rik, 2310076G13Rik, ALS2CR17, A530083I02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269198
Homologene: 16453
Tmco3
Name: transmembrane and coiled-coil domains 3
Synonyms: B230339H12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234076
Homologene: 32376
Enpp1
Name: ectonucleotide pyrophosphatase/phosphodiesterase 1
Synonyms: Pca, Pca-1, E-NPP1, CD203c, NPP1, twy, 4833416E15Rik, PC-1, Ly-41, Npps, Pdnp1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18605
HGNC: HGNC:3356
Homologene: 38151
Txndc11
Name: thioredoxin domain containing 11
Synonyms: Txdc11, EFP1, 2810408E11Rik, EF-hand binding protein 1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 106200
Homologene: 9301
Fsd1l
Name: fibronectin type III and SPRY domain containing 1-like
Synonyms: Fsd1nl, Csdufd1, Ccdc10, A230072O16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 319636
Homologene: 45825
Trpm1
Name: transient receptor potential cation channel, subfamily M, member 1
Synonyms: 4732499L03Rik, Mlsn1, melastatin, LTRPC1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17364
HGNC: HGNC:7146
Homologene: 19940
Ints11
Name: integrator complex subunit 11
Synonyms: 2410006F12Rik, Cpsf3l
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71957
Homologene: 9894
Stx18
Name: syntaxin 18
Synonyms: 4933425D03Rik, 1810035L21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71116
Homologene: 9655
Qng1
Name: Q-nucleotide N-glycosylase 1
Synonyms: 2210016F16Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 70153
Homologene: 13005
Fscb
Name: fibrous sheath CABYR binding protein
Synonyms: EG623046
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 623046
VEGA: 12
Homologene: 136275
Irs2
Name: insulin receptor substrate 2
Synonyms: Irs-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 384783
HGNC: HGNC:6126
Homologene: 2778
Cdh4
Name: cadherin 4
Synonyms: R-Cadh, Rcad, R-cadherin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12561
HGNC: HGNC:1763
Homologene: 48044
Or2t44
Name: olfactory receptor family 2 subfamily T member 44
Synonyms: GA_x6K02T2NKPP-622179-621244, Olfr314, MOR278-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 257917
Homologene: 133891
Tinag
Name: tubulointerstitial nephritis antigen
Synonyms: TIN-ag
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 26944
Homologene: 8082
Abcc3
Name: ATP-binding cassette, sub-family C member 3
Synonyms: 1700019L09Rik, MRP3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76408
HGNC: HGNC:54
Homologene: 68364
Inpp5e
Name: inositol polyphosphate-5-phosphatase E
Synonyms: 1200002L24Rik, 72kDa
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 64436
Homologene: 56863
Clca3b
Name: chloride channel accessory 3B
Synonyms: Clca4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229927
HGNC: HGNC:2017
Homologene: 135610
Efcab5
Name: EF-hand calcium binding domain 5
Synonyms: 4930563A03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319634
Homologene: 63366
Meioc
Name: meiosis specific with coiled-coil domain
Synonyms: LOC380729, LOC268491, Gm1564
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268491
Homologene: 19559
Vmn1r233
Name: vomeronasal 1 receptor 233
Synonyms: V1rf5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 171236
Homologene: 128343
Cldn15
Name: claudin 15
Synonyms: 2210009B08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 60363
HGNC: HGNC:2036
Homologene: 8646
Gm340
Name: predicted gene 340
Synonyms: LOC381224
Type: Gene
Species: Mouse
Chromosome: 19
Cyp4a30b
Name: cytochrome P450, family 4, subfamily a, polypeptide 30b
Synonyms: OTTMUSG00000008626, Cyp4a30b-ps
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 435802
Prss27
Name: serine protease 27
Synonyms: Mpn, Pancreasin, CAPH2, marapsin
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 213171
Homologene: 23743
Adam1b
Name: a disintegrin and metallopeptidase domain 1b
Synonyms: PH-30 alpha, Ftna, fertilin alpha
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 280667
Homologene: 136485
Pudp
Name: pseudouridine 5'-phosphatase
Synonyms: Hdhd1a, 1700121L12Rik, GS1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67365
VEGA: 18
Homologene: 8093
Or5d20-ps1
Name: olfactory receptor family 5 subfamily D member 20, pseudogene 1
Synonyms: GA_x6K02T2Q125-49593880-49592930, Olfr1165-ps, MOR174-7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258642
Lbx2
Name: ladybird homeobox 2
Synonyms: Lbx2h
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16815
Homologene: 36314
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 4,841,098 bp
  • G to C, chromosome 1 at 60,237,151 bp
  • A to T, chromosome 1 at 71,349,155 bp
  • T to C, chromosome 1 at 71,637,339 bp
  • G to A, chromosome 2 at 26,397,858 bp
  • A to T, chromosome 2 at 88,101,705 bp
  • A to T, chromosome 2 at 179,797,465 bp
  • T to A, chromosome 3 at 16,203,885 bp
  • T to A, chromosome 3 at 95,255,046 bp
  • G to A, chromosome 3 at 104,034,114 bp
  • T to C, chromosome 3 at 144,837,758 bp
  • T to A, chromosome 4 at 53,682,200 bp
  • T to A, chromosome 4 at 106,571,519 bp
  • T to C, chromosome 4 at 115,456,651 bp
  • T to A, chromosome 4 at 137,913,763 bp
  • C to T, chromosome 4 at 148,053,599 bp
  • C to T, chromosome 4 at 155,886,111 bp
  • C to T, chromosome 5 at 38,104,907 bp
  • T to G, chromosome 5 at 121,500,993 bp
  • A to T, chromosome 5 at 136,972,473 bp
  • A to G, chromosome 5 at 143,244,689 bp
  • A to G, chromosome 6 at 83,087,896 bp
  • G to T, chromosome 7 at 64,209,981 bp
  • T to C, chromosome 7 at 79,660,862 bp
  • G to A, chromosome 7 at 112,093,108 bp
  • T to G, chromosome 7 at 134,745,008 bp
  • A to G, chromosome 8 at 11,006,797 bp
  • G to A, chromosome 8 at 13,319,605 bp
  • C to A, chromosome 9 at 57,127,299 bp
  • T to A, chromosome 9 at 59,563,939 bp
  • T to C, chromosome 9 at 77,045,661 bp
  • A to T, chromosome 9 at 115,223,703 bp
  • G to A, chromosome 10 at 24,660,161 bp
  • T to A, chromosome 11 at 58,786,484 bp
  • A to G, chromosome 11 at 77,137,344 bp
  • A to G, chromosome 11 at 77,138,215 bp
  • T to C, chromosome 11 at 78,143,181 bp
  • C to T, chromosome 11 at 94,357,047 bp
  • G to A, chromosome 11 at 102,666,342 bp
  • A to T, chromosome 12 at 64,471,549 bp
  • C to T, chromosome 13 at 46,752,455 bp
  • T to C, chromosome 13 at 58,384,385 bp
  • A to G, chromosome 14 at 32,210,508 bp
  • G to A, chromosome 14 at 48,661,465 bp
  • A to T, chromosome 15 at 84,282,784 bp
  • A to G, chromosome 15 at 85,237,628 bp
  • A to G, chromosome 16 at 11,084,299 bp
  • A to T, chromosome 16 at 17,845,080 bp
  • G to A, chromosome 16 at 24,977,279 bp
  • A to G, chromosome 17 at 20,993,959 bp
  • A to G, chromosome 17 at 24,045,691 bp
  • A to T, chromosome 17 at 24,894,569 bp
  • A to T, chromosome 18 at 6,111,920 bp
  • C to G, chromosome 18 at 50,568,216 bp
  • G to A, chromosome 18 at 76,993,575 bp
  • A to G, chromosome 19 at 4,737,443 bp
  • A to G, chromosome 19 at 41,584,315 bp
  • T to A, chromosome 19 at 61,119,112 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7285 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045393-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.