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Strain Name:
C57BL/6J-MtgxR7419Btlr/Mmmh
Stock Number:
045497-MU
Citation ID:
RRID:MMRRC_045497-MU
Other Names:
R7419 (G1)
Major Collection:

Strain Information

Atf2
Name: activating transcription factor 2
Synonyms: mXBP, CRE-BP, Creb2, D130078H02Rik, ATF-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11909
HGNC: HGNC:784
Homologene: 31061
Zranb3
Name: zinc finger, RAN-binding domain containing 3
Synonyms: 4933425L19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226409
Homologene: 32770
Ltbp4
Name: latent transforming growth factor beta binding protein 4
Synonyms: 2310046A13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108075
HGNC: HGNC:6717
Homologene: 2645
Celf1
Name: CUGBP, Elav-like family member 1
Synonyms: CUG-BP, Brunol2, D2Wsu101e, 1600010O03Rik, CUG-BP1, Cugbp1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13046
HGNC: HGNC:2549
Homologene: 134102
Plxna1
Name: plexin A1
Synonyms: NOV, Plxn1, 2600013D04Rik, PlexA1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18844
HGNC: HGNC:9099
Homologene: 56426
Cdc40
Name: cell division cycle 40
Synonyms: PRP17, EHB3, 1200003H23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71713
VEGA: 10
Homologene: 5716
Gpatch2l
Name: G patch domain containing 2 like
Synonyms: 1700020O03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70373
VEGA: 12
Homologene: 9942
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 15,711,027 bp
  • G to A, chromosome 1 at 23,382,982 bp
  • C to T, chromosome 1 at 82,955,781 bp
  • A to T, chromosome 1 at 127,963,851 bp
  • T to A, chromosome 1 at 131,171,056 bp
  • C to A, chromosome 1 at 140,105,466 bp
  • A to G, chromosome 1 at 174,028,308 bp
  • A to T, chromosome 2 at 25,915,999 bp
  • A to T, chromosome 2 at 44,996,347 bp
  • C to A, chromosome 2 at 58,014,925 bp
  • A to G, chromosome 2 at 73,842,433 bp
  • C to T, chromosome 2 at 86,228,213 bp
  • A to T, chromosome 2 at 87,847,062 bp
  • A to G, chromosome 2 at 90,401,459 bp
  • A to G, chromosome 2 at 91,003,243 bp
  • A to T, chromosome 2 at 97,629,761 bp
  • G to A, chromosome 2 at 111,912,090 bp
  • A to T, chromosome 2 at 119,380,014 bp
  • A to T, chromosome 2 at 163,411,444 bp
  • A to G, chromosome 2 at 173,209,165 bp
  • T to A, chromosome 3 at 39,000,236 bp
  • A to T, chromosome 4 at 43,174,023 bp
  • A to T, chromosome 4 at 43,493,512 bp
  • A to G, chromosome 4 at 63,416,093 bp
  • T to G, chromosome 4 at 106,683,918 bp
  • T to G, chromosome 4 at 115,611,037 bp
  • T to C, chromosome 4 at 134,058,900 bp
  • A to T, chromosome 4 at 145,115,503 bp
  • T to A, chromosome 5 at 37,278,885 bp
  • A to G, chromosome 6 at 24,556,556 bp
  • A to G, chromosome 6 at 39,523,463 bp
  • A to G, chromosome 6 at 89,357,602 bp
  • A to G, chromosome 6 at 122,040,570 bp
  • T to C, chromosome 6 at 124,458,129 bp
  • A to C, chromosome 7 at 9,075,355 bp
  • A to T, chromosome 7 at 26,314,763 bp
  • A to G, chromosome 7 at 27,329,767 bp
  • A to G, chromosome 7 at 46,229,255 bp
  • G to T, chromosome 7 at 89,736,719 bp
  • G to T, chromosome 7 at 104,388,265 bp
  • T to C, chromosome 7 at 106,818,344 bp
  • A to G, chromosome 7 at 106,972,146 bp
  • G to A, chromosome 7 at 126,444,170 bp
  • G to T, chromosome 7 at 127,306,875 bp
  • A to G, chromosome 8 at 13,471,456 bp
  • A to G, chromosome 8 at 105,056,424 bp
  • G to A, chromosome 9 at 14,702,395 bp
  • A to G, chromosome 9 at 18,641,962 bp
  • A to C, chromosome 9 at 19,175,346 bp
  • C to T, chromosome 9 at 20,891,844 bp
  • T to C, chromosome 9 at 31,428,038 bp
  • A to C, chromosome 9 at 37,402,809 bp
  • T to A, chromosome 9 at 39,060,169 bp
  • T to A, chromosome 9 at 56,888,443 bp
  • T to A, chromosome 9 at 103,323,344 bp
  • T to A, chromosome 9 at 116,822,826 bp
  • T to A, chromosome 9 at 121,661,473 bp
  • A to G, chromosome 10 at 27,266,634 bp
  • A to T, chromosome 10 at 40,841,443 bp
  • A to G, chromosome 10 at 43,021,808 bp
  • T to C, chromosome 10 at 64,088,146 bp
  • A to T, chromosome 10 at 76,259,986 bp
  • A to T, chromosome 10 at 130,472,123 bp
  • T to C, chromosome 11 at 9,276,959 bp
  • T to C, chromosome 11 at 9,297,833 bp
  • C to T, chromosome 11 at 22,996,420 bp
  • T to A, chromosome 11 at 50,969,325 bp
  • A to G, chromosome 11 at 69,127,527 bp
  • C to T, chromosome 11 at 102,438,802 bp
  • T to C, chromosome 12 at 52,023,267 bp
  • T to G, chromosome 12 at 86,265,251 bp
  • T to C, chromosome 12 at 102,227,091 bp
  • A to G, chromosome 12 at 103,689,842 bp
  • A to G, chromosome 13 at 120,173,458 bp
  • T to A, chromosome 14 at 30,914,773 bp
  • T to C, chromosome 14 at 31,349,822 bp
  • A to C, chromosome 14 at 50,237,991 bp
  • C to T, chromosome 15 at 11,317,279 bp
  • T to A, chromosome 15 at 39,130,220 bp
  • C to T, chromosome 15 at 79,305,698 bp
  • T to A, chromosome 15 at 81,648,514 bp
  • A to G, chromosome 16 at 20,422,423 bp
  • T to C, chromosome 16 at 33,497,141 bp
  • T to A, chromosome 16 at 36,912,919 bp
  • C to A, chromosome 16 at 62,928,070 bp
  • G to A, chromosome 16 at 63,598,294 bp
  • T to G, chromosome 16 at 87,367,566 bp
  • T to G, chromosome 17 at 67,717,174 bp
  • G to A, chromosome 17 at 68,641,542 bp
  • T to C, chromosome 17 at 74,423,429 bp
  • T to C, chromosome 18 at 24,108,779 bp
  • A to C, chromosome 19 at 34,116,481 bp
  • T to A, chromosome 19 at 40,913,763 bp
  • C to T, chromosome 19 at 61,227,053 bp
  • G to A, chromosome X at 136,927,722 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7419 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045497-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.