Strain Name:
C57BL/6J-MtgxR7541Btlr/Mmmh
Stock Number:
045613-MU
Citation ID:
RRID:MMRRC_045613-MU
Other Names:
R7541 (G1)
Major Collection:

Strain Information

Atrn
Name: attractin
Synonyms: Mgca
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11990
HGNC: HGNC:885
Homologene: 22542
Rnf220
Name: ring finger protein 220
Synonyms: 5730503K05Rik, 4931406I20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66743
Homologene: 10036
Luc7l3
Name: LUC7-like 3 (S. cerevisiae)
Synonyms: 3300001P08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67684
Homologene: 75056
Clasp1
Name: CLIP associating protein 1
Synonyms: CLASP1alpha, CLASP1, mCLASP1, 1700030C23Rik, 5730583A19Rik, B130045P17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 76707
Homologene: 41024
Comp
Name: cartilage oligomeric matrix protein
Synonyms: TSP5, thrombospondin-5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12845
HGNC: HGNC:2227
Homologene: 74
Mmachc
Name: methylmalonic aciduria cblC type, with homocystinuria
Synonyms: 1810037K07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67096
Homologene: 12082
Rsf1
Name: remodeling and spacing factor 1
Synonyms: Hbxap, p325, XAP8, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Dbnl
Name: drebrin-like
Synonyms: mAbp1, SH3P7, ABP1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13169
HGNC: HGNC:2696
Homologene: 8468
Als2
Name: alsin Rho guanine nucleotide exchange factor
Synonyms: Als2cr6, 3222402C23Rik, 9430073A21Rik, Alsin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74018
HGNC: HGNC:443
Homologene: 23264
Ncapd3
Name: non-SMC condensin II complex, subunit D3
Synonyms: 2810487N22Rik, B130055D15Rik, 4632407J06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78658
VEGA: 9
Homologene: 41021
Bicc1
Name: BicC family RNA binding protein 1
Synonyms: Bic-C, jcpk
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 83675
Homologene: 12856
Lmbr1l
Name: limb region 1 like
Synonyms: 1110013E13Rik, D15Ertd735e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 74775
Homologene: 10011
Lef1
Name: lymphoid enhancer binding factor 1
Synonyms: Lef-1, lymphoid enhancer factor 1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16842
HGNC: HGNC:6551
Homologene: 7813
Ooep
Name: oocyte expressed protein
Synonyms: 2410146L05Rik, Moep19, Floped
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67968
Homologene: 12217
Hsd17b14
Name: hydroxysteroid (17-beta) dehydrogenase 14
Synonyms: 0610039E24Rik, Dhrs10, retSDR3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66065
Homologene: 133800
Aplp2
Name: amyloid beta precursor-like protein 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11804
VEGA: 9
HGNC: HGNC:598
Homologene: 20396
Vav2
Name: vav 2 oncogene
Synonyms: 2810040F13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22325
Homologene: 2530
Pcdhb18
Name: protocadherin beta 18
Synonyms: PcdhbR, Pcdhb9
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93889
Homologene: 137649
Zp2
Name: zona pellucida glycoprotein 2
Synonyms: Zp-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22787
Homologene: 48194
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77505
Homologene: 131117
Stxbp1
Name: syntaxin binding protein 1
Synonyms: nsec1, Sxtbp1, Munc-18a, Unc18h, Munc18-1, N-sec1, Rb-sec1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20910
Homologene: 2382
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Iqch
Name: IQ motif containing H
Synonyms: 4921504K03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78250
Homologene: 11258
Fam184b
Name: family with sequence similarity 184, member B
Synonyms: 9630031F12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 58227
Homologene: 137353
Trappc11
Name: trafficking protein particle complex 11
Synonyms: D030016E14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320714
Homologene: 11076
Fcgbpl1
Name: Fc fragment of IgG binding protein like 1
Synonyms: 9530053A07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319482
Homologene: 130055
Col6a6
Name: collagen, type VI, alpha 6
Synonyms: E330026B02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245026
Homologene: 18260
Rmdn2
Name: regulator of microtubule dynamics 2
Synonyms: Fam82a1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381110
VEGA: 17
Homologene: 71930
Metrnl
Name: meteorin, glial cell differentiation regulator-like
Synonyms: 9430048M07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 210029
Homologene: 16993
Cdh4
Name: cadherin 4
Synonyms: R-Cadh, Rcad, R-cadherin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12561
HGNC: HGNC:1763
Homologene: 48044
Dgkz
Name: diacylglycerol kinase zeta
Synonyms: mDGK[z], E130307B02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 104418
HGNC: HGNC:2857
Homologene: 37831
Elmo3
Name: engulfment and cell motility 3
Synonyms: CED-12
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234683
Homologene: 23475
Adamts10
Name: ADAM metallopeptidase with thrombospondin type 1 motif 10
Synonyms: ZnMP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224697
Homologene: 81940
Krt87
Name: keratin 87
Synonyms: Krt2-25, Krt83
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 406219
VEGA: 15
Homologene: 133804
Lrrc49
Name: leucine rich repeat containing 49
Synonyms: D430025H09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102747
Homologene: 9782
Or13c25
Name: olfactory receptor family 13 subfamily C member 25
Synonyms: Olfr272, GA_x6K02T2N78B-7084885-7085844, MOR262-7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258836
Homologene: 17409
Kcnt2
Name: potassium channel, subfamily T, member 2
Synonyms: E330038N15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240776
Homologene: 16121
Pou2f2
Name: POU domain, class 2, transcription factor 2
Synonyms: Oct-2, Otf2, Oct2d, Oct2a, Oct2c, Otf-2, Oct2b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18987
HGNC: HGNC:9213
Homologene: 55674
Fbh1
Name: F-box DNA helicase 1
Synonyms: Fbx18, Fbxo18
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 50755
Homologene: 9272
Gata6
Name: GATA binding protein 6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14465
VEGA: 18
HGNC: HGNC:4174
Homologene: 68449
Gnas
Name: GNAS complex locus
Synonyms: Galphas, Oedsml, Nespl, Gnas1, XLalphas, Nesp, G alpha s, SCG6, neuroendocrine-specific Golgi protein p55 isoform 1, Gs alpha, Gs-alpha, Gsa, P1, P3, Nesp55, P2, Gnasxl
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14683
HGNC: HGNC:4392
Homologene: 55534
Or2y1g
Name: olfactory receptor family 2 subfamily Y member 1G
Synonyms: Olfr1393, GA_x6K02T2QP88-6154577-6153642, MOR256-24, MOR256-67_i
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258463
Homologene: 81347
Pigz
Name: phosphatidylinositol glycan anchor biosynthesis, class Z
Synonyms: F630022B06Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239827
Homologene: 130742
Marchf2
Name: membrane associated ring-CH-type finger 2
Synonyms: March2, 9530046H09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224703
Homologene: 9539
Reep6
Name: receptor accessory protein 6
Synonyms: Dp1l1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70335
Homologene: 133833
Acss2
Name: acyl-CoA synthetase short-chain family member 2
Synonyms: Acas1, AceCS1, Acs1, acetyl-CoA synthetase 1, Acas2, ACAS
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 60525
Homologene: 6469
Vmn1r169
Name: vomeronasal 1 receptor 169
Synonyms: Gm4232
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043103
Homologene: 128341
Mrps7
Name: mitchondrial ribosomal protein S7
Synonyms: Rpms7, MRP-S7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 50529
Homologene: 9321
Bnip5
Name: BCL2 interacting protein 5
Synonyms: 4930539E08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 207819
Homologene: 52098
Nscme3l
Name: NSE3 homolog, SMC5-SMC6 complex component like
Synonyms: 1700020D05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 75555
HGNC: HGNC:7677
Homologene: 137364
Tcstv7b
Name: Tcstv family member 7B
Synonyms: Gm21731
Type: Gene
Species: Mouse
Chromosome: 13
Cd200l2
Name: CD200 molecule like 2
Synonyms: Gm17783, iSEC2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 100047671
VEGA: 16
Homologene: 86707
Gm29609
Name: predicted gene 29609
Type: Gene
Species: Mouse
Chromosome: 5
Gm3424
Name: predicted gene 3424
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100041598
Homologene: 115686
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 59,167,616 bp
  • T to A, chromosome 1 at 118,542,997 bp
  • T to C, chromosome 1 at 140,376,384 bp
  • T to C, chromosome 2 at 11,749,537 bp
  • T to A, chromosome 2 at 27,275,002 bp
  • A to T, chromosome 2 at 32,818,505 bp
  • G to T, chromosome 2 at 76,791,301 bp
  • G to A, chromosome 2 at 91,942,675 bp
  • A to G, chromosome 2 at 130,961,571 bp
  • G to A, chromosome 2 at 155,574,690 bp
  • T to A, chromosome 2 at 174,298,099 bp
  • A to G, chromosome 2 at 179,444,810 bp
  • A to G, chromosome 3 at 131,191,099 bp
  • A to T, chromosome 4 at 52,911,376 bp
  • G to A, chromosome 4 at 116,705,885 bp
  • A to T, chromosome 4 at 117,489,930 bp
  • A to G, chromosome 5 at 31,154,232 bp
  • A to G, chromosome 5 at 45,542,232 bp
  • T to A, chromosome 7 at 23,577,987 bp
  • A to T, chromosome 7 at 25,116,128 bp
  • T to A, chromosome 7 at 28,144,256 bp
  • C to A, chromosome 7 at 45,566,146 bp
  • CGGCGGCGG to CGGCGGCGGGGGCGGCGG, chromosome 7 at 97,579,911 bp
  • C to T, chromosome 7 at 105,678,309 bp
  • A to T, chromosome 7 at 120,136,056 bp
  • T to C, chromosome 8 at 47,505,582 bp
  • G to T, chromosome 8 at 70,381,350 bp
  • T to C, chromosome 8 at 105,306,714 bp
  • A to G, chromosome 9 at 27,067,040 bp
  • A to T, chromosome 9 at 31,152,356 bp
  • T to C, chromosome 9 at 60,610,403 bp
  • C to T, chromosome 9 at 63,445,521 bp
  • T to A, chromosome 9 at 78,378,065 bp
  • A to G, chromosome 9 at 105,767,324 bp
  • T to C, chromosome 10 at 70,946,604 bp
  • G to T, chromosome 10 at 80,335,199 bp
  • T to G, chromosome 11 at 5,795,486 bp
  • T to A, chromosome 11 at 49,280,333 bp
  • T to C, chromosome 11 at 94,295,965 bp
  • T to G, chromosome 11 at 115,606,870 bp
  • T to A, chromosome 11 at 121,715,970 bp
  • A to T, chromosome 13 at 120,240,979 bp
  • T to C, chromosome 14 at 5,829,330 bp
  • A to T, chromosome 15 at 98,909,386 bp
  • A to G, chromosome 15 at 101,438,634 bp
  • T to C, chromosome 16 at 31,945,131 bp
  • T to A, chromosome 16 at 45,528,492 bp
  • G to A, chromosome 17 at 28,905,324 bp
  • G to A, chromosome 17 at 33,531,616 bp
  • A to T, chromosome 17 at 33,703,058 bp
  • A to T, chromosome 17 at 79,627,868 bp
  • A to G, chromosome 18 at 11,059,108 bp
  • A to T, chromosome 18 at 37,491,609 bp
  • G to A, chromosome 19 at 5,503,411 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7541 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045613-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.