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Strain Name:
C57BL/6J-MtgxR7570Btlr/Mmmh
Stock Number:
045631-MU
Citation ID:
RRID:MMRRC_045631-MU
Other Names:
R7570 (G1)
Major Collection:

Strain Information

Gsr
Name: glutathione reductase
Synonyms: Gr-1, Gr1, D8Ertd238e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14782
HGNC: HGNC:4623
Homologene: 531
Fam3c
Name: FAM3 metabolism regulating signaling molecule C
Synonyms: Fam3c, D6Wsu176e, Ilei
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 27999
Homologene: 8926
Cdk19
Name: cyclin dependent kinase 19
Synonyms: 2700084L06Rik, Cdc2l6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 78334
VEGA: 10
Homologene: 22862
Zbtb25
Name: zinc finger and BTB domain containing 25
Synonyms: Zfp-50, Kup, 2810462M08Rik, Zfp50, 2900064P18Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 109929
Homologene: 5070
Sh3gl3
Name: SH3-domain GRB2-like 3
Synonyms: SH3P13, EEN-B2, endophilin III, Sh3d2c, Sh3d2c2, endophilin A3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20408
Homologene: 37723
Thbs3
Name: thrombospondin 3
Synonyms: Thbs-3, TSP3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 21827
Homologene: 5159
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 36,185,838 bp
  • T to C, chromosome 1 at 37,890,192 bp
  • C to T, chromosome 1 at 53,348,258 bp
  • T to C, chromosome 1 at 64,937,906 bp
  • G to A, chromosome 1 at 69,996,841 bp
  • T to C, chromosome 1 at 73,953,479 bp
  • A to T, chromosome 1 at 153,243,275 bp
  • A to T, chromosome 1 at 157,531,395 bp
  • C to A, chromosome 1 at 192,137,876 bp
  • G to A, chromosome 1 at 195,169,340 bp
  • A to G, chromosome 2 at 24,965,630 bp
  • G to A, chromosome 2 at 27,951,383 bp
  • A to T, chromosome 2 at 31,423,911 bp
  • A to G, chromosome 2 at 32,768,968 bp
  • A to G, chromosome 2 at 69,175,806 bp
  • A to G, chromosome 2 at 88,831,128 bp
  • G to T, chromosome 2 at 125,397,852 bp
  • A to G, chromosome 2 at 153,676,699 bp
  • A to T, chromosome 2 at 154,262,263 bp
  • T to A, chromosome 3 at 86,139,089 bp
  • T to A, chromosome 3 at 87,536,031 bp
  • C to T, chromosome 3 at 89,219,052 bp
  • T to C, chromosome 4 at 41,712,529 bp
  • T to A, chromosome 4 at 46,083,632 bp
  • C to T, chromosome 4 at 61,834,674 bp
  • T to A, chromosome 4 at 98,424,500 bp
  • T to A, chromosome 4 at 99,228,560 bp
  • T to G, chromosome 4 at 129,930,164 bp
  • T to A, chromosome 5 at 65,030,059 bp
  • T to A, chromosome 5 at 125,030,089 bp
  • T to A, chromosome 6 at 22,326,405 bp
  • T to A, chromosome 6 at 29,717,338 bp
  • A to T, chromosome 6 at 40,746,433 bp
  • T to C, chromosome 6 at 73,149,430 bp
  • C to T, chromosome 6 at 91,934,610 bp
  • T to C, chromosome 6 at 113,494,488 bp
  • T to G, chromosome 6 at 120,427,842 bp
  • T to A, chromosome 7 at 12,849,340 bp
  • C to A, chromosome 7 at 18,722,735 bp
  • T to A, chromosome 7 at 29,078,585 bp
  • T to C, chromosome 7 at 35,293,812 bp
  • T to C, chromosome 7 at 44,632,426 bp
  • T to C, chromosome 7 at 45,340,748 bp
  • A to G, chromosome 7 at 62,378,910 bp
  • A to G, chromosome 7 at 66,033,898 bp
  • T to C, chromosome 7 at 82,285,077 bp
  • A to T, chromosome 7 at 101,502,834 bp
  • C to A, chromosome 7 at 103,660,881 bp
  • T to A, chromosome 7 at 104,179,748 bp
  • A to T, chromosome 7 at 104,860,397 bp
  • C to T, chromosome 7 at 121,674,963 bp
  • T to A, chromosome 7 at 127,385,283 bp
  • CT to C, chromosome 7 at 139,923,775 bp
  • T to G, chromosome 8 at 3,744,151 bp
  • T to A, chromosome 8 at 33,669,165 bp
  • T to G, chromosome 8 at 41,267,344 bp
  • T to C, chromosome 8 at 84,952,927 bp
  • C to T, chromosome 8 at 85,079,834 bp
  • C to T, chromosome 8 at 90,994,580 bp
  • T to C, chromosome 8 at 105,378,684 bp
  • A to T, chromosome 9 at 39,873,455 bp
  • A to G, chromosome 9 at 45,070,687 bp
  • A to T, chromosome 9 at 78,304,469 bp
  • A to G, chromosome 9 at 102,542,329 bp
  • T to C, chromosome 9 at 108,113,543 bp
  • C to T, chromosome 10 at 40,477,958 bp
  • A to T, chromosome 10 at 75,585,594 bp
  • T to C, chromosome 10 at 80,055,041 bp
  • A to G, chromosome 10 at 95,480,965 bp
  • A to G, chromosome 10 at 128,518,932 bp
  • G to T, chromosome 11 at 31,367,798 bp
  • T to A, chromosome 11 at 46,770,542 bp
  • A to C, chromosome 11 at 94,778,990 bp
  • A to T, chromosome 11 at 105,937,644 bp
  • A to T, chromosome 11 at 106,320,473 bp
  • G to A, chromosome 12 at 69,590,880 bp
  • A to T, chromosome 12 at 71,063,142 bp
  • T to A, chromosome 12 at 76,369,592 bp
  • T to C, chromosome 12 at 83,979,644 bp
  • A to T, chromosome 12 at 103,853,837 bp
  • A to G, chromosome 12 at 115,468,738 bp
  • A to G, chromosome 13 at 3,573,621 bp
  • T to C, chromosome 13 at 25,119,373 bp
  • A to G, chromosome 14 at 20,388,644 bp
  • T to C, chromosome 14 at 52,075,099 bp
  • T to C, chromosome 14 at 54,576,402 bp
  • T to A, chromosome 14 at 64,031,574 bp
  • A to G, chromosome 15 at 28,346,952 bp
  • T to C, chromosome 15 at 77,423,474 bp
  • A to C, chromosome 16 at 29,266,963 bp
  • T to A, chromosome 16 at 58,424,569 bp
  • T to A, chromosome 16 at 87,491,322 bp
  • A to T, chromosome 16 at 96,426,239 bp
  • T to C, chromosome 17 at 15,555,652 bp
  • T to C, chromosome 17 at 21,819,013 bp
  • A to G, chromosome 17 at 31,527,622 bp
  • A to G, chromosome 17 at 34,837,640 bp
  • A to T, chromosome 17 at 56,106,776 bp
  • C to T, chromosome 17 at 65,985,360 bp
  • T to G, chromosome 17 at 90,162,379 bp
  • T to A, chromosome 18 at 20,527,780 bp
  • G to T, chromosome 18 at 36,695,592 bp
  • T to A, chromosome 18 at 49,893,957 bp
  • T to C, chromosome 19 at 5,423,352 bp
  • A to T, chromosome 19 at 39,404,743 bp
  • A to T, chromosome 19 at 39,859,898 bp
  • C to A, chromosome 19 at 45,235,248 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7570 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045631-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.