Strain Name:
C57BL/6J-MtgxR7648Btlr/Mmmh
Stock Number:
045726-MU
Citation ID:
RRID:MMRRC_045726-MU
Other Names:
R7648 (G1)
Major Collection:

Strain Information

Uso1
Name: USO1 vesicle docking factor
Synonyms: Vdp, transcytosis associated protein p115, TAP
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56041
Homologene: 2754
Cnnm2
Name: cyclin M2
Synonyms: Acdp2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 94219
VEGA: 19
HGNC: HGNC:103
Homologene: 9761
Slc4a7
Name: solute carrier family 4, sodium bicarbonate cotransporter, member 7
Synonyms: E430014N10Rik, NBCn1, NBC3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218756
VEGA: 14
Homologene: 2680
Pcm1
Name: pericentriolar material 1
Synonyms: C030044G17Rik, 9430077F19Rik, 2600002H09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18536
HGNC: HGNC:8727
Homologene: 4518
Cdc42bpb
Name: CDC42 binding protein kinase beta
Synonyms: DMPK-like
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217866
VEGA: 12
HGNC: HGNC:1738
Homologene: 55945
2610021A01Rik
Name: RIKEN cDNA 2610021A01 gene
Type: Gene
Species: Mouse
Chromosome: 7
Nup98
Name: nucleoporin 98
Synonyms: Nup96
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269966
HGNC: HGNC:8068
Homologene: 35472
Tars2
Name: threonyl-tRNA synthetase 2, mitochondrial (putative)
Synonyms: Tarsl1, 2610024N01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71807
Homologene: 23520
Eif4b
Name: eukaryotic translation initiation factor 4B
Synonyms: 2310046H11Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75705
VEGA: 15
HGNC: HGNC:3285
Homologene: 83162
Atxn2
Name: ataxin 2
Synonyms: ATX2, Sca2, 9630045M23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20239
Homologene: 2234
Tenm2
Name: teneurin transmembrane protein 2
Synonyms: 2610040L17Rik, 9330187F13Rik, D3Bwg1534e, Ten-m2, Odz2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23964
Homologene: 22672
Gls
Name: glutaminase
Synonyms: B230365M23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14660
HGNC: HGNC:4331
Homologene: 22726
Gucy1a1
Name: guanylate cyclase 1, soluble, alpha 1
Synonyms: alpha 1 sGC, Gucy1a3, 1200016O07Rik, sGC-alpha1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 60596
HGNC: HGNC:4685
Homologene: 37360
Trf
Name: transferrin
Synonyms: Tfn, HP
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22041
Homologene: 68153
Fam193a
Name: family with sequence homology 193, member A
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231128
Homologene: 2746
Car14
Name: carbonic anhydrase 14
Synonyms: CA XIV
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 23831
HGNC: HGNC:1372
Homologene: 69105
Gramd1c
Name: GRAM domain containing 1C
Synonyms: 4921521N14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207798
Homologene: 129735
Msh3
Name: mutS homolog 3
Synonyms: D13Em1, Rep3, Rep-3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17686
HGNC: HGNC:7326
Homologene: 1829
E4f1
Name: E4F transcription factor 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13560
VEGA: 17
HGNC: HGNC:3121
Homologene: 3259
Ice1
Name: interactor of little elongation complex ELL subunit 1
Synonyms: BC018507
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218333
VEGA: 13
Homologene: 18902
Atad2b
Name: ATPase family, AAA domain containing 2B
Synonyms: D530031C13Rik, 1110014E10Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320817
VEGA: 12
Homologene: 86351
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269700
Homologene: 28297
Enam
Name: enamelin
Synonyms: abte
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13801
HGNC: HGNC:3344
Homologene: 9698
Mlph
Name: melanophilin
Synonyms: D1Wsu84e, Slac-2a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 171531
Homologene: 11465
Trank1
Name: tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms: C030048J01Rik, LOC235639, A230061D21Rik, Lba1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320429
Homologene: 45845
Xcr1
Name: chemokine (C motif) receptor 1
Synonyms: C motif-1/lymphotactin receptor, Ccxcr1, GPR5, XCR1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 23832
HGNC: HGNC:1625
Homologene: 21095
Tmem175
Name: transmembrane protein 175
Synonyms: 3010001K23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72392
Homologene: 12461
Cstf2t
Name: cleavage stimulation factor, 3' pre-RNA subunit 2, tau
Synonyms: 64kDa, tCstF-64
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 83410
VEGA: 19
Homologene: 80230
Xab2
Name: XPA binding protein 2
Synonyms: 0610041O14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67439
Homologene: 5738
Mndal
Name: myeloid nuclear differentiation antigen like
Synonyms: Ifi212
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100040462
HGNC: HGNC:5395
Homologene: 115929
Plekhh1
Name: pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
Synonyms: D630024D12Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 211945
VEGA: 12
Homologene: 121939
Mylk
Name: myosin, light polypeptide kinase
Synonyms: MLCK210, 9530072E15Rik, nmMlck, telokin, Mlck, MLCK108, A930019C19Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 107589
HGNC: HGNC:7590
Homologene: 14202
Ttc28
Name: tetratricopeptide repeat domain 28
Synonyms: 2310015L07Rik, TPRBK
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 209683
Homologene: 41023
Klhdc7a
Name: kelch domain containing 7A
Synonyms: B230308G19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242721
Homologene: 17567
Fam163b
Name: family with sequence similarity 163, member B
Synonyms: C630035N08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 109349
Homologene: 106097
Asprv1
Name: aspartic peptidase, retroviral-like 1
Synonyms: 2300003P22Rik, SASP, TPA-induced aspartic proteinase-like, SASPase, Taps
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67855
Homologene: 23582
Cyp2c40
Name: cytochrome P450, family 2, subfamily c, polypeptide 40
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13099
Homologene: 74936
Cpt1b
Name: carnitine palmitoyltransferase 1b, muscle
Synonyms: M-CPTI, Cpt1, M-CPT I
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12895
HGNC: HGNC:2329
Homologene: 22548
Ctif
Name: CBP80/20-dependent translation initiation factor
Synonyms: LOC269037, Gm672
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 269037
VEGA: 18
Homologene: 56682
Ddx49
Name: DEAD box helicase 49
Synonyms: R27090_2, DEAD (Asp-Glu-Ala-Asp) box polypeptide 49
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234374
Homologene: 41308
Or8b35
Name: olfactory receptor family 8 subfamily B member 35
Synonyms: MOR162-7, Olfr881, GA_x6K02T2PVTD-31676771-31677700
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258413
Homologene: 74013
Kif28
Name: kinesin family member 28
Synonyms: LOC383592, Gm1305
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 383592
Homologene: 130945
Nfxl1
Name: nuclear transcription factor, X-box binding-like 1
Synonyms: D430033A06Rik, TCF9, 1700012H24Rik, LOC381696
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100978
Homologene: 26752
Cyp2j8
Name: cytochrome P450, family 2, subfamily j, polypeptide 8
Synonyms: OTTMUSG00000007938, Cyp2j8-ps
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 665095
HGNC: HGNC:2634
Homologene: 133819
Usp49
Name: ubiquitin specific peptidase 49
Synonyms: C330046L10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224836
Homologene: 10235
Asb13
Name: ankyrin repeat and SOCS box-containing 13
Synonyms: 2210015B19Rik, 6430573K02Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 142688
Homologene: 11666
Relb
Name: avian reticuloendotheliosis viral (v-rel) oncogene related B
Synonyms: shep
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19698
HGNC: HGNC:9956
Homologene: 4747
Rabl3
Name: RAB, member RAS oncogene family-like 3
Synonyms: 4930553C05Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67657
Homologene: 12171
Ceacam16
Name: CEA cell adhesion molecule 16
Synonyms: LOC330483
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330483
Homologene: 19857
Unc50
Name: unc-50 homolog
Synonyms: 1110002A21Rik, GMH1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67387
Homologene: 6391
Mrgpra2a
Name: MAS-related GPR, member A2A
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 668727
Homologene: 79615
Msantd5
Name: Myb/SANT DNA binding domain containing 5
Synonyms: Gm12569
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 622699
Homologene: 141209
Crygc
Name: crystallin, gamma C
Synonyms: Cryg-5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12966
HGNC: HGNC:2410
Homologene: 36281
Eppk1
Name: epiplakin 1
Synonyms: EPPK, EPIPL1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223650
VEGA: 15
Homologene: 20006
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 37,431,321 bp
  • C to A, chromosome 1 at 52,196,780 bp
  • A to G, chromosome 1 at 65,073,325 bp
  • G to A, chromosome 1 at 90,933,526 bp
  • T to A, chromosome 1 at 173,857,395 bp
  • A to G, chromosome 1 at 179,709,424 bp
  • G to T, chromosome 2 at 27,112,740 bp
  • C to T, chromosome 3 at 82,108,707 bp
  • G to A, chromosome 3 at 95,750,982 bp
  • T to C, chromosome 3 at 95,898,195 bp
  • T to A, chromosome 4 at 96,499,603 bp
  • T to C, chromosome 4 at 139,965,939 bp
  • A to T, chromosome 5 at 34,431,182 bp
  • T to C, chromosome 5 at 72,523,536 bp
  • A to T, chromosome 5 at 88,504,157 bp
  • T to A, chromosome 5 at 92,194,002 bp
  • A to G, chromosome 5 at 108,644,566 bp
  • A to G, chromosome 5 at 111,183,392 bp
  • T to C, chromosome 5 at 121,254,371 bp
  • G to T, chromosome 5 at 121,796,377 bp
  • A to G, chromosome 6 at 86,628,870 bp
  • T to C, chromosome 7 at 19,619,842 bp
  • G to T, chromosome 7 at 19,852,278 bp
  • T to C, chromosome 7 at 41,612,462 bp
  • A to T, chromosome 7 at 47,426,663 bp
  • T to G, chromosome 7 at 102,124,197 bp
  • T to C, chromosome 8 at 3,610,638 bp
  • A to G, chromosome 8 at 41,275,699 bp
  • A to G, chromosome 8 at 70,297,955 bp
  • A to C, chromosome 9 at 37,992,560 bp
  • A to G, chromosome 9 at 103,227,969 bp
  • A to G, chromosome 9 at 111,391,685 bp
  • T to C, chromosome 9 at 123,856,592 bp
  • T to A, chromosome 11 at 36,106,736 bp
  • G to A, chromosome 11 at 51,234,786 bp
  • T to A, chromosome 12 at 5,027,182 bp
  • T to A, chromosome 12 at 79,055,131 bp
  • T to C, chromosome 12 at 111,377,153 bp
  • C to A, chromosome 13 at 3,649,332 bp
  • A to G, chromosome 13 at 70,589,797 bp
  • A to T, chromosome 13 at 92,274,028 bp
  • G to A, chromosome 14 at 14,773,348 bp
  • T to C, chromosome 15 at 76,110,671 bp
  • C to T, chromosome 15 at 89,421,367 bp
  • T to C, chromosome 15 at 102,089,000 bp
  • G to C, chromosome 16 at 34,879,524 bp
  • A to T, chromosome 16 at 37,563,758 bp
  • A to G, chromosome 16 at 43,989,869 bp
  • A to T, chromosome 17 at 24,445,448 bp
  • A to T, chromosome 17 at 47,674,828 bp
  • A to T, chromosome 18 at 75,637,142 bp
  • A to G, chromosome 19 at 31,083,592 bp
  • A to G, chromosome 19 at 39,803,845 bp
  • A to G, chromosome 19 at 46,877,900 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7648 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045726-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.