Strain Name:
C57BL/6J-MtgxR7728Btlr/Mmmh
Stock Number:
045784-MU
Citation ID:
RRID:MMRRC_045784-MU
Other Names:
R7728 (G1)
Major Collection:

Strain Information

Utp20
Name: UTP20 small subunit processome component
Synonyms: 3830408P06Rik, DRIM, mDRIM
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70683
VEGA: 10
Homologene: 38373
Slk
Name: STE20-like kinase
Synonyms: mSLK, Etk4, SLK, Stk2, 9A2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20874
Homologene: 22515
Trp53bp1
Name: transformation related protein 53 binding protein 1
Synonyms: p53BP1, 53BP1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27223
Homologene: 4137
Dnajc2
Name: DnaJ heat shock protein family (Hsp40) member C2
Synonyms: Mida1, Zrf2, Zrf1, MIDA1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22791
Homologene: 31656
Zcchc17
Name: zinc finger, CCHC domain containing 17
Synonyms: Ps1d, HSPC251, 2810055E05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 619605
Homologene: 32319
Shroom3
Name: shroom family member 3
Synonyms: Shrm3, Shrm, D5Ertd287e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27428
Homologene: 9263
Acly
Name: ATP citrate lyase
Synonyms: A730098H14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104112
HGNC: HGNC:115
Homologene: 854
Gars1
Name: glycyl-tRNA synthetase 1
Synonyms: Gena201, Sgrp23, GENA202, Gars
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 353172
HGNC: HGNC:4162
Homologene: 1547
Zfhx3
Name: zinc finger homeobox 3
Synonyms: Atbf1, WBP9, A230102L03Rik, Sci
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11906
HGNC: HGNC:777
Homologene: 21366
Rexo4
Name: REX4, 3'-5' exonuclease
Synonyms: XPMC2H, Rex4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227656
Homologene: 133948
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: D630005A10Rik, apollon, A430032G04Rik, A430040A19Rik, Bruce
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12211
Homologene: 7248
Kat7
Name: K(lysine) acetyltransferase 7
Synonyms: Hboa, Hbo1, Myst2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217127
Homologene: 5134
Ralgapb
Name: Ral GTPase activating protein, beta subunit (non-catalytic)
Synonyms: B230339M05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228850
Homologene: 10666
Dhx40
Name: DEAH-box helicase 40
Synonyms: ARG147, 2410016C14Rik, DDX40
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67487
Homologene: 57000
Arhgef17
Name: Rho guanine nucleotide exchange factor 17
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 207212
Homologene: 129601
Syvn1
Name: synovial apoptosis inhibitor 1, synoviolin
Synonyms: 1200010C09Rik, Hrd1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74126
Homologene: 32700
Acsl5
Name: acyl-CoA synthetase long-chain family member 5
Synonyms: 1700030F05Rik, Facl5
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 433256
VEGA: 19
Homologene: 69208
Kif7
Name: kinesin family member 7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16576
Homologene: 72555
Hp1bp3
Name: heterochromatin protein 1, binding protein 3
Synonyms: Hp1bp74
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15441
Homologene: 7774
Pwp2
Name: PWP2 periodic tryptophan protein homolog (yeast)
Synonyms: Pwp2h, Pwp2, 6530411D08Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 110816
VEGA: 10
HGNC: HGNC:9711
Homologene: 3702
Zfp81
Name: zinc finger protein 81
Synonyms: Hszfp36, KRAB13, D330034E10Rik, C330034P10Rik, Zfp78
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224694
Homologene: 138633
1700017B05Rik
Name: RIKEN cDNA 1700017B05 gene
Synonyms: D9Ertd278e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74211
VEGA: 9
Homologene: 19283
Nbeal1
Name: neurobeachin like 1
Synonyms: A530050O19Rik, 2310076G13Rik, ALS2CR17, A530083I02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269198
Homologene: 16453
St6galnac2
Name: ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
Synonyms: Siat7b, Siat7, ST6GalNAc II
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20446
Homologene: 4714
Itpr3
Name: inositol 1,4,5-triphosphate receptor 3
Synonyms: Ip3r3, Itpr-3, tf
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16440
HGNC: HGNC:6182
Homologene: 1675
Clec9a
Name: C-type lectin domain family 9, member a
Synonyms: 9830005G06Rik, DNGR-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232414
Homologene: 52106
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Ttll5
Name: tubulin tyrosine ligase-like family, member 5
Synonyms: 1700048H13Rik, 4930556H18Rik, STAMP, 2310009M18Rik, D630041K24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320244
Homologene: 9013
Epha5
Name: Eph receptor A5
Synonyms: bsk, Hek7, Rek7, Ehk1, Els1, Cek7
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13839
HGNC: HGNC:3389
Homologene: 55824
Mlkl
Name: mixed lineage kinase domain-like
Synonyms: 9130019I15Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74568
Homologene: 77416
Pcdhb11
Name: protocadherin beta 11
Synonyms: PcdhbK, Pcdhb5E
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93882
HGNC: HGNC:8690
Homologene: 62178
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Mdh1b
Name: malate dehydrogenase 1B, NAD (soluble)
Synonyms: 1700124B08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 76668
Homologene: 57110
Slco1a8
Name: solute carrier organic anion transporter family, member 1a8
Synonyms: Gm6614
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 625716
Homologene: 87075
Krt34
Name: keratin 34
Synonyms: Krt1-4, 4733401E01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16672
HGNC: HGNC:6452
Homologene: 31083
Slc16a10
Name: solute carrier family 16 (monocarboxylic acid transporters), member 10
Synonyms: PRO0813, TAT1, 2610103N14Rik, Mct10
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72472
VEGA: 10
Homologene: 75089
Trmt11
Name: tRNA methyltransferase 11
Synonyms: 2410075D05Rik, 3110045I18Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 73681
VEGA: 10
Homologene: 6876
Tbc1d9
Name: TBC1 domain family, member 9
Synonyms: C76116, 4933431N12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71310
Homologene: 57079
Nebl
Name: nebulette
Synonyms: D830029A09Rik, 1200007O21Rik, Lnebl, A630080F05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74103
Homologene: 128431
Krt81
Name: keratin 81
Synonyms: Krt2-19
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 64818
VEGA: 15
HGNC: HGNC:6458
Homologene: 55645
Lrrk1
Name: leucine-rich repeat kinase 1
Synonyms: D130026O16Rik, C230002E15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233328
Homologene: 23464
Fkbp6
Name: FK506 binding protein 6
Synonyms: 1700008G22Rik, D5Ertd724e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 94244
HGNC: HGNC:3722
Homologene: 2672
Ccdc7b
Name: coiled-coil domain containing 7B
Synonyms: 1700008F21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75453
Homologene: 49919
Disp2
Name: dispatched RND transporter family member 2
Synonyms: DispB, B230210L08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214240
Homologene: 24916
Abcg3
Name: ATP binding cassette subfamily G member 3
Synonyms: Abcp2, Mxr2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27405
HGNC: HGNC:74
Homologene: 86845
Mmp13
Name: matrix metallopeptidase 13
Synonyms: Collagenase-3, interstitial collagenase, collagenase-1, MMP-13, Clg, Mmp1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17386
VEGA: 9
HGNC: HGNC:7159
Homologene: 20548
Rrs1
Name: ribosome biogenesis regulator 1
Synonyms: 5730466A07Rik, D1Ertd701e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 59014
Homologene: 41014
2210408I21Rik
Name: RIKEN cDNA 2210408I21 gene
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72371
Homologene: 89234
Cpvl
Name: carboxypeptidase, vitellogenic-like
Synonyms: 4933436L16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71287
Homologene: 80235
H2-Q10
Name: histocompatibility 2, Q region locus 10
Synonyms: Qa10, Q10, H-2Q10
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15007
Homologene: 128352
C1ra
Name: complement component 1, r subcomponent A
Synonyms: mC1rA
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 50909
HGNC: HGNC:1246
Homologene: 1313
Fam13a
Name: family with sequence similarity 13, member A
Synonyms: D430015B01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58909
Homologene: 135847
Vmn2r109
Name: vomeronasal 2, receptor 109
Synonyms: EG627814
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627814
Homologene: 129678
Or11h6
Name: olfactory receptor family 11 subfamily H member 6
Synonyms: MOR106-11, GA_x6K02T2PMLR-6361495-6362481, Olfr745
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258296
Homologene: 27116
Nanp
Name: N-acetylneuraminic acid phosphatase
Synonyms: Hdhd4, 1600031M04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67311
Homologene: 12112
Harbi1
Name: harbinger transposase derived 1
Synonyms: D230010M03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241547
Homologene: 24535
Cracd
Name: capping protein inhibiting regulator of actin
Synonyms: C530008M17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320827
Homologene: 136278
Cndp2
Name: CNDP dipeptidase 2
Synonyms: Dip-2, Pep-1, 0610010E05Rik, Pep1, Cn2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 66054
VEGA: 18
Homologene: 10085
Tmtc2
Name: transmembrane and tetratricopeptide repeat containing 2
Synonyms: D330034A10Rik, 8430438D04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 278279
Homologene: 25521
Lrrc36
Name: leucine rich repeat containing 36
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270091
Homologene: 23090
Bhlha9
Name: basic helix-loop-helix family, member a9
Synonyms: Fingerin, A830053O21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 320522
Homologene: 82363
Stambpl1
Name: STAM binding protein like 1
Synonyms: 8230401J17Rik, 1700095N21Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 76630
Homologene: 23253
Gm12258
Name: predicted gene 12258
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 108167848
Pcdhgb2
Name: protocadherin gamma subfamily B, 2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93700
HGNC: HGNC:8709
Homologene: 49571
Churc1
Name: churchill domain containing 1
Synonyms: My015, chch, 1700030P15Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 211151
Homologene: 17046
Gm3127
Name: predicted gene 3127
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100041076
Homologene: 115686
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 9,546,398 bp
  • T to C, chromosome 1 at 60,244,824 bp
  • T to A, chromosome 1 at 63,715,270 bp
  • G to T, chromosome 2 at 17,370,514 bp
  • G to A, chromosome 2 at 26,964,230 bp
  • G to A, chromosome 2 at 52,183,299 bp
  • A to G, chromosome 2 at 91,712,281 bp
  • A to T, chromosome 2 at 118,791,480 bp
  • A to C, chromosome 2 at 121,207,899 bp
  • A to G, chromosome 2 at 151,030,915 bp
  • T to C, chromosome 2 at 158,482,503 bp
  • A to G, chromosome 4 at 130,337,019 bp
  • T to A, chromosome 4 at 138,225,996 bp
  • C to T, chromosome 5 at 21,770,540 bp
  • T to C, chromosome 5 at 76,857,469 bp
  • A to T, chromosome 5 at 84,067,408 bp
  • C to A, chromosome 5 at 92,683,707 bp
  • T to G, chromosome 5 at 104,936,078 bp
  • A to G, chromosome 5 at 135,339,544 bp
  • C to T, chromosome 6 at 53,925,290 bp
  • G to T, chromosome 6 at 55,050,386 bp
  • T to C, chromosome 6 at 58,954,299 bp
  • G to A, chromosome 6 at 124,517,725 bp
  • T to C, chromosome 6 at 129,415,235 bp
  • C to A, chromosome 6 at 141,987,710 bp
  • A to G, chromosome 7 at 66,262,715 bp
  • A to G, chromosome 7 at 79,710,730 bp
  • G to A, chromosome 7 at 100,930,068 bp
  • G to A, chromosome 7 at 119,938,828 bp
  • A to T, chromosome 8 at 16,231,271 bp
  • A to T, chromosome 8 at 83,259,350 bp
  • A to T, chromosome 8 at 105,449,498 bp
  • A to G, chromosome 8 at 108,951,569 bp
  • A to G, chromosome 8 at 111,333,619 bp
  • A to T, chromosome 8 at 129,072,690 bp
  • T to A, chromosome 9 at 7,274,004 bp
  • G to A, chromosome 9 at 57,256,539 bp
  • A to G, chromosome 10 at 30,587,501 bp
  • T to A, chromosome 10 at 40,040,758 bp
  • T to C, chromosome 10 at 78,178,561 bp
  • A to G, chromosome 10 at 88,798,341 bp
  • A to C, chromosome 10 at 105,271,497 bp
  • C to A, chromosome 11 at 58,859,692 bp
  • T to A, chromosome 11 at 76,673,089 bp
  • A to T, chromosome 11 at 86,771,933 bp
  • T to C, chromosome 11 at 95,300,081 bp
  • A to G, chromosome 11 at 100,039,985 bp
  • A to T, chromosome 11 at 100,516,797 bp
  • C to T, chromosome 11 at 100,519,687 bp
  • T to A, chromosome 11 at 116,679,985 bp
  • T to A, chromosome 12 at 76,773,278 bp
  • C to T, chromosome 12 at 85,956,632 bp
  • T to A, chromosome 13 at 77,316,477 bp
  • A to G, chromosome 14 at 4,166,059 bp
  • G to A, chromosome 14 at 50,642,392 bp
  • A to G, chromosome 15 at 101,460,206 bp
  • T to A, chromosome 17 at 20,552,855 bp
  • T to G, chromosome 17 at 27,098,114 bp
  • T to C, chromosome 17 at 33,336,817 bp
  • T to A, chromosome 17 at 35,470,838 bp
  • A to G, chromosome 17 at 74,622,105 bp
  • A to T, chromosome 18 at 37,423,477 bp
  • A to G, chromosome 18 at 37,691,207 bp
  • T to A, chromosome 18 at 84,672,077 bp
  • A to G, chromosome 19 at 6,051,205 bp
  • T to G, chromosome 19 at 34,236,321 bp
  • C to A, chromosome 19 at 47,620,816 bp
  • T to A, chromosome 19 at 55,287,853 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7728 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045784-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.