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Strain Name:
C57BL/6J-MtgxR7784Btlr/Mmmh
Stock Number:
045840-MU
Citation ID:
RRID:MMRRC_045840-MU
Other Names:
R7784 (G1)
Major Collection:

Strain Information

Septin4
Name: septin 4
Synonyms: cell division control-related protein 2b, Pnutl2, Bh5, septin H5, Gm11492, ARTS, Sept4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18952
HGNC: HGNC:9165
Homologene: 6107
Erbb4
Name: erb-b2 receptor tyrosine kinase 4
Synonyms: ErbB4, Her4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13869
HGNC: HGNC:3432
Homologene: 21084
Ddc
Name: dopa decarboxylase
Synonyms: aromatic L-amino acid decarboxylase, Aadc
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13195
HGNC: HGNC:2719
Homologene: 618
Eps8
Name: epidermal growth factor receptor pathway substrate 8
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13860
HGNC: HGNC:3420
Homologene: 3272
Adgrg1
Name: adhesion G protein-coupled receptor G1
Synonyms: Cyt28, Gpr56
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14766
HGNC: HGNC:4512
Homologene: 4156
Lcmt1
Name: leucine carboxyl methyltransferase 1
Synonyms: Lcmt, LCMT-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 30949
Homologene: 41123
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 4,142,658 bp
  • T to C, chromosome 1 at 40,600,776 bp
  • T to A, chromosome 1 at 68,075,499 bp
  • A to G, chromosome 1 at 78,664,943 bp
  • T to A, chromosome 1 at 85,212,474 bp
  • T to A, chromosome 1 at 93,497,444 bp
  • T to A, chromosome 1 at 173,730,132 bp
  • G to A, chromosome 1 at 174,202,451 bp
  • A to T, chromosome 1 at 188,444,592 bp
  • T to A, chromosome 2 at 25,232,225 bp
  • G to A, chromosome 2 at 37,487,532 bp
  • T to A, chromosome 2 at 52,235,488 bp
  • G to A, chromosome 2 at 87,903,193 bp
  • A to G, chromosome 2 at 112,775,695 bp
  • G to A, chromosome 2 at 120,436,668 bp
  • T to G, chromosome 2 at 121,034,435 bp
  • C to T, chromosome 4 at 129,632,157 bp
  • A to G, chromosome 4 at 155,388,932 bp
  • A to T, chromosome 5 at 146,182,828 bp
  • T to A, chromosome 6 at 43,217,388 bp
  • A to G, chromosome 6 at 48,619,249 bp
  • C to A, chromosome 6 at 66,535,413 bp
  • T to A, chromosome 6 at 137,499,587 bp
  • C to T, chromosome 6 at 141,713,193 bp
  • T to A, chromosome 6 at 141,943,388 bp
  • T to C, chromosome 7 at 4,472,122 bp
  • T to C, chromosome 7 at 30,819,258 bp
  • T to A, chromosome 7 at 75,610,328 bp
  • T to C, chromosome 7 at 82,573,989 bp
  • G to T, chromosome 7 at 123,401,495 bp
  • G to A, chromosome 8 at 95,012,882 bp
  • A to G, chromosome 8 at 95,110,692 bp
  • A to G, chromosome 8 at 105,328,833 bp
  • A to G, chromosome 8 at 123,213,252 bp
  • T to C, chromosome 9 at 44,630,142 bp
  • C to T, chromosome 9 at 109,650,119 bp
  • A to T, chromosome 9 at 111,364,103 bp
  • C to T, chromosome 10 at 24,902,448 bp
  • C to A, chromosome 10 at 34,394,218 bp
  • A to G, chromosome 11 at 11,839,396 bp
  • T to A, chromosome 11 at 29,741,048 bp
  • TCACACTCGGCACA to TCACA, chromosome 11 at 50,815,240 bp
  • A to G, chromosome 11 at 87,579,008 bp
  • A to T, chromosome 11 at 99,521,031 bp
  • A to T, chromosome 11 at 110,154,417 bp
  • G to A, chromosome 11 at 115,861,340 bp
  • A to G, chromosome 12 at 91,505,305 bp
  • A to G, chromosome 12 at 112,178,147 bp
  • T to C, chromosome 13 at 91,896,082 bp
  • T to A, chromosome 13 at 111,255,411 bp
  • A to T, chromosome 14 at 21,660,841 bp
  • A to T, chromosome 14 at 27,898,594 bp
  • T to A, chromosome 14 at 30,123,439 bp
  • A to T, chromosome 14 at 32,659,840 bp
  • A to T, chromosome 14 at 33,954,158 bp
  • A to G, chromosome 14 at 37,061,780 bp
  • A to G, chromosome 14 at 60,300,445 bp
  • A to T, chromosome 14 at 75,275,040 bp
  • C to T, chromosome 14 at 76,416,701 bp
  • C to T, chromosome 15 at 27,763,994 bp
  • C to T, chromosome 17 at 35,658,158 bp
  • T to C, chromosome 17 at 37,336,578 bp
  • A to G, chromosome 17 at 37,337,055 bp
  • A to G, chromosome 17 at 46,648,591 bp
  • A to G, chromosome 18 at 77,254,550 bp
  • A to G, chromosome 19 at 59,327,863 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7784 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045840-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.