Strain Name:
C57BL/6J-MtgxR7799Btlr/Mmmh
Stock Number:
045854-MU
Citation ID:
RRID:MMRRC_045854-MU
Other Names:
R7799 (G1)
Major Collection:

Strain Information

Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, trabeculin alpha, Acf7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Syt4
Name: synaptotagmin IV
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20983
VEGA: 18
Homologene: 7559
Wnk1
Name: WNK lysine deficient protein kinase 1
Synonyms: Hsn2, 6430573H23Rik, EG406236, Prkwnk1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232341
Homologene: 14253
Tfr2
Name: transferrin receptor 2
Synonyms: Tfr2, Trfr2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 50765
Homologene: 2428
Iars1
Name: isoleucyl-tRNA synthetase 1
Synonyms: 2510016L12Rik, Iars, E430001P04Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105148
HGNC: HGNC:5330
Homologene: 5325
Thoc1
Name: THO complex 1
Synonyms: NMP-84, 3110002N20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225160
VEGA: 18
Homologene: 38012
Mon2
Name: MON2 homolog, regulator of endosome to Golgi trafficking
Synonyms: SF21, 2610528O22Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67074
VEGA: 10
Homologene: 44309
Kpna3
Name: karyopherin subunit alpha 3
Synonyms: IPOA4, importin alpha 4, importin alpha 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16648
VEGA: 14
HGNC: HGNC:6396
Homologene: 20520
Cit
Name: citron
Synonyms: citron-N, Cit-k, citron kinase, C030025P15Rik, CRIK-SK
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12704
HGNC: HGNC:1985
Homologene: 21404
Afap1
Name: actin filament associated protein 1
Synonyms: 2600003E23Rik, 9630044L16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70292
Homologene: 11009
Mmp16
Name: matrix metallopeptidase 16
Synonyms: Membrane type 3-MMP, MT3-MMP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17389
HGNC: HGNC:7162
Homologene: 55939
Flrt1
Name: fibronectin leucine rich transmembrane protein 1
Synonyms: D630040I23Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 396184
VEGA: 19
HGNC: HGNC:3760
Homologene: 40864
Rbm15
Name: RNA binding motif protein 15
Synonyms: C230088J01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229700
Homologene: 23383
Adam17
Name: a disintegrin and metallopeptidase domain 17
Synonyms: Tace, CD156b
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 11491
HGNC: HGNC:195
Homologene: 2395
Bsdc1
Name: BSD domain containing 1
Synonyms: 1110063F24Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100383
Homologene: 32386
Ccdc47
Name: coiled-coil domain containing 47
Synonyms: asp4, 2610204L23Rik, calumin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67163
Homologene: 41351
Zfp748
Name: zinc finger protein 748
Synonyms: 2610014M12Rik, KRAB-O, Zfp208, mszf54
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 212276
Homologene: 134552
Golm2
Name: golgi membrane protein 2
Synonyms: Casc4, D130060C09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 319996
Homologene: 16310
Ell3
Name: elongation factor RNA polymerase II-like 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269344
Homologene: 11859
Kcna4
Name: potassium voltage-gated channel, shaker-related subfamily, member 4
Synonyms: Kv1.4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16492
HGNC: HGNC:6222
Homologene: 20514
Ppp2r5b
Name: protein phosphatase 2, regulatory subunit B', beta
Synonyms: B'beta
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225849
HGNC: HGNC:9310
Homologene: 38157
Qrfprl
Name: pyroglutamylated RFamide peptide receptor like
Synonyms: C130060K24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243407
Homologene: 135976
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: skrr, calcium release channel isoform 1, Ryr
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20190
Homologene: 68069
Sirt4
Name: sirtuin 4
Synonyms: 4930596O17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75387
Homologene: 8164
Afm
Name: afamin
Synonyms: Alf, alpha albumin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 280662
HGNC: HGNC:316
Homologene: 881
Ltbp1
Name: latent transforming growth factor beta binding protein 1
Synonyms: Ltbp1L, b2b1000Clo, 9430031G15Rik, LTBP-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268977
HGNC: HGNC:6714
Homologene: 522
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 229003
Homologene: 14118
Syde1
Name: synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
Synonyms: mSYD1A, 1200008N06Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71709
VEGA: 10
Homologene: 13195
Adcy3
Name: adenylate cyclase 3
Synonyms: AC3, ACIII
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104111
HGNC: HGNC:234
Homologene: 2978
Cpne8
Name: copine VIII
Synonyms: 1200003E11Rik, 1500031E20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66871
Homologene: 12049
Zfp14
Name: zinc finger protein 14
Synonyms: Zfp-14, Krox-9, 4732429I09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243906
Homologene: 45619
Or52s1
Name: olfactory receptor family 52 subfamily S member 1
Synonyms: GA_x6K02T2PBJ9-5927412-5928362, Olfr593, MOR24-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258378
Homologene: 27147
Or2j6
Name: olfactory receptor family 2 subfamily J member 6
Synonyms: GA_x6K02T2PBJ9-42551260-42550346, Olfr531, MOR251-3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258955
Kcnh1
Name: potassium voltage-gated channel, subfamily H (eag-related), member 1
Synonyms: ether a go-go, Kv10.1, Eag1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16510
HGNC: HGNC:6250
Homologene: 68242
Sirpd
Name: signal regulatory protein delta
Synonyms: Gm9733
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 751864
Homologene: 135594
Tgm1
Name: transglutaminase 1, K polypeptide
Synonyms: TGase 1, TG K, K polypeptide, TGase1, 2310004J08Rik, protein-glutamine-gamma-glutamyltransferase
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21816
VEGA: 14
Homologene: 306
Vmn2r24
Name: vomeronasal 2, receptor 24
Synonyms: EG243628
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243628
Homologene: 135915
Or5w14
Name: olfactory receptor family 5 subfamily W member 14
Synonyms: GA_x6K02T2Q125-49215724-49214792, Olfr1137, MOR177-20, MOR40-9P
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258101
Homologene: 79380
Slc25a11
Name: solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11
Synonyms: 2oxoc, 2310022P18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67863
Homologene: 2637
Zfp9
Name: zinc finger protein 9
Synonyms: Zfp-9, 1810048F22Rik, Krox-4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22750
Homologene: 49280
Ppp1r3e
Name: protein phosphatase 1, regulatory subunit 3E
Synonyms: A630071A11Rik, LOC382898
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105651
Homologene: 34797
Rgs18
Name: regulator of G-protein signaling 18
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 64214
Homologene: 11281
Lrrc56
Name: leucine rich repeat containing 56
Synonyms: 5730427C23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70552
Homologene: 115748
Wbp1
Name: WW domain binding protein 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22377
Homologene: 8267
Ccdc121rt2
Name: coiled-coil domain containing 121, retrogene 2
Synonyms: Gm6588
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 625464
Homologene: 116059
Gkn1
Name: gastrokine 1
Synonyms: BRICD1, AMP-18, 2200002K21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66283
Homologene: 10487
Gm3159
Name: predicted gene 3159
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100041139
Homologene: 115686
Cnga3
Name: cyclic nucleotide gated channel alpha 3
Synonyms: CNG3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12790
HGNC: HGNC:2150
Homologene: 994
Or2b2
Name: olfactory receptor family 2 subfamily B member 2
Synonyms: Olfr1359, GA_x6K02T2QHY8-11534186-11533245, MOR256-60, MOR256-35
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 258067
Homologene: 11056
Or5p61
Name: olfactory receptor family 5 subfamily P member 61
Synonyms: GA_x6K02T2PBJ9-10489044-10488091, MOR204-40_p, MOR204-30P, Olfr485
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258041
Homologene: 110483
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 37,261,771 bp
  • A to G, chromosome 1 at 135,889,957 bp
  • A to G, chromosome 1 at 144,753,865 bp
  • T to C, chromosome 1 at 192,434,875 bp
  • G to T, chromosome 2 at 87,711,084 bp
  • A to C, chromosome 2 at 107,295,892 bp
  • TCTCCTC to TCTC, chromosome 2 at 121,439,456 bp
  • T to C, chromosome 2 at 121,933,541 bp
  • C to A, chromosome 2 at 177,193,820 bp
  • G to T, chromosome 2 at 177,315,797 bp
  • A to G, chromosome 2 at 181,237,989 bp
  • T to A, chromosome 3 at 15,296,663 bp
  • C to T, chromosome 3 at 107,332,143 bp
  • T to C, chromosome 3 at 138,069,601 bp
  • A to T, chromosome 4 at 18,112,112 bp
  • A to G, chromosome 4 at 123,527,113 bp
  • T to A, chromosome 4 at 129,465,348 bp
  • T to A, chromosome 5 at 35,974,398 bp
  • A to G, chromosome 5 at 90,523,854 bp
  • A to G, chromosome 5 at 94,683,428 bp
  • T to G, chromosome 5 at 112,449,832 bp
  • T to G, chromosome 5 at 115,479,746 bp
  • T to G, chromosome 5 at 115,862,968 bp
  • T to A, chromosome 5 at 137,571,724 bp
  • G to T, chromosome 6 at 65,456,137 bp
  • A to T, chromosome 6 at 83,120,195 bp
  • A to T, chromosome 6 at 87,348,181 bp
  • A to T, chromosome 6 at 118,464,882 bp
  • A to G, chromosome 6 at 119,949,176 bp
  • C to T, chromosome 6 at 123,780,463 bp
  • T to C, chromosome 7 at 29,003,560 bp
  • T to C, chromosome 7 at 30,038,943 bp
  • A to G, chromosome 7 at 103,211,979 bp
  • T to A, chromosome 7 at 108,159,430 bp
  • A to T, chromosome 7 at 140,400,464 bp
  • T to C, chromosome 7 at 141,209,602 bp
  • A to G, chromosome 10 at 78,589,907 bp
  • T to C, chromosome 10 at 123,042,331 bp
  • A to G, chromosome 11 at 70,645,179 bp
  • T to C, chromosome 11 at 106,210,317 bp
  • A to G, chromosome 12 at 4,204,762 bp
  • C to A, chromosome 12 at 21,340,492 bp
  • T to A, chromosome 13 at 21,703,199 bp
  • T to A, chromosome 13 at 49,723,018 bp
  • T to C, chromosome 13 at 67,541,489 bp
  • A to T, chromosome 14 at 4,397,585 bp
  • T to C, chromosome 14 at 54,877,215 bp
  • C to T, chromosome 14 at 55,712,475 bp
  • T to C, chromosome 14 at 61,384,733 bp
  • T to A, chromosome 15 at 90,540,247 bp
  • A to G, chromosome 17 at 6,037,823 bp
  • A to G, chromosome 17 at 75,252,356 bp
  • A to T, chromosome 18 at 9,984,441 bp
  • A to T, chromosome 18 at 31,440,192 bp
  • C to A, chromosome 19 at 6,232,598 bp
  • C to A, chromosome 19 at 7,095,864 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7799 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045854-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.