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Strain Name:
C57BL/6J-MtgxR7799Btlr/Mmmh
Stock Number:
045854-MU
Citation ID:
RRID:MMRRC_045854-MU
Other Names:
R7799 (G1)
Major Collection:

Strain Information

Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Syt4
Name: synaptotagmin IV
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20983
VEGA: 18
Homologene: 7559
Wnk1
Name: WNK lysine deficient protein kinase 1
Synonyms: 6430573H23Rik, Prkwnk1, EG406236, Hsn2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232341
Homologene: 14253
Tfr2
Name: transferrin receptor 2
Synonyms: Tfr2, Trfr2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 50765
Homologene: 2428
Iars1
Name: isoleucyl-tRNA synthetase 1
Synonyms: E430001P04Rik, 2510016L12Rik, Iars
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105148
HGNC: HGNC:5330
Homologene: 5325
Thoc1
Name: THO complex 1
Synonyms: 3110002N20Rik, NMP-84
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225160
VEGA: 18
Homologene: 38012
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 37,261,771 bp
  • A to G, chromosome 1 at 135,889,957 bp
  • A to G, chromosome 1 at 144,753,865 bp
  • T to C, chromosome 1 at 192,434,875 bp
  • G to T, chromosome 2 at 87,711,084 bp
  • A to C, chromosome 2 at 107,295,892 bp
  • TCTCCTC to TCTC, chromosome 2 at 121,439,456 bp
  • T to C, chromosome 2 at 121,933,541 bp
  • C to A, chromosome 2 at 177,193,820 bp
  • G to T, chromosome 2 at 177,315,797 bp
  • A to G, chromosome 2 at 181,237,989 bp
  • T to A, chromosome 3 at 15,296,663 bp
  • C to T, chromosome 3 at 107,332,143 bp
  • T to C, chromosome 3 at 138,069,601 bp
  • A to T, chromosome 4 at 18,112,112 bp
  • A to G, chromosome 4 at 123,527,113 bp
  • T to A, chromosome 4 at 129,465,348 bp
  • T to A, chromosome 5 at 35,974,398 bp
  • A to G, chromosome 5 at 90,523,854 bp
  • A to G, chromosome 5 at 94,683,428 bp
  • T to G, chromosome 5 at 112,449,832 bp
  • T to G, chromosome 5 at 115,479,746 bp
  • T to G, chromosome 5 at 115,862,968 bp
  • T to A, chromosome 5 at 137,571,724 bp
  • G to T, chromosome 6 at 65,456,137 bp
  • A to T, chromosome 6 at 83,120,195 bp
  • A to T, chromosome 6 at 87,348,181 bp
  • A to T, chromosome 6 at 118,464,882 bp
  • A to G, chromosome 6 at 119,949,176 bp
  • C to T, chromosome 6 at 123,780,463 bp
  • T to C, chromosome 7 at 29,003,560 bp
  • T to C, chromosome 7 at 30,038,943 bp
  • A to G, chromosome 7 at 103,211,979 bp
  • T to A, chromosome 7 at 108,159,430 bp
  • A to T, chromosome 7 at 140,400,464 bp
  • T to C, chromosome 7 at 141,209,602 bp
  • A to G, chromosome 10 at 78,589,907 bp
  • T to C, chromosome 10 at 123,042,331 bp
  • A to G, chromosome 11 at 70,645,179 bp
  • T to C, chromosome 11 at 106,210,317 bp
  • A to G, chromosome 12 at 4,204,762 bp
  • C to A, chromosome 12 at 21,340,492 bp
  • T to A, chromosome 13 at 21,703,199 bp
  • T to A, chromosome 13 at 49,723,018 bp
  • T to C, chromosome 13 at 67,541,489 bp
  • A to T, chromosome 14 at 4,397,585 bp
  • T to C, chromosome 14 at 54,877,215 bp
  • C to T, chromosome 14 at 55,712,475 bp
  • T to C, chromosome 14 at 61,384,733 bp
  • T to A, chromosome 15 at 90,540,247 bp
  • A to G, chromosome 17 at 6,037,823 bp
  • A to G, chromosome 17 at 75,252,356 bp
  • A to T, chromosome 18 at 9,984,441 bp
  • A to T, chromosome 18 at 31,440,192 bp
  • C to A, chromosome 19 at 6,232,598 bp
  • C to A, chromosome 19 at 7,095,864 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7799 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045854-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.