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Strain Name:
C57BL/6J-MtgxR7838Btlr/Mmmh
Stock Number:
045892-MU
Citation ID:
RRID:MMRRC_045892-MU
Other Names:
R7838 (G1)
Major Collection:

Strain Information

Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: E330008K23Rik, HALR, Mll3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231051
Homologene: 46480
Grm1
Name: glutamate receptor, metabotropic 1
Synonyms: mGluR1, Grm1, Gprc1a, nmf373, rcw, 4930455H15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14816
HGNC: HGNC:4593
Homologene: 649
Mcoln3
Name: mucolipin 3
Synonyms: varitint-waddler, Va, 6720490O21Rik, TRPML3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 171166
Homologene: 10118
Ubap2
Name: ubiquitin-associated protein 2
Synonyms: 1190005K07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68926
Homologene: 73649
Fbxo22
Name: F-box protein 22
Synonyms: 1600016C16Rik, 0610033L19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71999
Homologene: 12433
Ylpm1
Name: YLP motif containing 1
Synonyms: ZAP, Zap3, A930013E17Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56531
Homologene: 87707
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, C130061D10Rik, Phr1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105689
Homologene: 9005
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 20,732,127 bp
  • T to C, chromosome 1 at 132,605,549 bp
  • T to C, chromosome 1 at 154,471,403 bp
  • G to A, chromosome 1 at 161,829,321 bp
  • C to T, chromosome 1 at 161,992,050 bp
  • A to G, chromosome 1 at 182,455,819 bp
  • A to T, chromosome 1 at 193,272,773 bp
  • A to G, chromosome 2 at 82,976,700 bp
  • T to C, chromosome 2 at 153,396,813 bp
  • A to G, chromosome 3 at 83,304,527 bp
  • G to T, chromosome 3 at 146,139,475 bp
  • A to T, chromosome 4 at 41,233,655 bp
  • G to A, chromosome 4 at 53,517,657 bp
  • A to T, chromosome 4 at 100,967,014 bp
  • G to A, chromosome 4 at 109,505,579 bp
  • A to G, chromosome 4 at 141,685,250 bp
  • T to A, chromosome 4 at 152,131,281 bp
  • T to C, chromosome 5 at 21,372,754 bp
  • A to G, chromosome 5 at 25,294,699 bp
  • G to A, chromosome 5 at 88,675,664 bp
  • A to G, chromosome 5 at 114,328,811 bp
  • A to G, chromosome 5 at 134,222,095 bp
  • T to C, chromosome 5 at 136,132,129 bp
  • T to C, chromosome 6 at 103,691,674 bp
  • A to T, chromosome 7 at 107,001,307 bp
  • G to T, chromosome 7 at 109,933,989 bp
  • A to G, chromosome 8 at 4,258,461 bp
  • C to T, chromosome 8 at 12,585,696 bp
  • A to G, chromosome 9 at 38,606,412 bp
  • A to C, chromosome 9 at 55,218,367 bp
  • G to A, chromosome 10 at 11,080,352 bp
  • A to G, chromosome 10 at 50,728,297 bp
  • A to T, chromosome 10 at 78,182,944 bp
  • G to A, chromosome 10 at 87,206,199 bp
  • G to A, chromosome 10 at 88,440,392 bp
  • A to G, chromosome 11 at 36,106,799 bp
  • T to C, chromosome 11 at 58,047,714 bp
  • T to A, chromosome 11 at 90,267,607 bp
  • A to T, chromosome 11 at 99,540,135 bp
  • A to T, chromosome 11 at 104,513,004 bp
  • A to G, chromosome 12 at 35,105,175 bp
  • A to G, chromosome 12 at 85,048,866 bp
  • T to C, chromosome 13 at 21,467,267 bp
  • T to A, chromosome 13 at 115,089,648 bp
  • T to C, chromosome 14 at 66,158,401 bp
  • T to C, chromosome 14 at 103,177,293 bp
  • A to T, chromosome 15 at 9,609,551 bp
  • T to A, chromosome 15 at 66,693,263 bp
  • G to A, chromosome 15 at 79,089,599 bp
  • A to T, chromosome 15 at 80,692,503 bp
  • T to A, chromosome 16 at 14,209,617 bp
  • T to G, chromosome 16 at 16,304,521 bp
  • T to A, chromosome 16 at 32,752,558 bp
  • T to C, chromosome 16 at 39,007,203 bp
  • T to C, chromosome 17 at 22,559,051 bp
  • G to A, chromosome 17 at 23,674,011 bp
  • A to G, chromosome 17 at 29,839,822 bp
  • A to G, chromosome 17 at 38,082,402 bp
  • G to T, chromosome 17 at 70,996,171 bp
  • A to T, chromosome 17 at 71,967,554 bp
  • A to C, chromosome 17 at 78,492,018 bp
  • A to G, chromosome 18 at 42,536,937 bp
  • G to A, chromosome 19 at 10,219,619 bp
  • A to G, chromosome 19 at 27,322,932 bp
  • A to G, chromosome 19 at 40,070,244 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7838 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045892-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.