Strain Name:
C57BL/6J-MtgxR7888Btlr/Mmmh
Stock Number:
045940-MU
Citation ID:
RRID:MMRRC_045940-MU
Other Names:
R7888 (G1)
Major Collection:

Strain Information

Mtss1
Name: MTSS I-BAR domain containing 1
Synonyms: MIM, 2310003N14Rik, D130001D01Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 211401
VEGA: 15
Homologene: 8841
Kansl1
Name: KAT8 regulatory NSL complex subunit 1
Synonyms: 1700081L11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76719
Homologene: 9140
Btaf1
Name: B-TFIID TATA-box binding protein associated factor 1
Synonyms: E430027O22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107182
Homologene: 31978
Cnot8
Name: CCR4-NOT transcription complex, subunit 8
Synonyms: 1810022F04Rik, 1500015I04Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69125
HGNC: HGNC:9207
Homologene: 48304
Brd2
Name: bromodomain containing 2
Synonyms: Rnf3, D17H6S113E, Ring3, Frg-1, Fsrg1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14312
HGNC: HGNC:1103
Homologene: 74540
Rabgap1
Name: RAB GTPase activating protein 1
Synonyms: Gapcena
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227800
Homologene: 49301
Sltm
Name: SAFB-like, transcription modulator
Synonyms: 5730555F13Rik, 5730455C01Rik, 9130215G10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66660
VEGA: 9
Homologene: 11696
Itgb2
Name: integrin beta 2
Synonyms: Mac-1 beta, Cd18, 2E6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16414
HGNC: HGNC:6155
Homologene: 20092
Niban2
Name: niban apoptosis regulator 2
Synonyms: Fam129b, 9130404D14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227737
Homologene: 11269
Ptcd3
Name: pentatricopeptide repeat domain 3
Synonyms: 2610034F17Rik, 2810422B04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 69956
Homologene: 41211
Rnf39
Name: ring finger protein 39
Synonyms: LOC386465, LOC386454, LIRF, LOC240094
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 386454
Homologene: 11891
Meaf6
Name: MYST/Esa1-associated factor 6
Synonyms: 2810036M01Rik, 2310005N01Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70088
Homologene: 11240
Fam72a
Name: family with sequence similarity 72, member A
Synonyms: 2700049P18Rik, P17
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108900
Homologene: 82352
Nsun6
Name: NOL1/NOP2/Sun domain family member 6
Synonyms: 4933403D21Rik, NOPD1, 4933414E04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74455
Homologene: 12564
Pfdn5
Name: prefoldin 5
Synonyms: D15Ertd697e, EIG-1, MM-1, 1190001O17Rik, 1700010A06Rik, c-myc binding protein MM-1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 56612
HGNC: HGNC:8869
Homologene: 1972
Scnn1g
Name: sodium channel, nonvoltage-gated 1 gamma
Synonyms: ENaC gamma
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20278
Homologene: 20280
Myo6
Name: myosin VI
Synonyms: Myo6rsv, rsv, Tlc
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17920
HGNC: HGNC:7605
Homologene: 56417
Lrrc37a
Name: leucine rich repeat containing 37A
Synonyms: LOC237954
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237954
Homologene: 138824
Pik3c2g
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18705
HGNC: HGNC:8973
Homologene: 3362
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 545030
Homologene: 83473
Or2t26
Name: olfactory receptor family 2 subfamily T member 26
Synonyms: Olfr1395, GA_x6K02T2QP88-6286247-6285294, MOR277-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258877
Homologene: 105890
Jakmip1
Name: janus kinase and microtubule interacting protein 1
Synonyms: Gababrbp, Marlin-1, 5830437M04Rik, C330021K24Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76071
Homologene: 90789
Slco2b1
Name: solute carrier organic anion transporter family, member 2b1
Synonyms: OATP-B, Slc21a9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101488
Homologene: 21419
Or5au1
Name: olfactory receptor family 5 subfamily AU member 1
Synonyms: Olfr221, GA_x6K02T2RJGY-959918-960853, GA_x6K02SYYB8M-929-258, MOR205-2, Olfr1514, MOR205-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258420
Homologene: 45823
Psme2b
Name: protease (prosome, macropain) activator subunit 2B
Synonyms: Psme2b, Psme2-like, PA28b2, Psme2b-ps
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 621823
HGNC: HGNC:9569
Or10al5
Name: olfactory receptor family 10 subfamily AL member 5
Synonyms: GA_x6K02T2PSCP-2211113-2212078, Olfr121, MOR263-4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258622
Homologene: 17195
Or8j3b
Name: olfactory receptor family 8 subfamily J member 3B
Synonyms: Olfr1057, MOR185-11, GA_x6K02T2Q125-47844843-47843896
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 404325
Homologene: 83135
Tmc3
Name: transmembrane channel-like gene family 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233424
Homologene: 45588
Ccdc40
Name: coiled-coil domain containing 40
Synonyms: B930008I02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207607
Homologene: 27890
Cenpb
Name: centromere protein B
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12616
HGNC: HGNC:1852
Homologene: 1370
Ccdc154
Name: coiled-coil domain containing 154
Synonyms: LOC207209, ntl
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 207209
Homologene: 19361
Mpz
Name: myelin protein zero
Synonyms: P0, Mpp
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17528
HGNC: HGNC:7225
Homologene: 445
Vmn2r4
Name: vomeronasal 2, receptor 4
Synonyms: EG637053
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 637053
Homologene: 129754
Or1e26
Name: olfactory receptor family 1 subfamily E member 26
Synonyms: GA_x6K02T2P1NL-3760313-3759375, Olfr385, MOR135-3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259025
Homologene: 133670
Ano3
Name: anoctamin 3
Synonyms: B230324K02Rik, Tmem16c
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228432
Homologene: 57147
Vps52
Name: VPS52 GARP complex subunit
Synonyms: Sacm2l, tclw5, tcl-w5, D430041K17Rik, ARE1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224705
Homologene: 5756
Acox2
Name: acyl-Coenzyme A oxidase 2, branched chain
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 93732
HGNC: HGNC:120
Homologene: 74473
Aoc3
Name: amine oxidase, copper containing 3
Synonyms: VAP1, semicarbazide-sensitive amine oxidase, SSAO
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11754
HGNC: HGNC:550
Homologene: 2770
Zfp773
Name: zinc finger protein 773
Synonyms: 2810409K11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76373
Homologene: 137393
Or52ae7
Name: olfactory receptor family 52 subfamily AE member 7
Synonyms: Olfr608, MOR26-3, GA_x6K02T2PBJ9-6191595-6192545
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258751
Atp4b
Name: ATPase, H+/K+ exchanging, beta polypeptide
Synonyms: H,K-ATPase-Beta, H+,K+-ATPase, H+/K+-ATPase beta
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11945
HGNC: HGNC:820
Homologene: 20182
Or1l4b
Name: olfactory receptor family 1 subfamily L member 4B
Synonyms: MOR138-7, MOR138-4P, Olfr364, GA_x6K02T2NLDC-33831282-33832243
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227794
HGNC: HGNC:8216
Blvrb
Name: biliverdin reductase B
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233016
HGNC: HGNC:1063
Homologene: 573
Slc16a13
Name: solute carrier family 16 (monocarboxylic acid transporters), member 13
Synonyms: 1700007D07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69309
Homologene: 71749
Cryba4
Name: crystallin, beta A4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12959
HGNC: HGNC:2396
Homologene: 1422
Gm27027
Name: predicted gene, 27027
Type: Gene
Species: Mouse
Chromosome: 2
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 131,528,840 bp
  • T to C, chromosome 1 at 171,159,635 bp
  • T to A, chromosome 2 at 14,996,544 bp
  • T to A, chromosome 2 at 32,922,125 bp
  • A to T, chromosome 2 at 37,146,322 bp
  • T to A, chromosome 2 at 37,537,307 bp
  • C to A, chromosome 2 at 86,374,926 bp
  • A to C, chromosome 2 at 93,957,535 bp
  • T to A, chromosome 2 at 110,666,428 bp
  • T to A, chromosome 2 at 131,179,842 bp
  • T to C, chromosome 3 at 64,406,522 bp
  • T to G, chromosome 4 at 125,109,420 bp
  • A to G, chromosome 5 at 37,104,864 bp
  • T to C, chromosome 5 at 112,251,052 bp
  • G to A, chromosome 6 at 71,883,447 bp
  • T to C, chromosome 6 at 139,896,744 bp
  • C to A, chromosome 7 at 7,132,979 bp
  • A to G, chromosome 7 at 27,465,734 bp
  • T to C, chromosome 7 at 83,600,009 bp
  • T to G, chromosome 7 at 99,688,843 bp
  • T to A, chromosome 7 at 103,470,799 bp
  • A to G, chromosome 7 at 121,743,655 bp
  • A to G, chromosome 8 at 13,389,811 bp
  • C to G, chromosome 9 at 70,586,673 bp
  • T to C, chromosome 9 at 80,296,665 bp
  • T to C, chromosome 10 at 77,564,644 bp
  • T to A, chromosome 11 at 48,945,575 bp
  • T to C, chromosome 11 at 49,148,439 bp
  • T to C, chromosome 11 at 58,111,311 bp
  • T to G, chromosome 11 at 70,218,980 bp
  • T to C, chromosome 11 at 73,589,528 bp
  • C to T, chromosome 11 at 101,332,497 bp
  • T to A, chromosome 11 at 103,501,481 bp
  • T to C, chromosome 11 at 104,342,422 bp
  • A to G, chromosome 11 at 119,229,141 bp
  • G to T, chromosome 14 at 8,246,415 bp
  • C to T, chromosome 14 at 33,090,963 bp
  • A to G, chromosome 14 at 52,035,890 bp
  • A to T, chromosome 15 at 58,972,524 bp
  • T to A, chromosome 15 at 102,328,589 bp
  • G to A, chromosome 17 at 25,164,604 bp
  • A to G, chromosome 17 at 33,965,751 bp
  • G to A, chromosome 17 at 34,117,021 bp
  • A to T, chromosome 17 at 36,947,241 bp
  • A to T, chromosome 17 at 37,751,997 bp
  • A to G, chromosome 19 at 36,965,636 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7888 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045940-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.