Strain Name:
C57BL/6J-MtgxR7959Btlr/Mmmh
Stock Number:
046003-MU
Citation ID:
RRID:MMRRC_046003-MU
Other Names:
R7959 (G1)
Major Collection:

Strain Information

Nrp2
Name: neuropilin 2
Synonyms: Npn2, NP-2, 1110048P06Rik, NP2, Npn-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18187
HGNC: HGNC:8005
Homologene: 2875
Gigyf1
Name: GRB10 interacting GYF protein 1
Synonyms: Perq1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 57330
HGNC: HGNC:9126
Homologene: 57145
Supt5
Name: suppressor of Ty 5, DSIF elongation factor subunit
Synonyms: Spt5, Supt5h
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20924
Homologene: 2384
Elp1
Name: elongator complex protein 1
Synonyms: C78473, Ikbkap, IKAP, 3110040G09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230233
HGNC: HGNC:5959
Homologene: 2699
Uhrf2
Name: ubiquitin-like, containing PHD and RING finger domains 2
Synonyms: 2310065A22Rik, D130071B19Rik, Nirf
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 109113
Homologene: 17001
Polr1b
Name: polymerase (RNA) I polypeptide B
Synonyms: RPA116, D630020H17Rik, RPA2, Rpo1-2, 128kDa
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20017
Homologene: 7133
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: Dnahc7, LOC381341, Dnahc7a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 627872
Homologene: 41287
Cldn8
Name: claudin 8
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 54420
HGNC: HGNC:2050
Homologene: 8117
Mia3
Name: MIA SH3 domain ER export factor 3
Synonyms: B230399H06Rik, Tango, LOC385255, 9130229H14Rik, A930039G15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 338366
Homologene: 85165
Mettl16
Name: methyltransferase 16, N6-methyladenosine
Synonyms: 2810013M15Rik, Mett10d, 2610100D03Rik, A830095F14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67493
Homologene: 34653
Heatr6
Name: HEAT repeat containing 6
Synonyms: 2700008B19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217026
Homologene: 11116
Nup160
Name: nucleoporin 160
Synonyms: 2810011M03Rik, Gtl1-13
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 59015
Homologene: 32509
Prmt9
Name: protein arginine methyltransferase 9
Synonyms: Prmt10
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102182
Homologene: 16298
Plxna2
Name: plexin A2
Synonyms: OCT, Plxn2, 2810428A13Rik, PlexA2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18845
HGNC: HGNC:9100
Homologene: 56427
Col4a4
Name: collagen, type IV, alpha 4
Synonyms: [a]4(IV), E130010M05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12829
HGNC: HGNC:2206
Homologene: 20071
Strbp
Name: spermatid perinuclear RNA binding protein
Synonyms: 6430510M02Rik, Spnr, C230082I21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20744
Homologene: 7548
Pierce1
Name: piercer of microtubule wall 1
Synonyms: 1700007K13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69327
Homologene: 35416
Bbs7
Name: Bardet-Biedl syndrome 7
Synonyms: 8430406N16Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71492
Homologene: 12395
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Gm11639
Name: predicted gene 11639
Synonyms: Gm11639, Efcab15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 105242472
Ccdc168
Name: coiled-coil domain containing 168
Synonyms: Gm8251
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 102636082
VEGA: 1
Homologene: 141149
Ahnak
Name: AHNAK nucleoprotein
Synonyms: DY6, 1110004P15Rik, 2310047C17Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Plcxd1
Name: phosphatidylinositol-specific phospholipase C, X domain containing 1
Synonyms: A330045H12Rik, LOC231597
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 403178
Homologene: 138628
Or8b1b
Name: olfactory receptor family 8 subfamily B member 1B
Synonyms: Olfr904, GA_x6K02T2PVTD-32156773-32157705, MOR167-3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258797
VEGA: 9
Homologene: 133629
Cyp27a1
Name: cytochrome P450, family 27, subfamily a, polypeptide 1
Synonyms: 1300013A03Rik, Cyp27, cholesterol 27 hydroxylase
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 104086
HGNC: HGNC:2605
Homologene: 36040
Tmem184c
Name: transmembrane protein 184C
Synonyms: 8430433H16Rik, Tmem34
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234463
Homologene: 32403
Vmn2r27
Name: vomeronasal 2, receptor27
Synonyms: EG232367
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232367
Or52a24
Name: olfactory receptor family 52 subfamily A member 24
Synonyms: MOR22-4P, MOR22-1, MOR22-4P, Olfr628, Olfr1526-ps1, GA_x6K02T2PBJ9-6457667-6458617
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259159
Homologene: 8420
Spata13
Name: spermatogenesis associated 13
Synonyms: ESTM11
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219140
Homologene: 19482
Pnpla2
Name: patatin-like phospholipase domain containing 2
Synonyms: desnutrin, 0610039C21Rik, Atgl, 1110001C14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66853
Homologene: 10687
Fmn1
Name: formin 1
Synonyms: Fmn, formin-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14260
HGNC: HGNC:3768
Homologene: 121778
Vmn2r24
Name: vomeronasal 2, receptor 24
Synonyms: EG243628
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243628
Homologene: 135915
Or2n1e
Name: olfactory receptor family 2 subfamily N member 1E
Synonyms: Olfr89, GA_x6K02T2PSCP-2718585-2719523, Olfr138, MOR256-40P
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 170648
Homologene: 119758
Apba2
Name: amyloid beta precursor protein binding family A member 2
Synonyms: X11-like, Mint 2, X11L
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11784
HGNC: HGNC:579
Homologene: 4021
Sh3rf3
Name: SH3 domain containing ring finger 3
Synonyms: Sh3md4, 4831416G18Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237353
Homologene: 77551
Mdfic
Name: MyoD family inhibitor domain containing
Synonyms: Kdt1, clone 1.5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16543
Homologene: 18404
Or1e1
Name: olfactory receptor family 1 subfamily E member 1
Synonyms: Olfr21, MOR135-11, Olfr20, MTPCR55, MTPCR06, GA_x6K02T2P1NL-3514066-3515010
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258925
Homologene: 128054
Or9s13
Name: olfactory receptor family 9 subfamily S member 13
Synonyms: MOR208-5, GA_x6K02T2R7CC-81134096-81133095, Olfr12
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 257890
Homologene: 114777
Serhl
Name: serine hydrolase-like
Synonyms: 1110019M09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68607
Homologene: 65196
Zfp994
Name: zinc finger protein 994
Synonyms: Gm4944
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240038
VEGA: 17
Homologene: 133246
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 44,057,568 bp
  • T to C, chromosome 1 at 53,643,462 bp
  • C to T, chromosome 1 at 62,745,408 bp
  • T to A, chromosome 1 at 74,737,077 bp
  • G to T, chromosome 1 at 82,507,059 bp
  • T to A, chromosome 1 at 92,620,307 bp
  • T to C, chromosome 1 at 183,344,339 bp
  • AT to A, chromosome 1 at 194,793,864 bp
  • C to A, chromosome 1 at 194,810,962 bp
  • A to T, chromosome 2 at 28,462,357 bp
  • G to A, chromosome 2 at 37,640,894 bp
  • T to C, chromosome 2 at 82,985,776 bp
  • T to C, chromosome 2 at 90,713,895 bp
  • T to A, chromosome 2 at 113,365,622 bp
  • T to A, chromosome 2 at 129,108,094 bp
  • C to T, chromosome 3 at 36,602,936 bp
  • A to T, chromosome 4 at 56,774,737 bp
  • A to T, chromosome 5 at 110,103,556 bp
  • C to T, chromosome 5 at 137,524,319 bp
  • T to C, chromosome 6 at 15,741,071 bp
  • T to A, chromosome 6 at 123,778,990 bp
  • T to C, chromosome 6 at 124,192,081 bp
  • T to C, chromosome 7 at 28,315,799 bp
  • A to G, chromosome 7 at 64,695,823 bp
  • T to A, chromosome 7 at 103,732,808 bp
  • T to A, chromosome 7 at 141,457,493 bp
  • T to A, chromosome 8 at 77,560,965 bp
  • A to G, chromosome 8 at 77,602,903 bp
  • T to A, chromosome 9 at 38,464,915 bp
  • A to T, chromosome 10 at 59,007,103 bp
  • T to C, chromosome 11 at 73,353,918 bp
  • A to G, chromosome 11 at 74,817,026 bp
  • A to T, chromosome 11 at 83,781,363 bp
  • A to G, chromosome 11 at 105,042,801 bp
  • C to T, chromosome 14 at 60,756,230 bp
  • A to T, chromosome 15 at 83,101,872 bp
  • A to G, chromosome 16 at 88,562,941 bp
  • A to G, chromosome 17 at 22,202,780 bp
  • A to G, chromosome 17 at 38,275,711 bp
  • T to C, chromosome 19 at 9,010,649 bp
  • A to G, chromosome 19 at 30,086,260 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7959 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
046003-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.