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Strain Name:
C57BL/6J-MtgxR7975Btlr/Mmmh
Stock Number:
046018-MU
Citation ID:
RRID:MMRRC_046018-MU
Other Names:
R7975 (G1)
Major Collection:

Strain Information

Mitf
Name: melanogenesis associated transcription factor
Synonyms: mi, wh, BCC2, bHLHe32, Gsfbcc2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17342
HGNC: HGNC:7105
Homologene: 4892
Mtrr
Name: 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 210009
VEGA: 13
HGNC: HGNC:7473
Homologene: 11419
Rasgrp2
Name: RAS, guanyl releasing protein 2
Synonyms: CalDAG-GEFI, Caldaggef1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19395
HGNC: HGNC:9879
Homologene: 4250
Mthfr
Name: methylenetetrahydrofolate reductase
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17769
HGNC: HGNC:7436
Homologene: 4349
Ubap2l
Name: ubiquitin-associated protein 2-like
Synonyms: 3110083O19Rik, NICE-4, 4932431F02Rik, A430103N23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74383
Homologene: 136291
Gstcd
Name: glutathione S-transferase, C-terminal domain containing
Synonyms: 4933434L15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67553
Homologene: 11693
Celf1
Name: CUGBP, Elav-like family member 1
Synonyms: Brunol2, CUG-BP, D2Wsu101e, 1600010O03Rik, CUG-BP1, Cugbp1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13046
HGNC: HGNC:2549
Homologene: 134102
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 58,309,028 bp
  • T to A, chromosome 1 at 72,612,991 bp
  • T to C, chromosome 1 at 117,948,090 bp
  • T to C, chromosome 1 at 136,171,173 bp
  • C to T, chromosome 1 at 173,641,156 bp
  • T to A, chromosome 2 at 52,160,666 bp
  • T to G, chromosome 2 at 66,484,253 bp
  • C to T, chromosome 2 at 89,363,069 bp
  • T to G, chromosome 2 at 91,001,078 bp
  • A to T, chromosome 2 at 119,456,467 bp
  • A to T, chromosome 3 at 53,453,545 bp
  • G to A, chromosome 3 at 90,038,769 bp
  • G to T, chromosome 3 at 94,764,529 bp
  • G to A, chromosome 3 at 105,458,994 bp
  • A to G, chromosome 3 at 133,072,102 bp
  • T to A, chromosome 4 at 25,214,730 bp
  • A to G, chromosome 4 at 44,537,465 bp
  • T to A, chromosome 4 at 63,131,115 bp
  • A to T, chromosome 4 at 65,294,468 bp
  • T to C, chromosome 4 at 96,470,539 bp
  • G to A, chromosome 4 at 108,012,276 bp
  • G to A, chromosome 4 at 137,555,221 bp
  • A to T, chromosome 4 at 148,043,463 bp
  • T to C, chromosome 5 at 9,129,169 bp
  • T to C, chromosome 5 at 41,816,277 bp
  • C to T, chromosome 5 at 105,221,101 bp
  • G to A, chromosome 5 at 120,871,827 bp
  • T to C, chromosome 6 at 98,018,029 bp
  • T to C, chromosome 7 at 10,037,345 bp
  • A to G, chromosome 7 at 28,840,921 bp
  • T to C, chromosome 7 at 42,043,775 bp
  • G to A, chromosome 7 at 46,657,254 bp
  • T to A, chromosome 7 at 51,566,538 bp
  • A to T, chromosome 7 at 108,893,812 bp
  • T to C, chromosome 7 at 128,762,477 bp
  • A to G, chromosome 7 at 141,409,868 bp
  • A to T, chromosome 8 at 3,925,948 bp
  • A to C, chromosome 8 at 106,255,622 bp
  • C to A, chromosome 8 at 122,495,765 bp
  • G to A, chromosome 8 at 124,598,776 bp
  • T to C, chromosome 9 at 71,725,322 bp
  • A to G, chromosome 9 at 119,672,220 bp
  • T to C, chromosome 10 at 5,031,786 bp
  • A to G, chromosome 10 at 13,190,709 bp
  • C to T, chromosome 10 at 82,283,989 bp
  • T to C, chromosome 10 at 89,116,985 bp
  • A to T, chromosome 11 at 83,187,156 bp
  • A to T, chromosome 11 at 98,221,102 bp
  • A to T, chromosome 12 at 69,593,040 bp
  • T to C, chromosome 13 at 68,579,547 bp
  • C to T, chromosome 13 at 100,020,376 bp
  • A to G, chromosome 13 at 113,319,307 bp
  • T to C, chromosome 14 at 41,980,165 bp
  • T to C, chromosome 14 at 69,707,144 bp
  • C to G, chromosome 14 at 70,143,469 bp
  • T to A, chromosome 16 at 19,407,551 bp
  • A to T, chromosome 17 at 34,115,450 bp
  • C to T, chromosome 18 at 12,537,739 bp
  • A to G, chromosome 18 at 56,485,379 bp
  • A to G, chromosome 19 at 6,408,559 bp
  • A to T, chromosome 19 at 33,512,628 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7975 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
046018-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.