Strain Name:
C57BL/6J-MtgxR8015Btlr/Mmmh
Stock Number:
067455-MU
Citation ID:
RRID:MMRRC_067455-MU
Other Names:
R8015 (G1)
Major Collection:

Strain Information

Nrp2
Name: neuropilin 2
Synonyms: 1110048P06Rik, Npn-2, NP2, NP-2, Npn2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18187
HGNC: HGNC:8005
Homologene: 2875
Phf20l1
Name: PHD finger protein 20-like 1
Synonyms: CGI-72, E130113K22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239510
VEGA: 15
Homologene: 9341
Specc1l
Name: sperm antigen with calponin homology and coiled-coil domains 1-like
Synonyms: Cytsa, 4930470P14Rik, Specc1l, 4932439K10Rik, 9530057A13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74392
VEGA: 10
Homologene: 15610
Ube3a
Name: ubiquitin protein ligase E3A
Synonyms: E6-AP ubiquitin protein ligase, Hpve6a, A130086L21Rik, 5830462N02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22215
Homologene: 7988
Anapc2
Name: anaphase promoting complex subunit 2
Synonyms: APC2, expressed during mesenchymal induction 4, Emi4, Imi4, 9230107K09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99152
Homologene: 8359
Polr2b
Name: polymerase (RNA) II (DNA directed) polypeptide B
Synonyms: RPB2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231329
HGNC: HGNC:9188
Homologene: 722
Il20rb
Name: interleukin 20 receptor beta
Synonyms: LOC213208, Fndc6, Il20R2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 213208
HGNC: HGNC:6004
Homologene: 86034
Itgb1
Name: integrin beta 1 (fibronectin receptor beta)
Synonyms: Gm9863, 4633401G24Rik, CD29, beta1 integrin, Fnrb
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16412
HGNC: HGNC:6153
Homologene: 22999
Zfp386
Name: zinc finger protein 386 (Kruppel-like)
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56220
Homologene: 51668
Lnpep
Name: leucyl/cystinyl aminopeptidase
Synonyms: vp165, 4732490P18Rik, gp160, 2010309L07Rik, IRAP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240028
VEGA: 17
HGNC: HGNC:6656
Homologene: 21148
Hspa1a
Name: heat shock protein 1A
Synonyms: Hsp70-3, Hsp68, Hsp70.3, Hsp70a1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 193740
Homologene: 74294
Atp10a
Name: ATPase, class V, type 10A
Synonyms: pfatp, Atp10c
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11982
Homologene: 56461
Hmcn1
Name: hemicentin 1
Synonyms: EG545370, LOC240793
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Spta1
Name: spectrin alpha, erythrocytic 1
Synonyms: Spna1, ihj, Spna-1, erythroid
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20739
Homologene: 74460
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 545030
Homologene: 83473
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329628
Homologene: 14377
Jakmip1
Name: janus kinase and microtubule interacting protein 1
Synonyms: C330021K24Rik, 5830437M04Rik, Gababrbp, Marlin-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76071
Homologene: 90789
Lox
Name: lysyl oxidase
Synonyms: ras recision gene (rrg), TSC-160
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 16948
VEGA: 18
HGNC: HGNC:6664
Homologene: 1741
Msto1
Name: misato 1, mitochondrial distribution and morphology regulator
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229524
Homologene: 41228
Jmjd8
Name: jumonji domain containing 8
Synonyms: 2610003J06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72106
Homologene: 12441
Bmal2
Name: basic helix-loop-helix ARNT like 2
Synonyms: 4632430A05Rik, MOP9, bHLHe6, Arntl2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 272322
Homologene: 10609
Dpp6
Name: dipeptidylpeptidase 6
Synonyms: LOC384168, In(5)6H-p, Dpp-6, Peplb, B930011P16Rik, Rw
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13483
HGNC: HGNC:3010
Homologene: 22560
Col6a5
Name: collagen, type VI, alpha 5
Synonyms: Col6a5, Gm7455
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 665033
Homologene: 122792
Spata16
Name: spermatogenesis associated 16
Synonyms: 4921511F01Rik, Nyd-sp12, 4930503K02Rik, spermatogenesis-related protein
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70862
Homologene: 49974
Speg
Name: SPEG complex locus
Synonyms: SPEGbeta, BPEG, SPEGalpha, Apeg1, SPEG, D1Bwg1450e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11790
Homologene: 55619
Defb13
Name: defensin beta 13
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 246083
Homologene: 86849
Mcrs1
Name: microspherule protein 1
Synonyms: ICP22BP, P78, MSP58, C78274
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 51812
VEGA: 15
HGNC: HGNC:6960
Homologene: 4622
Or2ad1
Name: olfactory receptor family 2 subfamily AD member 1
Synonyms: Olfr1368, GA_x6K02T2QHY8-12104556-12105500, MOR256-15
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 258527
Homologene: 105156
Pnliprp2
Name: pancreatic lipase-related protein 2
Synonyms: PLRP2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18947
VEGA: 19
HGNC: HGNC:9157
Homologene: 3936
Tex14
Name: testis expressed gene 14 intercellular bridge forming factor
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 83560
Homologene: 12838
Cttnbp2
Name: cortactin binding protein 2
Synonyms: 9130022E09Rik, Cortbp2, 4732477G22Rik, 3010022N24Rik, ORF4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 30785
Homologene: 14125
Txndc17
Name: thioredoxin domain containing 17
Synonyms: D11Ertd672e, 4831443O22Rik, TRP14, Txnl5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52700
Homologene: 41683
Tnfrsf14
Name: tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
Synonyms: Atar, Hvem, HveA
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230979
Homologene: 2833
Rcn3
Name: reticulocalbin 3, EF-hand calcium binding domain
Synonyms: 6030455P07Rik, RLP49, D530026G20Rik, D7Ertd671e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 52377
Homologene: 10775
Ptdss1
Name: phosphatidylserine synthase 1
Synonyms: PSS-1, PtdSer Synthase-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19210
VEGA: 13
HGNC: HGNC:9587
Homologene: 7494
Krtap15-1
Name: keratin associated protein 15-1
Synonyms: Pmg-2, Krtap15
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 26560
Homologene: 8439
Hycc2
Name: hyccin PI4KA lipid kinase complex subunit 2
Synonyms: Fam126b, D1Ertd53e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213056
Homologene: 18184
Vmn2r23
Name: vomeronasal 2, receptor 23
Synonyms: EG435916
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 435916
Homologene: 135826
Cacnb4
Name: calcium channel, voltage-dependent, beta 4 subunit
Synonyms: 3110038O15Rik, Cchb4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12298
HGNC: HGNC:1404
Homologene: 20188
Vmn1r14
Name: vomeronasal 1 receptor 14
Synonyms: V1rc7
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113864
Homologene: 74373
Best2
Name: bestrophin 2
Synonyms: Vmd2l1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212989
Homologene: 41187
Pate2
Name: prostate and testis expressed 2
Synonyms: LOC330921, mANLP1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330921
Homologene: 86016
Or5g25
Name: olfactory receptor family 5 subfamily G member 25
Synonyms: MOR175-2, Olfr1002, GA_x6K02T2Q125-47127746-47126790
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258566
Homologene: 104131
Mfsd8
Name: major facilitator superfamily domain containing 8
Synonyms: 2810423E13Rik, Cln7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72175
Homologene: 115814
Slc30a2
Name: solute carrier family 30 (zinc transporter), member 2
Synonyms: Znt2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230810
Homologene: 40855
Vmn2r31
Name: vomeronasal 2, receptor 31
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100042591
Homologene: 113703
Pate9
Name: prostate and testis expressed 9
Synonyms: Gm5615
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 434396
Rhbdl1
Name: rhomboid like 1
Synonyms: Rhbdl
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 214951
Homologene: 2946
Tmem150b
Name: transmembrane protein 150B
Synonyms: Tmem224
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330460
Homologene: 19603
Alad
Name: aminolevulinate, delta-, dehydratase
Synonyms: Lv
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17025
HGNC: HGNC:395
Homologene: 16
Iqcn
Name: IQ motif containing N
Synonyms: Gm16486
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 637079
Homologene: 141171
Lce3d
Name: late cornified envelope 3D
Synonyms: Gm9782
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 630994
Homologene: 134278
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 58,535,482 bp
  • C to T, chromosome 1 at 62,745,408 bp
  • G to T, chromosome 1 at 75,415,421 bp
  • T to G, chromosome 1 at 150,598,311 bp
  • T to A, chromosome 1 at 174,240,171 bp
  • T to A, chromosome 2 at 25,284,676 bp
  • A to G, chromosome 2 at 52,464,643 bp
  • G to T, chromosome 2 at 85,647,792 bp
  • A to G, chromosome 3 at 26,667,659 bp
  • A to G, chromosome 3 at 38,981,916 bp
  • G to A, chromosome 3 at 40,846,835 bp
  • G to T, chromosome 3 at 88,911,556 bp
  • A to T, chromosome 3 at 92,958,503 bp
  • A to G, chromosome 4 at 62,511,922 bp
  • A to G, chromosome 4 at 134,347,450 bp
  • T to G, chromosome 4 at 154,926,661 bp
  • C to T, chromosome 5 at 26,817,810 bp
  • T to C, chromosome 5 at 37,159,765 bp
  • A to G, chromosome 5 at 77,336,506 bp
  • G to C, chromosome 6 at 18,426,093 bp
  • A to G, chromosome 6 at 57,234,030 bp
  • G to A, chromosome 6 at 123,704,541 bp
  • T to C, chromosome 6 at 146,820,590 bp
  • C to T, chromosome 7 at 4,716,328 bp
  • C to T, chromosome 7 at 7,384,200 bp
  • T to A, chromosome 7 at 45,084,907 bp
  • G to T, chromosome 7 at 58,803,497 bp
  • T to A, chromosome 7 at 59,284,756 bp
  • G to T, chromosome 8 at 21,946,812 bp
  • C to T, chromosome 8 at 70,716,792 bp
  • A to G, chromosome 8 at 85,009,354 bp
  • T to A, chromosome 8 at 128,722,401 bp
  • A to T, chromosome 9 at 35,670,518 bp
  • A to G, chromosome 9 at 36,534,954 bp
  • T to A, chromosome 9 at 100,474,894 bp
  • T to C, chromosome 9 at 105,881,741 bp
  • A to G, chromosome 10 at 75,241,068 bp
  • A to G, chromosome 11 at 72,207,742 bp
  • G to A, chromosome 11 at 87,509,600 bp
  • T to G, chromosome 12 at 116,059,407 bp
  • T to C, chromosome 13 at 21,142,133 bp
  • T to A, chromosome 13 at 66,963,343 bp
  • T to C, chromosome 14 at 33,107,747 bp
  • T to G, chromosome 15 at 66,639,948 bp
  • T to A, chromosome 15 at 99,248,854 bp
  • A to G, chromosome 16 at 88,829,209 bp
  • C to A, chromosome 17 at 17,546,499 bp
  • T to A, chromosome 17 at 25,829,328 bp
  • C to G, chromosome 17 at 25,835,851 bp
  • T to A, chromosome 17 at 34,970,649 bp
  • G to A, chromosome 18 at 52,528,348 bp
  • G to T, chromosome 19 at 58,766,282 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8015 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067455-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.