Strain Name:
C57BL/6J-MtgxR8031Btlr/Mmmh
Stock Number:
067469-MU
Citation ID:
RRID:MMRRC_067469-MU
Other Names:
R8031 (G1)
Major Collection:

Strain Information

Ppp1cc
Name: protein phosphatase 1 catalytic subunit gamma
Synonyms: PP1C gamma 2, PP1C gamma 1, PP1C gamma, PP1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19047
HGNC: HGNC:9283
Homologene: 135423
Ntrk2
Name: neurotrophic tyrosine kinase, receptor, type 2
Synonyms: trkB, C030027L06Rik, Tkrb
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18212
VEGA: 13
HGNC: HGNC:8032
Homologene: 4504
Itga8
Name: integrin alpha 8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241226
HGNC: HGNC:6144
Homologene: 37396
Cacng6
Name: calcium channel, voltage-dependent, gamma subunit 6
Synonyms: 2310033H20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 54378
Homologene: 15427
Pcif1
Name: phosphorylated CTD interacting factor 1
Synonyms: 2310022K11Rik, F730014I05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228866
Homologene: 11134
Kazn
Name: kazrin, periplakin interacting protein
Synonyms: 2310007B04Rik, 9030409G11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71529
Homologene: 16235
Zc3h13
Name: zinc finger CCCH type containing 13
Synonyms: C87618, 4930570G11Rik, 2600010B19Rik, 3110050K21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67302
VEGA: 14
Taf1d
Name: TATA-box binding protein associated factor, RNA polymerase I, D
Synonyms: 4930553M18Rik, Josd3, TAFI41, TAF(I)41
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75316
VEGA: 9
Homologene: 11472
Traf3ip1
Name: TRAF3 interacting protein 1
Synonyms: 3930402D05Rik, MIP-T3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74019
Homologene: 22913
Sorbs1
Name: sorbin and SH3 domain containing 1
Synonyms: c-Cbl-associated protein, CAP, Sh3d5, 9530001P15Rik, 2310065E01Rik, Ponsin
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20411
VEGA: 19
Homologene: 83252
Cdc40
Name: cell division cycle 40
Synonyms: PRP17, EHB3, 1200003H23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71713
VEGA: 10
Homologene: 5716
Slc25a25
Name: solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25
Synonyms: 1110030N17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227731
Homologene: 62165
Atxn10
Name: ataxin 10
Synonyms: TEG-169, E46, Sca10, Tex169
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 54138
VEGA: 15
Homologene: 40858
Eif4a3
Name: eukaryotic translation initiation factor 4A3
Synonyms: 2400003O03Rik, Ddx48
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192170
Homologene: 5602
Myo9a
Name: myosin IXa
Synonyms: 4732465J09Rik, C130068I12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270163
HGNC: HGNC:7608
Homologene: 21371
Ube2n
Name: ubiquitin-conjugating enzyme E2N
Synonyms: UBC13
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 93765
VEGA: 10
Homologene: 128406
Arhgdib
Name: Rho, GDP dissociation inhibitor beta
Synonyms: D4, Ly-GDI, Gdid4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11857
HGNC: HGNC:679
Homologene: 20318
Fam3b
Name: FAM3 metabolism regulating signaling molecule B
Synonyms: D16Jhu19e, 9030624C24Rik, ORF9, Pander
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 52793
HGNC: HGNC:1253
Homologene: 10766
Il17rc
Name: interleukin 17 receptor C
Synonyms: IL17-RL, Il17rl, 1110025H02Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171095
Homologene: 15894
Hk1
Name: hexokinase 1
Synonyms: Hk-1, mHk1-s, Hk1-s
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15275
HGNC: HGNC:4922
Homologene: 100530
Erc2
Name: ELKS/RAB6-interacting/CAST family member 2
Synonyms: D14Ertd171e, ELKS2alpha, CAST
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 238988
Homologene: 69188
Cdc23
Name: CDC23 cell division cycle 23
Synonyms: D18Ertd243e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 52563
HGNC: HGNC:1724
Homologene: 3426
Psmd4
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
Synonyms: Mcb1, multiubiquitin-chain-binding protein, Af1, angiocidin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19185
HGNC: HGNC:9561
Homologene: 55691
Slc38a6
Name: solute carrier family 38, member 6
Synonyms: EG625098
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 625098
Homologene: 27550
Spink5
Name: serine peptidase inhibitor, Kazal type 5
Synonyms: LEKT1, 2310065D10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 72432
Homologene: 4987
Efcab6
Name: EF-hand calcium binding domain 6
Synonyms: 4932408N08Rik, 4931407K02Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 77627
Homologene: 11259
Nlrp1b
Name: NLR family, pyrin domain containing 1B
Synonyms: Nalp1b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 637515
Homologene: 19080
Vmn2r103
Name: vomeronasal 2, receptor 103
Synonyms: EG627636
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627636
Homologene: 115024
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 192190
Homologene: 16332
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Gm11639
Name: predicted gene 11639
Synonyms: Gm11639, Efcab15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 105242472
Inhba
Name: inhibin beta-A
Synonyms: activin beta-A
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16323
VEGA: 13
HGNC: HGNC:6066
Homologene: 1653
Vmn2r78
Name: vomeronasal 2, receptor 78
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637896
Homologene: 115466
Pgm2l1
Name: phosphoglucomutase 2-like 1
Synonyms: BM32A, 4931406N15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70974
Homologene: 12374
Or8k33
Name: olfactory receptor family 8 subfamily K member 33
Synonyms: GA_x6K02T2Q125-48039418-48038477, MOR192-1, Olfr1080
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258404
Homologene: 104285
Ptprt
Name: protein tyrosine phosphatase receptor type T
Synonyms: RPTPrho
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19281
HGNC: HGNC:9682
Homologene: 56924
Kcnt1
Name: potassium channel, subfamily T, member 1
Synonyms: slo2, Slack, C030030G16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227632
Homologene: 11055
Ror2
Name: receptor tyrosine kinase-like orphan receptor 2
Synonyms: Ntrkr2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26564
Homologene: 55831
Flg2
Name: filaggrin family member 2
Synonyms: EG229574
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229574
Homologene: 134146
Vmn2r104
Name: vomeronasal 2, receptor 104
Synonyms: V2r7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22313
Homologene: 129751
Top2b
Name: topoisomerase (DNA) II beta
Synonyms: Top-2, D230016L12Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21974
Homologene: 134711
Zfp235
Name: zinc finger protein 235
Synonyms: 0610030O19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56525
Homologene: 122146
Pla2g4a
Name: phospholipase A2, group IVA (cytosolic, calcium-dependent)
Synonyms: cPLA2, Type IV PLA2, cytosolic PLA2, cPLA2alpha, cytosolic phospholipase A2, Pla2g4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18783
HGNC: HGNC:9035
Homologene: 32059
Or5k14
Name: olfactory receptor family 5 subfamily K member 14
Synonyms: GA_x54KRFPKG5P-55091371-55090442, MOR184-7, Olfr177, MOR184-8, GA_x54KRFPKG5P-55043245-55042289, Olfr176
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258998
Homologene: 121500
Krt42
Name: keratin 42
Synonyms: Ka22, K17n, ecat6, 2410039E07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68239
Homologene: 107091
Or52h7
Name: olfactory receptor family 52 subfamily H member 7
Synonyms: GA_x6K02T2PBJ9-7191524-7192471, MOR31-8, Olfr652
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259050
Homologene: 17477
Or4c112
Name: olfactory receptor family 4 subfamily C member 112
Synonyms: GA_x6K02T2Q125-50504545-50503631, MOR233-4, Olfr1217
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258903
Homologene: 73985
Smarca5
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
Synonyms: Snf2h, D330027N15Rik, 4933427E24Rik, D030040M08Rik, MommeD4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 93762
Homologene: 55764
Dsc2
Name: desmocollin 2
Synonyms: Dsc2b, Dsc2a
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13506
HGNC: HGNC:3036
Homologene: 8397
Vmn2r49
Name: vomeronasal 2, receptor 49
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 625605
Homologene: 113703
Vmn1r34
Name: vomeronasal 1 receptor 34
Synonyms: Gm5991
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 546901
Homologene: 110800
Tmem225
Name: transmembrane protein 225
Synonyms: 1700030E15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75667
VEGA: 9
Homologene: 52854
Fmo4
Name: flavin containing monooxygenase 4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226564
HGNC: HGNC:3772
Homologene: 68219
P4ha3
Name: procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III
Synonyms: D930031A02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320452
Homologene: 27943
Ubl7
Name: ubiquitin-like 7 (bone marrow stromal cell-derived)
Synonyms: 2300004C15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69459
VEGA: 9
Homologene: 12312
Ace3
Name: angiotensin I converting enzyme 3
Synonyms: EG217246
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217246
Homologene: 80337
Gm16503
Name: predicted gene 16503
Type: Gene
Species: Mouse
Chromosome: 4
Kcnk13
Name: potassium channel, subfamily K, member 13
Synonyms: LOC381712, LOC380778, F730021E22Rik, THIK-1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217826
HGNC: HGNC:6275
Homologene: 69351
Hes7
Name: hes family bHLH transcription factor 7
Synonyms: bHLHb37
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 84653
Homologene: 23779
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 91,501,419 bp
  • T to A, chromosome 1 at 149,901,213 bp
  • G to T, chromosome 1 at 162,798,852 bp
  • G to T, chromosome 2 at 12,155,486 bp
  • C to A, chromosome 2 at 25,908,042 bp
  • A to T, chromosome 2 at 32,421,505 bp
  • A to G, chromosome 2 at 82,986,891 bp
  • G to A, chromosome 2 at 86,554,103 bp
  • A to T, chromosome 2 at 89,023,628 bp
  • G to A, chromosome 2 at 162,135,457 bp
  • A to G, chromosome 2 at 164,886,522 bp
  • T to A, chromosome 3 at 93,220,214 bp
  • T to C, chromosome 3 at 95,035,892 bp
  • T to C, chromosome 4 at 142,154,551 bp
  • A to T, chromosome 4 at 147,541,310 bp
  • G to A, chromosome 5 at 122,174,088 bp
  • A to T, chromosome 6 at 66,637,181 bp
  • A to G, chromosome 6 at 113,482,821 bp
  • A to G, chromosome 6 at 136,924,276 bp
  • T to C, chromosome 7 at 3,424,885 bp
  • T to C, chromosome 7 at 9,986,481 bp
  • T to A, chromosome 7 at 24,141,689 bp
  • T to C, chromosome 7 at 86,954,867 bp
  • C to A, chromosome 7 at 100,272,418 bp
  • A to G, chromosome 7 at 100,292,698 bp
  • T to A, chromosome 7 at 104,565,109 bp
  • T to A, chromosome 8 at 21,085,237 bp
  • A to T, chromosome 8 at 80,704,682 bp
  • T to G, chromosome 9 at 15,310,399 bp
  • A to G, chromosome 9 at 40,149,393 bp
  • C to T, chromosome 9 at 57,923,206 bp
  • A to G, chromosome 9 at 59,780,091 bp
  • T to A, chromosome 10 at 40,852,516 bp
  • T to A, chromosome 10 at 62,296,699 bp
  • C to T, chromosome 10 at 95,541,382 bp
  • C to T, chromosome 11 at 69,122,765 bp
  • T to C, chromosome 11 at 71,216,921 bp
  • G to C, chromosome 11 at 100,265,039 bp
  • T to C, chromosome 11 at 104,881,469 bp
  • T to C, chromosome 11 at 105,998,098 bp
  • T to C, chromosome 11 at 119,288,905 bp
  • C to A, chromosome 11 at 119,430,281 bp
  • G to A, chromosome 12 at 73,350,603 bp
  • A to G, chromosome 12 at 99,966,179 bp
  • T to A, chromosome 13 at 16,026,275 bp
  • C to T, chromosome 13 at 53,113,157 bp
  • T to C, chromosome 13 at 58,874,379 bp
  • A to G, chromosome 14 at 16,412,986 bp
  • A to T, chromosome 14 at 28,011,692 bp
  • C to T, chromosome 14 at 61,204,191 bp
  • T to A, chromosome 14 at 75,330,630 bp
  • A to G, chromosome 15 at 44,512,834 bp
  • T to C, chromosome 15 at 83,983,498 bp
  • T to G, chromosome 15 at 85,393,393 bp
  • T to C, chromosome 16 at 58,872,691 bp
  • A to C, chromosome 16 at 97,481,852 bp
  • C to T, chromosome 17 at 19,793,497 bp
  • T to C, chromosome 17 at 20,042,786 bp
  • C to T, chromosome 18 at 20,032,274 bp
  • A to G, chromosome 18 at 34,651,688 bp
  • T to A, chromosome 18 at 44,010,236 bp
  • C to A, chromosome 19 at 40,326,489 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8031 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067469-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.