Strain Name:
C57BL/6J-MtgxR8063Btlr/Mmmh
Stock Number:
067499-MU
Citation ID:
RRID:MMRRC_067499-MU
Other Names:
R8063 (G1)
Major Collection:

Strain Information

Lasp1
Name: LIM and SH3 protein 1
Synonyms: SH3P6, Def-4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16796
HGNC: HGNC:6513
Homologene: 4480
Cep70
Name: centrosomal protein 70
Synonyms: 6720484E09Rik, C030018L16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68121
Homologene: 11387
Rictor
Name: RPTOR independent companion of MTOR, complex 2
Synonyms: 6030405M08Rik, D530039E11Rik, 4921505C17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78757
VEGA: 15
Homologene: 34317
Usp30
Name: ubiquitin specific peptidase 30
Synonyms: 6330590F17Rik, D5Ertd483e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100756
Homologene: 32789
Sin3b
Name: transcriptional regulator, SIN3B (yeast)
Synonyms: 2810430C10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20467
Homologene: 81810
Asxl2
Name: ASXL transcriptional regulator 2
Synonyms: 4930556B16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 75302
Homologene: 10102
Cnot4
Name: CCR4-NOT transcription complex, subunit 4
Synonyms: Not4h, Not4, Not4hp
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 53621
HGNC: HGNC:7880
Homologene: 40870
Eif2ak4
Name: eukaryotic translation initiation factor 2 alpha kinase 4
Synonyms: GCN2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27103
Homologene: 40891
Tcof1
Name: treacle ribosome biogenesis factor 1
Synonyms: treacle
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 21453
Homologene: 68049
Agk
Name: acylglycerol kinase
Synonyms: MuLK, 2610037M15Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 69923
Homologene: 41239
Armc10
Name: armadillo repeat containing 10
Synonyms: 2810037C14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67211
Homologene: 12097
Uba6
Name: ubiquitin-like modifier activating enzyme 6
Synonyms: 5730469D23Rik, Ube1l2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231380
Homologene: 10080
Vps13d
Name: vacuolar protein sorting 13D
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230895
Homologene: 15583
Zfp960
Name: zinc finger protein 960
Synonyms: BC018101
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 449000
Homologene: 133884
Bend5
Name: BEN domain containing 5
Synonyms: 2310026E23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67621
Homologene: 41574
Megf9
Name: multiple EGF-like-domains 9
Synonyms: 4933405H16Rik, Egfl5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230316
HGNC: HGNC:3234
Homologene: 18209
Canx
Name: calnexin
Synonyms: 1110069N15Rik, CNX
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12330
HGNC: HGNC:1473
Homologene: 1324
Bicra
Name: BRD4 interacting chromatin remodeling complex associated protein
Synonyms: Gltscr1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243842
HGNC: HGNC:4332
Homologene: 9250
Atp12a
Name: ATPase, H+/K+ transporting, nongastric, alpha polypeptide
Synonyms: HKalpha2, cHKA, Atp1al1, ATPase H+K+-transporting, alpha 2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 192113
VEGA: 14
Homologene: 68197
Cyp4f18
Name: cytochrome P450, family 4, subfamily f, polypeptide 18
Synonyms: 1810054N16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72054
Homologene: 128623
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: Mdnah5, b2b1537Clo, b2b1565Clo, b2b1154Clo, b2b1134Clo, Dnahc5, b2b3491Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Ms4a10
Name: membrane-spanning 4-domains, subfamily A, member 10
Synonyms: 2010001N17Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 69826
Homologene: 11355
Tet3
Name: tet methylcytosine dioxygenase 3
Synonyms: D230004J03Rik, B430006D22Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 194388
Homologene: 35360
Sorcs1
Name: sortilin-related VPS10 domain containing receptor 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 58178
Homologene: 10967
Ralgapa2
Name: Ral GTPase activating protein, alpha subunit 2 (catalytic)
Synonyms: A230067G21Rik, RGC2, AS250
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241694
Homologene: 28131
Sctr
Name: secretin receptor
Synonyms: 6530402O03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 319229
Homologene: 68290
Vmn2r26
Name: vomeronasal 2, receptor 26
Synonyms: V2r1b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56552
Homologene: 135915
Zscan20
Name: zinc finger and SCAN domains 20
Synonyms: Zfp31
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269585
Homologene: 51463
Lrrc37
Name: leucine rich repeat containing 37
Synonyms: LOC380730, Gm884
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380730
Homologene: 134511
Impg2
Name: interphotoreceptor matrix proteoglycan 2
Synonyms: PG10.2, IPM200, Spacrcan
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224224
Homologene: 9439
Kcnh2
Name: potassium voltage-gated channel, subfamily H (eag-related), member 2
Synonyms: merg1a, ether a go-go related, M-erg, LQT, Lqt2, ERG1, merg1b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16511
HGNC: HGNC:6251
Homologene: 201
Alpk2
Name: alpha-kinase 2
Synonyms: Hak
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225638
Homologene: 50475
Pappa2
Name: pappalysin 2
Synonyms: placenta-specific 3, pregnancy-associated plasma preproprotein-A2, pregnancy-associated plasma protein-E, PAPP-A2, PLAC3, Pappe
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23850
Homologene: 10661
Krt42
Name: keratin 42
Synonyms: Ka22, K17n, ecat6, 2410039E07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68239
Homologene: 107091
Rad51d
Name: RAD51 paralog D
Synonyms: R51H3, Rad51l3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19364
HGNC: HGNC:9823
Homologene: 2156
Dsc2
Name: desmocollin 2
Synonyms: Dsc2b, Dsc2a
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13506
HGNC: HGNC:3036
Homologene: 8397
Vmn1r5
Name: vomeronasal 1 receptor 5
Synonyms: V1rc19
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171192
Homologene: 128340
Tnfsf11
Name: tumor necrosis factor (ligand) superfamily, member 11
Synonyms: RANKL, OPGL, ODF, Ly109l, Trance, OPGL, osteoclast differentiation factor
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21943
VEGA: 14
Homologene: 2744
Ace
Name: angiotensin I converting enzyme
Synonyms: CD143
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11421
HGNC: HGNC:2707
Homologene: 37351
Fars2
Name: phenylalanine-tRNA synthetase 2, mitochondrial
Synonyms: 2810431B21Rik, 6720478K01Rik, Fars1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69955
VEGA: 13
Homologene: 4788
Edem2
Name: ER degradation enhancer, mannosidase alpha-like 2
Synonyms: 9530090G24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 108687
Homologene: 10075
Mstn
Name: myostatin
Synonyms: Gdf8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17700
HGNC: HGNC:4223
Homologene: 3850
Il18r1
Name: interleukin 18 receptor 1
Synonyms: Il1rrp, Il18ralpha
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16182
HGNC: HGNC:5988
Homologene: 2861
Rdm1
Name: RAD52 motif 1
Synonyms: 2410008M22Rik, Rad52b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66599
Homologene: 11992
Sirt5
Name: sirtuin 5
Synonyms: 0610012J09Rik, 1500032M05Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68346
VEGA: 13
Homologene: 40825
Wdr5b
Name: WD repeat domain 5B
Synonyms: 2310009C03Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 69544
VEGA: 16
Homologene: 41307
Slc17a1
Name: solute carrier family 17 (sodium phosphate), member 1
Synonyms: Npt1, NAPI-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20504
Homologene: 48324
Lrrc52
Name: leucine rich repeat containing 52
Synonyms: 4930413P14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240899
Homologene: 35430
Casp14
Name: caspase 14
Synonyms: mini-ICE, MICE
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12365
VEGA: 10
HGNC: HGNC:1502
Homologene: 36304
Or10d4b
Name: olfactory receptor family 10 subfamily D member 4B
Synonyms: GA_x6K02T2PVTD-33320043-33320987, MOR224-12, Olfr960
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258276
VEGA: 9
Homologene: 17168
Cisd3
Name: CDGSH iron sulfur domain 3
Synonyms: Mel13
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217149
Homologene: 35399
Ighv1-20
Name: immunoglobulin heavy variable V1-20
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 668497
HGNC: HGNC:5553
Ndufs8
Name: NADH:ubiquinone oxidoreductase core subunit S8
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225887
VEGA: 19
HGNC: HGNC:7715
Homologene: 1867
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 40,487,038 bp
  • T to A, chromosome 1 at 53,066,448 bp
  • T to C, chromosome 1 at 120,063,275 bp
  • C to T, chromosome 1 at 158,936,556 bp
  • A to G, chromosome 1 at 167,466,521 bp
  • G to A, chromosome 2 at 118,410,901 bp
  • A to G, chromosome 2 at 146,443,855 bp
  • A to T, chromosome 2 at 155,702,456 bp
  • A to G, chromosome 4 at 70,488,258 bp
  • G to T, chromosome 4 at 111,459,834 bp
  • C to T, chromosome 4 at 128,586,235 bp
  • T to C, chromosome 4 at 145,114,757 bp
  • T to C, chromosome 5 at 21,648,770 bp
  • T to C, chromosome 5 at 24,321,672 bp
  • A to T, chromosome 5 at 86,152,685 bp
  • A to G, chromosome 5 at 114,100,463 bp
  • A to T, chromosome 6 at 35,068,643 bp
  • T to A, chromosome 6 at 40,329,556 bp
  • T to G, chromosome 6 at 56,985,598 bp
  • T to C, chromosome 6 at 83,402,741 bp
  • T to A, chromosome 6 at 124,024,955 bp
  • A to G, chromosome 7 at 15,979,044 bp
  • A to G, chromosome 8 at 71,998,231 bp
  • G to A, chromosome 8 at 72,725,541 bp
  • A to T, chromosome 9 at 39,623,527 bp
  • C to T, chromosome 9 at 66,097,394 bp
  • T to A, chromosome 9 at 99,296,122 bp
  • A to G, chromosome 10 at 78,714,031 bp
  • A to T, chromosome 11 at 50,308,346 bp
  • A to G, chromosome 11 at 82,889,771 bp
  • T to C, chromosome 11 at 97,685,884 bp
  • T to C, chromosome 11 at 97,834,131 bp
  • G to C, chromosome 11 at 100,265,039 bp
  • C to A, chromosome 11 at 101,630,868 bp
  • T to C, chromosome 11 at 103,542,261 bp
  • T to A, chromosome 11 at 105,971,364 bp
  • A to G, chromosome 12 at 3,500,768 bp
  • T to C, chromosome 12 at 114,723,785 bp
  • T to C, chromosome 13 at 23,875,541 bp
  • G to A, chromosome 13 at 36,204,897 bp
  • A to T, chromosome 13 at 43,370,847 bp
  • A to G, chromosome 14 at 56,366,088 bp
  • A to T, chromosome 14 at 78,278,658 bp
  • C to T, chromosome 15 at 6,772,154 bp
  • T to A, chromosome 15 at 28,230,583 bp
  • T to A, chromosome 16 at 36,041,788 bp
  • T to A, chromosome 16 at 56,261,456 bp
  • C to A, chromosome 17 at 17,088,361 bp
  • C to T, chromosome 18 at 20,032,274 bp
  • A to G, chromosome 18 at 60,838,762 bp
  • G to A, chromosome 18 at 65,350,346 bp
  • T to C, chromosome 19 at 3,911,019 bp
  • T to C, chromosome 19 at 10,964,772 bp
  • T to A, chromosome 19 at 50,143,977 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8063 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067499-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.