Strain Name:
C57BL/6J-MtgxR8071Btlr/Mmmh
Stock Number:
067506-MU
Citation ID:
RRID:MMRRC_067506-MU
Other Names:
R8071 (G1)
Major Collection:

Strain Information

Slc12a1
Name: solute carrier family 12, member 1
Synonyms: Nkcc2, mBSC1, D630042G03Rik, urehr3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20495
Homologene: 286
Nrp2
Name: neuropilin 2
Synonyms: Npn2, Npn-2, NP2, NP-2, 1110048P06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18187
HGNC: HGNC:8005
Homologene: 2875
Erbb4
Name: erb-b2 receptor tyrosine kinase 4
Synonyms: ErbB4, Her4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13869
HGNC: HGNC:3432
Homologene: 21084
Arhgap39
Name: Rho GTPase activating protein 39
Synonyms: D15Wsu169e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223666
Homologene: 27825
Rapgef2
Name: Rap guanine nucleotide exchange factor (GEF) 2
Synonyms: 5830453M24Rik, CNRasGEF, RA-GEF-1, Pdzgef1, nRapGEP
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76089
Homologene: 35477
Eprs1
Name: glutamyl-prolyl-tRNA synthetase 1
Synonyms: Qprs, 3010002K18Rik, 2410081F06Rik, Eprs
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 107508
HGNC: HGNC:3418
Homologene: 5870
Rnmt
Name: RNA (guanine-7-) methyltransferase
Synonyms: 2610002P10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67897
Homologene: 2816
Dhx38
Name: DEAH-box helicase 38
Synonyms: 5730550P09Rik, Prp16, Ddx38
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 64340
Homologene: 8512
Ptpn23
Name: protein tyrosine phosphatase, non-receptor type 23
Synonyms: PTP-TD14
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 104831
Homologene: 135706
Map2k4
Name: mitogen-activated protein kinase kinase 4
Synonyms: MKK4, JNKK1, Sek1, Serk1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 26398
HGNC: HGNC:6844
Homologene: 48159
Stat3
Name: signal transducer and activator of transcription 3
Synonyms: Aprf, 1110034C02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20848
Homologene: 7960
Ccar2
Name: cell cycle activator and apoptosis regulator 2
Synonyms: 2610301G19Rik, Dbc1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219158
VEGA: 14
Homologene: 10910
Ruvbl1
Name: RuvB-like AAA ATPase 1
Synonyms: Tip49a, Pontin52, 2510009G06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56505
Homologene: 37839
Cramp1
Name: cramped chromatin regulator 1
Synonyms: Cramp1l, 5830477H08Rik, Tce4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57354
VEGA: 17
Homologene: 35373
Myo9a
Name: myosin IXa
Synonyms: 4732465J09Rik, C130068I12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270163
HGNC: HGNC:7608
Homologene: 21371
Sfxn5
Name: sideroflexin 5
Synonyms: C230001H08Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 94282
Homologene: 16936
Casp12
Name: caspase 12
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12364
Homologene: 7654
Chd2
Name: chromodomain helicase DNA binding protein 2
Synonyms: 5630401D06Rik, 2810040A01Rik, 2810013C04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244059
HGNC: HGNC:1917
Homologene: 37462
Prr14l
Name: proline rich 14-like
Synonyms: C330019G07Rik, 6030436E02Rik, Prl14l
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 215476
Homologene: 65866
Gigyf2
Name: GRB10 interacting GYF protein 2
Synonyms: 2610016F01Rik, Tnrc15, A830080H02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227331
Homologene: 41048
Ubr3
Name: ubiquitin protein ligase E3 component n-recognin 3
Synonyms: Zfp650, 1110059H15Rik, A130030D10Rik, 4833421P10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68795
Homologene: 52092
Rbl2
Name: RB transcriptional corepressor like 2
Synonyms: p130, retinoblastoma-like 2, Rb2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 19651
HGNC: HGNC:9894
Homologene: 4098
Haus8
Name: 4HAUS augmin-like complex, subunit 8
Synonyms: Hice1, 2410004L22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76478
Homologene: 12644
Scamp5
Name: secretory carrier membrane protein 5
Synonyms: Sc5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56807
VEGA: 9
Homologene: 56880
Piezo1
Name: piezo-type mechanosensitive ion channel component 1
Synonyms: Fam38a, Piezo1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234839
Homologene: 124356
Eps8l2
Name: EPS8-like 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 98845
Homologene: 69358
Galnt3
Name: polypeptide N-acetylgalactosaminyltransferase 3
Synonyms: ppGaNTase-T3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14425
HGNC: HGNC:4125
Homologene: 55827
Jag1
Name: jagged 1
Synonyms: Gsfabe2, Headturner, ABE2, Ozz, Serrate-1, Htu
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16449
HGNC: HGNC:6188
Homologene: 180
Skic2
Name: SKI2 subunit of superkiller complex
Synonyms: 4930534J06Rik, Skiv2l, Ski2w
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 108077
Homologene: 123971
Wnt16
Name: wingless-type MMTV integration site family, member 16
Synonyms: E130309I19Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 93735
Homologene: 62175
Fhip1a
Name: FHF complex subunit HOOK interacting protein 1A
Synonyms: Fam160a1, 9930021J17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229488
Homologene: 85149
Ptprq
Name: protein tyrosine phosphatase receptor type Q
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
Pcdhb11
Name: protocadherin beta 11
Synonyms: PcdhbK, Pcdhb5E
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93882
HGNC: HGNC:8690
Homologene: 62178
Dnah14
Name: dynein, axonemal, heavy chain 14
Synonyms: Gm980, Dnahc14, LOC381311, A230079K17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240960
HGNC: HGNC:2945
Homologene: 90078
Efr3b
Name: EFR3 homolog B
Synonyms: C030014M07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 668212
VEGA: 12
Homologene: 66195
Cracdl
Name: capping protein inhibiting regulator of actin like
Synonyms: 2010300C02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72097
Homologene: 19208
Rims1
Name: regulating synaptic membrane exocytosis 1
Synonyms: RIM1alpha, RIM1a, C030033M19Rik, RIM1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 116837
Homologene: 128399
Ino80c
Name: INO80 complex subunit C
Synonyms: D030070L09Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225280
Homologene: 45426
Sult6b2
Name: sulfotransferase family 6B, member 2
Synonyms: Gm766, LOC330440
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330440
Homologene: 66632
Mug1
Name: murinoglobulin 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17836
HGNC: HGNC:9750
Homologene: 136663
Ctns
Name: cystinosis, nephropathic
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 83429
HGNC: HGNC:2518
Homologene: 3625
Csmd2
Name: CUB and Sushi multiple domains 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329942
Homologene: 89034
Flnc
Name: filamin C, gamma
Synonyms: 1110055E19Rik, actin binding protein 280, Fln2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68794
HGNC: HGNC:3756
Homologene: 37481
Per3
Name: period circadian clock 3
Synonyms: 2810049O06Rik, mPer3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18628
HGNC: HGNC:8847
Homologene: 7886
Ccndbp1
Name: cyclin D-type binding-protein 1
Synonyms: Maid, GCIP, DIP1, stage specific embryonic cDNA-8, SSEC-8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17151
HGNC: HGNC:1587
Homologene: 7826
Mmrn1
Name: multimerin 1
Synonyms: 4921530G03Rik, Emilin4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70945
HGNC: HGNC:7178
Homologene: 49134
Zfp692
Name: zinc finger protein 692
Synonyms: Zfp692-ps
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103836
Homologene: 9889
Hif3a
Name: hypoxia inducible factor 3, alpha subunit
Synonyms: MOP7, Nepas, bHLHe17
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 53417
Homologene: 9646
Rimbp3
Name: RIMS binding protein 3
Synonyms: LOC385766, RIM-BP3, LOC239731
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239731
Homologene: 77940
Nlrp5
Name: NLR family, pyrin domain containing 5
Synonyms: Mater, Nalp5, Op1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23968
Homologene: 65105
Fndc1
Name: fibronectin type III domain containing 1
Synonyms: 1110027O12Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68655
Lrrc27
Name: leucine rich repeat containing 27
Synonyms: 1700071K18Rik, 2310044E02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76612
Homologene: 19268
Kcnj12
Name: potassium inwardly-rectifying channel, subfamily J, member 12
Synonyms: IRK2, Kir2.2, MB-IRK2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16515
Homologene: 7793
Tuba4a
Name: tubulin, alpha 4A
Synonyms: M[a]4, Tuba4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22145
Homologene: 68496
Vmn2r69
Name: vomeronasal 2, receptor 69
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330581
Homologene: 115466
Acads
Name: acyl-Coenzyme A dehydrogenase, short chain
Synonyms: Bcd-1, SCAD, Hdlq8, Bcd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11409
HGNC: HGNC:90
Homologene: 20057
Cd200r3
Name: CD200 receptor 3
Synonyms: mCD200RLb, 4733401I18Rik, 4833409J19Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74603
Tacc3
Name: transforming, acidic coiled-coil containing protein 3
Synonyms: Aint, Arnt interacting protein
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21335
Homologene: 81618
Agmo
Name: alkylglycerol monooxygenase
Synonyms: A530016O06Rik, Tmem195
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319660
Homologene: 45620
Sowahb
Name: sosondowah ankyrin repeat domain family member B
Synonyms: 5730467H21Rik, Ankrd56
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 78088
Homologene: 18429
Speer4e1
Name: spermatogenesis associated glutamate (E)-rich protein 4E1
Synonyms: SPEER-4E, Speer4e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 624245
Homologene: 69402
Crtac1
Name: cartilage acidic protein 1
Synonyms: 2810454P21Rik, Lotus, Crtac1B
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 72832
VEGA: 19
Homologene: 23070
Dpf1
Name: double PHD fingers 1
Synonyms: neuro-d4, Neud4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 29861
Homologene: 3415
Lyzl4
Name: lysozyme-like 4
Synonyms: LYC4, 1810009N24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69032
Homologene: 23604
D630044L22Rik
Name: RIKEN cDNA gene D630044L22 gene
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240054
VEGA: 17
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 22,288,536 bp
  • C to A, chromosome 1 at 37,623,929 bp
  • C to T, chromosome 1 at 62,745,408 bp
  • T to C, chromosome 1 at 68,396,311 bp
  • C to T, chromosome 1 at 75,216,951 bp
  • T to C, chromosome 1 at 87,446,433 bp
  • A to T, chromosome 1 at 181,615,894 bp
  • G to T, chromosome 1 at 185,394,456 bp
  • A to G, chromosome 2 at 66,091,211 bp
  • T to A, chromosome 2 at 69,988,876 bp
  • C to A, chromosome 2 at 121,014,565 bp
  • T to C, chromosome 2 at 125,186,314 bp
  • T to A, chromosome 2 at 137,101,797 bp
  • T to G, chromosome 3 at 79,093,036 bp
  • T to C, chromosome 3 at 85,730,561 bp
  • A to T, chromosome 4 at 128,393,538 bp
  • A to G, chromosome 4 at 151,028,813 bp
  • T to C, chromosome 5 at 14,937,097 bp
  • T to C, chromosome 5 at 32,831,164 bp
  • C to T, chromosome 5 at 33,663,825 bp
  • T to C, chromosome 5 at 93,043,063 bp
  • T to C, chromosome 5 at 115,113,167 bp
  • G to A, chromosome 6 at 22,288,998 bp
  • A to T, chromosome 6 at 29,457,446 bp
  • C to T, chromosome 6 at 60,944,524 bp
  • T to A, chromosome 6 at 85,267,939 bp
  • T to C, chromosome 6 at 88,473,126 bp
  • C to T, chromosome 6 at 121,873,672 bp
  • A to T, chromosome 6 at 142,790,142 bp
  • A to G, chromosome 7 at 17,048,761 bp
  • A to G, chromosome 7 at 23,418,444 bp
  • T to C, chromosome 7 at 29,314,141 bp
  • T to A, chromosome 7 at 73,537,384 bp
  • A to T, chromosome 7 at 85,406,505 bp
  • A to G, chromosome 7 at 139,236,986 bp
  • A to G, chromosome 7 at 141,342,947 bp
  • A to G, chromosome 8 at 71,256,051 bp
  • A to G, chromosome 8 at 91,113,989 bp
  • A to C, chromosome 8 at 109,558,701 bp
  • T to C, chromosome 8 at 122,487,011 bp
  • T to C, chromosome 9 at 5,346,647 bp
  • T to C, chromosome 9 at 57,443,686 bp
  • T to A, chromosome 9 at 59,874,648 bp
  • G to T, chromosome 9 at 110,388,199 bp
  • G to T, chromosome 9 at 110,388,200 bp
  • C to T, chromosome 9 at 121,578,094 bp
  • T to C, chromosome 10 at 107,644,035 bp
  • C to T, chromosome 11 at 58,307,734 bp
  • C to A, chromosome 11 at 61,069,999 bp
  • A to T, chromosome 11 at 65,707,001 bp
  • T to C, chromosome 11 at 73,184,934 bp
  • T to C, chromosome 11 at 100,893,981 bp
  • A to G, chromosome 12 at 3,982,898 bp
  • A to G, chromosome 12 at 37,398,729 bp
  • T to C, chromosome 14 at 70,152,453 bp
  • A to G, chromosome 15 at 76,737,502 bp
  • T to C, chromosome 16 at 17,210,863 bp
  • G to A, chromosome 16 at 44,954,140 bp
  • T to A, chromosome 17 at 7,772,530 bp
  • T to A, chromosome 17 at 24,982,700 bp
  • A to G, chromosome 17 at 25,960,144 bp
  • A to T, chromosome 17 at 34,849,999 bp
  • G to A, chromosome 18 at 24,106,650 bp
  • A to C, chromosome 18 at 37,422,369 bp
  • A to G, chromosome 18 at 68,307,652 bp
  • C to T, chromosome 19 at 42,297,800 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8071 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067506-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.