Strain Name:
C57BL/6J-MtgxR8146Btlr/Mmmh
Stock Number:
067574-MU
Citation ID:
RRID:MMRRC_067574-MU
Other Names:
R8146 (G1)
Major Collection:

Strain Information

Mafb
Name: MAF bZIP transcription factor B
Synonyms: Kreisler, Krml, Krml1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16658
HGNC: HGNC:6408
Homologene: 31315
Dop1b
Name: DOP1 leucine zipper like protein B
Synonyms: 0610038M01Rik, 2610510B01Rik, Dopey2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70028
VEGA: 16
HGNC: HGNC:1291
Homologene: 21068
Kdm5b
Name: lysine demethylase 5B
Synonyms: Plu1, 2010009J12Rik, D1Ertd202e, Rb-Bp2, Jarid1b, 2210016I17Rik, PLU-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75605
Homologene: 48448
Exoc6b
Name: exocyst complex component 6B
Synonyms: G430127E12Rik, Sec15l2, 4930569O18Rik, Sec15b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75914
Homologene: 44781
Birc2
Name: baculoviral IAP repeat-containing 2
Synonyms: HIAP1, MIHB, IAP1, mcIAP1, Api1, cIAP-1, MIAP1, cIAP1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11797
HGNC: HGNC:590
Homologene: 900
Hcn4
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330953
VEGA: 9
Homologene: 3997
Rlf
Name: rearranged L-myc fusion sequence
Synonyms: MommeD8, 9230110M18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 109263
Homologene: 8243
Sart3
Name: squamous cell carcinoma antigen recognized by T cells 3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 53890
Homologene: 40977
Cep78
Name: centrosomal protein 78
Synonyms: 5730599I05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 208518
VEGA: 19
Homologene: 11030
Cbl
Name: Casitas B-lineage lymphoma
Synonyms: c-Cbl, 4732447J05Rik, Cbl-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12402
HGNC: HGNC:1541
Homologene: 3802
Adgrl1
Name: adhesion G protein-coupled receptor L1
Synonyms: 2900070I05Rik, lectomedin-2, Lec2, Lphn1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330814
Homologene: 8951
Tuba1c
Name: tubulin, alpha 1C
Synonyms: M[a]6, Tuba6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22146
VEGA: 15
Homologene: 69045
Tap1
Name: transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Synonyms: TAP, Abcb2, PSF-1, RING4, Ham1, Ham-1, Tap-1, MTP1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21354
HGNC: HGNC:43
Homologene: 495
Cul1
Name: cullin 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 26965
HGNC: HGNC:2551
Homologene: 2663
Sec24b
Name: SEC24 homolog B, COPII coat complex component
Synonyms: SEC24
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99683
Homologene: 55968
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Ptgdr2
Name: prostaglandin D2 receptor 2
Synonyms: Crth2, PGD2 receptor, Gpr44
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14764
HGNC: HGNC:4502
Homologene: 3508
Fyttd1
Name: forty-two-three domain containing 1
Synonyms: 2010005M05Rik, 4933423A17Rik, 3830421F13Rik, 3830411L18Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 69823
Homologene: 12334
Kcnh4
Name: potassium voltage-gated channel, subfamily H (eag-related), member 4
Synonyms: BEC2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380728
HGNC: HGNC:6253
Homologene: 8180
Exoc3
Name: exocyst complex component 3
Synonyms: E430013E20Rik, Sec6l1, 2810050O03Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 211446
VEGA: 13
Homologene: 38296
Unc79
Name: unc-79 homolog
Synonyms: 9030205A07Rik, Mlca3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217843
Homologene: 41397
Cdh4
Name: cadherin 4
Synonyms: R-cadherin, Rcad, R-Cadh
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12561
HGNC: HGNC:1763
Homologene: 48044
Bbs10
Name: Bardet-Biedl syndrome 10
Synonyms: 1300007O09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71769
VEGA: 10
Homologene: 49781
Rtl1
Name: retrotransposon Gaglike 1
Synonyms: Mart1, Mar, Mor1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 353326
VEGA: 12
Homologene: 120261
Phykpl
Name: 5-phosphohydroxy-L-lysine phospholyase
Synonyms: 2900006B13Rik, Agxt2l2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72947
Homologene: 75268
Mvp
Name: major vault protein
Synonyms: LRP, VAULT1, 2310009M24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78388
HGNC: HGNC:7531
Homologene: 3752
Rasip1
Name: Ras interacting protein 1
Synonyms: 2610025P08Rik, Rain
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69903
Homologene: 9847
Inpp5e
Name: inositol polyphosphate-5-phosphatase E
Synonyms: 72kDa, 1200002L24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 64436
Homologene: 56863
4930550C14Rik
Name: RIKEN cDNA 4930550C14 gene
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75311
VEGA: 9
Homologene: 12595
Prag1
Name: PEAK1 related kinase activating pseudokinase 1
Synonyms: NACK, D8Ertd82e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244418
Homologene: 18256
Slc18a1
Name: solute carrier family 18 (vesicular monoamine), member 1
Synonyms: 4832416I10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 110877
Homologene: 20664
Slamf1
Name: signaling lymphocytic activation molecule family member 1
Synonyms: IPO-3, CDw150, Slam, CD150, ESTM51
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 27218
Homologene: 48162
Zbtb22
Name: zinc finger and BTB domain containing 22
Synonyms: Bing1, Zfp297, 1110008J20Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 81630
Homologene: 3982
4921504E06Rik
Name: RIKEN cDNA 4921504E06 gene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70909
Homologene: 87049
Lrfn3
Name: leucine rich repeat and fibronectin type III domain containing 3
Synonyms: A530045B06Rik, SALM4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233067
Homologene: 11558
Gbp8
Name: guanylate-binding protein 8
Synonyms: 5830443L24Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76074
Anks6
Name: ankyrin repeat and sterile alpha motif domain containing 6
Synonyms: SamCystin, LOC269533, 2210417J20Rik, b2b1801.1Clo, Samd6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 75691
Homologene: 19545
Adgra2
Name: adhesion G protein-coupled receptor A2
Synonyms: Gpr124, 9530074E10Rik, Tem5, 8430414O08Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78560
Homologene: 13112
Cnbd2
Name: cyclic nucleotide binding domain containing 2
Synonyms: 4921517L17Rik, 5430421B09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70873
Homologene: 15440
Anks1b
Name: ankyrin repeat and sterile alpha motif domain containing 1B
Synonyms: LOC380650, C030032C09Rik, E530015N03Rik, Gm10937, AIDA-1b
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77531
Homologene: 51570
Or51l4
Name: olfactory receptor family 51 subfamily L member 4
Synonyms: GA_x6K02T2PBJ9-6483085-6482126, Olfr630, MOR17-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259102
Homologene: 133674
Med24
Name: mediator complex subunit 24
Synonyms: D11Ertd307e, 100kDa, Trap100, Pparb2, R75526, Gse2, Thrap4, DRIP100
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23989
Homologene: 40795
Hacd1
Name: 3-hydroxyacyl-CoA dehydratase 1
Synonyms: Ptpla
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 30963
HGNC: HGNC:9639
Homologene: 69153
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 134,625,126 bp
  • C to T, chromosome 1 at 171,792,319 bp
  • T to A, chromosome 2 at 14,044,794 bp
  • T to G, chromosome 2 at 19,494,003 bp
  • T to A, chromosome 2 at 26,399,262 bp
  • T to G, chromosome 2 at 156,328,361 bp
  • A to G, chromosome 2 at 160,366,378 bp
  • C to A, chromosome 2 at 179,874,078 bp
  • G to T, chromosome 3 at 129,995,924 bp
  • C to A, chromosome 4 at 47,043,605 bp
  • G to A, chromosome 4 at 121,147,232 bp
  • T to A, chromosome 5 at 105,030,978 bp
  • G to A, chromosome 5 at 113,747,957 bp
  • T to C, chromosome 6 at 47,495,093 bp
  • A to C, chromosome 6 at 84,908,194 bp
  • A to G, chromosome 7 at 30,359,879 bp
  • T to G, chromosome 7 at 45,630,280 bp
  • A to G, chromosome 7 at 103,755,303 bp
  • G to T, chromosome 7 at 126,986,999 bp
  • T to A, chromosome 8 at 27,114,174 bp
  • T to G, chromosome 8 at 36,104,210 bp
  • C to A, chromosome 8 at 69,042,749 bp
  • C to A, chromosome 8 at 83,930,989 bp
  • A to G, chromosome 9 at 7,818,796 bp
  • A to T, chromosome 9 at 44,164,874 bp
  • A to G, chromosome 9 at 53,422,970 bp
  • A to C, chromosome 9 at 58,823,744 bp
  • G to A, chromosome 10 at 90,307,698 bp
  • T to A, chromosome 10 at 111,300,535 bp
  • T to C, chromosome 11 at 9,397,829 bp
  • T to C, chromosome 11 at 51,585,581 bp
  • C to T, chromosome 11 at 98,718,114 bp
  • T to C, chromosome 11 at 100,755,279 bp
  • T to A, chromosome 12 at 103,070,157 bp
  • T to C, chromosome 12 at 109,590,711 bp
  • T to C, chromosome 13 at 74,192,665 bp
  • A to G, chromosome 15 at 99,037,615 bp
  • A to G, chromosome 16 at 32,902,492 bp
  • T to A, chromosome 16 at 93,749,939 bp
  • G to T, chromosome 17 at 33,916,982 bp
  • A to T, chromosome 17 at 34,189,232 bp
  • A to T, chromosome 18 at 3,288,007 bp
  • T to C, chromosome 19 at 10,940,997 bp
  • A to G, chromosome 19 at 15,956,363 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8146 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067574-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.