Strain Name:
C57BL/6J-MtgxR8164Btlr/Mmmh
Stock Number:
067590-MU
Citation ID:
RRID:MMRRC_067590-MU
Other Names:
R8164 (G1)
Major Collection:

Strain Information

Tln2
Name: talin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70549
VEGA: 9
Homologene: 56692
Lhx9
Name: LIM homeobox protein 9
Synonyms: LH2B, 3110009O07Rik, Lhx9 alpha
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16876
Homologene: 7816
Sbno1
Name: strawberry notch 1
Synonyms: sno, 9330180L10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243272
Homologene: 10055
Golph3l
Name: golgi phosphoprotein 3-like
Synonyms: 2010204I15Rik, GPP34R
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229593
Homologene: 23082
Tet2
Name: tet methylcytosine dioxygenase 2
Synonyms: E130014J05Rik, Ayu17-449
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 214133
Homologene: 49498
Zc3hc1
Name: zinc finger, C3HC type 1
Synonyms: Nipa, HSPC216, 1110054L24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232679
Homologene: 32315
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: 9930018I23Rik, MAP1C, Swl, Dnec1, Loa, Dnchc1, dynein heavy chain, retrograde transport
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
N4bp2
Name: NEDD4 binding protein 2
Synonyms: LOC386488, LOC333789, B3bp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 333789
Homologene: 32396
Rnf39
Name: ring finger protein 39
Synonyms: LOC386465, LOC386454, LIRF, LOC240094
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 386454
Homologene: 11891
Cdhr1
Name: cadherin-related family member 1
Synonyms: Prcad, Pcdh21
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 170677
VEGA: 14
Homologene: 13215
Myh14
Name: myosin, heavy polypeptide 14
Synonyms: NMHC II-C, 2400004E04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71960
Homologene: 23480
Tardbp
Name: TAR DNA binding protein
Synonyms: 1190002A23Rik, Tdp43, TDP-43
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230908
Homologene: 7221
Lrrtm1
Name: leucine rich repeat transmembrane neuronal 1
Synonyms: 4632401D06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74342
Homologene: 41763
Cnih4
Name: cornichon family AMPA receptor auxiliary protein 4
Synonyms: D530030D03Rik, E430023H19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98417
Homologene: 5932
Sbk1
Name: SH3-binding kinase 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 104175
Homologene: 17084
Tnfrsf25
Name: tumor necrosis factor receptor superfamily, member 25
Synonyms: WSL-1, APO-3, TR3, DDR3, Tnfrsf12, WSL-LR, LARD, TRAMP, DR3, Wsl
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 85030
Homologene: 13202
Gcdh
Name: glutaryl-Coenzyme A dehydrogenase
Synonyms: D17825
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270076
HGNC: HGNC:4189
Homologene: 130
Acaa2
Name: acetyl-CoA acyltransferase 2
Synonyms: 0610011L04Rik, D18Ertd240e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 52538
VEGA: 18
HGNC: HGNC:83
Homologene: 4456
F10
Name: coagulation factor X
Synonyms: AI194738, fX, Cf10
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14058
HGNC: HGNC:3528
Homologene: 30976
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Nlrp1b
Name: NLR family, pyrin domain containing 1B
Synonyms: Nalp1b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 637515
Homologene: 19080
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Wdr24
Name: WD repeat domain 24
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268933
Homologene: 6870
Naip6
Name: NLR family, apoptosis inhibitory protein 6
Synonyms: Naip-rs4, Birc1f, Naip-rs4A
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17952
HGNC: HGNC:7634
Homologene: 113589
Morc2b
Name: microrchidia 2B
Synonyms: 4932411A10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240069
Homologene: 18615
Mei4
Name: meiotic double-stranded break formation protein 4
Synonyms: 4930486G11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75033
Homologene: 87251
Ctsj
Name: cathepsin J
Synonyms: CatRLP, Cat P, CATP, Ctsp, rat gene/Cathepsin L-related protein
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26898
VEGA: 13
Homologene: 137246
Dab2
Name: disabled 2, mitogen-responsive phosphoprotein
Synonyms: 5730435J12Rik, p96, D15Wsu122e, D630005B22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 13132
HGNC: HGNC:2662
Homologene: 1026
Tmprss11c
Name: transmembrane protease, serine 11c
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 435845
Homologene: 78847
Niban1
Name: niban apoptosis regulator 1
Synonyms: Niban, Fam129a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 63913
Homologene: 62170
Ccdc57
Name: coiled-coil domain containing 57
Synonyms: 4933434G05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71276
Homologene: 52351
Brinp1
Name: bone morphogenic protein/retinoic acid inducible neural specific 1
Synonyms: Dbc1, Dbccr1, Fam5a
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56710
HGNC: HGNC:2687
Homologene: 8754
Slc2a13
Name: solute carrier family 2 (facilitated glucose transporter), member 13
Synonyms: A630029G22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239606
Homologene: 43139
Ankrd44
Name: ankyrin repeat domain 44
Synonyms: E130014H08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329154
Homologene: 27547
Pcdhb21
Name: protocadherin beta 21
Synonyms: PcdhbU, Pcdhb18
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93892
Homologene: 134302
Trpc4
Name: transient receptor potential cation channel, subfamily C, member 4
Synonyms: STRPC4, CCE1, Trrp4, Trp4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22066
Homologene: 22955
Vav3
Name: vav 3 oncogene
Synonyms: A530094I06Rik, Idd18.1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 57257
Homologene: 38143
Rftn1
Name: raftlin lipid raft linker 1
Synonyms: 2310015N21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 76438
Homologene: 18745
Brox
Name: BRO1 domain and CAAX motif containing
Synonyms: 0610010K06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71678
Homologene: 13499
Gm340
Name: predicted gene 340
Synonyms: LOC381224
Type: Gene
Species: Mouse
Chromosome: 19
P2ry12
Name: purinergic receptor P2Y, G-protein coupled 12
Synonyms: P2Y12, 4921504D23Rik, 2900079B22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70839
Homologene: 11260
1810055G02Rik
Name: RIKEN cDNA 1810055G02 gene
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 72056
VEGA: 19
HGNC: HGNC:1174
Homologene: 11174
Aurkaip1
Name: aurora kinase A interacting protein 1
Synonyms: 0610033H09Rik, AIP, Aurora-A kinase interacting protein
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66077
Homologene: 11916
Igkv2-109
Name: immunoglobulin kappa variable 2-109
Synonyms: ENSMUSG00000060986
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 628268
D930015E06Rik
Name:
Type: Gene
Species: Mouse
Chromosome: 3
Or1p1b
Name: olfactory receptor family 1 subfamily P member 1B
Synonyms: GA_x6K02T2P1NL-4385196-4386167, Olfr404-ps1, MOR133-5P
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 257920
G530012D18Rik
Name: RIKEN cDNA G530012D1 gene
Type: Gene
Species: Mouse
Chromosome: 1
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 54,663,979 bp
  • C to G, chromosome 1 at 85,577,214 bp
  • A to T, chromosome 1 at 138,832,780 bp
  • G to A, chromosome 1 at 151,717,588 bp
  • A to G, chromosome 1 at 181,162,126 bp
  • A to T, chromosome 1 at 183,280,927 bp
  • A to T, chromosome 3 at 54,315,805 bp
  • C to T, chromosome 3 at 59,217,616 bp
  • A to T, chromosome 3 at 83,926,188 bp
  • G to A, chromosome 3 at 95,617,206 bp
  • A to G, chromosome 3 at 109,341,052 bp
  • G to T, chromosome 3 at 133,467,134 bp
  • A to T, chromosome 4 at 68,762,921 bp
  • A to T, chromosome 4 at 148,618,603 bp
  • C to T, chromosome 4 at 152,117,420 bp
  • T to A, chromosome 4 at 155,832,505 bp
  • T to A, chromosome 5 at 65,809,223 bp
  • T to A, chromosome 5 at 86,231,853 bp
  • T to C, chromosome 5 at 124,374,621 bp
  • A to T, chromosome 6 at 30,390,896 bp
  • A to G, chromosome 6 at 68,302,869 bp
  • A to T, chromosome 6 at 77,244,216 bp
  • A to G, chromosome 7 at 44,625,033 bp
  • A to G, chromosome 7 at 119,967,614 bp
  • G to A, chromosome 7 at 126,292,539 bp
  • A to G, chromosome 8 at 13,050,781 bp
  • A to G, chromosome 8 at 84,892,552 bp
  • G to A, chromosome 9 at 67,319,420 bp
  • A to G, chromosome 9 at 81,927,589 bp
  • A to T, chromosome 11 at 9,615,799 bp
  • A to T, chromosome 11 at 71,228,417 bp
  • A to T, chromosome 11 at 74,239,960 bp
  • C to T, chromosome 11 at 120,897,962 bp
  • A to G, chromosome 12 at 110,616,360 bp
  • T to C, chromosome 13 at 61,002,520 bp
  • T to A, chromosome 13 at 100,316,289 bp
  • A to T, chromosome 14 at 37,079,542 bp
  • C to A, chromosome 15 at 6,430,968 bp
  • A to G, chromosome 15 at 91,276,078 bp
  • C to A, chromosome 17 at 25,825,949 bp
  • T to C, chromosome 17 at 33,138,040 bp
  • C to G, chromosome 17 at 36,943,400 bp
  • G to T, chromosome 17 at 50,047,380 bp
  • C to A, chromosome 18 at 37,516,004 bp
  • C to A, chromosome 18 at 74,795,247 bp
  • T to C, chromosome 19 at 3,717,454 bp
  • T to A, chromosome 19 at 41,585,410 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8164 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067590-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.