Strain Name:
C57BL/6J-MtgxR8187Btlr/Mmmh
Stock Number:
067610-MU
Citation ID:
RRID:MMRRC_067610-MU
Other Names:
R8187 (G1)
Major Collection:

Strain Information

Adgre1
Name: adhesion G protein-coupled receptor E1
Synonyms: F4/80, DD7A5-7, TM7LN3, EGF-TM7, Ly71, Emr1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13733
VEGA: 17
HGNC: HGNC:3336
Homologene: 1493
Spen
Name: spen family transcription repressor
Synonyms: Mint
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56381
Homologene: 124461
Chuk
Name: conserved helix-loop-helix ubiquitous kinase
Synonyms: Chuk1, IKK1, IKK[a], IKK-alpha, IkappaB kinase alpha, IKK 1, IKK alpha, IKKalpha, IKK-1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12675
HGNC: HGNC:1974
Homologene: 979
Adgrg1
Name: adhesion G protein-coupled receptor G1
Synonyms: Cyt28, Gpr56
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14766
HGNC: HGNC:4512
Homologene: 4156
Pck1
Name: phosphoenolpyruvate carboxykinase 1, cytosolic
Synonyms: PEPCK, Pck-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18534
HGNC: HGNC:8724
Homologene: 1944
Dhdds
Name: dehydrodolichyl diphosphate synthase
Synonyms: 3222401G21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67422
Homologene: 32615
Zfp729a
Name: zinc finger protein 729a
Synonyms: A530054K11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 212281
Homologene: 133713
Daam1
Name: dishevelled associated activator of morphogenesis 1
Synonyms: 1700066F09Rik, 2310028E21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 208846
VEGA: 12
Homologene: 36635
Brwd1
Name: bromodomain and WD repeat domain containing 1
Synonyms: 5330419I02Rik, D530019K20Rik, G1-403-16, Wdr9, repro5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 93871
Homologene: 23130
Smpd4
Name: sphingomyelin phosphodiesterase 4
Synonyms: 4122402O22Rik, neutral membrane (neutral sphingomyelinase-3)
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77626
Homologene: 9813
Nsmce4a
Name: NSE4 homolog A, SMC5-SMC6 complex component
Synonyms: 2410003A14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67872
Homologene: 9745
Mgrn1
Name: mahogunin, ring finger 1
Synonyms: 2610042J20Rik, nc
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17237
VEGA: 16
Homologene: 41020
Cnot10
Name: CCR4-NOT transcription complex, subunit 10
Synonyms: 2600001P13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78893
VEGA: 9
Homologene: 41040
F2rl2
Name: coagulation factor II thrombin receptor like 2
Synonyms: PAR3, PAR-3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14064
HGNC: HGNC:3539
Homologene: 36151
Prom1
Name: prominin 1
Synonyms: AC133, Prom-1, CD133, 4932416E19Rik, Prom
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19126
HGNC: HGNC:9454
Homologene: 4390
Hdac2
Name: histone deacetylase 2
Synonyms: D10Wsu179e, Yy1bp
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15182
HGNC: HGNC:4853
Homologene: 68187
Ccnh
Name: cyclin H
Synonyms: 6330408H09Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66671
HGNC: HGNC:1594
Homologene: 946
Il36g
Name: interleukin 36G
Synonyms: Il1f9, If36g, IL-36gamma
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 215257
Homologene: 49595
Dync1i2
Name: dynein cytoplasmic 1 intermediate chain 2
Synonyms: 3110079H08Rik, Dncic2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13427
HGNC: HGNC:2964
Homologene: 37921
Nbeal1
Name: neurobeachin like 1
Synonyms: A530050O19Rik, 2310076G13Rik, ALS2CR17, A530083I02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269198
Homologene: 16453
Zfp599
Name: zinc finger protein 599
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235048
Homologene: 138456
Gjc1
Name: gap junction protein, gamma 1
Synonyms: Cx45, connexin 45, Gja7, C130009G16Rik, Gja-7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14615
HGNC: HGNC:4280
Homologene: 4016
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: b2b1565Clo, b2b3491Clo, Mdnah5, b2b1154Clo, b2b1537Clo, Dnahc5, b2b1134Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Ttn
Name: titin
Synonyms: connectin, shru, D330041I19Rik, 2310057K23Rik, mdm, D830007G01Rik, 2310074I15Rik, 1100001C23Rik, 2310036G12Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Efhc1
Name: EF-hand domain (C-terminal) containing 1
Synonyms: myoclonin1, mRib72-1, 1700029F22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71877
Homologene: 10003
Mcc
Name: mutated in colorectal cancers
Synonyms: D18Ertd451e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 328949
HGNC: HGNC:6935
Homologene: 20539
Cdh16
Name: cadherin 16
Synonyms: KSP-cadherin
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12556
HGNC: HGNC:1755
Homologene: 2997
Irs1
Name: insulin receptor substrate 1
Synonyms: IRS-1, G972R
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16367
HGNC: HGNC:6125
Homologene: 4049
3110009E18Rik
Name: RIKEN cDNA 3110009E18 gene
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 73103
Homologene: 41754
Nr1h5
Name: nuclear receptor subfamily 1, group H, member 5
Synonyms: FXRB
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 381463
Homologene: 131277
Bpifb9a
Name: BPI fold containing family B, member 9A
Synonyms: vomeromodulin, 4833413D08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71425
Homologene: 128535
Vmn1r231
Name: vomeronasal 1 receptor 231
Synonyms: V1re7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 171230
Kansl1l
Name: KAT8 regulatory NSL complex subunit 1-like
Synonyms: C430010P07Rik, 1110028C15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68691
Homologene: 27376
Rev3l
Name: REV3 like, DNA directed polymerase zeta catalytic subunit
Synonyms: Sez4, Rev
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19714
HGNC: HGNC:9968
Homologene: 48147
Mybpc2
Name: myosin binding protein C, fast-type
Synonyms: Fast-type C-protein
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233199
HGNC: HGNC:7550
Homologene: 3331
Rin3
Name: Ras and Rab interactor 3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217835
Homologene: 11748
Osmr
Name: oncostatin M receptor
Synonyms: OSMRB
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18414
HGNC: HGNC:8507
Homologene: 2972
Eri2
Name: exoribonuclease 2
Synonyms: Exod1, 4933424N09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71151
Homologene: 12383
Hsd3b1
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Synonyms: D3Ertd383e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 15492
Homologene: 69149
Srrm4
Name: serine/arginine repetitive matrix 4
Synonyms: fp, B230202K19Rik, bv, nSR100, 1500001A10Rik, flopsy
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68955
Homologene: 49869
Idh1
Name: isocitrate dehydrogenase 1 (NADP+), soluble
Synonyms: Id-1, Idh-1, IDPc, E030024J03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15926
HGNC: HGNC:5382
Homologene: 21195
Vmn2r14
Name: vomeronasal 2, receptor 14
Synonyms: EG231591
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231591
Homologene: 129606
Emilin3
Name: elastin microfibril interfacer 3
Synonyms: 1110013O17Rik, EMILIN-T, Emilin5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 280635
Homologene: 18817
Arhgef39
Name: Rho guanine nucleotide exchange factor 39
Synonyms: E130306D19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230098
Homologene: 19225
Or5w14
Name: olfactory receptor family 5 subfamily W member 14
Synonyms: Olfr1137, MOR177-20, MOR40-9P, GA_x6K02T2Q125-49215724-49214792
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258101
Homologene: 79380
Gpam
Name: glycerol-3-phosphate acyltransferase, mitochondrial
Synonyms: GPAT1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14732
Homologene: 7343
Cyp4f37
Name: cytochrome P450, family 4, subfamily f, polypeptide 37
Synonyms: Gm9705
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 677156
VEGA: 17
Homologene: 135840
4930438A08Rik
Name: RIKEN cDNA 4930438A08 gene
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 73988
Homologene: 104884
Semg1
Name: semenogelin 1
Synonyms: Svs2, SVS II, semenoclotin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 53878
Homologene: 49325
Tmem158
Name: transmembrane protein 158
Synonyms: Ris1, 2310037P21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72309
VEGA: 9
Homologene: 9141
Or6y1
Name: olfactory receptor family 6 subfamily Y member 1
Synonyms: GA_x6K02SYWY4V-595-239, GA_x6K02T2P20D-20731742-20730694, Olfr413-ps1, MOR103-17, Olfr220, MOR103-13P, EG546747
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 546747
Homologene: 67062
Slc37a4
Name: solute carrier family 37 (glucose-6-phosphate transporter), member 4
Synonyms: G6pt1, G6PT
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14385
VEGA: 9
HGNC: HGNC:4061
Homologene: 37482
Gm2832
Name: predicted gene 2832
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100040545
Gm19965
Name: predicted gene, 19965
Type: Gene
Species: Mouse
Chromosome: 1
Hmha1
Name:
Type: Gene
Species: Mouse
Chromosome: 10
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 20,960,172 bp
  • G to C, chromosome 1 at 60,237,151 bp
  • T to C, chromosome 1 at 65,159,541 bp
  • T to A, chromosome 1 at 66,801,737 bp
  • G to T, chromosome 1 at 82,288,300 bp
  • T to A, chromosome 1 at 116,821,802 bp
  • A to T, chromosome 1 at 120,188,183 bp
  • TTGTGTG to TTGTG, chromosome 1 at 174,449,272 bp
  • T to G, chromosome 2 at 24,192,605 bp
  • A to G, chromosome 2 at 71,214,521 bp
  • A to G, chromosome 2 at 76,729,446 bp
  • A to G, chromosome 2 at 76,795,725 bp
  • A to G, chromosome 2 at 76,803,391 bp
  • T to G, chromosome 2 at 87,711,280 bp
  • A to G, chromosome 2 at 154,269,457 bp
  • T to C, chromosome 2 at 160,908,080 bp
  • A to G, chromosome 2 at 164,237,772 bp
  • G to T, chromosome 2 at 173,155,240 bp
  • T to A, chromosome 3 at 98,852,617 bp
  • G to T, chromosome 3 at 102,954,670 bp
  • A to T, chromosome 4 at 43,498,999 bp
  • A to G, chromosome 4 at 134,000,368 bp
  • T to C, chromosome 4 at 141,472,905 bp
  • A to T, chromosome 5 at 44,034,366 bp
  • A to G, chromosome 5 at 109,220,554 bp
  • A to C, chromosome 5 at 116,449,621 bp
  • T to A, chromosome 7 at 44,512,470 bp
  • A to G, chromosome 7 at 119,785,544 bp
  • A to G, chromosome 7 at 130,542,789 bp
  • G to T, chromosome 8 at 16,127,174 bp
  • A to G, chromosome 8 at 95,005,818 bp
  • T to C, chromosome 8 at 104,618,238 bp
  • G to T, chromosome 9 at 22,249,815 bp
  • T to C, chromosome 9 at 44,399,994 bp
  • A to T, chromosome 9 at 114,597,488 bp
  • T to A, chromosome 9 at 123,259,810 bp
  • T to C, chromosome 10 at 36,988,136 bp
  • C to A, chromosome 10 at 39,806,697 bp
  • G to A, chromosome 10 at 80,027,872 bp
  • A to G, chromosome 11 at 58,289,722 bp
  • A to C, chromosome 11 at 102,800,555 bp
  • A to G, chromosome 12 at 71,895,828 bp
  • T to A, chromosome 12 at 102,325,807 bp
  • T to A, chromosome 13 at 67,621,799 bp
  • T to A, chromosome 13 at 85,189,537 bp
  • A to T, chromosome 13 at 95,701,403 bp
  • A to T, chromosome 14 at 41,278,958 bp
  • T to A, chromosome 15 at 6,821,004 bp
  • T to C, chromosome 15 at 28,384,209 bp
  • A to G, chromosome 16 at 4,920,365 bp
  • T to A, chromosome 16 at 17,629,135 bp
  • A to T, chromosome 16 at 96,002,734 bp
  • A to T, chromosome 17 at 20,890,631 bp
  • T to C, chromosome 17 at 32,635,197 bp
  • T to A, chromosome 17 at 57,420,349 bp
  • A to G, chromosome 18 at 44,534,260 bp
  • T to C, chromosome 19 at 44,091,112 bp
  • T to C, chromosome 19 at 55,077,837 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8187 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067610-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.