Strain Name:
C57BL/6J-MtgxR8195Btlr/Mmmh
Stock Number:
067618-MU
Citation ID:
RRID:MMRRC_067618-MU
Other Names:
R8195 (G1)
Major Collection:

Strain Information

Sptbn4
Name: spectrin beta, non-erythrocytic 4
Synonyms: Spnb4, dyn, 5830426A08Rik, 1700022P15Rik, nmf261, SpbIV, ROSA62, neuroaxonal dystrophy
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 80297
Homologene: 11879
Itgb8
Name: integrin beta 8
Synonyms: 4832412O06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320910
HGNC: HGNC:6163
Homologene: 18567
Rgs16
Name: regulator of G-protein signaling 16
Synonyms: Rgsr
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19734
HGNC: HGNC:9997
Homologene: 2196
Rai14
Name: retinoic acid induced 14
Synonyms: 1700020L11Rik, 1700008J19Rik, Ankycorbin, Norpeg
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75646
VEGA: 15
Homologene: 9199
Zdbf2
Name: zinc finger, DBF-type containing 2
Synonyms: 4930431J08Rik, 9330107J05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 73884
Homologene: 52868
Utp23
Name: UTP23 small subunit processome component
Synonyms: D530033C11Rik, 1700010I21Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78581
Homologene: 41789
Ggta1
Name: glycoprotein galactosyltransferase alpha 1, 3
Synonyms: Ggta, GALT, glycoprotein alpha galactosyl transferase 1, Ggta-1, Gal, alpha Gal, alpha3GalT
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14594
HGNC: HGNC:4253
Homologene: 7730
Fzd6
Name: frizzled class receptor 6
Synonyms: rst, Fz6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14368
VEGA: 15
HGNC: HGNC:4044
Homologene: 2617
Fxr1
Name: FMR1 autosomal homolog 1
Synonyms: 9530073J07Rik, Fxr1h, 1110050J02Rik, Fxr1p
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14359
HGNC: HGNC:4023
Homologene: 3573
Eif2ak4
Name: eukaryotic translation initiation factor 2 alpha kinase 4
Synonyms: GCN2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27103
Homologene: 40891
Arfgef1
Name: ADP ribosylation factor guanine nucleotide exchange factor 1
Synonyms: BIG1, P200, ARFGEP1, D730028O18Rik, D130059B05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 211673
Homologene: 4687
Slc38a1
Name: solute carrier family 38, member 1
Synonyms: NAT2, SNAT1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105727
VEGA: 15
Homologene: 12745
Prom1
Name: prominin 1
Synonyms: Prom-1, Prom, AC133, 4932416E19Rik, CD133
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19126
HGNC: HGNC:9454
Homologene: 4390
Pgm3
Name: phosphoglucomutase 3
Synonyms: 2810473H05Rik, Pgm-3, GlcNAc-P mutase
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 109785
HGNC: HGNC:8907
Homologene: 9205
Gpsm1
Name: G-protein signalling modulator 1 (AGS3-like, C. elegans)
Synonyms: Ags3, 1810037C22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67839
Homologene: 16987
Tjp1
Name: tight junction protein 1
Synonyms: ZO-1, ZO1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 21872
Homologene: 2445
Cmtm2a
Name: CKLF-like MARVEL transmembrane domain containing 2A
Synonyms: 1700041N15Rik, Cklfsf2a, 1700063K20Rik, ARR19, Cklf, 1700001K04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 73381
Homologene: 88508
Lrrn2
Name: leucine rich repeat protein 2, neuronal
Synonyms: 5730406J09Rik, NLRR-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16980
Homologene: 21274
Gnb1l
Name: guanine nucleotide binding protein (G protein), beta polypeptide 1-like
Synonyms: ESTM55, Wdvcf, Wdr14, Me49f07
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13972
HGNC: HGNC:4397
Homologene: 41515
Aldob
Name: aldolase B, fructose-bisphosphate
Synonyms: Aldo2, Aldo-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230163
HGNC: HGNC:417
Homologene: 20060
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Or8b54
Name: olfactory receptor family 8 subfamily B member 54
Synonyms: MOR165-8, Olfr921, GA_x6K02T2PVTD-32478047-32478988
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258778
VEGA: 9
Homologene: 128138
Ttc38
Name: tetratricopeptide repeat domain 38
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239570
Homologene: 41208
Or7e169
Name: olfactory receptor family 7 subfamily E member 169
Synonyms: MOR146-2, GA_x6K02T2PVTD-13586614-13585661, Olfr860
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258521
Homologene: 134093
Vmn2r111
Name: vomeronasal 2, receptor 111
Synonyms: EG210876
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210876
Homologene: 86604
Rbm46
Name: RNA binding motif protein 46
Synonyms: ENSMUSG00000033882, LOC329687
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 633285
Homologene: 17016
Abca9
Name: ATP-binding cassette, sub-family A member 9
Synonyms: D630040K07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217262
HGNC: HGNC:39
Homologene: 33332
Ankhd1
Name: ankyrin repeat and KH domain containing 1
Synonyms: 9130019P20Rik, 4933432B13Rik, A530027J04Rik, 1110004O12Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 108857
Homologene: 87006
Necab3
Name: N-terminal EF-hand calcium binding protein 3
Synonyms: XB51, Apba2bp, Nip1, 2900010M17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56846
Homologene: 10992
Mybpc1
Name: myosin binding protein C, slow-type
Synonyms: Slow-type C-protein, 8030451F13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 109272
HGNC: HGNC:7549
Homologene: 1846
Sox30
Name: SRY (sex determining region Y)-box 30
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 214105
Homologene: 34027
Trim65
Name: tripartite motif-containing 65
Synonyms: 4732463G12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 338364
Homologene: 27844
Kctd1
Name: potassium channel tetramerisation domain containing 1
Synonyms: 4933402K10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 106931
VEGA: 18
Homologene: 65999
Nek8
Name: NIMA (never in mitosis gene a)-related expressed kinase 8
Synonyms: 4632401F23Rik, b2b1449Clo
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 140859
Homologene: 84442
Or10p21
Name: olfactory receptor family 10 subfamily P member 21
Synonyms: MOR269-2, Olfr763, GA_x6K02T2PULF-10696986-10697915
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258861
Homologene: 85121
Arhgef40
Name: Rho guanine nucleotide exchange factor 40
Synonyms: E130112L23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 268739
Homologene: 19560
Zfp788
Name: zinc finger protein 788
Synonyms: 2810426N06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67607
Homologene: 137363
Fcnb
Name: ficolin B
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14134
Homologene: 1518
Ppp2r3a
Name: protein phosphatase 2, regulatory subunit B'', alpha
Synonyms: 3222402P14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235542
HGNC: HGNC:9307
Homologene: 20595
Meioc
Name: meiosis specific with coiled-coil domain
Synonyms: LOC380729, LOC268491, Gm1564
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268491
Homologene: 19559
Vmn1r121
Name: vomeronasal 1 receptor 121
Synonyms: Gm8533
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 667240
Homologene: 104166
Nlrp5
Name: NLR family, pyrin domain containing 5
Synonyms: Op1, Mater, Nalp5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23968
Homologene: 65105
Kbtbd12
Name: kelch repeat and BTB (POZ) domain containing 12
Synonyms: 4833415F11Rik, 4933428M03Rik, Klhdc6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74589
Homologene: 52613
Cfap61
Name: cilia and flagella associated protein 61
Synonyms: 4930529M08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 78774
Or52ac1
Name: olfactory receptor family 52 subfamily AC member 1
Synonyms: MOR38-1, Olfr655, GA_x6K02T2PBJ9-7224628-7223702
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258817
Homologene: 17403
Cdk14
Name: cyclin dependent kinase 14
Synonyms: Pftk1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18647
HGNC: HGNC:8883
Homologene: 7888
Cd276
Name: CD276 antigen
Synonyms: 6030411F23Rik, B7-H3, B7h3, B7RP-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102657
VEGA: 9
Homologene: 11892
Hecw1
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Synonyms: NEDL1, E130207I19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 94253
VEGA: 13
Homologene: 9004
Cblc
Name: Casitas B-lineage lymphoma c
Synonyms: 2310079L19Rik, 2310076I21Rik, Cbl3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 80794
Homologene: 8108
Ccdc17
Name: coiled-coil domain containing 17
Synonyms: 1100001F07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 622665
Homologene: 77410
Tulp1
Name: TUB like protein 1
Synonyms: Tulp1l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22157
Homologene: 2491
Lrrc36
Name: leucine rich repeat containing 36
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270091
Homologene: 23090
Lzts3
Name: leucine zipper, putative tumor suppressor family member 3
Synonyms: Prosapip1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241638
Homologene: 8824
Slc2a6
Name: solute carrier family 2 (facilitated glucose transporter), member 6
Synonyms: Glut6, F630103L12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227659
Homologene: 69236
Lysmd2
Name: LysM, putative peptidoglycan-binding, domain containing 2
Synonyms: 2210402C18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70082
VEGA: 9
Homologene: 12347
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 10,173,253 bp
  • T to C, chromosome 1 at 63,304,066 bp
  • A to G, chromosome 1 at 132,937,344 bp
  • T to C, chromosome 1 at 153,740,943 bp
  • A to G, chromosome 2 at 26,324,917 bp
  • T to G, chromosome 2 at 27,027,826 bp
  • C to T, chromosome 2 at 28,078,318 bp
  • T to A, chromosome 2 at 35,422,267 bp
  • T to C, chromosome 2 at 118,450,338 bp
  • A to G, chromosome 2 at 130,635,185 bp
  • C to T, chromosome 2 at 145,947,175 bp
  • G to A, chromosome 2 at 154,547,443 bp
  • A to T, chromosome 3 at 34,047,729 bp
  • C to T, chromosome 3 at 82,865,468 bp
  • T to C, chromosome 4 at 49,538,822 bp
  • T to A, chromosome 4 at 116,599,014 bp
  • T to A, chromosome 4 at 116,599,016 bp
  • C to T, chromosome 5 at 5,227,159 bp
  • C to T, chromosome 5 at 44,037,428 bp
  • T to A, chromosome 6 at 88,617,931 bp
  • A to T, chromosome 7 at 19,785,337 bp
  • A to T, chromosome 7 at 21,098,303 bp
  • A to G, chromosome 7 at 23,413,337 bp
  • C to A, chromosome 7 at 27,408,889 bp
  • T to G, chromosome 7 at 41,649,377 bp
  • A to T, chromosome 7 at 65,343,722 bp
  • A to T, chromosome 7 at 104,596,926 bp
  • A to G, chromosome 8 at 104,293,038 bp
  • A to G, chromosome 8 at 105,452,085 bp
  • A to T, chromosome 9 at 19,846,484 bp
  • G to A, chromosome 9 at 38,775,281 bp
  • G to A, chromosome 9 at 58,537,472 bp
  • C to A, chromosome 9 at 75,626,028 bp
  • G to A, chromosome 9 at 86,570,321 bp
  • A to G, chromosome 9 at 101,213,032 bp
  • A to G, chromosome 10 at 88,558,691 bp
  • T to C, chromosome 10 at 129,011,575 bp
  • G to A, chromosome 11 at 9,274,735 bp
  • C to T, chromosome 11 at 45,991,765 bp
  • G to T, chromosome 11 at 78,170,761 bp
  • T to A, chromosome 11 at 102,675,067 bp
  • T to C, chromosome 11 at 110,138,329 bp
  • T to C, chromosome 11 at 116,126,211 bp
  • T to C, chromosome 12 at 119,168,170 bp
  • A to G, chromosome 13 at 14,306,107 bp
  • T to A, chromosome 14 at 51,988,769 bp
  • C to T, chromosome 15 at 10,575,216 bp
  • T to A, chromosome 15 at 39,031,564 bp
  • T to C, chromosome 15 at 51,882,202 bp
  • A to T, chromosome 15 at 85,844,515 bp
  • G to A, chromosome 15 at 96,592,566 bp
  • T to A, chromosome 16 at 18,544,215 bp
  • T to C, chromosome 17 at 22,559,051 bp
  • T to C, chromosome 17 at 28,364,326 bp
  • C to T, chromosome 18 at 15,063,243 bp
  • T to C, chromosome 18 at 36,654,177 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8195 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067618-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.