Strain Name:
C57BL/6J-MtgxR8287Btlr/Mmmh
Stock Number:
067709-MU
Citation ID:
RRID:MMRRC_067709-MU
Other Names:
R8287 (G1)
Major Collection:

Strain Information

Xrcc1
Name: X-ray repair complementing defective repair in Chinese hamster cells 1
Synonyms: Xrcc-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22594
Homologene: 31368
Cdon
Name: cell adhesion molecule-related/down-regulated by oncogenes
Synonyms: CAM-related/down-regulated by oncogenes, CDO
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 57810
Homologene: 22996
Ncam2
Name: neural cell adhesion molecule 2
Synonyms: RNCAM, R4B12 antigen, Ncam-2, Ocam
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17968
HGNC: HGNC:7657
Homologene: 3336
Foxj2
Name: forkhead box J2
Synonyms: Fhx
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 60611
Homologene: 10187
Cops2
Name: COP9 signalosome subunit 2
Synonyms: Trip15, Sgn2, alien-like, alien homologue, Csn2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12848
Homologene: 3124
Actn1
Name: actinin, alpha 1
Synonyms: 3110023F10Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 109711
VEGA: 12
HGNC: HGNC:163
Homologene: 55553
Dock7
Name: dedicator of cytokinesis 7
Synonyms: 3110056M06Rik, LOC242555, m
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67299
Homologene: 23566
Gcnt2
Name: glucosaminyl (N-acetyl) transferase 2 (I blood group)
Synonyms: IGnTC, 5330430K10Rik, IGnTA, IGnTB, IGnT
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14538
VEGA: 13
HGNC: HGNC:4204
Homologene: 41535
Blnk
Name: B cell linker
Synonyms: BCA, Bca, Ly-57, BLNK, BASH, Ly57, SLP-65
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17060
Homologene: 32038
Dock8
Name: dedicator of cytokinesis 8
Synonyms: 1200017A24Rik, 5830472H07Rik, A130095G14Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 76088
VEGA: 19
Homologene: 52414
Dnah12
Name: dynein, axonemal, heavy chain 12
Synonyms: Dnahc12, HL19, DLP12, LOC380889, Dnahc7l, 4921531P07Rik, Hdhc3, DHC3, HL-19
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110083
HGNC: HGNC:2943
Homologene: 56821
Zscan18
Name: zinc finger and SCAN domain containing 18
Synonyms: EG232875
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232875
Homologene: 122136
Vmn2r19
Name: vomeronasal 2, receptor 19
Synonyms: EG232358
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232358
Homologene: 84037
Cntnap4
Name: contactin associated protein-like 4
Synonyms: Caspr4, E130114F09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170571
Homologene: 24912
Stxbp5
Name: syntaxin binding protein 5 (tomosyn)
Synonyms: 4930565N16Rik, LGL3, 0710001E20Rik, tomosyn 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 78808
Homologene: 16402
Apcs
Name: amyloid P component, serum
Synonyms: Sap
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20219
HGNC: HGNC:584
Homologene: 123932
Npsr1
Name: neuropeptide S receptor 1
Synonyms: VRR1, Gpr154, PGR14, 9330128H10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319239
Homologene: 45515
Arsa
Name: arylsulfatase A
Synonyms: ASA, As-2, As2, AS-A
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11883
HGNC: HGNC:713
Homologene: 20138
Speg
Name: SPEG complex locus
Synonyms: D1Bwg1450e, BPEG, Apeg1, SPEG, SPEGalpha, SPEGbeta
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11790
Homologene: 55619
Dlg5
Name: discs large MAGUK scaffold protein 5
Synonyms: 4933429D20Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71228
HGNC: HGNC:2904
Homologene: 3486
Gm14180
Name: predicted gene 14180
Type: Gene
Species: Mouse
Chromosome: 11
Gucy1b2
Name: guanylate cyclase 1, soluble, beta 2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239134
HGNC: HGNC:4686
Homologene: 136630
Cyp2c40
Name: cytochrome P450, family 2, subfamily c, polypeptide 40
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13099
Homologene: 74936
Atg10
Name: autophagy related 10
Synonyms: 5430428K15Rik, Apg10p, APG10, 5330424L23Rik, Apg10l
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66795
VEGA: 13
Homologene: 12036
Hyou1
Name: hypoxia up-regulated 1
Synonyms: Orp150, Cab140, CBP-140, Grp170, 140 kDa
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12282
Homologene: 4658
Fcrlb
Name: Fc receptor-like B
Synonyms: FREB2, Fcry, FcRL2, FREB-2, mFCRL2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 435653
Homologene: 83202
Or8g51
Name: olfactory receptor family 8 subfamily G member 51
Synonyms: Olfr919, GA_x6K02T2PVTD-32400678-32399743, MOR171-23
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258432
VEGA: 9
Slc50a1
Name: solute carrier family 50 (sugar transporter), member 1
Synonyms: Rga, Rag1ap1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19729
Homologene: 40647
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 75,422,236 bp
  • T to A, chromosome 1 at 170,912,084 bp
  • T to G, chromosome 1 at 172,894,247 bp
  • T to A, chromosome 2 at 125,859,117 bp
  • G to A, chromosome 3 at 89,270,403 bp
  • T to C, chromosome 4 at 98,977,920 bp
  • G to A, chromosome 6 at 122,828,267 bp
  • A to G, chromosome 6 at 123,331,629 bp
  • T to G, chromosome 7 at 12,775,371 bp
  • G to A, chromosome 7 at 24,572,278 bp
  • T to C, chromosome 8 at 112,859,143 bp
  • T to C, chromosome 9 at 24,289,962 bp
  • A to G, chromosome 9 at 35,463,929 bp
  • T to C, chromosome 9 at 38,698,337 bp
  • A to G, chromosome 9 at 44,388,133 bp
  • T to C, chromosome 10 at 9,784,385 bp
  • A to G, chromosome 11 at 99,734,242 bp
  • A to G, chromosome 12 at 80,174,078 bp
  • T to C, chromosome 13 at 40,860,632 bp
  • A to T, chromosome 13 at 91,022,680 bp
  • T to A, chromosome 14 at 24,164,385 bp
  • A to G, chromosome 14 at 26,812,603 bp
  • T to C, chromosome 14 at 62,411,816 bp
  • G to T, chromosome 15 at 89,473,390 bp
  • A to G, chromosome 16 at 81,526,995 bp
  • T to C, chromosome 19 at 25,130,461 bp
  • T to A, chromosome 19 at 39,767,455 bp
  • T to C, chromosome 19 at 40,929,291 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8287 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067709-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.