Strain Name:
C57BL/6J-MtgxR8442Btlr/Mmmh
Stock Number:
067779-MU
Citation ID:
RRID:MMRRC_067779-MU
Other Names:
R8442 (G1)
Major Collection:

Strain Information

Igf2bp2
Name: insulin-like growth factor 2 mRNA binding protein 2
Synonyms: IMP-2, C330012H03Rik, IMP2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 319765
Homologene: 4774
Septin7
Name: septin 7
Synonyms: Cdc10, Sept7
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235072
VEGA: 9
HGNC: HGNC:1717
Homologene: 1354
Kif18a
Name: kinesin family member 18A
Synonyms: B130001M12Rik, N-8 kinesin, gcd2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228421
Homologene: 41820
Hspb8
Name: heat shock protein 8
Synonyms: HSP22, HSP20-like, H11K, D5Ucla4, E2IG1, H11, Cryac
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 80888
Homologene: 8654
Unc13d
Name: unc-13 homolog D
Synonyms: Jinx, 2610108D09Rik, Munc13-4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70450
Homologene: 26714
Prkab2
Name: protein kinase, AMP-activated, beta 2 non-catalytic subunit
Synonyms: 5730553K21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 108097
HGNC: HGNC:9379
Homologene: 38046
Cd72
Name: CD72 antigen
Synonyms: Ly-19, Ly-m19, Ly-32, Lyb-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12517
HGNC: HGNC:1696
Homologene: 1350
Sfrp5
Name: secreted frizzled-related sequence protein 5
Synonyms: SARP3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 54612
Homologene: 2268
Ptprm
Name: protein tyrosine phosphatase receptor type M
Synonyms: RPTPmu
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19274
VEGA: 17
HGNC: HGNC:9675
Homologene: 37694
Msh3
Name: mutS homolog 3
Synonyms: Rep3, Rep-3, D13Em1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17686
HGNC: HGNC:7326
Homologene: 1829
Txndc5
Name: thioredoxin domain containing 5
Synonyms: PC-TRP, ERp46
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105245
Homologene: 11125
Uggt1
Name: UDP-glucose glycoprotein glucosyltransferase 1
Synonyms: Ugcgl1, A930007H10Rik, C820010P03Rik, 0910001L17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 320011
Homologene: 10586
Tek
Name: TEK receptor tyrosine kinase
Synonyms: tie-2, Hyk, Cd202b, Tie2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21687
Homologene: 397
Cubn
Name: cubilin
Synonyms: intrinsic factor-cobalamin receptor, D2Wsu88e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 665700
Homologene: 90772
Efcab2
Name: EF-hand calcium binding domain 2
Synonyms: 1700073K01Rik, D830011E08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68226
Homologene: 12248
Col12a1
Name: collagen, type XII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12816
HGNC: HGNC:2188
Homologene: 3217
Dnah14
Name: dynein, axonemal, heavy chain 14
Synonyms: Gm980, Dnahc14, LOC381311, A230079K17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240960
HGNC: HGNC:2945
Homologene: 90078
Flt1
Name: FMS-like tyrosine kinase 1
Synonyms: vascular endothelial growth factor receptor-1, Flt-1, VEGFR1, VEGFR-1, sFlt1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14254
HGNC: HGNC:3763
Homologene: 134179
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Taar1
Name: trace amine-associated receptor 1
Synonyms: Tar1, Trar1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 111174
VEGA: 10
Homologene: 24938
Gucy2g
Name: guanylate cyclase 2g
Synonyms: GC-G, 2410077I05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 73707
Homologene: 44544
Sema3d
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
Synonyms: 4631426B19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108151
Homologene: 23664
BC048671
Name: cDNA sequence BC048671
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243535
Homologene: 135985
Bsn
Name: bassoon
Synonyms: presynaptic cytomatrix protein
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12217
HGNC: HGNC:1117
Homologene: 31161
Kif2b
Name: kinesin family member 2B
Synonyms: 1700063D03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 73470
Homologene: 23775
Lrrc49
Name: leucine rich repeat containing 49
Synonyms: D430025H09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102747
Homologene: 9782
P3h2
Name: prolyl 3-hydroxylase 2
Synonyms: Leprel1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 210530
Homologene: 10062
Il5
Name: interleukin 5
Synonyms: Il-5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16191
HGNC: HGNC:6016
Homologene: 679
Pcdhb21
Name: protocadherin beta 21
Synonyms: Pcdhb18, PcdhbU
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93892
Homologene: 134302
Tmem132a
Name: transmembrane protein 132A
Synonyms: 6720481D13Rik, Hspa5bp1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 98170
Homologene: 75076
Dagla
Name: diacylglycerol lipase, alpha
Synonyms: Nsddr
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 269060
HGNC: HGNC:1165
Homologene: 4468
Or4d6
Name: olfactory receptor family 4 subfamily D member 6
Synonyms: MOR239-5, Olfr1428, GA_x6K02T2RE5P-2468394-2467450
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258673
Homologene: 17339
C2cd4a
Name: C2 calcium-dependent domain containing 4A
Synonyms: Fam148a, EG244911
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244911
VEGA: 9
Homologene: 77917
Scarf2
Name: scavenger receptor class F, member 2
Synonyms: SREC-II, Srec2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224024
VEGA: 16
Homologene: 17817
Gm572
Name: predicted gene 572
Synonyms: LOC230909, b2b1167Clo
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230909
Homologene: 52134
Uck1
Name: uridine-cytidine kinase 1
Synonyms: URK1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22245
Homologene: 7990
Vmn1r26
Name: vomeronasal 1 receptor 26
Synonyms: V1rc17
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171190
Med24
Name: mediator complex subunit 24
Synonyms: D11Ertd307e, 100kDa, Trap100, Pparb2, R75526, Gse2, Thrap4, DRIP100
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23989
Homologene: 40795
Apof
Name: apolipoprotein F
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103161
VEGA: 10
HGNC: HGNC:615
Homologene: 48030
Igkv9-129
Name: immunoglobulin kappa variable 9-129
Synonyms: immunoglobulin kappa light chain
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 692182
Foxl1
Name: forkhead box L1
Synonyms: fkh6, Fkh6, FREAC7, fkh-6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14241
HGNC: HGNC:3817
Homologene: 48335
Or5p75-ps1
Name: olfactory receptor family 5 subfamily P member 75, pseudogene 1
Synonyms: GA_x6K02T2PBJ9-10838051-10838996, Olfr501-ps1, MOR204-27P
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258054
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 36,173,487 bp
  • A to T, chromosome 1 at 178,437,436 bp
  • A to G, chromosome 1 at 181,741,284 bp
  • T to C, chromosome 2 at 13,314,044 bp
  • C to A, chromosome 2 at 31,391,076 bp
  • C to A, chromosome 2 at 32,260,141 bp
  • T to C, chromosome 2 at 52,287,208 bp
  • T to C, chromosome 2 at 109,294,973 bp
  • G to T, chromosome 3 at 97,658,686 bp
  • T to A, chromosome 4 at 43,450,109 bp
  • T to A, chromosome 4 at 94,827,685 bp
  • G to T, chromosome 4 at 148,658,993 bp
  • A to G, chromosome 5 at 12,542,641 bp
  • T to C, chromosome 5 at 116,422,445 bp
  • C to T, chromosome 5 at 147,576,173 bp
  • T to C, chromosome 6 at 58,008,743 bp
  • T to A, chromosome 6 at 67,839,800 bp
  • T to C, chromosome 6 at 90,305,113 bp
  • A to C, chromosome 7 at 108,508,644 bp
  • T to A, chromosome 8 at 121,128,485 bp
  • T to C, chromosome 9 at 25,252,642 bp
  • A to G, chromosome 9 at 60,593,625 bp
  • C to T, chromosome 9 at 67,831,757 bp
  • A to G, chromosome 9 at 79,635,499 bp
  • G to A, chromosome 9 at 108,111,452 bp
  • T to A, chromosome 10 at 23,920,624 bp
  • T to C, chromosome 10 at 128,269,022 bp
  • C to T, chromosome 11 at 53,721,824 bp
  • T to A, chromosome 11 at 91,576,314 bp
  • A to G, chromosome 11 at 98,707,557 bp
  • A to T, chromosome 11 at 116,067,831 bp
  • T to C, chromosome 13 at 38,527,869 bp
  • T to C, chromosome 13 at 92,212,512 bp
  • A to G, chromosome 16 at 17,806,367 bp
  • A to C, chromosome 16 at 22,065,091 bp
  • A to G, chromosome 16 at 25,987,205 bp
  • C to A, chromosome 17 at 66,944,317 bp
  • A to T, chromosome 18 at 37,513,788 bp
  • A to G, chromosome 19 at 10,263,092 bp
  • A to G, chromosome 19 at 10,271,519 bp
  • A to C, chromosome 19 at 10,858,469 bp
  • A to T, chromosome 19 at 12,108,727 bp
  • A to G, chromosome 19 at 42,198,797 bp
  • T to C, chromosome 19 at 55,217,401 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8442 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067779-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.