Strain Name:
C57BL/6J-MtgxR8508Btlr/Mmmh
Stock Number:
067844-MU
Citation ID:
RRID:MMRRC_067844-MU
Other Names:
R8508 (G1)
Major Collection:

Strain Information

Setd5
Name: SET domain containing 5
Synonyms: 2900045N06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72895
Homologene: 12485
Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: Mll3, E330008K23Rik, HALR
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231051
Homologene: 46480
Angpt2
Name: angiopoietin 2
Synonyms: Ang-2, Ang2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11601
HGNC: HGNC:485
Homologene: 22401
Slc1a2
Name: solute carrier family 1 (glial high affinity glutamate transporter), member 2
Synonyms: Eaat2, 2900019G14Rik, GLT-1, GLT1, MGLT1, 1700091C19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20511
Homologene: 3075
Dock1
Name: dedicator of cytokinesis 1
Synonyms: Dock180, 9130006G06Rik, D630004B07Rik, b2b3190Clo
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330662
HGNC: HGNC:2987
Homologene: 55575
Med13l
Name: mediator complex subunit 13-like
Synonyms: 6330591G05Rik, 9030618F05Rik, Thrap2, Trap240L, 2210413I17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76199
Homologene: 25256
Arhgap21
Name: Rho GTPase activating protein 21
Synonyms: ARHGAP10, 5530401C11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71435
Homologene: 10822
Flnb
Name: filamin, beta
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 286940
HGNC: HGNC:3755
Homologene: 37480
Npepps
Name: aminopeptidase puromycin sensitive
Synonyms: MP100, Psa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19155
HGNC: HGNC:7900
Homologene: 36199
Pdcd11
Name: programmed cell death 11
Synonyms: 1110021I22Rik, ALG-4
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18572
VEGA: 19
Homologene: 74968
Supt16
Name: SPT16, facilitates chromatin remodeling subunit
Synonyms: Spt16, Fact140, Cdc68, Supt16h
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 114741
VEGA: 14
Homologene: 5207
Atp6v1a
Name: ATPase, H+ transporting, lysosomal V1 subunit A
Synonyms: VPP2, Atp6a1, VA68, lysosomal 70kDa
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11964
HGNC: HGNC:851
Homologene: 123934
Ppm1g
Name: protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform
Synonyms: Fin13
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14208
HGNC: HGNC:9278
Homologene: 31106
Dhx16
Name: DEAH-box helicase 16
Synonyms: DBP2, Ddx16, 2410006N22Rik, DEAH (Asp-Glu-Ala-His) box polypeptide 16
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 69192
HGNC: HGNC:2739
Homologene: 2658
Ccdc141
Name: coiled-coil domain containing 141
Synonyms: CAMDI, 2610301F02Rik, ENSMUSG00000075261
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 545428
Homologene: 52149
Ankrd27
Name: ankyrin repeat domain 27
Synonyms: D330003H11Rik, Varp
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 245886
Homologene: 12956
Gpatch2
Name: G patch domain containing 2
Synonyms: 5830433G22Rik, 5830436K05Rik, Gpatc2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67769
Homologene: 9976
Osbpl2
Name: oxysterol binding protein-like 2
Synonyms: ORP-2, C130070J12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228983
Homologene: 77324
Hey1
Name: hairy/enhancer-of-split related with YRPW motif 1
Synonyms: hesr-1, Herp2, HRT1, CHF2, bHLHb31, Hesr1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 15213
HGNC: HGNC:4880
Homologene: 7756
Ckmt1
Name: creatine kinase, mitochondrial 1, ubiquitous
Synonyms: mi-CK, Mt-CK, UbCKmit
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12716
Homologene: 69058
Fbf1
Name: Fas binding factor 1
Synonyms: 1110033G01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217335
Homologene: 16531
Mphosph8
Name: M-phase phosphoprotein 8
Synonyms: 4930548G07Rik, 1500035L22Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 75339
Homologene: 11380
Canx
Name: calnexin
Synonyms: CNX, 1110069N15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12330
HGNC: HGNC:1473
Homologene: 1324
Dna2
Name: DNA replication helicase/nuclease 2
Synonyms: E130315B21Rik, Dna2l
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 327762
HGNC: HGNC:2939
Homologene: 6124
Tctn1
Name: tectonic family member 1
Synonyms: G730031O11Rik, Tect1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 654470
Homologene: 49770
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hyrh, 1700034M11Rik, hy3, 4930545D19Rik, hy-3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Mipol1
Name: mirror-image polydactyly 1
Synonyms: 6030439O22Rik, 1700081O04Rik, D12Ertd19e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 73490
Homologene: 16340
Eogt
Name: EGF domain specific O-linked N-acetylglucosamine transferase
Synonyms: A130022J15Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101351
Homologene: 65276
Krt6a
Name: keratin 6A
Synonyms: Krt2-6c, Krt2-6a, MK6a, mK6[a]
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16687
VEGA: 15
Homologene: 136794
Atp13a4
Name: ATPase type 13A4
Synonyms: 4631413J11Rik, 9330174J19Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224079
Homologene: 75330
Or1n1b
Name: olfactory receptor family 1 subfamily N member 1B
Synonyms: MOR127-3, GA_x6K02T2NLDC-33585366-33584431, Olfr353
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258943
HGNC: HGNC:8221
Homologene: 115503
Slc2a9
Name: solute carrier family 2 (facilitated glucose transporter), member 9
Synonyms: SLC2a9A, Glut9, SLC2A9B
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 117591
Homologene: 69290
Ntn4
Name: netrin 4
Synonyms: beta-netrin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 57764
Homologene: 10934
Epcip
Name: exosomal polycystin 1 interacting protein
Synonyms: 4932438H23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74387
HGNC: HGNC:1305
Homologene: 49594
Pnliprp2
Name: pancreatic lipase-related protein 2
Synonyms: PLRP2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18947
VEGA: 19
HGNC: HGNC:9157
Homologene: 3936
Ttc28
Name: tetratricopeptide repeat domain 28
Synonyms: TPRBK, 2310015L07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 209683
Homologene: 41023
Rnf130
Name: ring finger protein 130
Synonyms: G1RP, 2510042A13Rik, G1RZFP
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 59044
Homologene: 41267
Trbc2
Name: T cell receptor beta, constant 2
Synonyms: BB153276, Tcrb-C2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 100125263
Arhgef33
Name: Rho guanine nucleotide exchange factor 33
Synonyms: Gm941, LOC381112
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381112
VEGA: 17
Homologene: 55190
Vmn2r120
Name: vomeronasal 2, receptor 120
Synonyms: EG224916
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224916
Angpt1
Name: angiopoietin 1
Synonyms: 1110046O21Rik, ang1, Ang-1, Angiopoietin-1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11600
VEGA: 15
HGNC: HGNC:484
Homologene: 37447
Or9i2
Name: olfactory receptor family 9 subfamily I member 2
Synonyms: MOR212-3, GA_x6K02T2RE5P-4171358-4170411, Olfr1501
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258626
Homologene: 64899
Sphkap
Name: SPHK1 interactor, AKAP domain containing
Synonyms: 4930544G21Rik, A930009L15Rik, SKIP
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77629
Homologene: 18172
Sgip1
Name: SH3-domain GRB2-like (endophilin) interacting protein 1
Synonyms: 3110007P09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73094
Homologene: 13001
Slc22a14
Name: solute carrier family 22 (organic cation transporter), member 14
Synonyms: LOC382113
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382113
HGNC: HGNC:8495
Homologene: 3530
Fbxl12
Name: F-box and leucine-rich repeat protein 12
Synonyms: 3110048D16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 30843
Homologene: 32198
Sorbs3
Name: sorbin and SH3 domain containing 3
Synonyms: vinexin beta, SH3P3, vinexin alpha, Sh3d4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 20410
VEGA: 14
Homologene: 4218
Ighe
Name: Immunoglobulin heavy constant epsilon
Synonyms: LOC380792, Gm900
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 380792
HGNC: HGNC:5522
Or11g1
Name: olfactory receptor family 11 subfamily G member 1
Synonyms: Olfr738, GA_x6K02T2PMLR-6110726-6111661, MOR106-3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258662
Homologene: 74220
Lats2
Name: large tumor suppressor 2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50523
HGNC: HGNC:6515
Homologene: 56678
Spata31d1e
Name: spermatogenesis associated 31 subfamily D, member 1E
Synonyms: 1700014D04Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 102638268
Homologene: 140986
Zfp354b
Name: zinc finger protein 354B
Synonyms: Kid2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 27274
Homologene: 32187
Slc22a12
Name: solute carrier family 22 (organic anion/cation transporter), member 12
Synonyms: URAT1, Rst
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20521
Homologene: 56442
Sytl3
Name: synaptotagmin-like 3
Synonyms: Slp3-a, Slp3-b, Slp3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 83672
Homologene: 12855
Zfp362
Name: zinc finger protein 362
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230761
Homologene: 77409
Hoxa11
Name: homeobox A11
Synonyms: Hox-1.9, Hoxa-11
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15396
HGNC: HGNC:5101
Homologene: 4033
Or2m12
Name: olfactory receptor family 2 subfamily M member 12
Synonyms: Olfr164, MOR279-2, GA_x54KRFPKG5P-15738260-15737319
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258443
Homologene: 51725
Eif1ad10
Name: eukaryotic translation initiation factor 1A domain containing 10
Synonyms: Gm8332
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 666862
VEGA: 12
Gm43518
Name: predicted gene 43518
Type: Gene
Species: Mouse
Chromosome: 5
Rps18-ps5
Name: ribosomal protein S18, pseudogene 5
Synonyms: Gm11361
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 100042388
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 83,276,500 bp
  • A to G, chromosome 1 at 187,304,355 bp
  • C to T, chromosome 2 at 20,854,180 bp
  • A to G, chromosome 2 at 36,890,354 bp
  • T to A, chromosome 2 at 77,132,244 bp
  • T to C, chromosome 2 at 102,736,085 bp
  • A to C, chromosome 2 at 121,362,691 bp
  • T to A, chromosome 2 at 180,155,343 bp
  • G to C, chromosome 3 at 8,664,776 bp
  • A to G, chromosome 4 at 102,915,071 bp
  • T to C, chromosome 4 at 128,774,606 bp
  • G to T, chromosome 5 at 25,314,122 bp
  • G to T, chromosome 5 at 31,204,528 bp
  • A to T, chromosome 5 at 38,382,078 bp
  • G to A, chromosome 5 at 111,233,341 bp
  • T to A, chromosome 5 at 118,754,321 bp
  • T to A, chromosome 5 at 122,246,611 bp
  • A to G, chromosome 5 at 123,938,259 bp
  • T to C, chromosome 6 at 41,547,777 bp
  • T to C, chromosome 6 at 52,245,802 bp
  • A to G, chromosome 6 at 97,143,998 bp
  • T to C, chromosome 6 at 113,121,087 bp
  • T to A, chromosome 7 at 35,601,626 bp
  • A to G, chromosome 7 at 134,782,409 bp
  • G to A, chromosome 8 at 18,741,119 bp
  • G to A, chromosome 8 at 110,582,018 bp
  • C to A, chromosome 9 at 20,638,864 bp
  • A to G, chromosome 9 at 119,180,585 bp
  • A to C, chromosome 10 at 62,950,894 bp
  • A to T, chromosome 10 at 93,741,104 bp
  • A to G, chromosome 11 at 50,087,437 bp
  • T to C, chromosome 11 at 50,311,647 bp
  • A to T, chromosome 11 at 50,923,470 bp
  • A to G, chromosome 11 at 97,244,426 bp
  • A to T, chromosome 11 at 116,165,881 bp
  • T to C, chromosome 12 at 57,306,088 bp
  • T to G, chromosome 12 at 88,249,685 bp
  • C to T, chromosome 12 at 113,271,793 bp
  • A to G, chromosome 13 at 28,257,711 bp
  • A to G, chromosome 13 at 59,743,598 bp
  • G to A, chromosome 14 at 7,950,394 bp
  • A to C, chromosome 14 at 50,413,675 bp
  • A to T, chromosome 14 at 52,181,589 bp
  • A to T, chromosome 14 at 56,676,546 bp
  • A to C, chromosome 14 at 57,722,705 bp
  • A to T, chromosome 14 at 70,202,947 bp
  • T to C, chromosome 15 at 42,512,399 bp
  • T to A, chromosome 15 at 101,692,735 bp
  • T to C, chromosome 16 at 19,286,701 bp
  • T to A, chromosome 16 at 29,454,769 bp
  • G to A, chromosome 16 at 44,101,862 bp
  • T to G, chromosome 16 at 91,055,612 bp
  • A to G, chromosome 17 at 6,728,291 bp
  • T to C, chromosome 17 at 35,885,920 bp
  • A to G, chromosome 17 at 57,525,843 bp
  • A to G, chromosome 17 at 80,367,335 bp
  • T to C, chromosome 19 at 6,542,437 bp
  • A to T, chromosome 19 at 13,838,402 bp
  • C to A, chromosome 19 at 47,119,806 bp
  • A to C, chromosome 19 at 58,763,374 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8508 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067844-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.