Strain Name:
C57BL/6J-MtgxR8518Btlr/Mmmh
Stock Number:
067850-MU
Citation ID:
RRID:MMRRC_067850-MU
Other Names:
R8518 (G1)
Major Collection:

Strain Information

Mindy3
Name: MINDY lysine 48 deubiquitinase 3
Synonyms: 2310047O13Rik, Fam188a, 1810041E18Rik, 5830410F13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66960
Homologene: 11478
Tns3
Name: tensin 3
Synonyms: TEM6, F830010I22Rik, Tens1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319939
Homologene: 49713
Mllt10
Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10
Synonyms: B130021D15Rik, D630001B22Rik, Af10
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17354
Homologene: 20973
E2f3
Name: E2F transcription factor 3
Synonyms: E2f3a, E2F3b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13557
HGNC: HGNC:3115
Homologene: 74413
Ttc3
Name: tetratricopeptide repeat domain 3
Synonyms: TPRD, D16Ium21e, D16Ium21, 2610202A04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22129
Homologene: 2487
Tpp2
Name: tripeptidyl peptidase II
Synonyms: TppII
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22019
Homologene: 2471
Smpd4
Name: sphingomyelin phosphodiesterase 4
Synonyms: neutral membrane (neutral sphingomyelinase-3), 4122402O22Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77626
Homologene: 9813
Heatr1
Name: HEAT repeat containing 1
Synonyms: B130016L12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 217995
VEGA: 13
Homologene: 34562
Tcof1
Name: treacle ribosome biogenesis factor 1
Synonyms: treacle
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 21453
Homologene: 68049
Xpo7
Name: exportin 7
Synonyms: 4930506C02Rik, Ranbp16
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 65246
VEGA: 14
Homologene: 22857
Nfrkb
Name: nuclear factor related to kappa B binding protein
Synonyms: A530090G11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235134
HGNC: HGNC:7802
Homologene: 4492
Abcc5
Name: ATP-binding cassette, sub-family C member 5
Synonyms: 2900011L11Rik, Abcc5a, Abcc5b, Mrp5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 27416
HGNC: HGNC:56
Homologene: 21164
Prpf31
Name: pre-mRNA processing factor 31
Synonyms: RP11, 1500019O16Rik, 2810404O06Rik, PRP31
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68988
Homologene: 5980
Gm6563
Name: predicted pseudogene 6563
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 625193
VEGA: 19
Numbl
Name: numb-like
Synonyms: nbl
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18223
HGNC: HGNC:8061
Homologene: 68413
Cxcl16
Name: C-X-C motif chemokine ligand 16
Synonyms: Scavenger Receptor, SR-PSOX/CXCL16, 0910001K24Rik, SR-PSOX
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66102
Homologene: 49694
Gpc6
Name: glypican 6
Synonyms: 6720429C22Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 23888
HGNC: HGNC:4454
Homologene: 55922
Muc16
Name: mucin 16
Synonyms: 1110008I14Rik, LOC385009, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Ampd2
Name: adenosine monophosphate deaminase 2
Synonyms: 1200014F01Rik, Ampd-2, m4521Dajl
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109674
HGNC: HGNC:469
Homologene: 2979
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: Dnchc2, m152Asp, m407Asp, b2b414Clo, D030010H02Rik, D330044F14Rik, 4432416O06Rik, DHC1b, DHC2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Mrpl48
Name: mitochondrial ribosomal protein L48
Synonyms: D4Ertd786e, CGI-118, 1810030E20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 52443
Homologene: 32294
Cdc7
Name: cell division cycle 7
Synonyms: Cdc7, Cdc7l1, muCdc7
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12545
HGNC: HGNC:1745
Homologene: 31166
Gpr107
Name: G protein-coupled receptor 107
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 277463
Homologene: 81077
Zswim4
Name: zinc finger SWIM-type containing 4
Synonyms: E130119J17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212168
Homologene: 18183
Myo7a
Name: myosin VIIA
Synonyms: nmf371, polka, Myo7, Hdb, USH1B
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17921
HGNC: HGNC:7606
Homologene: 219
Bltp2
Name: bridge-like lipid transfer protein family member 2
Synonyms: 2610507B11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72503
Homologene: 34730
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Bmpr1b
Name: bone morphogenetic protein receptor, type 1B
Synonyms: Alk6, CFK-43a, BMPR-IB, Acvrlk6
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12167
HGNC: HGNC:1077
Homologene: 20322
Chchd1
Name: coiled-coil-helix-coiled-coil-helix domain containing 1
Synonyms: 2400010G13Rik, 1110001O19Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66121
VEGA: 14
Homologene: 11923
Adamts2
Name: ADAM metallopeptidase with thrombospondin type 1 motif 2
Synonyms: a disintegrin and metalloproteinase with thrombospondin repeats, procollagen N-proteinase, ADAM-TS2, hPCPNI
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216725
HGNC: HGNC:218
Homologene: 8597
Skint6
Name: selection and upkeep of intraepithelial T cells 6
Synonyms: OTTMUSG00000008519
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230622
Homologene: 135888
Cacna1i
Name: calcium channel, voltage-dependent, alpha 1I subunit
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239556
HGNC: HGNC:1396
Homologene: 69331
Adra2b
Name: adrenergic receptor, alpha 2b
Synonyms: a2b-AR, alpha2B, [a]2B, Adra-2b
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11552
HGNC: HGNC:282
Homologene: 553
Frem3
Name: Fras1 related extracellular matrix protein 3
Synonyms: LOC333315
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 333315
Homologene: 35388
Or5b12
Name: olfactory receptor family 5 subfamily B member 12
Synonyms: MOR202-5, Olfr1448, GA_x6K02T2RE5P-3249780-3248836
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258696
Homologene: 64904
Rbm20
Name: RNA binding motif protein 20
Synonyms: 2010003H22Rik, 1110018J23Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 73713
Homologene: 28386
Fhod3
Name: formin homology 2 domain containing 3
Synonyms: A930009H06Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225288
VEGA: 18
Homologene: 45323
Lrrc27
Name: leucine rich repeat containing 27
Synonyms: 2310044E02Rik, 1700071K18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76612
Homologene: 19268
Tfpt
Name: TCF3 (E2A) fusion partner
Synonyms: Amida, 2400004F01Rik, FB1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69714
Homologene: 8349
Dync1i1
Name: dynein cytoplasmic 1 intermediate chain 1
Synonyms: DIC, IC74, Dncic1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13426
HGNC: HGNC:2963
Homologene: 68398
Pdia2
Name: protein disulfide isomerase associated 2
Synonyms: Pdip, Pdipl, 1810041F13Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 69191
Homologene: 55994
Bag2
Name: BCL2-associated athanogene 2
Synonyms: 2610042A13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213539
HGNC: HGNC:938
Homologene: 31233
Fermt1
Name: fermitin family member 1
Synonyms: 5830467P10Rik, Kindlin-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241639
Homologene: 9773
Or51t4
Name: olfactory receptor family 51 subfamily T member 4
Synonyms: GA_x6K02T2PBJ9-5659738-5660748, MOR14-9, Olfr574
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258357
Homologene: 27137
Or6y1
Name: olfactory receptor family 6 subfamily Y member 1
Synonyms: GA_x6K02T2P20D-20731742-20730694, MOR103-17, Olfr413-ps1, MOR103-13P, GA_x6K02SYWY4V-595-239, Olfr220, EG546747
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 546747
Homologene: 67062
Krtap10-31
Name: keratin associated protein 10-31
Synonyms: EG622629, Gm10318
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 622629
Homologene: 115744
Trav15-1-dv6-1
Name: T cell receptor alpha variable 15-1-DV6-1
Synonyms: Gm16591
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 386446
Tnp2
Name: transition protein 2
Synonyms: TP2, Tp-2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 21959
VEGA: 16
Homologene: 137259
Msantd5f5
Name: Myb/SANT DNA binding domain containing 5 family member 5
Synonyms: Gm11237
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 623197
Homologene: 128423
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 33,748,277 bp
  • T to A, chromosome 1 at 43,980,385 bp
  • T to A, chromosome 1 at 174,449,176 bp
  • T to G, chromosome 2 at 12,355,343 bp
  • T to C, chromosome 2 at 18,146,859 bp
  • C to A, chromosome 2 at 31,176,927 bp
  • T to C, chromosome 2 at 127,364,136 bp
  • T to C, chromosome 2 at 132,906,715 bp
  • C to A, chromosome 3 at 108,080,116 bp
  • T to C, chromosome 3 at 141,857,582 bp
  • T to A, chromosome 4 at 73,624,404 bp
  • A to G, chromosome 4 at 113,238,268 bp
  • T to A, chromosome 5 at 106,972,998 bp
  • T to G, chromosome 6 at 5,913,330 bp
  • A to G, chromosome 7 at 3,629,066 bp
  • A to T, chromosome 7 at 3,632,743 bp
  • T to C, chromosome 7 at 27,264,936 bp
  • T to C, chromosome 7 at 98,091,063 bp
  • G to A, chromosome 7 at 100,583,062 bp
  • T to C, chromosome 7 at 102,948,597 bp
  • T to C, chromosome 7 at 139,228,774 bp
  • A to T, chromosome 8 at 80,612,595 bp
  • G to A, chromosome 8 at 84,211,957 bp
  • A to G, chromosome 9 at 7,051,452 bp
  • T to C, chromosome 9 at 18,519,631 bp
  • T to C, chromosome 9 at 31,399,965 bp
  • T to A, chromosome 10 at 77,852,878 bp
  • A to T, chromosome 11 at 8,492,971 bp
  • A to G, chromosome 11 at 50,776,130 bp
  • T to C, chromosome 11 at 70,455,684 bp
  • T to C, chromosome 11 at 78,265,238 bp
  • T to A, chromosome 11 at 119,462,217 bp
  • T to G, chromosome 13 at 12,410,534 bp
  • T to A, chromosome 13 at 29,913,470 bp
  • T to C, chromosome 14 at 20,704,143 bp
  • A to G, chromosome 14 at 53,560,209 bp
  • A to G, chromosome 14 at 70,707,397 bp
  • T to C, chromosome 14 at 116,925,972 bp
  • C to A, chromosome 15 at 80,358,894 bp
  • A to G, chromosome 16 at 10,788,508 bp
  • T to A, chromosome 16 at 17,641,020 bp
  • A to G, chromosome 16 at 20,404,648 bp
  • T to C, chromosome 16 at 94,457,379 bp
  • A to T, chromosome 17 at 26,198,170 bp
  • A to G, chromosome 18 at 25,056,333 bp
  • G to C, chromosome 18 at 60,829,051 bp
  • G to A, chromosome 19 at 12,919,595 bp
  • T to A, chromosome 19 at 23,676,116 bp
  • A to G, chromosome 19 at 53,851,492 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8518 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067850-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.