Strain Name:
C57BL/6J-MtgxR8372Btlr/Mmmh
Stock Number:
067875-MU
Citation ID:
RRID:MMRRC_067875-MU
Other Names:
R8372 (G1)
Major Collection:

Strain Information

Ptprk
Name: protein tyrosine phosphatase receptor type K
Synonyms: RPTPkappa, PTPk
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19272
VEGA: 10
HGNC: HGNC:9674
Homologene: 55693
Xrn1
Name: 5'-3' exoribonuclease 1
Synonyms: mXrn1, Dhm2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 24127
Homologene: 5894
Cep290
Name: centrosomal protein 290
Synonyms: Kiaa, b2b1752Clo, Nphp6, b2b1454Clo
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216274
VEGA: 10
Homologene: 77213
Xpo4
Name: exportin 4
Synonyms: B430309A01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 57258
Homologene: 10733
Rsf1
Name: remodeling and spacing factor 1
Synonyms: 4832420A03Rik, p325, C030033M12Rik, Hbxap, XAP8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Rapgef1
Name: Rap guanine nucleotide exchange factor (GEF) 1
Synonyms: C3G, 4932418O06Rik, Grf2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 107746
HGNC: HGNC:4568
Homologene: 50501
Gfm2
Name: G elongation factor, mitochondrial 2
Synonyms: MST027, 6530419G12Rik, A930009M04Rik, EFG2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 320806
Homologene: 6238
C2cd3
Name: C2 calcium-dependent domain containing 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 277939
Homologene: 19524
Plxnb2
Name: plexin B2
Synonyms: 1110007H23Rik, Debt
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 140570
HGNC: HGNC:9104
Homologene: 66630
Clec4g
Name: C-type lectin domain family 4, member g
Synonyms: 4930572L20Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75863
Homologene: 18879
Slc39a7
Name: solute carrier family 39 (zinc transporter), member 7
Synonyms: Ring5, KE4, Zip7, H2-Ke4, Ke-4, H-2Ke4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14977
HGNC: HGNC:4927
Homologene: 5072
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: DHC1b, DHC2, b2b414Clo, Dnchc2, 4432416O06Rik, D330044F14Rik, D030010H02Rik, m152Asp, m407Asp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Elavl1
Name: ELAV like RNA binding protein 1
Synonyms: W91709, 2410055N02Rik, ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R), HuR, Hua
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 15568
HGNC: HGNC:3312
Homologene: 20367
Tmprss3
Name: transmembrane protease, serine 3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 140765
Homologene: 56985
Dclk3
Name: doublecortin-like kinase 3
Synonyms: Click-I, -II related, Dcamkl3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245038
Homologene: 70580
Spp1
Name: secreted phosphoprotein 1
Synonyms: Ric, bone sialoprotein 1, 44kDa bone phosphoprotein, osteopontin, Opnl, BNSP, ETA-1, Opn, osteopontin-like protein, minopontin, OP, 2ar, Spp-1, Apl-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20750
Homologene: 20156
Rbm15b
Name: RNA binding motif protein 15B
Synonyms: 1810017N16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 109095
Homologene: 8325
Zcchc4
Name: zinc finger, CCHC domain containing 4
Synonyms: 4930449I23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 78796
Homologene: 14632
4930562C15Rik
Name: RIKEN cDNA 4930562C15 gene
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78809
Homologene: 53527
Cspg4
Name: chondroitin sulfate proteoglycan 4
Synonyms: 4732461B14Rik, NG2, AN2, Cspg4a
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 121021
VEGA: 9
HGNC: HGNC:2466
Homologene: 20445
Scnn1a
Name: sodium channel, nonvoltage-gated 1 alpha
Synonyms: ENaC alpha, Scnn1, mENaC
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20276
Homologene: 811
Agap2
Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Synonyms: Centg1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216439
VEGA: 10
Homologene: 86815
Bcl9l
Name: B cell CLL/lymphoma 9-like
Synonyms: DLNB11
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 80288
VEGA: 9
Homologene: 65615
Rbm42
Name: RNA binding motif protein 42
Synonyms: 1700003D06Rik, 3100004P22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68035
Homologene: 32579
Ercc6l2
Name: excision repair cross-complementing rodent repair deficiency, complementation group 6 like 2
Synonyms: 0610007P08Rik, 1700019D06Rik, 9330134C04Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76251
Homologene: 32564
Dab2
Name: disabled 2, mitogen-responsive phosphoprotein
Synonyms: 5730435J12Rik, D15Wsu122e, D630005B22Rik, p96
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 13132
HGNC: HGNC:2662
Homologene: 1026
Klhl33
Name: kelch-like 33
Synonyms: EG546611
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 546611
VEGA: 14
Homologene: 52385
Klhl9
Name: kelch-like 9
Synonyms: C530050O22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242521
Homologene: 23125
Parp8
Name: poly (ADP-ribose) polymerase family, member 8
Synonyms: 2810430O08Rik, D13Ertd275e
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 52552
VEGA: 13
Homologene: 11621
Psg16
Name: pregnancy specific beta-1-glycoprotein 16
Synonyms: Cea11, bCEA
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26436
Ccdc7a
Name: coiled-coil domain containing 7A
Synonyms: 4930540C21Rik, 4930517G15Rik, Ccdc7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74703
Homologene: 134760
Cyth4
Name: cytohesin 4
Synonyms: 2510004M07Rik, Pscd4, 5830469K17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72318
VEGA: 15
HGNC: HGNC:9505
Homologene: 22750
Vmn1r75
Name: vomeronasal 1 receptor 75
Synonyms: V1rg6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171241
Homologene: 44234
B4galnt2
Name: beta-1,4-N-acetyl-galactosaminyl transferase 2
Synonyms: Dlb1, Dlb-1, Galgt2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14422
Homologene: 7329
Or9k2b
Name: olfactory receptor family 9 subfamily K member 2B
Synonyms: Olfr826, MOR210-2, GA_x6K02T2PULF-11851623-11850682
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258671
Homologene: 121503
Adgrg7
Name: adhesion G protein-coupled receptor G7
Synonyms: Gpr128, 9130020O16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239853
Homologene: 13115
Kcnq5
Name: potassium voltage-gated channel, subfamily Q, member 5
Synonyms: 9230107O05Rik, D1Mgi1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226922
HGNC: HGNC:6299
Homologene: 28270
Fcgr2b
Name: Fc receptor, IgG, low affinity IIb
Synonyms: Fcr-3, Fc gamma RIIB, FcgammaRIIB, F630109E10Rik, CD32, FcgRII, Fc[g]RII, Fcgr2a, Fcr-2, Ly-m20, Ly-17, LyM-1, Fcgr2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14130
Homologene: 2974
Gpr15
Name: G protein-coupled receptor 15
Synonyms: 4933439K08Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 71223
VEGA: 16
HGNC: HGNC:4469
Homologene: 3869
Tigd5
Name: tigger transposable element derived 5
Synonyms: FLJ14926
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105734
Homologene: 129878
Ighv13-2
Name: immunoglobulin heavy variable 13-2
Synonyms: Gm15449
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 629842
HGNC: HGNC:5623
Krtap6-3
Name: keratin associated protein 6-3
Synonyms: Gm10229
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 100040201
VEGA: 16
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 21,479,424 bp
  • A to G, chromosome 1 at 170,965,761 bp
  • G to A, chromosome 2 at 29,710,231 bp
  • A to G, chromosome 4 at 88,721,359 bp
  • T to C, chromosome 5 at 52,796,164 bp
  • A to G, chromosome 5 at 104,440,256 bp
  • A to G, chromosome 6 at 125,343,718 bp
  • A to T, chromosome 7 at 11,880,730 bp
  • A to G, chromosome 7 at 17,095,315 bp
  • A to G, chromosome 7 at 30,641,206 bp
  • T to C, chromosome 7 at 97,662,417 bp
  • C to T, chromosome 7 at 100,455,280 bp
  • T to C, chromosome 8 at 3,707,990 bp
  • T to C, chromosome 8 at 4,289,664 bp
  • T to C, chromosome 8 at 128,821,104 bp
  • A to G, chromosome 9 at 7,111,514 bp
  • A to G, chromosome 9 at 44,507,231 bp
  • A to G, chromosome 9 at 56,887,195 bp
  • A to G, chromosome 9 at 96,024,113 bp
  • T to C, chromosome 9 at 106,885,563 bp
  • A to G, chromosome 9 at 111,485,013 bp
  • A to G, chromosome 10 at 28,354,692 bp
  • T to C, chromosome 10 at 100,549,341 bp
  • T to C, chromosome 10 at 127,089,316 bp
  • A to G, chromosome 10 at 130,180,787 bp
  • T to C, chromosome 11 at 95,869,280 bp
  • A to T, chromosome 12 at 114,358,061 bp
  • T to C, chromosome 13 at 63,853,749 bp
  • T to C, chromosome 13 at 97,165,044 bp
  • T to A, chromosome 13 at 116,855,250 bp
  • C to T, chromosome 14 at 50,892,232 bp
  • A to G, chromosome 14 at 57,597,884 bp
  • A to C, chromosome 15 at 6,416,925 bp
  • A to G, chromosome 15 at 75,910,488 bp
  • A to G, chromosome 15 at 78,597,135 bp
  • A to G, chromosome 15 at 89,158,493 bp
  • A to G, chromosome 16 at 4,864,288 bp
  • T to A, chromosome 16 at 56,795,751 bp
  • A to G, chromosome 16 at 58,718,487 bp
  • G to C, chromosome 16 at 89,015,497 bp
  • C to T, chromosome 17 at 31,184,697 bp
  • T to C, chromosome 17 at 34,030,665 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8372 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067875-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.