Strain Name:
C57BL/6J-MtgxR8822Btlr/Mmmh
Stock Number:
068655-MU
Citation ID:
RRID:MMRRC_068655-MU
Other Names:
R8822 (G1)
Major Collection:

Strain Information

Pkd1
Name: polycystin 1, transient receptor potential channel interacting
Synonyms: polycystin-1, PC-1, PC1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Tyr
Name: tyrosinase
Synonyms: Oca1, skc35
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22173
Homologene: 30969
Ptprz1
Name: protein tyrosine phosphatase receptor type Z, polypeptide 1
Synonyms: Rptpbeta, phosphacan, Ptpz, DSD-1-PG, PTPzeta, PTPbeta, Ptprz, RPTPz
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Cd28
Name: CD28 antigen
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12487
HGNC: HGNC:1653
Homologene: 4473
Sash1
Name: SAM and SH3 domain containing 1
Synonyms: 1100001C18Rik, A330076K04Rik, 2500002E12Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70097
Homologene: 69182
Rprd2
Name: regulation of nuclear pre-mRNA domain containing 2
Synonyms: 6720469I21Rik, 2810036A19Rik, 4930535B03Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 75137
Homologene: 19997
Gpr26
Name: G protein-coupled receptor 26
Synonyms: 9630036A11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233919
HGNC: HGNC:4481
Homologene: 17764
Atp2a2
Name: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Synonyms: D5Wsu150e, sarco/endoplasmic reticulum Ca2+-ATPase 2, 9530097L16Rik, SERCA2, SERCA2B, Serca2a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11938
HGNC: HGNC:812
Homologene: 80167
Helb
Name: helicase (DNA) B
Synonyms: D10Ertd664e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 117599
Homologene: 50463
Prr12
Name: proline rich 12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233210
Homologene: 18957
Snx16
Name: sorting nexin 16
Synonyms: 4930522N22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74718
Homologene: 11169
Usp24
Name: ubiquitin specific peptidase 24
Synonyms: 2810030C21Rik, 2700066K03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329908
Homologene: 35420
Zfp318
Name: zinc finger protein 318
Synonyms: 2610034E08Rik, TZF, D530032D06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57908
Homologene: 22808
Zbtb21
Name: zinc finger and BTB domain containing 21
Synonyms: Zfp295, Znf295, B430213I24Rik, 5430437K12Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 114565
VEGA: 16
Homologene: 10799
Plxna4
Name: plexin A4
Synonyms: Plxa4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243743
HGNC: HGNC:9102
Homologene: 77587
Ticam1
Name: TIR domain containing adaptor molecule 1
Synonyms: TICAM-1, Trif
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106759
Homologene: 8605
Uba6
Name: ubiquitin-like modifier activating enzyme 6
Synonyms: 5730469D23Rik, Ube1l2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231380
Homologene: 10080
Platr25
Name: pluripotency associated transcript 25
Synonyms: 6720490N10Rik, Gm5665
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 435366
Lmo7
Name: LIM domain only 7
Synonyms: FBXO20, LOC380928
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 380928
HGNC: HGNC:6646
Homologene: 83924
Setd1a
Name: SET domain containing 1A
Synonyms: KMT2F
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233904
Homologene: 52251
Fam151a
Name: family with sequence simliarity 151, member A
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230579
Homologene: 17143
Lman1l
Name: lectin, mannose-binding 1 like
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235416
HGNC: HGNC:6632
Homologene: 11047
Rbl2
Name: RB transcriptional corepressor like 2
Synonyms: p130, Rb2, retinoblastoma-like 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 19651
HGNC: HGNC:9894
Homologene: 4098
Zfp644
Name: zinc finger protein 644
Synonyms: BM-005, 1110068L01Rik, Zep-2, D5Ertd689e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52397
Homologene: 12971
Rhpn2
Name: rhophilin, Rho GTPase binding protein 2
Synonyms: D7Ertd784e, 1300002E07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 52428
Homologene: 12407
Zfp668
Name: zinc finger protein 668
Synonyms: E130018B19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244219
Homologene: 11667
Pkd1l1
Name: polycystic kidney disease 1 like 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 171395
Homologene: 51376
Zfp808
Name: zinc finger protein 808
Synonyms: Gm7036
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 630579
Homologene: 134631
Myo15a
Name: myosin XVA
Synonyms: Myo15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17910
HGNC: HGNC:7594
Homologene: 56504
Sec31b
Name: SEC31 homolog B, COPII coat complex component
Synonyms: Sec31l2, LOC240667
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240667
Homologene: 56708
Hps3
Name: HPS3, biogenesis of lysosomal organelles complex 2 subunit 1
Synonyms: Hermansky-Pudlak syndrome 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12807
Homologene: 13019
Pkp1
Name: plakophilin 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18772
HGNC: HGNC:9023
Homologene: 253
Cdcp3
Name: CUB domain containing protein 3
Synonyms: 5430419D17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71395
Homologene: 138430
Slc38a4
Name: solute carrier family 38, member 4
Synonyms: 1110012E16Rik, Ata3, SNAT4, 1700012A18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69354
VEGA: 15
Homologene: 75077
Fyco1
Name: FYVE and coiled-coil domain containing 1
Synonyms: ZFYVE7, 2810409M01Rik, Mem2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17281
Homologene: 11561
Cacna1d
Name: calcium channel, voltage-dependent, L type, alpha 1D subunit
Synonyms: C79217, D-LTCC, 8430418G19Rik, Cchl1a2, Cacnl1a2, Cchl1a, Cav1.3alpha1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12289
VEGA: 14
HGNC: HGNC:1391
Homologene: 578
Cplane1
Name: ciliogenesis and planar polarity effector 1
Synonyms: 2410089E03Rik, Jbts17, Hug, b2b012Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 73692
Homologene: 11315
Ceacam12
Name: CEA cell adhesion molecule 12
Synonyms: Ceacam12-C1, Ceacam12-C3, 1600031J20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67315
Homologene: 137375
Tnfrsf12a
Name: tumor necrosis factor receptor superfamily, member 12a
Synonyms: TWEAK-R, TweakR, Fn14
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27279
VEGA: 17
Homologene: 8451
Wdr64
Name: WD repeat domain 64
Synonyms: 4930511H01Rik, 4930415O10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75820
Homologene: 51634
Scn9a
Name: sodium channel, voltage-gated, type IX, alpha
Synonyms: PN1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20274
Homologene: 2237
Or8g4
Name: olfactory receptor family 8 subfamily G member 4
Synonyms: GA_x6K02T2PVTD-33447884-33448816, MOR171-30P, Olfr967
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258086
VEGA: 9
HGNC: HGNC:8484
Homologene: 115535
Or52b2
Name: olfactory receptor family 52 subfamily B member 2
Synonyms: Olfr691, MOR31-6, GA_x6K02T2PBJ9-7966695-7965727
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259063
Homologene: 17483
Slc27a1
Name: solute carrier family 27 (fatty acid transporter), member 1
Synonyms: Fatp, FATP1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 26457
Homologene: 8063
Bank1
Name: B cell scaffold protein with ankyrin repeats 1
Synonyms: A530094C12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242248
Homologene: 9926
Slc52a3
Name: solute carrier protein family 52, member 3
Synonyms: 2310046K01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69698
Homologene: 12324
Adrb1
Name: adrenergic receptor, beta 1
Synonyms: Adrb-1, beta 1-AR
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 11554
VEGA: 19
HGNC: HGNC:285
Homologene: 20171
Klhl35
Name: kelch-like 35
Synonyms: 2810406K13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72184
Homologene: 27849
Cyp4a31
Name: cytochrome P450, family 4, subfamily a, polypeptide 31
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 666168
HGNC: HGNC:2642
Homologene: 128044
Or10d3
Name: olfactory receptor family 10 subfamily D member 3
Synonyms: GA_x6K02T2PVTD-33247839-33246901, MOR224-9, Olfr958
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258327
VEGA: 9
HGNC: HGNC:8168
Homologene: 27128
Pde6b
Name: phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Synonyms: Pdeb, rd, rd1, r, rd10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18587
HGNC: HGNC:8786
Homologene: 237
Slc10a2
Name: solute carrier family 10, member 2
Synonyms: 9130221J18Rik, ASBT
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20494
Homologene: 390
Igdcc4
Name: immunoglobulin superfamily, DCC subclass, member 4
Synonyms: WI-16786, Nope, WI-18508, 9330155G14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56741
VEGA: 9
Homologene: 10570
Chpt1
Name: choline phosphotransferase 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 212862
Homologene: 69297
Or5d47
Name: olfactory receptor family 5 subfamily D member 47
Synonyms: Olfr74, MOR174-4, GA_x6K02T2Q125-49458388-49457432, mOR-EV
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 117005
Homologene: 74078
Stox1
Name: storkhead box 1
Synonyms: 4732470K04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216021
Homologene: 17649
Obp2a
Name: odorant binding protein 2A
Synonyms: Lcn13
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227627
Homologene: 136130
Zfp263
Name: zinc finger protein 263
Synonyms: mFPM315, NT2, 1200014J04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74120
Homologene: 4197
S100a4
Name: S100 calcium binding protein A4
Synonyms: PeL98, FSp1, Fibroblast-specific protein 1, metastasin, Capl, 18A2, CAPL, Mts1, 42a, pk9a, calvasculin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20198
Homologene: 7924
Or13a22
Name: olfactory receptor family 13 subfamily A member 22
Synonyms: MOR253-7, GA_x6K02T2PBJ9-42641642-42642574, Olfr535
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258956
Homologene: 138320
Tcap
Name: titin-cap
Synonyms: Telethonin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21393
Homologene: 2724
Samd11
Name: sterile alpha motif domain containing 11
Synonyms: mr-s
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 231004
VEGA: 4
Homologene: 34983
Cfap54
Name: cilia and flagella associated protein 54
Synonyms: Gm872, 4930485B16Rik, LOC380653
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 380654
Homologene: 133438
Gm6685
Name: predicted pseudogene 6685
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 626571
VEGA: 11
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 60,769,661 bp
  • T to A, chromosome 1 at 135,879,923 bp
  • T to C, chromosome 1 at 175,717,354 bp
  • A to T, chromosome 2 at 25,700,176 bp
  • A to G, chromosome 2 at 66,540,635 bp
  • A to G, chromosome 2 at 87,974,441 bp
  • T to G, chromosome 2 at 152,004,593 bp
  • T to C, chromosome 3 at 10,419,065 bp
  • A to G, chromosome 3 at 20,003,227 bp
  • T to C, chromosome 3 at 90,605,051 bp
  • A to G, chromosome 3 at 95,784,301 bp
  • T to A, chromosome 3 at 136,103,879 bp
  • G to A, chromosome 4 at 106,412,213 bp
  • A to T, chromosome 4 at 106,745,645 bp
  • G to A, chromosome 4 at 115,565,028 bp
  • A to G, chromosome 4 at 144,330,522 bp
  • A to T, chromosome 4 at 156,252,307 bp
  • A to G, chromosome 5 at 86,147,073 bp
  • G to T, chromosome 5 at 106,635,221 bp
  • A to G, chromosome 5 at 108,403,462 bp
  • A to G, chromosome 5 at 122,491,709 bp
  • T to A, chromosome 6 at 23,002,589 bp
  • T to C, chromosome 6 at 32,150,496 bp
  • T to C, chromosome 7 at 18,069,453 bp
  • A to T, chromosome 7 at 35,390,803 bp
  • A to G, chromosome 7 at 45,050,339 bp
  • G to A, chromosome 7 at 87,493,122 bp
  • T to C, chromosome 7 at 99,472,848 bp
  • A to G, chromosome 7 at 105,337,602 bp
  • C to T, chromosome 7 at 127,786,160 bp
  • A to T, chromosome 7 at 127,867,143 bp
  • A to T, chromosome 7 at 131,241,977 bp
  • A to G, chromosome 7 at 131,967,268 bp
  • A to G, chromosome 7 at 140,493,013 bp
  • T to G, chromosome 8 at 5,089,149 bp
  • T to A, chromosome 8 at 71,580,664 bp
  • A to T, chromosome 8 at 91,106,718 bp
  • C to A, chromosome 9 at 39,550,516 bp
  • A to G, chromosome 9 at 39,750,404 bp
  • A to G, chromosome 9 at 57,607,188 bp
  • C to T, chromosome 9 at 65,124,016 bp
  • A to T, chromosome 9 at 123,819,119 bp
  • G to A, chromosome 10 at 8,885,871 bp
  • A to T, chromosome 10 at 62,664,121 bp
  • A to G, chromosome 10 at 88,488,406 bp
  • G to A, chromosome 10 at 93,039,141 bp
  • A to T, chromosome 10 at 120,105,484 bp
  • A to T, chromosome 11 at 8,856,312 bp
  • T to G, chromosome 11 at 28,339,768 bp
  • C to T, chromosome 11 at 60,476,914 bp
  • G to A, chromosome 11 at 98,384,438 bp
  • T to A, chromosome 13 at 62,173,055 bp
  • T to C, chromosome 13 at 62,700,844 bp
  • A to G, chromosome 14 at 30,178,735 bp
  • A to G, chromosome 14 at 101,884,174 bp
  • T to C, chromosome 15 at 8,171,778 bp
  • G to A, chromosome 15 at 97,009,071 bp
  • G to T, chromosome 16 at 3,744,140 bp
  • G to A, chromosome 16 at 97,951,316 bp
  • T to C, chromosome 17 at 23,676,214 bp
  • T to C, chromosome 17 at 24,565,641 bp
  • A to G, chromosome 17 at 46,412,905 bp
  • A to G, chromosome 17 at 56,271,444 bp
  • C to A, chromosome 19 at 44,519,263 bp
  • T to C, chromosome 19 at 56,723,417 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8822 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068655-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.