Strain Name:
C57BL/6J-MtgxR8854Btlr/Mmmh
Stock Number:
068676-MU
Citation ID:
RRID:MMRRC_068676-MU
Other Names:
R8854 (G1)
Major Collection:

Strain Information

Spidr
Name: scaffolding protein involved in DNA repair
Synonyms: 2310008H04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224008
VEGA: 16
Homologene: 51693
Arhgef10
Name: Rho guanine nucleotide exchange factor 10
Synonyms: 6430549H08Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234094
Homologene: 22827
Nkx2-1
Name: NK2 homeobox 1
Synonyms: thyroid-specific enhancer-binding protein, T/EBP, tinman, Ttf-1, thyroid transcription factor-1, Titf1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 21869
Homologene: 2488
Net1
Name: neuroepithelial cell transforming gene 1
Synonyms: mNET1, Net1 homolog, 9530071N24Rik, 0610025H04Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56349
VEGA: 13
Homologene: 4283
Suclg2
Name: succinate-Coenzyme A ligase, GDP-forming, beta subunit
Synonyms: D6Wsu120e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20917
Homologene: 2854
Mark2
Name: MAP/microtubule affinity regulating kinase 2
Synonyms: Par-1, Emk
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13728
HGNC: HGNC:3332
Homologene: 69013
Snd1
Name: staphylococcal nuclease and tudor domain containing 1
Synonyms: p100 co-activator, Tudor-SN
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56463
Homologene: 8665
Ankib1
Name: ankyrin repeat and IBR domain containing 1
Synonyms: 2310061P20Rik, 4631416I11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70797
Homologene: 19076
Tfap4
Name: transcription factor AP4
Synonyms: AP-4, D930048N17Rik, bHLHc41, Tcfap4
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 83383
VEGA: 16
Homologene: 2424
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: nesprin-1, SYNE-1, enaptin165, A330049M09Rik, C130039F11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Dbf4
Name: DBF4 zinc finger
Synonyms: Ask
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27214
Homologene: 40892
Atoh1
Name: atonal bHLH transcription factor 1
Synonyms: Math1, Hath1, bHLHa14
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11921
HGNC: HGNC:797
Homologene: 31297
Trf
Name: transferrin
Synonyms: Tfn, HP
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22041
Homologene: 68153
Cpt1a
Name: carnitine palmitoyltransferase 1a, liver
Synonyms: CPTI, L-CPT I, Cpt1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12894
VEGA: 19
HGNC: HGNC:2328
Homologene: 1413
Clca2
Name: chloride channel accessory 2
Synonyms: Clca5
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229933
HGNC: HGNC:2016
Homologene: 4765
Bbs9
Name: Bardet-Biedl syndrome 9
Synonyms: EST 3159894, E130103I17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319845
Homologene: 44480
Bach2
Name: BTB and CNC homology, basic leucine zipper transcription factor 2
Synonyms: E030004N02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12014
Homologene: 7240
Zfy1
Name: zinc finger protein 1, Y-linked
Synonyms: Zfy-1
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 22767
Homologene: 56456
Nipbl
Name: NIPBL cohesin loading factor
Synonyms: 4921518A06Rik, 4933421G18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71175
VEGA: 15
Homologene: 15850
Sass6
Name: SAS-6 centriolar assembly protein
Synonyms: 2810453L12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72776
Homologene: 45668
Usp42
Name: ubiquitin specific peptidase 42
Synonyms: 3110031A07Rik, 2410140K03Rik, D5Ertd591e, A630018G05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76800
Homologene: 35425
Usp33
Name: ubiquitin specific peptidase 33
Synonyms: Vdu1, 9830169D19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 170822
Homologene: 8996
Cxcl13
Name: C-X-C motif chemokine ligand 13
Synonyms: BCA-1, BLC, Scyb13, ANGIE2, 4631412M08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 55985
Homologene: 48431
Aldh1a1
Name: aldehyde dehydrogenase family 1, subfamily A1
Synonyms: ALDH1, E1, Ahd-2, Ahd2, Raldh1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 11668
HGNC: HGNC:402
Homologene: 110441
Spata31d1c
Name: spermatogenesis associated 31 subfamily D, member 1C
Synonyms: Fam75d1c, 4932441B19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238683
VEGA: 13
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: CD91, A2mr, b2b1554Clo
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Fermt3
Name: fermitin family member 3
Synonyms: C79673, Kindlin-3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 108101
VEGA: 19
Homologene: 12877
Or5p76
Name: olfactory receptor family 5 subfamily P member 76
Synonyms: GA_x6K02T2PBJ9-10853935-10852991, MOR204-8, Olfr502
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258734
Homologene: 72021
Plpp4
Name: phospholipid phosphatase 4
Synonyms: LOC381925, C030048B12Rik, Ppapdc1a
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381925
Homologene: 38751
Eogt
Name: EGF domain specific O-linked N-acetylglucosamine transferase
Synonyms: A130022J15Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101351
Homologene: 65276
Vmn2r10
Name: vomeronasal 2, receptor 10
Synonyms: VR16, V2r16
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22307
Homologene: 129606
Slc22a30
Name: solute carrier family 22, member 30
Synonyms: C730048C13Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 319800
Homologene: 77136
Sirpb1c
Name: signal-regulatory protein beta 1C
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100038947
Homologene: 82993
Kcnv2
Name: potassium channel, subfamily V, member 2
Synonyms: KV11.1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240595
Homologene: 26423
Cps1
Name: carbamoyl-phosphate synthetase 1
Synonyms: CPS, CPSase I, 4732433M03Rik, D1Ucla3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227231
HGNC: HGNC:2323
Homologene: 68208
Arpc1b
Name: actin related protein 2/3 complex, subunit 1B
Synonyms: SOP2Hs, p41-ARC, L72
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11867
HGNC: HGNC:704
Homologene: 4179
Pnma8a
Name: PNMA family member 8A
Synonyms: 0710005I19Rik, 4930488B01Rik, Pnmal1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71691
Homologene: 10073
Megf6
Name: multiple EGF-like-domains 6
Synonyms: 2600001P17Rik, Egfl3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230971
HGNC: HGNC:3232
Homologene: 45412
Kif26b
Name: kinesin family member 26B
Synonyms: N-11 kinesin, D230039L06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269152
Homologene: 18623
Ildr1
Name: immunoglobulin-like domain containing receptor 1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 106347
Homologene: 15892
Cadps2
Name: Ca2+-dependent activator protein for secretion 2
Synonyms: cpd2, A230044C21Rik, Caps2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320405
Homologene: 23060
Cfap20dc
Name: CFAP20 domain containing
Synonyms: 4930452B06Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 74430
Homologene: 18873
Niban1
Name: niban apoptosis regulator 1
Synonyms: Niban, Fam129a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 63913
Homologene: 62170
Tcn2
Name: transcobalamin 2
Synonyms: Tcn-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21452
Homologene: 303
Meioc
Name: meiosis specific with coiled-coil domain
Synonyms: LOC380729, LOC268491, Gm1564
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268491
Homologene: 19559
Cd1d1
Name: CD1d1 antigen
Synonyms: CD1.1, Cd1a, Cd1d, Ly-38
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12479
HGNC: HGNC:1637
Homologene: 1337
Pcare
Name: photoreceptor cilium actin regulator
Synonyms: BC027072
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 225004
VEGA: 17
Homologene: 19792
Ngly1
Name: N-glycanase 1
Synonyms: 1110002C09Rik, Png1, PNGase
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 59007
Homologene: 10117
Uap1
Name: UDP-N-acetylglucosamine pyrophosphorylase 1
Synonyms: ESTM38, SPAG2, AGX1, AgX
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 107652
Homologene: 2342
Cryzl2
Name: crystallin zeta like 2
Synonyms: BC026585, quinone reductase-like 2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226527
Homologene: 41713
Tbrg4
Name: transforming growth factor beta regulated gene 4
Synonyms: TB-12, Cpr2, 2310042P22Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21379
Homologene: 31259
Zfp28
Name: zinc finger protein 28
Synonyms: mkr-5, Zfp-28, 2810438M17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22690
Homologene: 69047
Trpc4
Name: transient receptor potential cation channel, subfamily C, member 4
Synonyms: CCE1, Trp4, STRPC4, Trrp4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22066
Homologene: 22955
Lancl1
Name: LanC (bacterial lantibiotic synthetase component C)-like 1
Synonyms: p40, LanC-like protein 1, Gpr69a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14768
HGNC: HGNC:6508
Homologene: 4417
Wfdc16
Name: WAP four-disulfide core domain 16
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 277345
Homologene: 86739
Or52ab7
Name: olfactory receptor family 52 subfamily AB member 7
Synonyms: GA_x6K02T2PBJ9-6037823-6038782, MOR23-4P, MOR23-5, Olfr598
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257975
Homologene: 132401
Il2rb
Name: interleukin 2 receptor, beta chain
Synonyms: CD122, Il-2Rbeta, IL15Rbeta, IL-2/15Rbeta, IL-15 receptor beta chain, IL-15Rbeta
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16185
VEGA: 15
HGNC: HGNC:6009
Homologene: 47955
Mlx
Name: MAX-like protein X
Synonyms: BigMax alpha, Tcfl4, bHLHd13
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21428
Homologene: 7969
Muc1
Name: mucin 1, transmembrane
Synonyms: EMA, CD227, Muc-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17829
HGNC: HGNC:7508
Homologene: 137248
Mfsd4b5
Name: major facilitator superfamily domain containing 4B5
Synonyms: BC021785
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215928
Homologene: 129849
Pcdhgb5
Name: protocadherin gamma subfamily B, 5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93702
HGNC: HGNC:8712
Homologene: 55773
Tcstv2b
Name: 2 cell stage variable group member 2B
Synonyms: Gm21761
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 106029237
Ms4a18
Name: membrane-spanning 4-domains, subfamily A, member 18
Synonyms: 5033428B15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 76002
Homologene: 89543
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 67,034,199 bp
  • A to G, chromosome 1 at 67,160,889 bp
  • A to G, chromosome 1 at 151,709,199 bp
  • A to G, chromosome 1 at 157,458,800 bp
  • G to T, chromosome 1 at 170,149,415 bp
  • G to A, chromosome 1 at 178,916,383 bp
  • G to A, chromosome 2 at 164,638,566 bp
  • A to T, chromosome 2 at 177,473,295 bp
  • T to C, chromosome 3 at 15,833,144 bp
  • A to T, chromosome 3 at 54,194,701 bp
  • T to A, chromosome 3 at 86,998,173 bp
  • C to T, chromosome 3 at 89,232,105 bp
  • C to A, chromosome 3 at 116,605,735 bp
  • C to T, chromosome 3 at 145,078,091 bp
  • C to A, chromosome 3 at 152,368,330 bp
  • T to A, chromosome 4 at 32,575,263 bp
  • C to T, chromosome 4 at 154,268,012 bp
  • C to A, chromosome 5 at 3,727,489 bp
  • T to A, chromosome 5 at 8,408,562 bp
  • T to C, chromosome 5 at 95,957,002 bp
  • T to C, chromosome 5 at 108,996,260 bp
  • T to C, chromosome 5 at 143,716,877 bp
  • C to A, chromosome 5 at 145,123,595 bp
  • G to A, chromosome 6 at 23,385,508 bp
  • A to G, chromosome 6 at 28,526,969 bp
  • A to T, chromosome 6 at 64,729,205 bp
  • A to T, chromosome 6 at 95,595,669 bp
  • A to T, chromosome 6 at 97,131,398 bp
  • T to C, chromosome 7 at 6,394,939 bp
  • T to C, chromosome 7 at 16,961,179 bp
  • T to C, chromosome 7 at 103,328,816 bp
  • T to A, chromosome 7 at 108,523,729 bp
  • T to A, chromosome 7 at 129,307,638 bp
  • A to G, chromosome 8 at 14,979,798 bp
  • T to C, chromosome 9 at 22,578,764 bp
  • A to G, chromosome 9 at 103,230,330 bp
  • A to T, chromosome 10 at 5,128,503 bp
  • C to A, chromosome 10 at 39,970,739 bp
  • T to A, chromosome 10 at 127,543,099 bp
  • A to G, chromosome 11 at 3,926,074 bp
  • A to T, chromosome 11 at 6,616,691 bp
  • T to A, chromosome 11 at 101,091,125 bp
  • T to C, chromosome 11 at 102,675,763 bp
  • A to T, chromosome 12 at 56,533,421 bp
  • G to T, chromosome 13 at 3,884,214 bp
  • C to A, chromosome 13 at 65,035,990 bp
  • T to A, chromosome 13 at 119,916,289 bp
  • A to T, chromosome 14 at 8,518,638 bp
  • T to C, chromosome 14 at 16,281,769 bp
  • A to T, chromosome 15 at 8,300,726 bp
  • T to C, chromosome 15 at 78,485,753 bp
  • T to C, chromosome 16 at 4,549,374 bp
  • A to G, chromosome 16 at 15,889,766 bp
  • T to A, chromosome 16 at 36,715,548 bp
  • T to C, chromosome 17 at 71,749,331 bp
  • C to T, chromosome 18 at 37,732,448 bp
  • T to C, chromosome 19 at 3,356,327 bp
  • T to A, chromosome 19 at 7,013,942 bp
  • A to G, chromosome 19 at 7,281,004 bp
  • A to G, chromosome 19 at 8,386,390 bp
  • G to A, chromosome 19 at 11,013,523 bp
  • G to A, chromosome 19 at 20,610,933 bp
  • A to T, chromosome 19 at 27,333,858 bp
  • A to T, chromosome Y at 726,501 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8854 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068676-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.