Strain Name:
C57BL/6J-MtgxR8875Btlr/Mmmh
Stock Number:
068687-MU
Citation ID:
RRID:MMRRC_068687-MU
Other Names:
R8875 (G1)
Major Collection:

Strain Information

Ap4e1
Name: adaptor-related protein complex AP-4, epsilon 1
Synonyms: 2310033A20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 108011
HGNC: HGNC:573
Homologene: 22397
Fiz1
Name: Flt3 interacting zinc finger protein 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23877
Homologene: 22663
Pum1
Name: pumilio RNA-binding family member 1
Synonyms: Pumm
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 80912
Homologene: 22830
Cdc5l
Name: cell division cycle 5-like
Synonyms: PCDC5RP, 1200002I02Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71702
VEGA: 17
HGNC: HGNC:1743
Homologene: 13291
Qrich1
Name: glutamine-rich 1
Synonyms: 2610028H07Rik, b2b2404Clo
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69232
Homologene: 9803
Fasn
Name: fatty acid synthase
Synonyms: FAS, A630082H08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14104
HGNC: HGNC:3594
Homologene: 55800
Ank3
Name: ankyrin 3, epithelial
Synonyms: Ank-3, Ankyrin-3, AnkG, 2900054D09Rik, Ankyrin-G
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: LOC381341, Dnahc7, Dnahc7a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 627872
Homologene: 41287
Chd2
Name: chromodomain helicase DNA binding protein 2
Synonyms: 2810040A01Rik, 2810013C04Rik, 5630401D06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244059
HGNC: HGNC:1917
Homologene: 37462
Cnpy3
Name: canopy FGF signaling regulator 3
Synonyms: 2410050O22Rik, ERDA5, CAG4A, 1600025D17Rik, Tnrc5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72029
Homologene: 4803
Rpl7
Name: ribosomal protein L7
Synonyms: Rpl7a, Surf-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19989
Homologene: 87772
Zfp982
Name: zinc finger protein 982
Synonyms: Gm13152
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 195531
Eif2s1
Name: eukaryotic translation initiation factor 2, subunit 1 alpha
Synonyms: 2410026C18Rik, eIF2alpha, Eif2a, 0910001O23Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13665
HGNC: HGNC:3265
Homologene: 3020
Ptprs
Name: protein tyrosine phosphatase receptor type S
Synonyms: PTP-NU3, PTPsigma, RPTPsigma, Ptpt9
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19280
HGNC: HGNC:9681
Homologene: 20626
Fat1
Name: FAT atypical cadherin 1
Synonyms: mFat1, 2310038E12Rik, Fath
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Tpst2
Name: protein-tyrosine sulfotransferase 2
Synonyms: grm, D5Ucla3, grt, Tango13b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22022
Homologene: 2666
Fnip1
Name: folliculin interacting protein 1
Synonyms: A730024A03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216742
Homologene: 28173
Nr2f1
Name: nuclear receptor subfamily 2, group F, member 1
Synonyms: COUP-TFI, Erbal3, Tcfcoup1, COUP-TF1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13865
HGNC: HGNC:7975
Homologene: 21158
Cp
Name: ceruloplasmin
Synonyms: D3Ertd555e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12870
HGNC: HGNC:2295
Homologene: 75
Pdcd1
Name: programmed cell death 1
Synonyms: PD-1, Pdc1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18566
HGNC: HGNC:8760
Homologene: 3681
Trpm3
Name: transient receptor potential cation channel, subfamily M, member 3
Synonyms: B930001P07Rik, 6330504P12Rik, MLSN2, melastatin 2, LTRPC3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226025
VEGA: 19
Homologene: 62287
Stab2
Name: stabilin 2
Synonyms: STAB-2, FEEL-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 192188
Homologene: 23022
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Nrp1
Name: neuropilin 1
Synonyms: Neuropilin-1, NP-1, NPN-1, Npn1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18186
HGNC: HGNC:8004
Homologene: 2876
Vmn2r85
Name: vomeronasal 2, receptor 85
Synonyms: EG623734
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 623734
Homologene: 129606
Ifi206
Name: interferon activated gene 206
Synonyms: Gm4955, Pyblhin-C
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 102639543
HGNC: HGNC:5395
Homologene: 115929
Plbd2
Name: phospholipase B domain containing 2
Synonyms: 66.3 kDa, p76, 1300012G16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71772
Homologene: 41528
Ablim1
Name: actin-binding LIM protein 1
Synonyms: Limab1, abLIM-S, abLIM-M, abLIM-L, 4833406P10Rik, 2610209L21Rik, 9330196J19Rik, 2210411C18Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226251
HGNC: HGNC:78
Homologene: 40994
Tle5
Name: TLE family member 5, transcriptional modulator
Synonyms: Grg5, Grg, AES, Aes
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14797
VEGA: 10
HGNC: HGNC:307
Homologene: 879
Spata31h1
Name: SPATA31 subfamily H member 1
Synonyms: 4932415D10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 102635990
VEGA: 10
Homologene: 82476
Or52h7
Name: olfactory receptor family 52 subfamily H member 7
Synonyms: GA_x6K02T2PBJ9-7191524-7192471, MOR31-8, Olfr652
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259050
Homologene: 17477
Bap1
Name: Brca1 associated protein 1
Synonyms: 2300006C11Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 104416
HGNC: HGNC:950
Homologene: 3421
Plin4
Name: perilipin 4
Synonyms: S3-12
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57435
Homologene: 69311
Gabrg3
Name: gamma-aminobutyric acid type A receptor, subunit gamma 3
Synonyms: Gabrg-3, B230362M20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14407
HGNC: HGNC:4088
Homologene: 22444
Rbm12
Name: RNA binding motif protein 12
Synonyms: 5730420G12Rik, SWAN, 9430070C08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75710
HGNC: HGNC:9898
Homologene: 34993
Plch1
Name: phospholipase C, eta 1
Synonyms: PLCeta1, Plcl3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269437
Homologene: 88833
Tm2d2
Name: TM2 domain containing 2
Synonyms: 2410018G23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69742
Homologene: 12328
Adra1a
Name: adrenergic receptor, alpha 1a
Synonyms: Adra1c
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11549
HGNC: HGNC:277
Homologene: 68078
Hsd17b2
Name: hydroxysteroid (17-beta) dehydrogenase 2
Synonyms: 17 HSD type 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 15486
HGNC: HGNC:5211
Homologene: 99709
Pira12
Name: paired-Ig-like receptor A12
Synonyms: Gm14548
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100038909
Homologene: 134028
Zc2hc1c
Name: zinc finger, C2HC-type containing 1C
Synonyms: 2810002I04Rik, Fam164c
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 72350
Homologene: 23461
Or51l4
Name: olfactory receptor family 51 subfamily L member 4
Synonyms: GA_x6K02T2PBJ9-6483085-6482126, MOR17-1, Olfr630
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259102
Homologene: 133674
Hoxd11
Name: homeobox D11
Synonyms: Hox-5.4, Hox-4.6, E230017H14Rik, Hox-5.5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15431
HGNC: HGNC:5134
Homologene: 7368
Tas1r1
Name: taste receptor, type 1, member 1
Synonyms: TR1, T1r1, Gpr70, T1R1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 110326
Homologene: 12888
Tmem158
Name: transmembrane protein 158
Synonyms: 2310037P21Rik, Ris1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72309
VEGA: 9
Homologene: 9141
D630039A03Rik
Name: RIKEN cDNA D630039A03 gene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242484
Homologene: 52276
Nherf2
Name: NHERF family PDZ scaffold protein 2
Synonyms: Nherf2, Octs2, Tka-1, Sip-1, E3karp, 1200011K07Rik, Sip1, 0610011L07Rik, 2010007A20Rik, Sryip1, Slc9a3r2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 65962
VEGA: 17
Homologene: 56962
Krtap2-20
Name: keratin associated protein 2-20
Synonyms: Gm11562
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 100502803
Homologene: 136079
Ttc6
Name: tetratricopeptide repeat domain 6
Synonyms: LOC217602, EG639426, Gm9813, 4921506M07Rik, AU024163
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70846
Homologene: 78002
0610010K14Rik
Name: RIKEN cDNA 0610010K14 gene
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104457
Homologene: 12273
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 16,103,529 bp
  • C to A, chromosome 1 at 53,643,523 bp
  • C to T, chromosome 1 at 94,039,367 bp
  • T to C, chromosome 1 at 173,473,787 bp
  • A to G, chromosome 2 at 74,683,021 bp
  • T to A, chromosome 2 at 82,990,438 bp
  • T to C, chromosome 2 at 127,035,180 bp
  • T to C, chromosome 2 at 156,096,921 bp
  • A to G, chromosome 3 at 19,973,830 bp
  • A to G, chromosome 3 at 63,710,970 bp
  • T to G, chromosome 4 at 57,910,320 bp
  • T to A, chromosome 4 at 130,779,875 bp
  • C to A, chromosome 4 at 147,510,863 bp
  • T to A, chromosome 4 at 152,028,590 bp
  • T to A, chromosome 5 at 112,309,848 bp
  • A to G, chromosome 5 at 120,499,056 bp
  • A to G, chromosome 7 at 3,894,257 bp
  • A to T, chromosome 7 at 5,009,094 bp
  • A to G, chromosome 7 at 56,729,766 bp
  • A to T, chromosome 7 at 73,502,035 bp
  • G to A, chromosome 7 at 103,755,255 bp
  • A to G, chromosome 7 at 104,564,463 bp
  • T to C, chromosome 8 at 25,017,427 bp
  • T to A, chromosome 8 at 45,040,563 bp
  • T to C, chromosome 8 at 117,742,362 bp
  • T to A, chromosome 8 at 128,480,991 bp
  • A to G, chromosome 9 at 108,559,303 bp
  • G to T, chromosome 9 at 123,260,067 bp
  • A to G, chromosome 10 at 69,824,403 bp
  • A to T, chromosome 10 at 81,564,700 bp
  • G to A, chromosome 10 at 82,287,642 bp
  • C to T, chromosome 10 at 86,996,864 bp
  • A to G, chromosome 10 at 130,418,302 bp
  • A to G, chromosome 11 at 54,515,554 bp
  • A to G, chromosome 11 at 70,235,554 bp
  • A to T, chromosome 11 at 99,620,351 bp
  • A to T, chromosome 11 at 120,812,398 bp
  • T to C, chromosome 12 at 57,704,413 bp
  • T to A, chromosome 12 at 57,729,408 bp
  • G to A, chromosome 12 at 78,866,687 bp
  • T to C, chromosome 12 at 85,289,775 bp
  • A to C, chromosome 13 at 78,189,851 bp
  • T to G, chromosome 14 at 31,253,565 bp
  • A to T, chromosome 14 at 66,637,765 bp
  • T to A, chromosome 17 at 24,647,729 bp
  • T to C, chromosome 17 at 45,392,989 bp
  • T to C, chromosome 17 at 46,737,259 bp
  • G to A, chromosome 17 at 56,104,010 bp
  • G to T, chromosome 17 at 56,435,946 bp
  • T to C, chromosome 19 at 22,910,129 bp
  • G to T, chromosome 19 at 57,130,954 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8875 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068687-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.