Strain Name:
C57BL/6J-MtgxR8779Btlr/Mmmh
Stock Number:
068721-MU
Citation ID:
RRID:MMRRC_068721-MU
Other Names:
R8779 (G1)
Major Collection:

Strain Information

Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Gm4392, Ankyrin-B, Ank-2, Ankyrin-2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Itch
Name: itchy, E3 ubiquitin protein ligase
Synonyms: AIP4, 6720481N21Rik, C230047C07Rik, 8030492O04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16396
Homologene: 88442
Dip2c
Name: disco interacting protein 2 homolog C
Synonyms: 2900024P20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 208440
Homologene: 40996
Ambra1
Name: autophagy/beclin 1 regulator 1
Synonyms: D030051N19Rik, 2310079H06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228361
Homologene: 18204
Kazn
Name: kazrin, periplakin interacting protein
Synonyms: 2310007B04Rik, 9030409G11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71529
Homologene: 16235
Rexo1
Name: REX1, RNA exonuclease 1
Synonyms: 1700021P10Rik, Rex1, 2610511M11Rik, Tceb3bp1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66932
Homologene: 41391
Thoc1
Name: THO complex 1
Synonyms: 3110002N20Rik, NMP-84
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225160
VEGA: 18
Homologene: 38012
Eif3c
Name: eukaryotic translation initiation factor 3, subunit C
Synonyms: NIPIL(A3), Xsl, Eif3s8, 3230401O13Rik, Xs, 110kDa
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56347
Homologene: 2781
Arid1b
Name: AT-rich interaction domain 1B
Synonyms: 9330189K18Rik, B230217J03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 239985
Homologene: 32344
Gcfc2
Name: GC-rich sequence DNA binding factor 2
Synonyms: AW146020
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330361
HGNC: HGNC:1317
Homologene: 2411
Rmnd5b
Name: required for meiotic nuclear division 5 homolog B
Synonyms: 0610039K22Rik, Gid2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66089
Homologene: 100777
Ahsa1
Name: AHA1, activator of heat shock protein ATPase 1
Synonyms: p38, Aha1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217737
VEGA: 12
HGNC: HGNC:1189
Homologene: 8106
Adap1
Name: ArfGAP with dual PH domains 1
Synonyms: 4930431P11Rik, Centa1, centaurin alpha 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231821
Homologene: 55997
Smpd3
Name: sphingomyelin phosphodiesterase 3, neutral
Synonyms: fro, neutral sphingomyelinase II, nSMase2, Nsm2, 4631433G07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 58994
Homologene: 10260
Scn1a
Name: sodium channel, voltage-gated, type I, alpha
Synonyms: Nav1.1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20265
Homologene: 21375
Myo3a
Name: myosin IIIA
Synonyms: 9030416P08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 667663
HGNC: HGNC:7601
Homologene: 49486
Or8g52
Name: olfactory receptor family 8 subfamily G member 52
Synonyms: GA_x6K02T2PVTD-33416730-33417668, Olfr965, MOR171-28
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258165
VEGA: 9
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329628
Homologene: 14377
Snrk
Name: SNF related kinase
Synonyms: SNRK, 2010012F07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20623
Homologene: 9797
Jakmip1
Name: janus kinase and microtubule interacting protein 1
Synonyms: Gababrbp, Marlin-1, 5830437M04Rik, C330021K24Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76071
Homologene: 90789
Sdk1
Name: sidekick cell adhesion molecule 1
Synonyms: 6720466O15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330222
Homologene: 27395
Zfp536
Name: zinc finger protein 536
Synonyms: 9630010P11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243937
Homologene: 8813
Irag2
Name: inositol 1,4,5-triphosphate receptor associated 2
Synonyms: D6Int5, Jaw1, Lrmp, D6Int7, D6Int8, D6Int4, D6Int3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16970
HGNC: HGNC:6690
Homologene: 4483
Cntn5
Name: contactin 5
Synonyms: NB-2, 6720426O10Rik, A830025P08Rik, LOC244683
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244682
HGNC: HGNC:2175
Homologene: 28447
Idh1
Name: isocitrate dehydrogenase 1 (NADP+), soluble
Synonyms: Id-1, E030024J03Rik, IDPc, Idh-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15926
HGNC: HGNC:5382
Homologene: 21195
Or5ae1
Name: olfactory receptor family 5 subfamily AE member 1
Synonyms: Olfr290, MOR254-1, GA_x6K02T2NHDJ-11170115-11169168
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258411
Homologene: 83130
Vmn2r81
Name: vomeronasal 2, receptor 81
Synonyms: pheromone recepter, V2rf2, EC1-VR2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216144
Homologene: 83483
Usp16
Name: ubiquitin specific peptidase 16
Synonyms: 1200004E02Rik, UBP-M, 2810483I07Rik, 6330514E22Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74112
Homologene: 38183
Galnt7
Name: polypeptide N-acetylgalactosaminyltransferase 7
Synonyms: ppGaNTase-T7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 108150
HGNC: HGNC:4129
Homologene: 9685
Cpox
Name: coproporphyrinogen oxidase
Synonyms: Cpo, M100835, clone 560, cac, nct
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12892
VEGA: 16
HGNC: HGNC:2321
Homologene: 76
Npas2
Name: neuronal PAS domain protein 2
Synonyms: bHLHe9, MOP4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18143
HGNC: HGNC:7895
Homologene: 1887
Gem
Name: GTP binding protein overexpressed in skeletal muscle
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14579
HGNC: HGNC:4234
Homologene: 38024
Or5v1
Name: olfactory receptor family 5 subfamily V member 1
Synonyms: GA_x6K02T2PSCP-1956307-1957260, MOR249-2, Olfr110
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258325
Homologene: 73968
Gm3248
Name: predicted gene 3248
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100041279
Homologene: 115686
Igkv14-130
Name: immunoglobulin kappa variable 14-130
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 628072
Pcdhgb4
Name: protocadherin gamma subfamily B, 4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93701
HGNC: HGNC:8711
Homologene: 74507
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 39,338,186 bp
  • CA to CAA, chromosome 1 at 65,165,188 bp
  • C to A, chromosome 2 at 22,245,593 bp
  • C to T, chromosome 2 at 66,350,913 bp
  • A to G, chromosome 2 at 91,917,374 bp
  • T to A, chromosome 2 at 155,172,520 bp
  • A to T, chromosome 3 at 38,979,749 bp
  • A to T, chromosome 3 at 126,965,102 bp
  • T to C, chromosome 4 at 11,711,166 bp
  • T to C, chromosome 4 at 142,154,545 bp
  • G to C, chromosome 5 at 37,229,328 bp
  • C to A, chromosome 5 at 139,273,418 bp
  • T to C, chromosome 5 at 141,962,702 bp
  • T to A, chromosome 6 at 67,791,327 bp
  • C to T, chromosome 6 at 81,948,317 bp
  • A to G, chromosome 6 at 145,138,199 bp
  • T to A, chromosome 7 at 37,568,267 bp
  • A to G, chromosome 7 at 84,916,189 bp
  • T to C, chromosome 7 at 126,563,728 bp
  • T to C, chromosome 8 at 57,584,211 bp
  • A to G, chromosome 8 at 106,265,489 bp
  • A to T, chromosome 9 at 10,171,915 bp
  • A to G, chromosome 9 at 39,719,340 bp
  • T to C, chromosome 9 at 122,166,622 bp
  • G to A, chromosome 10 at 79,267,384 bp
  • A to G, chromosome 10 at 80,548,458 bp
  • T to C, chromosome 11 at 51,627,632 bp
  • A to G, chromosome 12 at 87,273,199 bp
  • T to C, chromosome 13 at 9,610,809 bp
  • A to T, chromosome 14 at 5,943,869 bp
  • G to C, chromosome 16 at 58,670,866 bp
  • A to G, chromosome 16 at 87,479,409 bp
  • G to A, chromosome 17 at 5,341,534 bp
  • A to G, chromosome 17 at 37,498,827 bp
  • A to G, chromosome 18 at 9,993,366 bp
  • G to T, chromosome 18 at 37,721,782 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8779 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068721-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.