Strain Name:
C57BL/6J-MtgxR8958Btlr/Mmmh
Stock Number:
068794-MU
Citation ID:
RRID:MMRRC_068794-MU
Other Names:
R8958 (G1)
Major Collection:

Strain Information

Zmpste24
Name: zinc metallopeptidase, STE24
Synonyms: A530043O15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230709
Homologene: 4277
Ptx3
Name: pentraxin related gene
Synonyms: pentraxin 3, TSG-14
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19288
HGNC: HGNC:9692
Homologene: 7500
Cr1l
Name: complement C3b/C4b receptor 1 like
Synonyms: mCRY, Crry
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12946
Homologene: 128275
Adck2
Name: aarF domain containing kinase 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 57869
Homologene: 49103
E2f7
Name: E2F transcription factor 7
Synonyms: A630014C11Rik, E2F7, D10Ertd739e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52679
Homologene: 18685
Cltc
Name: clathrin heavy chain
Synonyms: CHC
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67300
HGNC: HGNC:2092
Homologene: 3572
Tcf3
Name: transcription factor 3
Synonyms: Pan2, ALF2, E2A, A1, E47, Tcfe2a, E12, bHLHb21, Pan1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21423
Homologene: 2408
Cdc5l
Name: cell division cycle 5-like
Synonyms: 1200002I02Rik, PCDC5RP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71702
VEGA: 17
HGNC: HGNC:1743
Homologene: 13291
Trappc8
Name: trafficking protein particle complex 8
Synonyms: 5033403J15Rik, Trs85, D030074E01Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 75964
VEGA: 18
Homologene: 40993
Parn
Name: poly(A)-specific ribonuclease (deadenylation nuclease)
Synonyms: DAN, 1200003I18Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74108
VEGA: 16
HGNC: HGNC:8609
Homologene: 31098
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: 9930018I23Rik, MAP1C, Swl, Dnec1, Loa, Dnchc1, dynein heavy chain, retrograde transport
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Cenpf
Name: centromere protein F
Synonyms: mitosin, Lek1, 6530404A22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108000
HGNC: HGNC:1857
Homologene: 22969
Eif3b
Name: eukaryotic translation initiation factor 3, subunit B
Synonyms: D5Wsu45e, Eif3s9, EIF3-P116
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27979
HGNC: HGNC:3280
Homologene: 2780
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: enaptin165, nesprin-1, A330049M09Rik, C130039F11Rik, SYNE-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Grm7
Name: glutamate receptor, metabotropic 7
Synonyms: Gpr1g, E130018M02Rik, mGluR7, mGlu7a receptor, 6330570A01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108073
HGNC: HGNC:4599
Homologene: 20233
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Arhgef17
Name: Rho guanine nucleotide exchange factor 17
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 207212
Homologene: 129601
Crebbp
Name: CREB binding protein
Synonyms: KAT3A, CBP
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12914
HGNC: HGNC:2348
Homologene: 68393
Ccdc187
Name: coiled-coil domain containing 187
Synonyms: 4932418E24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329366
Homologene: 77630
Chrdl2
Name: chordin-like 2
Synonyms: Chl2, 1810022C01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69121
Homologene: 128795
H2-M5
Name: histocompatibility 2, M region locus 5
Synonyms: D130003B22Rik, CRW2, H-2M5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240095
Homologene: 128812
Glg1
Name: golgi apparatus protein 1
Synonyms: CFR, Selel, CFR-1, MG-160, MG160, ESL-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20340
HGNC: HGNC:4316
Homologene: 7533
Adam17
Name: a disintegrin and metallopeptidase domain 17
Synonyms: CD156b, Tace
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 11491
HGNC: HGNC:195
Homologene: 2395
Ino80
Name: INO80 complex subunit
Synonyms: 2310079N15Rik, INO80, Inoc1, 4632409L19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68142
Homologene: 75070
Cachd1
Name: cache domain containing 1
Synonyms: Vwcd1, 1190007F10Rik, B430218L07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320508
Homologene: 10854
Kdm4a
Name: lysine (K)-specific demethylase 4A
Synonyms: Jmjd2, Jmjd2a, JHDM3A, D4Ertd222e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230674
Homologene: 27780
H3c6
Name: H3 clustered histone 6
Synonyms: H3-f, Hist1h3e, H3.1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319151
Homologene: 134496
Pax1
Name: paired box 1
Synonyms: wt, hbs, hunchback, wavy tail, Pax-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18503
HGNC: HGNC:8615
Homologene: 4514
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Pico, Acz
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26875
Homologene: 69111
Ptpn13
Name: protein tyrosine phosphatase, non-receptor type 13
Synonyms: PTPL1, PTP-BL, Ptpri
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19249
HGNC: HGNC:9646
Homologene: 7909
Naip5
Name: NLR family, apoptosis inhibitory protein 5
Synonyms: Naip-rs3, Lgn1, Birc1e
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17951
HGNC: HGNC:7634
Homologene: 113589
Adgrb3
Name: adhesion G protein-coupled receptor B3
Synonyms: Bai3, A830096D10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210933
HGNC: HGNC:945
Homologene: 1289
Prdm1
Name: PR domain containing 1, with ZNF domain
Synonyms: Blimp1, Blimp-1, PRDI-BF1, b2b1765Clo
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12142
HGNC: HGNC:9346
Homologene: 925
Lrrc7
Name: leucine rich repeat containing 7
Synonyms: densin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242274
Homologene: 10817
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: OTTMUSG00000005786, LOC380698
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Gbe1
Name: 1,4-alpha-glucan branching enzyme 1
Synonyms: D16Ertd536e, 2310045H19Rik, 2810426P10Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74185
HGNC: HGNC:4180
Homologene: 129
Arvcf
Name: armadillo repeat gene deleted in velocardiofacial syndrome
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11877
HGNC: HGNC:728
Homologene: 31046
Rab11fip1
Name: RAB11 family interacting protein 1 (class I)
Synonyms: 4833414G05Rik, 2010200K21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75767
Homologene: 11853
Ros1
Name: Ros1 proto-oncogene
Synonyms: Ros-1, c-ros
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19886
Homologene: 2207
Fbxw14
Name: F-box and WD-40 domain protein 14
Synonyms: Fbxo12, Fbx12, E330009N23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 50757
Homologene: 110776
Hycc1
Name: hyccin PI4KA lipid kinase complex subunit 1
Synonyms: hyccin, Fam126a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 84652
Homologene: 57175
Ephb1
Name: Eph receptor B1
Synonyms: Net, Elkh, Elk, C130099E04Rik, Hek6, Cek6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270190
HGNC: HGNC:3392
Homologene: 20936
Trim46
Name: tripartite motif-containing 46
Synonyms: TRIFIC
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 360213
Homologene: 11815
Or10d1
Name: olfactory receptor family 10 subfamily D member 1
Synonyms: Olfr959, GA_x6K02T2PVTD-33270211-33269276, MOR224-3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258501
VEGA: 9
Homologene: 71989
Gp1ba
Name: glycoprotein 1b, alpha polypeptide
Synonyms: GP Ib-alpha, GPIb-alpha, GPIba
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14723
HGNC: HGNC:4439
Homologene: 143
Il18rap
Name: interleukin 18 receptor accessory protein
Synonyms: AcPL accessory protein-like)
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16174
HGNC: HGNC:5989
Homologene: 2859
Ccdc28a
Name: coiled-coil domain containing 28A
Synonyms: 1700009P13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215814
Homologene: 56705
Lipo2
Name: lipase, member O2
Synonyms: Gm8981
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 101055671
Homologene: 103863
Or4k48
Name: olfactory receptor family 4 subfamily K member 48
Synonyms: MOR248-6, GA_x6K02T2Q125-72697413-72696475, Olfr1298
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258888
Homologene: 121521
Ism1
Name: isthmin 1, angiogenesis inhibitor
Synonyms: 5430433G21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 319909
Homologene: 19061
Ppp2r3a
Name: protein phosphatase 2, regulatory subunit B'', alpha
Synonyms: 3222402P14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235542
HGNC: HGNC:9307
Homologene: 20595
Foxg1
Name: forkhead box G1
Synonyms: Hfh9, 2900064B05Rik, BF-1, Bf1, Hfhbf1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 15228
HGNC: HGNC:3811
Homologene: 3843
Mkrn2os
Name: makorin, ring finger protein 2, opposite strand
Synonyms: 2510049J12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70291
Homologene: 66298
Brdt
Name: bromodomain, testis-specific
Synonyms: Fsrg3, 7420412D09Rik, Brd6
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 114642
HGNC: HGNC:1105
Homologene: 21064
Myzap
Name: myocardial zonula adherens protein
Synonyms: Myozap, Gcom1, Grinl1a7
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102371
Homologene: 134156
Ch25h
Name: cholesterol 25-hydroxylase
Synonyms: m25OH
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12642
VEGA: 19
HGNC: HGNC:1907
Homologene: 2942
Tmem215
Name: transmembrane protein 215
Synonyms: A930001M12Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320500
Homologene: 27946
Zfp513
Name: zinc finger protein 513
Synonyms: D430028M17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 101023
Homologene: 16955
Naa11
Name: N(alpha)-acetyltransferase 11, NatA catalytic subunit
Synonyms: Ard1b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 97243
Homologene: 39206
Wdr97
Name: WD repeat domain 97
Synonyms: Gm35339
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 102638882
Homologene: 131539
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 25,826,109 bp
  • C to T, chromosome 1 at 40,543,017 bp
  • A to T, chromosome 1 at 189,653,153 bp
  • C to G, chromosome 1 at 195,129,935 bp
  • A to C, chromosome 2 at 26,275,565 bp
  • T to C, chromosome 2 at 111,645,725 bp
  • C to T, chromosome 2 at 119,383,381 bp
  • T to A, chromosome 2 at 139,732,075 bp
  • T to A, chromosome 2 at 147,368,597 bp
  • T to C, chromosome 2 at 180,193,799 bp
  • G to A, chromosome 3 at 66,220,970 bp
  • T to C, chromosome 3 at 89,236,453 bp
  • T to C, chromosome 3 at 158,240,501 bp
  • A to G, chromosome 4 at 40,474,376 bp
  • A to G, chromosome 4 at 100,994,086 bp
  • A to G, chromosome 4 at 118,142,376 bp
  • C to A, chromosome 4 at 121,087,311 bp
  • A to T, chromosome 5 at 14,675,355 bp
  • A to G, chromosome 5 at 14,713,042 bp
  • A to G, chromosome 5 at 23,964,936 bp
  • C to A, chromosome 5 at 31,199,481 bp
  • T to C, chromosome 5 at 97,392,225 bp
  • T to C, chromosome 5 at 103,551,107 bp
  • T to C, chromosome 5 at 107,378,011 bp
  • A to G, chromosome 5 at 140,425,439 bp
  • T to C, chromosome 6 at 39,583,914 bp
  • C to T, chromosome 6 at 111,495,822 bp
  • G to C, chromosome 6 at 115,585,356 bp
  • C to A, chromosome 7 at 100,020,922 bp
  • T to C, chromosome 7 at 100,929,812 bp
  • T to C, chromosome 8 at 27,154,912 bp
  • A to T, chromosome 8 at 111,172,484 bp
  • T to C, chromosome 9 at 39,572,795 bp
  • G to T, chromosome 9 at 71,550,203 bp
  • A to T, chromosome 9 at 101,211,435 bp
  • A to G, chromosome 9 at 102,195,415 bp
  • A to T, chromosome 9 at 109,278,742 bp
  • T to C, chromosome 10 at 5,231,768 bp
  • T to C, chromosome 10 at 18,214,178 bp
  • T to G, chromosome 10 at 44,440,733 bp
  • G to T, chromosome 10 at 52,096,094 bp
  • T to C, chromosome 10 at 80,410,257 bp
  • C to A, chromosome 10 at 110,765,754 bp
  • C to T, chromosome 11 at 59,073,332 bp
  • C to G, chromosome 11 at 70,640,904 bp
  • A to T, chromosome 11 at 86,695,577 bp
  • A to T, chromosome 12 at 21,349,933 bp
  • T to C, chromosome 12 at 49,385,161 bp
  • G to A, chromosome 12 at 110,620,371 bp
  • T to C, chromosome 13 at 23,562,247 bp
  • T to A, chromosome 13 at 100,217,609 bp
  • A to T, chromosome 15 at 76,361,494 bp
  • G to A, chromosome 16 at 4,213,308 bp
  • T to A, chromosome 16 at 13,648,458 bp
  • A to G, chromosome 16 at 18,402,626 bp
  • T to C, chromosome 16 at 70,478,322 bp
  • T to A, chromosome 17 at 36,988,628 bp
  • T to C, chromosome 17 at 45,393,201 bp
  • T to C, chromosome 18 at 20,870,610 bp
  • T to A, chromosome 19 at 33,720,961 bp
  • A to T, chromosome 19 at 34,475,014 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8958 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068794-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.