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Strain Name:
C57BL/6J-MtgxR9049Btlr/Mmmh
Stock Number:
068875-MU
Citation ID:
RRID:MMRRC_068875-MU
Other Names:
R9049 (G1)
Major Collection:

Strain Information

Polr3e
Name: polymerase (RNA) III (DNA directed) polypeptide E
Synonyms: RPC5, Sin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26939
Homologene: 14052
Prkacb
Name: protein kinase, cAMP dependent, catalytic, beta
Synonyms: cAMP-dependent protein kinase C beta, Pkacb
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18749
HGNC: HGNC:9381
Homologene: 121718
Htr3a
Name: 5-hydroxytryptamine (serotonin) receptor 3A
Synonyms: 5-HT3 receptor
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15561
VEGA: 9
HGNC: HGNC:5297
Homologene: 671
Vcan
Name: versican
Synonyms: PG-M, hdf, heart defect, 5430420N07Rik, Cspg2, DPEAAE
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Bpifb3
Name: BPI fold containing family B, member 3
Synonyms: Rya3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 378700
Homologene: 18807
Pipox
Name: pipecolic acid oxidase
Synonyms: Pso
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19193
Homologene: 40640
Aopep
Name: aminopeptidase O
Synonyms: ApO, 2010111I01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72061
HGNC: HGNC:1361
Homologene: 66273
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 11,185,906 bp
  • T to C, chromosome 1 at 43,953,342 bp
  • T to A, chromosome 1 at 90,779,344 bp
  • A to G, chromosome 1 at 120,188,170 bp
  • C to G, chromosome 2 at 37,219,947 bp
  • A to G, chromosome 2 at 85,983,891 bp
  • A to T, chromosome 2 at 120,679,937 bp
  • C to A, chromosome 2 at 153,925,890 bp
  • A to G, chromosome 2 at 154,228,176 bp
  • T to C, chromosome 3 at 35,897,849 bp
  • T to C, chromosome 3 at 89,007,364 bp
  • T to A, chromosome 3 at 145,027,382 bp
  • A to T, chromosome 3 at 146,755,763 bp
  • T to A, chromosome 3 at 151,835,767 bp
  • T to A, chromosome 4 at 21,854,391 bp
  • A to G, chromosome 4 at 35,192,964 bp
  • C to A, chromosome 4 at 43,549,786 bp
  • G to T, chromosome 4 at 64,000,010 bp
  • T to C, chromosome 4 at 144,273,916 bp
  • T to C, chromosome 5 at 4,064,597 bp
  • T to A, chromosome 5 at 121,313,892 bp
  • A to G, chromosome 6 at 34,396,626 bp
  • A to G, chromosome 6 at 48,597,712 bp
  • A to C, chromosome 6 at 73,142,292 bp
  • A to G, chromosome 6 at 142,682,932 bp
  • T to A, chromosome 7 at 3,816,891 bp
  • T to C, chromosome 7 at 12,684,981 bp
  • C to T, chromosome 7 at 27,535,868 bp
  • A to G, chromosome 7 at 46,066,173 bp
  • T to C, chromosome 7 at 114,266,529 bp
  • A to G, chromosome 7 at 120,939,239 bp
  • A to C, chromosome 7 at 141,808,975 bp
  • T to C, chromosome 8 at 34,841,778 bp
  • T to C, chromosome 8 at 86,709,107 bp
  • T to C, chromosome 9 at 19,845,749 bp
  • G to T, chromosome 9 at 40,000,623 bp
  • C to A, chromosome 9 at 48,899,787 bp
  • G to A, chromosome 10 at 8,307,454 bp
  • C to A, chromosome 10 at 81,316,876 bp
  • C to T, chromosome 10 at 118,146,700 bp
  • G to C, chromosome 11 at 50,952,121 bp
  • A to T, chromosome 11 at 67,695,742 bp
  • A to G, chromosome 11 at 74,270,289 bp
  • A to G, chromosome 11 at 77,881,554 bp
  • G to A, chromosome 11 at 119,209,264 bp
  • T to A, chromosome 13 at 27,276,184 bp
  • A to G, chromosome 13 at 63,061,038 bp
  • G to T, chromosome 13 at 84,294,635 bp
  • A to T, chromosome 13 at 89,678,105 bp
  • T to C, chromosome 13 at 98,259,270 bp
  • G to T, chromosome 14 at 25,694,412 bp
  • T to A, chromosome 14 at 26,722,120 bp
  • C to A, chromosome 14 at 68,525,225 bp
  • T to C, chromosome 15 at 59,317,862 bp
  • A to G, chromosome 16 at 22,600,588 bp
  • T to G, chromosome 16 at 59,110,400 bp
  • A to G, chromosome 17 at 29,160,358 bp
  • T to A, chromosome 17 at 32,486,991 bp
  • G to A, chromosome 17 at 37,903,873 bp
  • C to A, chromosome 17 at 47,824,554 bp
  • T to C, chromosome 17 at 55,785,094 bp
  • G to A, chromosome 17 at 57,741,831 bp
  • A to G, chromosome 17 at 85,402,484 bp
  • A to T, chromosome 18 at 57,921,791 bp
  • C to T, chromosome 19 at 6,849,074 bp
  • A to T, chromosome 19 at 48,026,718 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9049 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068875-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.